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Article: Diffusion lung capacity of patients with arterial hypertension.

Zelenika, Diana / Karanović, Nenad

2009 Volume 33 Suppl 2, Page(s) 165–167

Abstract: The aim of this study was to investigate the diffusion lung capacity in patients with untreated hypertension. For this purpose, a total of 30 cases and 30 controls were included in the present study, which was based on several spirometry indicators in ... ...

Abstract	The aim of this study was to investigate the diffusion lung capacity in patients with untreated hypertension. For this purpose, a total of 30 cases and 30 controls were included in the present study, which was based on several spirometry indicators in the analysis. The measurements were based on "single breath approach". The results indicated that the two groups differed in several spirometry results, including vital capacity, maximum willing ventilation, but the overall lung diffusion capacity did not seem to be significantly different between cases and controls. The results suggest that although there is a strong link between respiratory and circulatory system, the overall lung diffusion capacity is not altered by the increased arterial pressure and hypertension. Furthermore, the results of this suggest the need for creation of the population-specific spirometry standards for the population of Herzegovina in order to provide more meaningful results of spirometry.
MeSH term(s)	Adult ; Bosnia and Herzegovina/epidemiology ; Case-Control Studies ; Health Status Indicators ; Humans ; Hypertension/epidemiology ; Hypertension/physiopathology ; Male ; Middle Aged ; Pulmonary Diffusing Capacity ; Spirometry
Language	English
Publishing date	2009-12
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	233430-6
ISSN	0350-6134 ; 0353-3735
ISSN	0350-6134 ; 0353-3735
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Article: Bolnicki ishod kod akutnog koronarnog sindroma u razdoblju 1987.-2001. u Zapadnohercegovackoj zupaniji--retrospektivna studija.

Vasilj, Ivan / Ostojić, Zdenko / Ostojić, Ljerka / Zelenika, D / Misković, J

Medicinski arhiv

2006 Volume 60, Issue 5, Page(s) 312–314

Abstract: Objective of the study is to show prevalence of hospital mortality of acute coronary syndrome in pre-war (1987-1991), war (1992-1996) and after war period (1997-2001) among inhabitants of West-Herzegovina canton living in the following municipalities: ... ...

Title translation	Hospital outcome in acute coronary syndrome in the period 1987-2001 in West-Herzegovina canton--retrospective study.
Abstract	Objective of the study is to show prevalence of hospital mortality of acute coronary syndrome in pre-war (1987-1991), war (1992-1996) and after war period (1997-2001) among inhabitants of West-Herzegovina canton living in the following municipalities: Siroki Brijeg, Posusje, Grude and Ljubuski (88,992 inhabitants). Collected were data on patients who were admitted in the hospital due to acute coronar syndrome (category I 20, 21, 22- X revision, ICD) in the above period in Mostar. Data were analyzed in regard to sex, age and disease output. Hospital morality in 15 year period for both sex were 15.0 %, men 12.1 %, and women 20.2 %. Statistically it was not found significant differences in the period 1987-2001 in regards to total hospital mortality of men and women and separate hospital mortality of men. Differences were found in women where considerable larger number was in pre-war and post-war period in comparison with war period. The largest hospital mortality was in total and for women in the pre-war period and for men was during the war period. The smallest hospital mortality was in total and for women during the war and for men in pre-war period. We find that lower hospital mortality in women was caused by lower hospital admission because of war time and problems with transport and that larger number of women deceased before admission to the hospital.
MeSH term(s)	Angina, Unstable/mortality ; Bosnia and Herzegovina/epidemiology ; Female ; Hospital Mortality ; Humans ; Male ; Myocardial Infarction/mortality ; Warfare
Language	Bosnian
Publishing date	2006
Publishing country	Bosnia and Herzegovina
Document type	English Abstract ; Journal Article
ZDB-ID	128782-5
ISSN	1986-5961 ; 0025-8083 ; 0350-199X
ISSN (online)	1986-5961
ISSN	0025-8083 ; 0350-199X
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Article ; Online: High-resolution autosomal radiation hybrid maps of the pig genome and their contribution to the genome sequence assembly.

Servin, Bertrand / Faraut, Thomas / Iannuccelli, Nathalie / Zelenika, Diana / Milan, Denis

BMC genomics

2012 Volume 13, Page(s) 585

Abstract: Background: The release of the porcine genome sequence offers great perspectives for Pig genetics and genomics, and more generally will contribute to the understanding of mammalian genome biology and evolution. The process of producing a complete genome ...

