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Article: Metal Allergy: State-of-the-Art Mechanisms, Biomarkers, Hypersensitivity to Implants.

Zemelka-Wiacek, Magdalena

2022 Volume 11, Issue 23

Abstract: Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While ... ...

Abstract	Metal allergy is mainly an environmental disorder which can cause allergic contact dermatitis. Environmental metal exposures include jewelry, everyday metal items, mobile phones, leather, metal-rich food and implants, including stents or anchors. While consumer exposure is liable for the majority of metal hypersensitivity cases, the significance of occupational exposure to metals remains relevant. Although the most common metal allergens are nickel, chromium, and cobalt; however, lately, gold, palladium, titanium, and some others have also attracted attention. This review highlights advances in metal allergy mechanisms, biomarkers for potential patients' stratification as well as biological treatments. The most recent evidence of human exposure to metal for risk assessment is discussed, as well as the relationship between the occurrence of metal hypersensitivity and implanted devices, including non-characteristic symptoms. The latest data on the diagnosis of metal hypersensitivity are also reported.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11236971
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Article ; Online: AIT 2023: Current innovation and future outlook.

Zemelka-Wiacek, Magdalena / Jutel, Marek

Allergologie select

2023 Volume 7, Page(s) 219–228

Abstract: Although used for over 100 years, allergen immunotherapy (AIT) is still an indispensable tool in modern allergy managemen20t due to its potential to cure allergic diseases. Its current rapid development through the application of personalized and ... ...

Abstract	Although used for over 100 years, allergen immunotherapy (AIT) is still an indispensable tool in modern allergy managemen20t due to its potential to cure allergic diseases. Its current rapid development through the application of personalized and precision medicine approaches is strongly supported by advances in mHealth, component-resolved diagnosis (CRD)-based diagnostics, validation of novel biomarkers, advanced data management, and development of novel preparations. This review summarizes the key advances in the field and shows the perspectives for further development of next-generation AIT treatments.
Language	English
Publishing date	2023-12-12
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2893503-2
ISSN	2512-8957 ; 2512-8957
ISSN (online)	2512-8957
ISSN	2512-8957
DOI	10.5414/ALX02379E
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Article ; Online: The potential impact of nano- and microplastics on human health: Understanding human health risks.

Winiarska, Ewa / Jutel, Marek / Zemelka-Wiacek, Magdalena

Environmental research

2024 Volume 251, Issue Pt 2, Page(s) 118535

Abstract: Plastics are used all over the world. Unfortunately, due to limited biodegradation, plastics cause a significant level of environmental pollution. The smallest recognized to date are termed nanoplastics (1 nm [nm] up to 1 μm [μm]) and microplastics (1 μm- ...

Abstract	Plastics are used all over the world. Unfortunately, due to limited biodegradation, plastics cause a significant level of environmental pollution. The smallest recognized to date are termed nanoplastics (1 nm [nm] up to 1 μm [μm]) and microplastics (1 μm-5 mm). These nano- and microplastics can enter the human body through the respiratory system via inhalation, the digestive tract via consumption of contaminated food and water, or penetration through the skin via cosmetics and clothes contact. Bioaccumulation of plastics in the human body can potentially lead to a range of health issues, including respiratory disorders like lung cancer, asthma and hypersensitivity pneumonitis, neurological symptoms such as fatigue and dizziness, inflammatory bowel disease and even disturbances in gut microbiota. Most studies to date have confirmed that nano- and microplastics can induce apoptosis in cells and have genotoxic and cytotoxic effects. Understanding the cellular and molecular mechanisms of plastics' actions may help extrapolate the risks to humans. The article provides a comprehensive review of articles in databases regarding the impact of nano- and microplastics on human health. The review included retrospective studies and case reports of people exposed to nanoplastics and microplastics. This research highlights the need for further research to fully understand the extent of the impact of plastics on human health.
Language	English
Publishing date	2024-03-07
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118535
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Article ; Online: Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber.

Zemelka-Wiacek, Magdalena / Kosowska, Anna / Jutel, Marek

Journal of visualized experiments : JoVE

2023 , Issue 193

Abstract: Allergen exposure chambers (AECs) are clinical facilities that allow the exposure of participants to allergenic and non-allergenic airborne particles. They provide stable particle concentrations under controlled environmental conditions. This is of great ...

