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  1. Article ; Online: La rétention trophoblastique hypervascularisée peut-elle être considérée comme une malformation vasculaire acquise ?

    Zenati, Nora / Seinturier, Christophe / Blaise, Sophie

    Gynecologie, obstetrique, fertilite & senologie

    2023  Volume 51, Issue 7-8, Page(s) 387–389

    Title translation Can retained products of conception be considered as an unclassified acquired vascular malformation?
    MeSH term(s) Humans ; Female ; Uterus ; Fertilization ; Vascular Diseases ; Vascular Malformations ; Retrospective Studies
    Language French
    Publishing date 2023-03-15
    Publishing country France
    Document type Letter
    ZDB-ID 2887456-0
    ISSN 2468-7189
    ISSN (online) 2468-7189
    DOI 10.1016/j.gofs.2023.03.006
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  2. Article: Negative pressure wound therapy with instillation and dwell time in debridement of fibrinous leg ulcers.

    Achiti, Alexandru / Zenati, Nora / Seinturier, Christophe / Cracowski, Jean-Luc / Blaise, Sophie

    Journal of wound care

    2024  Volume 33, Issue 3, Page(s) 166–170

    Abstract: Objective: In conjunction with appropriate wound care, negative pressure wound therapy with instillation and dwell time (NPWTi-d) may be used as an adjunct therapy for acute or hard-to-heal (chronic) wounds, especially when infected. However, there are ... ...

    Abstract Objective: In conjunction with appropriate wound care, negative pressure wound therapy with instillation and dwell time (NPWTi-d) may be used as an adjunct therapy for acute or hard-to-heal (chronic) wounds, especially when infected. However, there are very few data on the use of NPWTi-d in the treatment of fibrinous wounds that are difficult to debride mechanically. The main objective of this study was to describe changes in the fibrin area of such wounds, before and after treatment with NPWTi-d.
    Method: This was a monocentric, observational, prospective pilot study evaluating the NPWTi-d medical device. Eligible patients included in the study were those with hard-to-heal lower limb ulcers who had previously undergone unsuccessful specific debridement treatment for their wound, with failure of manual mechanic debridement for at least six weeks' duration, and whose wounds had a fibrinous surface area of >70% of the total wound surface area. The primary endpoint was the difference in the percentage of fibrinous surface area before and after treatment.
    Results: A total of 14 patients who received treatment for lower limb ulcers between October 2017 and August 2019 were included in the study. There was a significant shrinkage rate of the fibrinous wound surface between the start and end of treatment (83.6±14.5% and 32.2±19.7%, respectively; p<0.001).
    Conclusion: This study showed a significant decrease in fibrin area in wounds treated with NPWTi-d, with good tolerance. We believe that NPWTi-d has its place in the multidisciplinary management of patients with hard-to-heal ulcers. Additional randomised studies are required to confirm these findings.
    Declaration of interest: The authors have no conflicts of interest.
    MeSH term(s) Humans ; Debridement ; Wound Infection/therapy ; Negative-Pressure Wound Therapy ; Ulcer ; Pilot Projects ; Prospective Studies ; Leg Ulcer/therapy ; Fibrin ; Therapeutic Irrigation
    Chemical Substances Fibrin (9001-31-4)
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2024.33.3.166
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  3. Article: Skin necrosis and calcifications after extravasation of vancomycin: a localised form of calciphylaxis?

    Zenati, Nora / Khouri, Charles / Schwebel, Carole / Blaise, Sophie

    Journal of wound care

    2021  Volume 30, Issue 5, Page(s) 390–393

    Abstract: Vancomycin is a tricyclic glycopeptide antibiotic produced ... ...