Abstract	Background: The release of the porcine genome sequence offers great perspectives for Pig genetics and genomics, and more generally will contribute to the understanding of mammalian genome biology and evolution. The process of producing a complete genome sequence of high quality, while facilitated by high-throughput sequencing technologies, remains a difficult task. The porcine genome was sequenced using a combination of a hierarchical shotgun strategy and data generated with whole genome shotgun. In addition to the BAC contig map used for the clone-by-clone approach, genomic mapping resources for the pig include two radiation hybrid (RH) panels at two different resolutions. These two panels have been used extensively for the physical mapping of pig genes and markers prior to the availability of the pig genome sequence. Results: In order to contribute to the assembly of the pig genome, we genotyped the two radiation hybrid (RH) panels with a SNP array (the Illumina porcineSNP60 array) and produced high density physical RH maps for each pig autosome. We first present the methods developed to obtain high density RH maps with 38,379 SNPs from the SNP array genotyping. We then show how they were useful to identify problems in a draft of the pig genome assembly, and how the RH maps enabled the problems to be corrected in the porcine genome sequence. Finally, we used the RH maps to predict the position of 2,703 SNPs and 1,328 scaffolds currently unplaced on the porcine genome assembly. Conclusions: A complete process, from genotyping of a high density SNP array on RH panels, to the construction of genome-wide high density RH maps, and finally their exploitation for validating and improving a genome assembly is presented here. The study includes the cross-validation of RH based findings with independent information from genetic data and comparative mapping with the Human genome. Several additional resources are also provided, in particular the predicted genomic location of currently unplaced SNPs and associated scaffolds summing up to a total of 72 megabases, that can be useful for the exploitation of the pig genome assembly.
MeSH term(s)	Animals ; Chromosomes/genetics ; Chromosomes/metabolism ; Genome ; Genotype ; Polymorphism, Single Nucleotide ; Radiation Hybrid Mapping ; Sequence Analysis, DNA ; Sus scrofa/genetics
Language	English
Publishing date	2012-11-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2164
ISSN (online)	1471-2164
DOI	10.1186/1471-2164-13-585
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Article: Prevalence and risk factors of the rheumatoid arthritis in Herzegovina region in 2003-2005.

Damjanović, Vesna / Vasilj, Ivan / Vlak, Tonko / Zelenika, Diana

Collegium antropologicum

2009 Volume 33 Suppl 2, Page(s) 73–77

Abstract: In this study we evidenced prevalence of the rheumatoid arthritis (RA) in Herzegovina region of the Bosnia and Herzegovina and studied selected RA risk factors. Sample of subjects comprised RA diagnosed subjects which were compared to randomly selected ... ...

Abstract	In this study we evidenced prevalence of the rheumatoid arthritis (RA) in Herzegovina region of the Bosnia and Herzegovina and studied selected RA risk factors. Sample of subjects comprised RA diagnosed subjects which were compared to randomly selected controls. In diagnosing the RA we used criteria for the classification of rheumatoid arthritis suggested by The American College of Rheumatology. Risk factors of RA included in this investigation were (1) educational status, (2) quality of nutrition, and (3) socioeconomic status. Average prevalence of the RA in our sample was 0.46/100, ranged from 0.36/100 to 0.64/100, which is comparable to other European samples. The RA occurrence is six times more often in females than in males. We have found indices that the Mediterranean diet has to be considered as protective factor against RA. Although RA occurrence is more frequent in the low socioeconomic samples of subjects, because of the methodological reasons we can not undoubtedly support the socioeconomic status as significant risk factor of the RA. Finally, it is interesting that we have found education level as risk factor significantly related to RA occurrence in our sample. All evidenced should be more precisely studied in some future study, while accurately controlling all relevant factors.
MeSH term(s)	Arthritis, Rheumatoid/epidemiology ; Arthritis, Rheumatoid/prevention & control ; Bosnia and Herzegovina/epidemiology ; Case-Control Studies ; Diet, Mediterranean ; Educational Status ; Female ; Humans ; Male ; Prevalence ; Risk Factors ; Sex Distribution ; Socioeconomic Factors
Language	English
Publishing date	2009-12
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	233430-6
ISSN	0350-6134 ; 0353-3735
ISSN	0350-6134 ; 0353-3735
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Article: Platelet receptor HPA-1 polymorphism of alphaIIbbeta3 and 807 C/T polymorphism of alpha2beta1 and Buerger's disease.

