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  1. AU="Zeiler, Frederick A"
  2. AU="de la Cueva, Pablo"
  3. AU="Fuh, Jerry Ying Hsi"
  4. AU="Park, Adrian J"
  5. AU="Joshi, K D"

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  1. Article ; Online: Advanced Bio-signal Analytics for Continuous Bedside Monitoring of Aneurysmal Subarachnoid Hemorrhage: The Future.

    Zeiler, Frederick A

    Neurocritical care

    2021  Volume 34, Issue 2, Page(s) 375–378

    MeSH term(s) Humans ; Intracranial Aneurysm/complications ; Intracranial Aneurysm/diagnosis ; Subarachnoid Hemorrhage/diagnosis
    Language English
    Publishing date 2021-01-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-020-01170-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6538: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Point-of-Care Noninvasive Assessments of Cerebrovascular Reactivity in Traumatic Brain Injury: Integrating the Physiome with Clinical Phenotype.

    Zeiler, Frederick A

    Annals of neurology

    2021  Volume 90, Issue 1, Page(s) 19–21

    MeSH term(s) Brain Injuries, Traumatic/diagnostic imaging ; Humans ; Intracranial Pressure ; Patient-Specific Modeling ; Phenotype ; Point-of-Care Systems
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26092
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1370: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 478: Show issues

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  3. Article ; Online: Identifying the Cerebral Physiologic Response to Aerobic Exercise Following Concussion: A Scoping Review.

    Cordingley, Dean M / Gomez, Alwyn / Ellis, Michael / Zeiler, Frederick A

    The Journal of head trauma rehabilitation

    2024  

    Abstract: Objective: The purpose of this study was to identify the cerebral physiologic response to aerobic exercise in individuals with a symptomatic concussion, highlighting available knowledge and knowledge gaps in the literature.: Design: A systematic ... ...

    Abstract Objective: The purpose of this study was to identify the cerebral physiologic response to aerobic exercise in individuals with a symptomatic concussion, highlighting available knowledge and knowledge gaps in the literature.
    Design: A systematic scoping review was conducted and reported in keeping with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. A search of EMBASE, MEDLINE, SCOPUS, BIOSIS, and Cochrane libraries was conducted on June 15, 2023 (from database inception). An online systematic/scoping review management system was used to remove duplicates, and the remaining articles were screened for inclusion by 2 researchers. Inclusion criteria required articles to be original research published in peer-reviewed journals. Additionally, studies were required to have an aerobic exercise component, include a measure of cerebral physiology during a bout of aerobic exercise, exclude moderate and/or severe traumatic brain injury (TBI) populations, and be in the English language. Both human and animal studies were included, with participants of any age who were diagnosed with a mild TBI/concussion only (ie, Glasgow Coma Scale score ≥ 13). Studies could be of any design as long as a measure of cerebral physiologic response to a bout of aerobic exercise was included.
    Results: The search resulted in 1773 articles to be screened and data from 3 eligible studies were extracted.
    Conclusions: There are currently too few studies investigating the cerebral physiologic response to aerobic exercise following concussion or mild TBI to draw definitive conclusions. Further research on this topic is necessary since understanding the cerebral physiologic response to aerobic exercise in the concussion and mild TBI populations could assist in optimizing exercise-based treatment prescription and identifying other targeted therapies.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639221-0
    ISSN 1550-509X ; 0885-9701
    ISSN (online) 1550-509X
    ISSN 0885-9701
    DOI 10.1097/HTR.0000000000000930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: A Promising New Noninvasive Measure of Cerebrovascular Reactivity: Not Yet Cerebral Autoregulation.

    Zeiler, Frederick A

    Neurocritical care

    2018  Volume 29, Issue 2, Page(s) 317–318

    MeSH term(s) Cerebrovascular Circulation ; Homeostasis ; Prospective Studies
    Language English
    Publishing date 2018-08-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-018-0592-y
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    Zs.A 6538: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Cerebral Perfusion Pressure Targets in Traumatic Brain Injury: The "Fuzzy" Spots Above Optimal Cerebral Perfusion Pressure.