    Abstract Vancomycin is a tricyclic glycopeptide antibiotic produced from
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Calcinosis/chemically induced ; Calciphylaxis/chemically induced ; Humans ; Male ; Methicillin-Resistant Staphylococcus aureus ; Middle Aged ; Necrosis/chemically induced ; Vancomycin/adverse effects
    Chemical Substances Anti-Bacterial Agents ; Vancomycin (6Q205EH1VU)
    Language English
    Publishing date 2021-05-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1353951-6
    ISSN 0969-0700
    ISSN 0969-0700
    DOI 10.12968/jowc.2021.30.5.390
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  4. Article ; Online: Shear Wave Elastography and Quantitative Ultrasound as Biomarkers to Characterize Deep Vein Thrombosis In Vivo.

    Bosio, Guillaume / Zenati, Nora / Destrempes, François / Chayer, Boris / Pernod, Gilles / Cloutier, Guy

    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

    2021  Volume 41, Issue 7, Page(s) 1807–1816

    Abstract: Objective: Investigate shear wave elastography (SWE) and quantitative ultrasound (QUS) parameters in patients hospitalized for lower limb deep vein thrombosis (DVT).: Method: Sixteen patients with DVT were recruited and underwent SWE and ... ...

    Abstract Objective: Investigate shear wave elastography (SWE) and quantitative ultrasound (QUS) parameters in patients hospitalized for lower limb deep vein thrombosis (DVT).
    Method: Sixteen patients with DVT were recruited and underwent SWE and radiofrequency data acquisitions for QUS on day 0, day 7, and day 30 after the beginning of symptoms, in both proximal and distal zones of the clot identified on B-mode scan. SWE and QUS features were computed to differentiate between thrombi at day 0, day 7, and day 30 following treatment with heparin or oral anticoagulant. The Young's modulus from SWE was computed, as well as QUS homodyned K-distribution (HKD) parameters reflecting blood clot structure. Median and interquartile range of SWE and QUS parameters within clot were taken as features.
    Results: In the proximal zone of the clot, the HKD ratio of coherent-to-diffuse backscatter median showed a significant decrease from day 7 to day 30 (P = .036), while the HKD ratio of diffuse-to-total backscatter median presented a significant increase from day 7 to day 30 (P = .0491). In the distal zone of the clot, the HKD normalized intensity of the echo envelope median showed a significant increase from day 0 to day 30 (P = .0062). No SWE features showed statistically significant differences over time. Nonetheless, a trend of lower median of Young's modulus within clot for patients who developed a pulmonary embolism was observed.
    Conclusion: QUS features may be relevant to characterize clot's evolution over time. Further analysis of their clinical interpretation and validation on a larger dataset would deserve to be studied.
    MeSH term(s) Biomarkers ; Elastic Modulus ; Elasticity Imaging Techniques ; Humans ; Ultrasonography ; Venous Thrombosis/diagnostic imaging
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 604829-8
    ISSN 1550-9613 ; 0278-4297
    ISSN (online) 1550-9613
    ISSN 0278-4297
    DOI 10.1002/jum.15863
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  5. Article ; Online: Prevalence and severity of peripheral arterial disease among patient with heel pressure ulcer: a retrospective study of 42 patients.

    Tisserand, Guillaume / Zenati, Nora / Seinturier, Christophe / Blaise, Sophie / Pernod, Gilles

    Geriatrie et psychologie neuropsychiatrie du vieillissement

    2017  Volume 15, Issue 3, Page(s) 242–246

    Abstract: Heel pressure ulcer is a major complication in elderly hospitalized patients. The association with peripheral arterial disease (PAD) which is also a frequent disease in this population is poorly known. The aim of this study was to assess the prevalence ... ...