Ostojic, L / Zelenika, D / Zotz, R B / Sucker, C / Ostojic, Z / Loncar, R

Angiology

2007 Volume 58, Issue 2, Page(s) 169–174

Abstract: Thromboangiitis obliterans or Buerger's disease is an episodic and segmental inflammatory and thrombotic process of the medium and small arteries of the lower extremities. Even though the disease was described 90 years ago, the etiopathogenesis is still ... ...

Abstract	Thromboangiitis obliterans or Buerger's disease is an episodic and segmental inflammatory and thrombotic process of the medium and small arteries of the lower extremities. Even though the disease was described 90 years ago, the etiopathogenesis is still under consideration. Afflicted patients are mostly young male cigarette smokers without signs of atherosclerosis or other risk factors for peripheral arterial occlusive disease. This indicates that hereditary thrombophilic factors could play a role in the etiopathogenesis. Recently, increasing evidence shows that platelet receptor polymorphisms (HPA-1 polymorphism of beta3 subunit of alphaIIbbeta3 and 807 C/T polymorphism alpha2beta1) are associated with early onset of arterial thrombosis (myocardial infarction, stroke). This case-control study was designed to assess whether the 807 C/T polymorphism or the HPA-1 polymorphism is involved in the pathogenesis of Buerger's disease or has any influence on the clinical course of Buerger's disease. Eighteen patients with Buerger's disease and 81 (sex and age matched) healthy control subjects (mean age 44 +/- 10 vs 45 +/- 8 years, respectively) were genotyped for platelet receptor HPA-1 and GPIa 807 C/T polymorphism. The gene frequency of HPA-1 and GPIa 807 C/T polymorphisms was identical in both groups. Prevalence of hetero- and homozygous carriers of the HPA-1b allel (1a1b and 1b1b genotype) as well as the prevalence of the 807 C/T and 807 T/T carriers did not differ significantly between the two groups, p >0.05. The grade of clinical disease manifestation as well as disease progression did not reveal any significant relationship with HPA-1 and 807 C/T polymorphisms. A relationship between the age at onset of the disease and HPA-1 polymorphism was not found. Otherwise analysis of the GPIa 807 C/T platelet receptor polymorphism showed that the average age of patients who are carriers of the T allele at early onset of disease was 32 +/- 6 years (range 27-48 years) compared to 42 +/- 6 years (range 34-53 years) of the C/C carriers (p <0.05). This indicates that the GPIa 807 C/T polymorphism does not represent a risk factor for Buerger's disease itself, but could be associated with premature onset of this disorder in predisposed individuals.
MeSH term(s)	Adult ; Antigens, Human Platelet/genetics ; Case-Control Studies ; Genotype ; Humans ; Integrin alpha2beta1/genetics ; Male ; Pilot Projects ; Platelet Glycoprotein GPIIb-IIIa Complex/genetics ; Polymorphism, Genetic ; Risk Factors ; Thromboangiitis Obliterans/genetics
Chemical Substances	Antigens, Human Platelet ; ITGB3 protein, human ; Integrin alpha2beta1 ; Platelet Glycoprotein GPIIb-IIIa Complex
Language	English
Publishing date	2007-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	80040-5
ISSN	0003-3197
ISSN	0003-3197
DOI	10.1177/0003319707300352
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Article ; Online: A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14.

Costantino, Félicie / Talpin, Alice / Said-Nahal, Roula / Leboime, Ariane / Zinovieva, Elena / Zelenika, Diana / Gut, Ivo / Charon, Céline / Izac, Brigitte / Weissman, Michael / Chiocchia, Gilles / Reveille, John / Breban, Maxime / Garchon, Henri-Jean

Annals of the rheumatic diseases

2017 Volume 76, Issue 1, Page(s) 310–314

Abstract: Objective: More than 40 loci have been associated with ankylosing spondylitis (AS), but less is known about genetic associations in spondyloarthritis (SpA) as a whole. We conducted a family-based genome-wide association study (GWAS) to identify new non- ... ...