    Zeiler, Frederick A

    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

    2018  Volume 45, Issue 6, Page(s) 721–722

    MeSH term(s) Brain Injuries, Traumatic ; Cerebrovascular Circulation ; Humans ; Respiratory Distress Syndrome, Adult
    Language English
    Publishing date 2018-11-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 197622-9
    ISSN 0317-1671
    ISSN 0317-1671
    DOI 10.1017/cjn.2018.337
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1203: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Non-Invasive Continuous Cerebrovascular Monitoring for Subacute Bedside and Outpatient Settings: An Important Advancement.

    Gomez, Alwyn / Zeiler, Frederick A

    Neurotrauma reports

    2021  Volume 2, Issue 1, Page(s) 25–26

    Language English
    Publishing date 2021-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2689-288X
    ISSN (online) 2689-288X
    DOI 10.1089/neur.2020.0064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Winnipeg Intraspinal Pressure Monitoring Study (WISP): A protocol for validation of fiberoptic pressure monitoring for acute traumatic spinal cord injury.

    Dhaliwal, Perry / Wilkinson, Marshall / Zeiler, Frederick A

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0263499

    Abstract: Background: Research efforts have been focused on limiting secondary injury after traumatic spinal cord injury by performing spinal decompression and early optimization of spinal cord perfusion. The Winnipeg Intraspinal Pressure Monitoring Study (WISP) ... ...

    Abstract Background: Research efforts have been focused on limiting secondary injury after traumatic spinal cord injury by performing spinal decompression and early optimization of spinal cord perfusion. The Winnipeg Intraspinal Pressure Monitoring Study (WISP) was designed to validate the technique of intraspinal pressure monitoring at the site of injury using a fiberoptic pressure monitor placed at the site of injury.
    Objectives: To describe the design of the WISP study.
    Study design: Descriptive.
    Methods: We explain the current limitations in the available scientific literature around the topic of blood pressure management for acute traumatic spinal cord injury and rational for the WISP study. Then, we describe the design of WISP including the patient selection criteria, study interventions, follow up schedules and outcome measurements. A multitude of future research avenues are also discussed.
    Results: The WISP study is a single center pilot study designed to validate the technique of intraspinal pressure monitoring following acute traumatic spinal cord injury. The study involves the measurement of intraspinal pressure from within the subarachnoid space at the site of injury to derive a number of physiological parameters including spinal cord perfusion pressure, spinal cord blood volume, measures of spinal cord compliance and vascular reactivity indices. Twenty eligible patients will be recruited and followed for a period of 12 months with visits scheduled for the first 5 days and 1, 3, 6, and 12 months following surgical intervention.
    Conclusions: The WISP study will provide the first attempt in North America at validation of intraspinal pressure monitoring with a fiberoptic pressure monitor at the site of injury. Successful validation will lead to future studies to define optimal spinal cord perfusion pressure, relationships of neural injury biomarkers and outcomes as well as epigenetic studies.
    Trial registration: This study has been registered at clinicaltrials.gov (registration# NCT04550117).
    MeSH term(s) Cerebrospinal Fluid Pressure/physiology ; Humans ; Monitoring, Physiologic/methods ; Pilot Projects ; Spinal Cord Injuries
    Language English
    Publishing date 2022-09-20
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0263499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Non-Invasive Mapping of Cerebral Autoregulation Using Near-Infrared Spectroscopy: A Study Protocol.

    Sainbhi, Amanjyot Singh / Vakitbilir, Nuray / Gomez, Alwyn / Stein, Kevin Y / Froese, Logan / Zeiler, Frederick A

    Methods and protocols

    2023  Volume 6, Issue 3

    Abstract: The ability of cerebral vessels to maintain a fairly constant cerebral blood flow is referred to as cerebral autoregulation (CA). Using near-infrared spectroscopy (NIRS) paired with arterial blood pressure (ABP) monitoring, continuous CA can be assessed ... ...