    Title translation Prévalence et sévérité de l’artériopathie oblitérante des membres inférieurs chez les patients atteints d’escarre talonnière : étude rétrospective de 42 patients.
    Abstract Heel pressure ulcer is a major complication in elderly hospitalized patients. The association with peripheral arterial disease (PAD) which is also a frequent disease in this population is poorly known. The aim of this study was to assess the prevalence of PAD and critical limb ischemia (CLI) in patients with heel pressure ulcer. Patients referred to the vascular medicine department for heel pressure ulcer from October 2014 to June 2015 were included in the study. The assessment of peripheral arterial disease was made with the results of ankle brachial index and/or doppler ultra sound of lower limb arteries. Toe systolic pressure and transcutaneous pressure (TcPO2) were also recorded, and the diagnosis of critical limb ischemia was made according to the TASC 2 criteria. The population was composed with 42 patients (women 43%, men 57%). The mean age was 81±11 years. Heel pressures ulcers were diagnosed in the following situations: lower limb fracture (31%), acute medical illness (21%), multiple chronic conditions (28%) and critical care unit hospitalization (7%). A peripheral arterial disease was present in 31 patients (73%), and a critical limb ischemia in 7 patients. For 18 patients, PAD was not known in their past medical history, and this was the case of 5 patients among those with critical limb ischemia. A revascularization was performed in 12 patients, and 5 patients undergo a lower limb amputation. 12 patients were died at 3 months. PAD is frequent among patients with heel pressure ulcer, and is often unknown. The functional and vital prognostic are poor, and the results of our study emphasize the importance of screening PAD in the evaluation of heel pressure ulcer risk.
    Language English
    Publishing date 2017-09-01
    Publishing country France
    Document type Journal Article
    ISSN 2115-7863
    ISSN (online) 2115-7863
    DOI 10.1684/pnv.2017.0680
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  6. Article ; Online: Anaemia as an independent key risk factor for major haemorrhage in patients treated with vitamin K antagonists: Results of the SCORE prospective cohort.

    Zenati, Nora / Gaboreau, Yoann / Provencher, Cynthia Brousseau / Albaladejo, Pierre / Bosson, Jean Luc / Pernod, Gilles

    Thrombosis research

    2017  Volume 151, Page(s) 83–88

    Abstract: Introduction: Risk scores for the prediction of haemorrhage are poorly predictive of major bleeding. The aim of this study was to refine the estimation of bleeding risk by identifying one or several parameters of prognostic significance among these ... ...

    Abstract Introduction: Risk scores for the prediction of haemorrhage are poorly predictive of major bleeding. The aim of this study was to refine the estimation of bleeding risk by identifying one or several parameters of prognostic significance among these algorithms.
    Materials and methods: The SCORE study was a prospective, multicentre cohort study conducted in France in 2009-2010. Patients were eligible if they had received vitamin K antagonist (VKA) for any therapeutic indication for at least 3months. The primary outcome was the occurrence of major bleeding at 1-year follow-up.
    Results: In total, 962 patients were included in this study and evaluated at 1year. The incidence of major bleeding at 1-year follow-up (Kaplan-Meier method) was 2.9% [95% confidence interval (CI) 1.9-4.2]. The rate of major bleeding was 8.2% (95 CI 3.4-16.2) per year in patients classified as high risk by at least four scores. In a multivariate Cox analysis, of the risk factors for the different scores, only anaemia <100g/l at inclusion was strongly associated with risk of major bleeding (hazard ratio 6.1, 95% CI 2.7-13.8, P<0.0001). Through an induction tree analysis performed to identify a common parameter in the majority of scores, anaemia was found to be the main predictor of correct classification as high risk by at least four scores (55% of patients classified as high risk by at least four scores vs 3.3% in the absence of anaemia).
    Conclusion: Anaemia with haemoglobin <100g/l is the most important predictor of high risk of bleeding in patients treated with VKA.
    MeSH term(s) Aged ; Aged, 80 and over ; Anemia/complications ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Female ; France/epidemiology ; Hemorrhage/chemically induced ; Hemorrhage/etiology ; Humans ; Incidence ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Vitamin K/antagonists & inhibitors
    Chemical Substances Anticoagulants ; Vitamin K (12001-79-5)
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2016.10.027
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