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  1. Article ; Online: Development of on-DNA Formation of Benzofuran for DNA-Encoded Library Synthesis.

    Luo, Ayun / Zhou, Hongxia / Wang, Xiuming / Zeng, Fanming / Yu, Weina / Yang, Kexin / Duchemin, Nicolas / Hu, Yun Jin

    Organic letters

    2024  Volume 26, Issue 8, Page(s) 1688–1693

    Abstract: Using a novel homologation-heterocyclization cascade, the on-DNA synthesis of benzofurans from aldehydes has been developed. The methodology, based on an innovative use of the Seyferth-Gilbert homologation, followed by a high yielding Sonogashira ... ...

    Abstract Using a novel homologation-heterocyclization cascade, the on-DNA synthesis of benzofurans from aldehydes has been developed. The methodology, based on an innovative use of the Seyferth-Gilbert homologation, followed by a high yielding Sonogashira coupling in situ intramolecular cyclization one-pot, two-step reaction, provides a powerful and unique pathway for DNA-encoded library (DEL) synthesis of a wide array of pharmaceutically relevant benzofuran-based scaffolds.
    MeSH term(s) Benzofurans ; Gene Library ; Cyclization ; DNA
    Chemical Substances benzofuran (LK6946W774) ; Benzofurans ; DNA (9007-49-2)
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: ZIF-8 and polyaniline modified coconut gel to fabricate composite aerogel for efficient removal of tetracycline

    Liu Qun / Zeng Fanming / Li Xiao / Su Zhongmin

    E3S Web of Conferences, Vol 185, p

    2020  Volume 04055

    Abstract: To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-8 onto polyaniline (PANI) modified coconut hydrogel (CCH). Firstly, PANI played the role of metal chelated layers, ... ...

    Abstract To overcome the limitations of large-scale applications for MOFs in the powder form, herein, we proposed a strategy of in-situ growth ZIF-8 onto polyaniline (PANI) modified coconut hydrogel (CCH). Firstly, PANI played the role of metal chelated layers, which were coated on CCH by in-situ polymerization. Then, ZIF-8 nanocrystals were in-situ growth on the surface of the PANI coated CCH to synthesise the composite adsorbent ZIF-8/PANI/CCH. Finally, after vacuum freeze-dried, a white and well structured ZIF-8/PANI/CCA(ZIF-8/polyaniline/coconut aerogel) was obtained. The loading mass ratios of ZIF-8 on CCA and PANI/CCA were 11.3% and 37.5%, respectively, which indicates that PANI as interface layers can effectively promote the in-situ growth of ZIF-8. The obtained composite adsorbent (ZIF-8/PANI/CCA) was applied for the adsorption of tetracycline (TC)，and the removal efficiency reaches over 91.6%. This strategy may provide an effective and versatile pathway to increase MOF loading mass on natural polysaccharide aerogel and sequentially branch out their applications in pollutant treatment fields.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Underwater superelastic MOF/polyacrylamide/chitosan composite aerogel for efficient 2, 4-dichlorophenoxyacetic acid adsorption

    Liu, Qun / Xu, Kun / Hu, Guangxu / Zeng, Fanming / Li, Xiao / Li, Chun / Zhang, Yu

    Colloids and surfaces. 2022 Feb. 20, v. 635

    2022  

    Abstract: MIL-101(Cr)/polyacrylamide/chitosan (named as MIL-101(Cr)/PAM/CSA) composite aerogel with large surface area is synthesized by incorporating MIL-101(Cr) into polyacrylamide/chitosan composite aerogel and used for efficient 2, 4-Dichlorophenoxyacetic acid ...