Abstract	Allergen exposure chambers (AECs) are clinical facilities that allow the exposure of participants to allergenic and non-allergenic airborne particles. They provide stable particle concentrations under controlled environmental conditions. This is of great importance both for diagnostic purposes and for the monitoring of treatment effects. Here, a protocol and the technical prerequisites for performing a safe and effective allergen challenge in subjects sensitized to airborne allergens (i.e., house dust mite [HDM]) in the ALL-MED AEC are presented. With this method, triggering allergic symptoms corresponds to natural exposure. This can be used for an allergy diagnosis or as a plausible endpoint in clinical trials, particularly for allergen immunotherapy (AIT). A controlled environment (temperature, humidity, and carbon dioxide [CO2]) in the chamber must be maintained. Allergen particles must be dispersed evenly within the AEC at stable levels throughout the challenge. For this presentation, allergic rhinitis (AR) patients sensitive to HDM allergens were enrolled. AR symptoms were assessed by the following parameters: total nasal symptom score (TNSS), acoustic rhinometry (ARM), peak nasal inspiratory flow (PNIF), and nasal secretion weight. The safety of the procedure was assessed by the peak expiratory flow rate (PEFR) and the forced expiratory volume in the first second (FEV1). The allergic subjects developed symptoms within 120 min of the trial. On average, the most intense symptoms appeared after 60-90 min and, after reaching a plateau, remained stable until the end of the trial.
MeSH term(s)	Animals ; Humans ; Symptom Assessment ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/therapy ; Allergens ; Nose ; Pyroglyphidae
Chemical Substances	Allergens
Language	English
Publishing date	2023-03-03
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/64801
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Article ; Online: Nanoplastics Penetrate Human Bronchial Smooth Muscle and Small Airway Epithelial Cells and Affect Mitochondrial Metabolism.

Winiarska, Ewa / Chaszczewska-Markowska, Monika / Ghete, Daniel / Jutel, Marek / Zemelka-Wiacek, Magdalena

International journal of molecular sciences

2024 Volume 25, Issue 9

Abstract: Micro- and nanoplastic particles, including common forms like polyethylene and polystyrene, have been identified as relevant pollutants, potentially causing health problems in living organisms. The mechanisms at the cellular level largely remain to be ... ...

Abstract	Micro- and nanoplastic particles, including common forms like polyethylene and polystyrene, have been identified as relevant pollutants, potentially causing health problems in living organisms. The mechanisms at the cellular level largely remain to be elucidated. This study aims to visualize nanoplastics in bronchial smooth muscle (BSMC) and small airway epithelial cells (SAEC), and to assess the impact on mitochondrial metabolism. Healthy and asthmatic human BSMC and SAEC in vitro cultures were stimulated with polystyrene nanoplastics (PS-NPs) of 25 or 50 nm size, for 1 or 24 h. Live cell, label-free imaging by holotomography microscopy and mitochondrial respiration and glycolysis assessment were performed. Furthermore, 25 and 50 nm NPs were shown to penetrate SAEC, along with healthy and diseased BSMC, and they impaired bioenergetics and induce mitochondrial dysfunction compared to cells not treated with NPs, including changes in oxygen consumption rate and extracellular acidification rate. NPs pose a serious threat to human health by penetrating airway tissues and cells, and affecting both oxidative and glycolytic metabolism.
MeSH term(s)	Humans ; Mitochondria/metabolism ; Mitochondria/drug effects ; Bronchi/metabolism ; Bronchi/cytology ; Epithelial Cells/metabolism ; Epithelial Cells/drug effects ; Glycolysis/drug effects ; Nanoparticles ; Myocytes, Smooth Muscle/metabolism ; Myocytes, Smooth Muscle/drug effects ; Cells, Cultured ; Polystyrenes ; Asthma/metabolism ; Asthma/pathology ; Muscle, Smooth/metabolism ; Microplastics/toxicity ; Oxygen Consumption/drug effects
Chemical Substances	Polystyrenes ; Microplastics
Language	English
Publishing date	2024-04-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25094724
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Article ; Online: Clinical validation of grass pollen exposure chamber in patients with allergic rhinitis triggered by timothy grass.

Kosowska, Anna / Zemelka-Wiącek, Magdalena / Smolińska, Sylwia / Wyrodek, Ewa / Adamczak, Bartosz / Jutel, Marek

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

2024

Abstract: Background: The fluctuation in concentrations of airborne allergens frequently presents a challenge to assessing the efficacy of allergen immunotherapy (AIT) in 'field' studies. Allergen exposure chambers (AECs) are specialized medical installations ... ...