Abstract	Objective: More than 40 loci have been associated with ankylosing spondylitis (AS), but less is known about genetic associations in spondyloarthritis (SpA) as a whole. We conducted a family-based genome-wide association study (GWAS) to identify new non-major histocompatibility complex (MHC) genetic factors associated with SpA. Methods: 906 subjects from 156 French multiplex families, including 438 with SpA, were genotyped using Affymetrix 250K microarrays. Association was tested with Unphased. The best-associated non-MHC single nucleotide polymorphisms (SNPs) were then genotyped in two independent familial cohorts (including 215 French and 294 North American patients with SpA, respectively) to replicate associations. Results: 43 non-MHC SNPs yielded an association signal with SpA in the discovery cohort (p<1×10 Conclusions: We report here for the first time a family-based GWAS study on SpA and identified an associated polymorphism near MAPK14. Further analyses are needed to better understand the functional basis of this genetic association.
MeSH term(s)	Adult ; Female ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Male ; Middle Aged ; Mitogen-Activated Protein Kinase 14/genetics ; Polymorphism, Single Nucleotide ; Spondylarthritis/genetics
Chemical Substances	Mitogen-Activated Protein Kinase 14 (EC 2.7.11.24)
Language	English
Publishing date	2017-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2016-209449
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Article: A novel glial fibrillary acidic protein mRNA lacking exon 1.

Zelenika, D / Grima, B / Brenner, M / Pessac, B

Brain research. Molecular brain research

1995 Volume 30, Issue 2, Page(s) 251–258

Abstract: Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein in the mature astrocytes. We have assayed for the presence of GFAP mRNA gene in mouse tissues outside the nervous system. Nuclease S1 protection experiments show that RNAs ... ...

Abstract	Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein in the mature astrocytes. We have assayed for the presence of GFAP mRNA gene in mouse tissues outside the nervous system. Nuclease S1 protection experiments show that RNAs lacking exon 1 are transcribed in bone marrow. From a mouse bone marrow cDNA library we isolated GFAP cDNAs which start in the 3' part of intron 1 and contain all the downstream GFAP exons. The new GFAP mRNAs, which we call GFAP gamma mRNAs, are already present in the brain at embryonic day 15 and in adult forebrain and cerebellum. Their presence in astrocytic cell lines suggests that astrocytes may be the site of in vivo expression of these mRNAs. In addition we have detected GFAP gamma mRNAs in mouse spleen. Furthermore in human an analogous GFAP mRNA containing the 3' part of intron 1 and lacking the exon 1 is also present in adult brain. These results suggest a new regulation of the GFAP gene expression.
MeSH term(s)	Animals ; Astrocytes/metabolism ; Axons/metabolism ; Base Sequence ; Blotting, Northern ; DNA, Complementary ; Gene Expression ; Glial Fibrillary Acidic Protein/biosynthesis ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; RNA, Messenger/metabolism
Chemical Substances	DNA, Complementary ; Glial Fibrillary Acidic Protein ; RNA, Messenger
Language	English
Publishing date	1995-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632883-0
ISSN	1872-6941 ; 0169-328X
ISSN (online)	1872-6941
ISSN	0169-328X
DOI	10.1016/0169-328x(95)00010-p
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Article ; Online: Association between circadian genes, bipolar disorders and chronotypes.

Etain, B / Jamain, S / Milhiet, V / Lajnef, M / Boudebesse, C / Dumaine, A / Mathieu, F / Gombert, A / Ledudal, K / Gard, S / Kahn, J P / Henry, C / Boland, A / Zelenika, D / Lechner, D / Lathrop, M / Leboyer, M / Bellivier, F

Chronobiology international

2014 Volume 31, Issue 7, Page(s) 807–814

Abstract: Abnormalities in circadian rhythms play an important role in the pathogenesis of bipolar disorders (BD). Previous genetic studies have reported discrepant results regarding associations between circadian genes and susceptibility to BD. Furthermore, ... ...