    Abstract MIL-101(Cr)/polyacrylamide/chitosan (named as MIL-101(Cr)/PAM/CSA) composite aerogel with large surface area is synthesized by incorporating MIL-101(Cr) into polyacrylamide/chitosan composite aerogel and used for efficient 2, 4-Dichlorophenoxyacetic acid adsorption. MIL-101(Cr)/PAM/CSA and polyacrylamide/chitosan composite aerogels exhibit good underwater superelastic properties with multi-level network synergistic cross-linking. After introducing MIL-101(Cr) with the mass loading of 30%, the specific surface area of the composite aerogels enlarge from 58.15 m² g⁻¹ to 310.94 m² g⁻¹. MIL-101(Cr)/PAM/CSA exhibits high adsorption capacity of 302.45 mg g⁻¹ for 2, 4-Dichlorophenoxyacetic acid (2, 4-D) and stable recycling capability. This work provides a general and effective method to synthesize composite aerogel with underwater superelastic properties, hierarchical pores and large surface area, promising to realize regeneration after compression with reduced solvent usage and costs.
    Keywords adsorption ; aerogels ; chitosan ; crosslinking ; polyacrylamide ; solvents ; surface area
    Language English
    Dates of publication 2022-0220
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1500517-3
    ISSN 0927-7757
    ISSN 0927-7757
    DOI 10.1016/j.colsurfa.2021.127970
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Numerical Simulation of Flow Field Characteristics of The Cooling Water Jacket of A Marine Diesel Engine

    Zhang Bo / Zhang Ping / Zhang Zhao / Yang Shaobo / Wang Chengli / Zeng Fanming

    E3S Web of Conferences, Vol 261, p

    2021  Volume 02040

    Abstract: In order to evaluate the flow field characteristics of a marine diesel engine cooling water jacket, and provide a theoretical basis for further optimizing the water jacket structure. A computational fluid dynamics (CFD) method was used to calculate the ... ...

    Abstract In order to evaluate the flow field characteristics of a marine diesel engine cooling water jacket, and provide a theoretical basis for further optimizing the water jacket structure. A computational fluid dynamics (CFD) method was used to calculate the three-dimensional flow field of the water jacket. Based on the CFD simulation model of the engine water jacket, the analysis of pressure field, velocity field, streamline distribution and flow uniformity of water jacket of diesel engine under rated condition were carried out. The results show that: the total pressure loss of water jacket is 30.3 kPa, in which the pressure loss of cylinder block is 8.4 kPa, and the one of cylinder head and outlet manifold is 21.9 kPa, which indicates that the flow resistance design of the cylinder block and head is reasonable; the flow rate of coolant in the nose zone of cylinder head is above 1.5 m/s, which meets the cooling demand of cylinder head; the cooling water flows circumferentially in the engine block water jacket, and the flow dead zones are easily formed by the mutual extrusion and collision of the water flows; the outlet of the cylinder head water jacket is connected with the outlet manifold at right angle, which leads to large energy loss of the flow field; the maximum non-uniformity of flow rate of water jacket of each cylinder is 5.85%, which can be further optimized by adjusting the position of water jacket inlet.
    Keywords Environmental sciences ; GE1-350
    Subject code 621
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Efficient catalytic reduction of 4-nitrophenol by Cu1.96S/NSC hybrid material derived from metal-organic framework

    Wang Dongsheng / Zhang Chengxin / Zeng Fanming / Hu Xiaoli / Li Chun / Su Zhongmin

    E3S Web of Conferences, Vol 252, p

    2021  Volume 02065

    Abstract: Designing carbon-based non-precious metal hybrid materials to replace precious metal catalysts to solve environmental pollution problems is a hot topic of research at this stage. In this work, a dual ligand Cu-MOF was synthesized by the solvothermal ... ...

    Abstract Designing carbon-based non-precious metal hybrid materials to replace precious metal catalysts to solve environmental pollution problems is a hot topic of research at this stage. In this work, a dual ligand Cu-MOF was synthesized by the solvothermal method and using Cu-MOF as a sacrificial template further vulcanized to obtain Cu1.96S/NSC hybrid material. The morphology and composition of Cu1.96S/NSC hybrid material were investigated by scanning electron microscope (SEM), high-resolution transmission electron microscope (HRTEM), x-ray diffraction (XRD), nitrogen adsorption-desorption, and x-ray photoelectron spectroscopy (XPS) in detail. Cu1.96S/NSC has excellent catalytic activity in the catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) showing the reaction rate constant k=0.0242 s-1, which can reach nearly 100% conversion rate in 3 min. Finally, the mechanism of Cu1.96S/NSC hybrid material’s efficient catalytic reduction of 4-NP was deeply explored.
    Keywords Environmental sciences ; GE1-350
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis.