Abstract	Background: The fluctuation in concentrations of airborne allergens frequently presents a challenge to assessing the efficacy of allergen immunotherapy (AIT) in 'field' studies. Allergen exposure chambers (AECs) are specialized medical installations developed to expose individuals to allergens at defined and consistent concentrations under a controlled environment. The aim of the study was to validate the provocation test with timothy grass pollen as well as to assess its safety in the AEC in patients with allergic rhinitis. Methods: In the ALLEC® AEC, varying concentrations of timothy grass pollen were dispersed. Allergic symptoms were measured by total nasal symptom score (TNSS), acoustic rhinometry, peak nasal inspiratory flow (PNIF) and nasal discharge volume. Lung function, assessed through peak expiratory flow rate (PEFR) and forced expiratory volume in the first second (FEV Results: The consistency of the test was proved by the stability of environmental conditions, including temperature, humidity and CO Conclusion: The study demonstrates that the ALLEC® grass pollen exposure chamber provides a reliable and safe method for inducing repeatable symptoms in patients with allergic rhinitis. This approach can be effectively applied for allergy diagnostics and clinical endpoint determination during AIT.
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	645204-8
ISSN	1365-2222 ; 0954-7894 ; 0960-2178
ISSN (online)	1365-2222
ISSN	0954-7894 ; 0960-2178
DOI	10.1111/cea.14482
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Article ; Online: Validated allergen exposure chamber is plausible tool for the assessment of house dust mite‐triggered allergic rhinitis

Zemelka‐Wiacek, Magdalena / Kosowska, Anna / Winiarska, Ewa / Sobanska, Ewa / Jutel, Marek

2023

Abstract: BACKGROUND: Allergen exposure chamber (AEC) is a clinical facility that allows exposure to allergenic airborne particles in controlled environment. Although AECs offer stable levels of airborne allergens, the validation of symptoms and other endpoints ... ...

Abstract	BACKGROUND: Allergen exposure chamber (AEC) is a clinical facility that allows exposure to allergenic airborne particles in controlled environment. Although AECs offer stable levels of airborne allergens, the validation of symptoms and other endpoints induced by allergen challenge is key for their recommendation as a plausible tool for the assessment of patients, especially in clinical research. This study aimed to demonstrate the reproducibility of defined clinical endpoints after AEC house dust mite (HDM) challenge under optimal conditions in patients with allergic rhinitis (AR). METHOD: HDM was distributed at different concentrations. The assessment was subjective by the patients: total nasal symptom score (TNSS), visual analog scale (VAS), and objective by the investigator: acoustic rhinometry, peak nasal inspiratory flow (PNIF), and nasal secretion weight. Safety was assessed clinically and by peak expiratory flow rate (PEFR) and forced expiratory volume in the first second (FEV₁). RESULTS: Constant environment: temperature, humidity, and carbon dioxide (CO₂) concentration were maintained during all challenges. The concentration of HDM on average remained stable within the targeted values: 1000, 3000, 5000, 7000 particles (p)/m³. Most symptoms were observed at concentrations 3000 p/m³ or higher. The symptoms severity and other endpoints results were reproducible. 5000 p/m³, and challenge duration of 120 min were found optimal. The procedure was safe with no lung function abnormalities due to challenge. CONCLUSION: HDM challenge in ALL‐MED AEC offers a safe and reliable method for inducing symptoms in AR patients for the use in controlled clinical studies including allergen immunotherapy.
Keywords	acoustics ; allergenicity ; allergens ; allergic rhinitis ; biomedical research ; carbon dioxide ; dust ; dust mites ; humidity ; immunotherapy ; lung function ; nose ; secretion ; temperature
Language	English
Dates of publication	2023-01
Size	p. 168-177
Document type	Article ; Online
Note	JOURNAL ARTICLE
DOI	10.1111/all.15485
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Assessment of autoantibodies in paediatric population with primary immunodeficiencies: a pilot study.

Pieniawska-Śmiech, Karolina / Lewandowicz-Uszyńska, Aleksandra / Zemelka-Wiacek, Magdalena / Jutel, Marek

BMC immunology

2023 Volume 24, Issue 1, Page(s) 8

Abstract: Background: The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population.: Methods: 58 children aged 1-17 and with ... ...