    Abstract The ability of cerebral vessels to maintain a fairly constant cerebral blood flow is referred to as cerebral autoregulation (CA). Using near-infrared spectroscopy (NIRS) paired with arterial blood pressure (ABP) monitoring, continuous CA can be assessed non-invasively. Recent advances in NIRS technology can help improve the understanding of continuously assessed CA in humans with high spatial and temporal resolutions. We describe a study protocol for creating a new wearable and portable imaging system that derives CA maps of the entire brain with high sampling rates at each point. The first objective is to evaluate the CA mapping system's performance during various perturbations using a block-trial design in 50 healthy volunteers. The second objective is to explore the impact of age and sex on regional disparities in CA using static recording and perturbation testing in 200 healthy volunteers. Using entirely non-invasive NIRS and ABP systems, we hope to prove the feasibility of deriving CA maps of the entire brain with high spatial and temporal resolutions. The development of this imaging system could potentially revolutionize the way we monitor brain physiology in humans since it would allow for an entirely non-invasive continuous assessment of regional differences in CA and improve our understanding of the impact of the aging process on cerebral vessel function.
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2409-9279
    ISSN (online) 2409-9279
    DOI 10.3390/mps6030058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Statistical properties of cerebral near infrared and intracranial pressure-based cerebrovascular reactivity metrics in moderate and severe neural injury: a machine learning and time-series analysis.

    Gomez, Alwyn / Sainbhi, Amanjyot Singh / Stein, Kevin Y / Vakitbilir, Nuray / Froese, Logan / Zeiler, Frederick A

    Intensive care medicine experimental

    2023  Volume 11, Issue 1, Page(s) 57

    Abstract: Background: Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity are limited by their invasive ... ...

    Abstract Background: Cerebrovascular reactivity has been identified as a key contributor to secondary injury following traumatic brain injury (TBI). Prevalent intracranial pressure (ICP) based indices of cerebrovascular reactivity are limited by their invasive nature and poor spatial resolution. Fortunately, interest has been building around near infrared spectroscopy (NIRS) based measures of cerebrovascular reactivity that utilize regional cerebral oxygen saturation (rSO
    Methods: High-resolution physiologic data were collected in a cohort of adult moderate to severe TBI patients at a single quaternary care site. From this data both ICP- and rSO
    Results: A total of 83 patients with 428,775 min of unique and complete physiologic data were obtained. Through agglomerative hierarchical clustering and principal component analysis, there was higher order clustering between rSO
    Conclusions: rSO
    Language English
    Publishing date 2023-08-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00541-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current state of high-fidelity multimodal monitoring in traumatic brain injury.

    Lindblad, Caroline / Raj, Rahul / Zeiler, Frederick A / Thelin, Eric P

    Acta neurochirurgica

    2022  Volume 164, Issue 12, Page(s) 3091–3100

    Abstract: Introduction: Multimodality monitoring of patients with severe traumatic brain injury (TBI) is primarily performed in neuro-critical care units to prevent secondary harmful brain insults and facilitate patient recovery. Several metrics are commonly ... ...

    Abstract Introduction: Multimodality monitoring of patients with severe traumatic brain injury (TBI) is primarily performed in neuro-critical care units to prevent secondary harmful brain insults and facilitate patient recovery. Several metrics are commonly monitored using both invasive and non-invasive techniques. The latest Brain Trauma Foundation guidelines from 2016 provide recommendations and thresholds for some of these. Still, high-level evidence for several metrics and thresholds is lacking.
    Methods: Regarding invasive brain monitoring, intracranial pressure (ICP) forms the cornerstone, and pressures above 22 mmHg should be avoided. From ICP, cerebral perfusion pressure (CPP) (mean arterial pressure (MAP)-ICP) and pressure reactivity index (PRx) (a correlation between slow waves MAP and ICP as a surrogate for cerebrovascular reactivity) may be derived. In terms of regional monitoring, partial brain tissue oxygen pressure (PbtO
    Conclusions: In multimodal monitoring, the most important aspect is data interpretation, which requires knowledge of each metric's strengths and limitations. Combinations of several modalities might make it possible to discern specific pathologic states suitable for treatment. However, the cost-benefit should be considered as the incremental benefit of adding several metrics has a low level of evidence, thus warranting additional research.
    MeSH term(s) Humans ; Retrospective Studies ; Intracranial Pressure ; Brain Injuries, Traumatic/diagnostic imaging ; Brain Injuries, Traumatic/therapy ; Cerebrovascular Circulation ; Brain Injuries ; Monitoring, Physiologic/methods
    Language English
    Publishing date 2022-10-19
    Publishing country Austria
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-022-05383-8
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