Abstract	Abnormalities in circadian rhythms play an important role in the pathogenesis of bipolar disorders (BD). Previous genetic studies have reported discrepant results regarding associations between circadian genes and susceptibility to BD. Furthermore, plausible behavioral consequences of at-risk variants remain unclear since there is a paucity of correlates with phenotypic biomarkers such as chronotypes. Here, we combined association studies with a genotype/phenotype correlation in order to determine which circadian genes variants may be associated with the circadian phenotypes observed in patients with BD. First, we compared the allele frequencies of 353 single nucleotide polymorphisms spanning 21 circadian genes in two independent samples of patients with BD and controls. The meta-analysis combining both samples showed a significant association between rs774045 in TIMELESS (OR = 1.49 95%CI[1.18-1.88]; p = 0.0008) and rs782931 in RORA (OR = 1.31 95%CI[1.12-1.54]; p = 0.0006) and BD. Then we used a "reverse phenotyping approach" to look for association between these two polymorphisms and circadian phenotypes in a subsample of patients and controls. We found that rs774045 was associated with eveningness (p = 0.04) and languid circadian type (p = 0.01), whereas rs782931 was associated with rigid circadian type (p = 0.01). Altogether, these findings suggest that these variants in the TIMELESS and RORA genes may confer susceptibility to BD and impact on circadian phenotypes in carriers who thus had lower ability to properly adapt to external cues.
MeSH term(s)	Bipolar Disorder/genetics ; CLOCK Proteins/genetics ; Cell Cycle Proteins/genetics ; Circadian Rhythm/genetics ; Female ; Gene Frequency/genetics ; Genetic Association Studies/methods ; Genetic Predisposition to Disease ; Genotype ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Male ; Nuclear Receptor Subfamily 1, Group F, Member 1/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Cell Cycle Proteins ; Intracellular Signaling Peptides and Proteins ; Nuclear Receptor Subfamily 1, Group F, Member 1 ; RORA protein, human ; TIMELESS protein, human ; CLOCK Proteins (EC 2.3.1.48)
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998996-1
ISSN	1525-6073 ; 0742-0528
ISSN (online)	1525-6073
ISSN	0742-0528
DOI	10.3109/07420528.2014.906445
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Article: [Clinical contributions to diabetes insipidus].

ZELENIKA, D

Medicinski arhiv

1960 Volume 14, Page(s) 93–98

MeSH term(s)	Diabetes Insipidus ; Humans ; Medical Records
Language	Undetermined
Publishing date	1960-11
Publishing country	Bosnia and Herzegovina
Document type	Case Reports ; Journal Article
ZDB-ID	128782-5
ISSN	1986-5961 ; 0025-8083 ; 0350-199X
ISSN (online)	1986-5961
ISSN	0025-8083 ; 0350-199X
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Article: A new family of transcripts of the myelin basic protein gene: expression in brain and in immune system.

Zelenika, D / Grima, B / Pessac, B

Journal of neurochemistry

1993 Volume 60, Issue 4, Page(s) 1574–1577

Abstract: A cDNA clone (MBP2) corresponding to a novel mouse myelin basic protein (MBP) mRNA has been isolated from an adult mouse bone marrow cDNA library. It contains the MBP exons 1a-7 except exon 5. Using PCR experiments we have determined that this MBP2 mRNA ... ...

Abstract	A cDNA clone (MBP2) corresponding to a novel mouse myelin basic protein (MBP) mRNA has been isolated from an adult mouse bone marrow cDNA library. It contains the MBP exons 1a-7 except exon 5. Using PCR experiments we have determined that this MBP2 mRNA belongs to a new MBP mRNA family initiated upstream from exon 1b. Their 5' end extends into exon 1a and/or the region 0' previously described. These mRNAs are generated by alternative splicing of the primary transcript involving excision of exon 1a, 1b, 2, 5, or 6. Thus, these new mRNAs are produced from a promoter(s) located upstream from the major promoter 1b. They are expressed in brain (at least from embryonic day 15), in bone marrow, and in other hemolymphopoietic tissues, particularly in macrophage cells. As their expression is not restricted to myelinating cells, the function of these novel MBP mRNAs and putative proteins might not be related to myelination.
MeSH term(s)	Animals ; Base Sequence ; Blotting, Northern ; Bone Marrow/chemistry ; Bone Marrow/metabolism ; Brain/metabolism ; Exons ; Gene Expression ; Immune System/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Myelin Basic Protein/genetics ; Polymerase Chain Reaction ; Promoter Regions, Genetic ; RNA Splicing ; RNA, Messenger/genetics ; RNA, Messenger/isolation & purification
Chemical Substances	Myelin Basic Protein ; RNA, Messenger
Language	English
Publishing date	1993-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/j.1471-4159.1993.tb03325.x
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