Abstract	Background: The correlation between primary immunodeficiencies (PIDs) and autoimmunity shows ethnic and geographical diversity. The aim of our study was to accumulate more data in paediatric PID population. Methods: 58 children aged 1-17 and with PID (study group) and 14 age-matched immunocompetent individuals (control group) were included in the study. Serum levels of 17 different specific IgG antibodies against autoantigens were measured by means of a quantitative enzyme immunoassay. Immunoglobulin levels were analysed in relation to a detailed medical examination. Results: Autoantibodies against one or more antigens were detected in the sera of 24.14% (n = 14) subjects in the study group. The most frequent were anti-thyroid peroxidase (anti-TPO) antibodies (n = 8; 13.8%). Anti-TPO antibody levels were elevated more often in PID patients with a positive family history of autoimmune diseases (p = 0.04). The screening for anti-deamidated gliadin peptide (DGP) and anti-tissue transglutaminase (tTG) antibodies in our series allowed identifying two previously undiagnosed cases of coeliac disease in PID patients. There was no statistically significant difference between the study and the control group in terms of the autoantibodies prevalence. Conclusions: This study provides data on the prevalence of autoantibodies in paediatric population diagnosed with PID. Selected autoantibodies (i.e. anti-tTG, anti-DGP) might be useful for the screening of PID to avoid the delay of diagnosis of an autoimmune disease.
MeSH term(s)	Child ; Humans ; Pilot Projects ; Transglutaminases ; Autoantibodies ; Autoimmunity ; Autoimmune Diseases ; Immunoglobulin A ; Gliadin
Chemical Substances	Transglutaminases (EC 2.3.2.13) ; Autoantibodies ; Immunoglobulin A ; Gliadin (9007-90-3)
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041500-X
ISSN	1471-2172 ; 1471-2172
ISSN (online)	1471-2172
ISSN	1471-2172
DOI	10.1186/s12865-023-00543-6
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Article ; Online: Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis.

Zemelka-Wiacek, Magdalena / Majewska-Szczepanik, Monika / Gajdanowicz, Pawel / Szczepanik, Marian

Journal of visualized experiments : JoVE

2022 , Issue 187

Abstract: Contact hypersensitivity (CHS) is an experimental model of allergic contact dermatitis (ACD) that can be studied in mice. This study aims to present an objective laboratory method that may help to study the CHS reaction in mice, which can be measured and ...

Abstract	Contact hypersensitivity (CHS) is an experimental model of allergic contact dermatitis (ACD) that can be studied in mice. This study aims to present an objective laboratory method that may help to study the CHS reaction in mice, which can be measured and quantified by various tests. To induce CHS, on day "0", mice were sensitized on a previously shaved spot by abdominal skin painting with the hapten 2,4,6-trinitrochlorobenzene (TNCB) in an acetone-ethanol mixture, whereas negative control mice were sham sensitized with vehicle alone-acetone-ethanol mixture. On day "4", the baseline ear thickness was measured with a micrometer prior to the elicitation of CHS (challenge) by painting both ears with diluted TNCB both in the test and control groups. After 24 h, the ear swelling was measured with a micrometer. CHS is an example of a T cell-mediated immune response that causes swelling in inflamed tissue, peaking 24 h after the skin challenge with the same hapten. An increase in ear edema correlated with augmented ear weight, myeloperoxidase (MPO) activity, pro-inflammatory cytokine concentration in the ear extracts, increased thickening of the edematous dermis in the histological examination, and ear vascular permeability. There was also an increase in the concentration of TNP-specific IgG1 antibodies in the sera of the test group when compared with the control mice. Additionally, CHS can be successfully transferred with the CHS-effector cells obtained from donors previously sensitized with TNCB. The CHS-effector cells were administered intravenously into naïve recipient mice, which were subsequently challenged with the same diluted hapten. Ear swelling was measured with a micrometer 24 h later.
MeSH term(s)	Mice ; Animals ; Picryl Chloride ; Peroxidase ; Disease Models, Animal ; Acetone ; Mice, Inbred BALB C ; Dermatitis, Allergic Contact/etiology ; Dermatitis, Allergic Contact/pathology ; Haptens ; Cytokines ; Immunoglobulin G ; Ethanol
Chemical Substances	Picryl Chloride (Z4ZG7O5SZ9) ; Peroxidase (EC 1.11.1.7) ; Acetone (1364PS73AF) ; Haptens ; Cytokines ; Immunoglobulin G ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/64329
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Article ; Online: Immunotherapy: State-of-the-art review of therapies and theratypes.

Agache, Ioana / Zemelka-Wiącek, Magdalena / Shamji, Mohamed H / Jutel, Marek

The Journal of allergy and clinical immunology

2022 Volume 150, Issue 6, Page(s) 1279–1288

Abstract: Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules ... ...

Abstract	Through its disease-modifying potential, immunotherapy is the keystone to curing allergic diseases. Allergen immunotherapy, applied for more than a century, is currently supported by novel modalities such as mAb-based therapies or small molecules targeting the key nodes of the allergic inflammation network. In this review, a summary of the most significant advances in immunotherapy is presented, addressing not only novel approaches to stratifying patients but also major controlled clinical trials and real-world evidence that strengthen the role of immunotherapy in the treatment of allergies.
Language	English
Publishing date	2022-10-31
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2022.10.007
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