    Xue, Lijun / Ma, Hangke / Liu, Weijie / Duchemin, Nicolas / Zeng, Fanming / Zhang, Jie / Zhang, Huanqing / Yang, Kexin / Hu, Yun Jin

    ACS omega

    2023  Volume 8, Issue 26, Page(s) 24072–24077

    Abstract: A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs. ...

    Abstract A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c03160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development of On-DNA Thiophene Synthesis for DEL Construction.

    Luo, Ayun / Duchemin, Nicolas / Wang, Xiuming / Zhou, Hongxia / Zeng, Fanming / Zhao, Xue / Yu, Weina / Yang, Kexin / Jin Hu, Yun

    Chemistry, an Asian journal

    2023  Volume 18, Issue 15, Page(s) e202300458

    Abstract: Thiophene and its substituted derivatives are a highly important class of heterocyclic compounds, with noteworthy applications in pharmaceutical ingredients. In this study, we leverage the unique reactivity of alkynes to generate thiophenes on-DNA, using ...

    Abstract Thiophene and its substituted derivatives are a highly important class of heterocyclic compounds, with noteworthy applications in pharmaceutical ingredients. In this study, we leverage the unique reactivity of alkynes to generate thiophenes on-DNA, using a cascade iodination, Cadiot-Chodkiewicz coupling and heterocyclization. This approach, tackling on-DNA thiophene synthesis for the first time, generates diverse, and unprecedented structural and chemical features, which could be significant motifs in DEL screening as molecular recognition agents for drug discovery.
    Language English
    Publishing date 2023-06-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202300458
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Constructive On-DNA Abramov Reaction and Pudovik Reaction for DEL Synthesis.

    Sun, Zhaomei / Xiao, Lingqian / Chen, Yahui / Wang, Jiangying / Zeng, Fanming / Zhang, Huanqing / Zhang, Jie / Yang, Kexin / Hu, Yun Jin

    ACS medicinal chemistry letters

    2023  Volume 14, Issue 4, Page(s) 473–478

    Abstract: Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library ... ...

    Abstract Organophosphonic compounds are distinctive among natural products in terms of stability and mimicry. Numerous synthetic organophosphonic compounds, including pamidronic acid, fosmidromycin, and zoledronic acid, are approved drugs. DNA encoded library technology (DELT) is a well-established platform for identifying small molecule recognition to target protein of interest (POI). Therefore, it is imperative to create an efficient procedure for the on-DNA synthesis of α-hydroxy phosphonates for DEL builds.
    Language English
    Publishing date 2023-03-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.3c00022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A novel single-phase color tunable LiYGeO

    Zuo, Chunyu / Chen, Rujia / Jiang, Xiliang / Leng, Zhuang / Yang, Yimin / Zhang, Zhipeng / Zhou, Lingbo / Li, Chun / Yang, Weiling / Lin, Hai / Liu, Lina / Li, Shasha / Zeng, Fanming / Su, Zhongmin

    Physical chemistry chemical physics : PCCP

    2024  Volume 26, Issue 4, Page(s) 3375–3388

    Abstract: ... ...

    Abstract LiYGeO
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp04754g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Garnet Structure-Activated Warm White Light Phosphors Ca

    Zhou, Lingbo / Chen, Rujia / Jiang, Xiliang / Zhang, Tianqing / Shi, Xueming / Leng, Zhuang / Yang, Yimin / Zhang, Zhipeng / Zuo, Chunyu / Li, Chun / Yang, Weiling / Lin, Hai / Liu, Lina / Li, Shasha / Zeng, Fanming / Su, Zhongmin

    Inorganic chemistry

    2024  Volume 63, Issue 2, Page(s) 1274–1287

    Abstract: A series of ... ...

    Abstract A series of Ca
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c03739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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