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  1. Article: Effects of chronic specific urogenital infections on contractility of the human isolated pregnant myometrium.

    Zefirova, Julia T / Zefirova, Tatiana P / Ziganshina, Lilia E / Ziganshin, Airat U

    Autonomic neuroscience : basic & clinical

    2002  Volume 99, Issue 1, Page(s) 58–61

    Abstract: The contractile activity of the isolated myometrium of pregnant women with mycoplasma, chlamydia and mixed infections has been studied by pharmacological organ bath method. We found that mycoplasma infection decreased while chlamydia or mixed infection ... ...

    Abstract The contractile activity of the isolated myometrium of pregnant women with mycoplasma, chlamydia and mixed infections has been studied by pharmacological organ bath method. We found that mycoplasma infection decreased while chlamydia or mixed infection increased myometrium contraction evoked by oxytocin or prostaglandin F2alpha. The results of this study could be important for the prediction of possible complications during pregnancy and labour in women with chronic specific urogenital infections.
    MeSH term(s) Chlamydia Infections/microbiology ; Chlamydia Infections/physiopathology ; Chronic Disease ; Dinoprost/pharmacology ; Down-Regulation/drug effects ; Down-Regulation/physiology ; Female ; Histamine/pharmacology ; Humans ; Mycoplasma Infections/microbiology ; Mycoplasma Infections/physiopathology ; Myometrium/drug effects ; Myometrium/microbiology ; Myometrium/physiopathology ; Organ Culture Techniques ; Oxytocin/pharmacology ; Potassium Chloride/pharmacology ; Pregnancy ; Pregnancy Complications, Infectious/microbiology ; Pregnancy Complications, Infectious/physiopathology ; Up-Regulation/drug effects ; Up-Regulation/physiology ; Uterine Contraction/drug effects ; Uterine Contraction/immunology
    Chemical Substances Oxytocin (50-56-6) ; Potassium Chloride (660YQ98I10) ; Histamine (820484N8I3) ; Dinoprost (B7IN85G1HY)
    Language English
    Publishing date 2002-08-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/s1566-0702(02)00058-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1533: Show issues Location:
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  2. Article: Potentiation of uterine effects of prostaglandin F2{alpha} by adenosine 5'-triphosphate.

    Ziganshin, Airat U / Zefirova, Julia T / Zefirova, Tatiana P / Ziganshina, Lilia E / Hoyle, Charles H V / Burnstock, Geoffrey

    Obstetrics and gynecology

    2005  Volume 105, Issue 6, Page(s) 1429–1436

    Abstract: Objective: To investigate the interaction of exogenous adenosine 5'-triphosphate (ATP), a P2 receptor agonist, with prostaglandin F(2alpha) (PGF(2alpha)) on pregnant women in labor as well as on isolated human pregnant uterus preparations.: Methods: ... ...

    Abstract Objective: To investigate the interaction of exogenous adenosine 5'-triphosphate (ATP), a P2 receptor agonist, with prostaglandin F(2alpha) (PGF(2alpha)) on pregnant women in labor as well as on isolated human pregnant uterus preparations.
    Methods: For an in vitro study, myometrial samples were obtained from 27 women undergoing elective cesarean delivery at term. Concentration-response relationships for ATP (10(-8) -3 x 10(-4) mol/L), PGF(2alpha) (10(-9) -10(-5) mol/L), and their combination were obtained by using routine pharmacological organ bath technique. An in vivo study was performed with 34 pregnant women with dysfunctional abnormalities of the active stage of labor who were randomly allocated into 2 study groups. The women in the control group (18 patients) received intravenous prostaglandin F(2alpha) at an initial rate of 7.5 mug/min, whereas the women in the ATP group (16 patients) received prostaglandin F(2alpha) concomitantly with ATP (0.45 nmol/min, intravenously).
    Results: Adenosine 5'-triphosphate at concentrations of 10(-6) -3 x 10(-4) mol/L and PGF(2alpha) at concentrations of 10(-8) -10(-5) mol/L caused concentration-dependent contractions of isolated smooth muscle preparations of the human pregnant uterus. At concentrations of 10(-6) mol/L and below, ATP had no effects on mechanical activity of the isolated uterus, but at concentrations of 10(-7) mol/L and 10(-6) mol/L, it significantly potentiated the contractile responses of the uterus induced by PGF(2alpha) (P < .05, 2-way analysis of variance). Patients receiving intravenous infusion of ATP as a supplement to PGF(2alpha) treatment, compared with those without ATP, had a significantly shorter interval from the start of the treatment to full cervical dilatation (3.31 +/- 1.49 hours and 4.67 +/- 1.11 hours in ATP and control groups, respectively; P = .014, Wilcoxon Mann-Whitney test). The total dose of prostaglandin received was significantly lower in the ATP group than that of controls (1,489.8 +/- 699.9 mug and 3,394.2 +/- 1,951.9 mug, respectively; P = .003, Wilcoxon Mann-Whitney test). No side effects of ATP treatment were observed during or after infusion.
    Conclusion: Adenosine 5'-triphosphate potentiates effects of PGF(2alpha) on pregnant human uterus in vitro and in vivo and thus could be a useful supplemental drug to increase uterine contractility at labor.
    MeSH term(s) Adenosine Triphosphate/administration & dosage ; Adenosine Triphosphate/pharmacology ; Dinoprost/administration & dosage ; Dinoprost/pharmacology ; Drug Synergism ; Female ; Humans ; In Vitro Techniques ; Pregnancy ; Purinergic P2 Receptor Agonists ; Uterine Contraction/drug effects ; Uterine Inertia/drug therapy ; Uterus/drug effects
    Chemical Substances Purinergic P2 Receptor Agonists ; Adenosine Triphosphate (8L70Q75FXE) ; Dinoprost (B7IN85G1HY)
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207330-4
    ISSN 1873-233X ; 0029-7844
    ISSN (online) 1873-233X
    ISSN 0029-7844
    DOI 10.1097/01.AOG.0000161314.50808.dd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um I Zs.230: Show issues Location:
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