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Article ; Online: Trait rumination in post-stress growth among Chinese college students: the chain mediating effect of distress disclosure and perceived social support.

Wang, Zengjian / Xu, Yining / Zeng, Huifang

2023 Volume 11, Page(s) 1265405

Abstract: Background: Rumination has emerged as a significant factor contributing to personal growth following periods of stress or trauma. The present study aimed to investigate the relationship between trait rumination and post-stress growth (PSG) within the ... ...

Abstract	Background: Rumination has emerged as a significant factor contributing to personal growth following periods of stress or trauma. The present study aimed to investigate the relationship between trait rumination and post-stress growth (PSG) within the context of Chinese college students who encounter mild stressors in their daily lives. Moreover, we aim to evaluate the potential mediating roles played by both distress disclosure and perceived social support in this dynamic relationship. Method: All participants completed assessments using the Adolescent Self-Rating Life Events Checklist, Rumination Response Scale, Post-Stress Growth Inventory, Distress Disclosure Index, and Perceived Social Support Scale. Correlation and mediation analyses were conducted using SPSS PROCESS 4 MACRO. Results: All students reported experiencing mild psychological impacts as a result of negative life events in the past year and displayed moderate levels of PSG. There was no significant correlation observed between the effects of negative life events and PSG. Significant negative correlations were found between trait rumination and distress disclosure, perceived social support, and PSG. Distress disclosure and perceived social support jointly operated as sequential mediators in the relationship between trait rumination and PSG among all the participants. Qualitative analyses revealed different correlation patterns of high- versus low-ruminator. Conclusion: Trait rumination affects PSG both directly and indirectly, through its influence on distress disclosure and perceived social support. Our results emphasize the significance of actively participating in distress disclosure and nurturing a robust sense of social support to counteract the detrimental effects of rumination on post-stress growth among Chinese college students.
MeSH term(s)	Adolescent ; Humans ; Disclosure ; Stress, Psychological/psychology ; Social Support ; Students/psychology
Language	English
Publishing date	2023-11-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1265405
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Article ; Online: Risk factors for premature rupture of membranes in pregnant women: a systematic review and meta-analysis.

Lin, Danna / Hu, Bing / Xiu, Yuqi / Ji, Ruiting / Zeng, Huifang / Chen, Hongyan / Wu, Yanchun

BMJ open

2024 Volume 14, Issue 3, Page(s) e077727

Abstract: Objective: To identify risk factors for premature rupture of membranes (PROM) in pregnant women.: Design: Systematic review and meta-analysis.: Data sources: Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, ...

Abstract	Objective: To identify risk factors for premature rupture of membranes (PROM) in pregnant women. Design: Systematic review and meta-analysis. Data sources: Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database (VIP) and China Biology Medicine Disc were searched from inception to October 2022. Eligibility criteria: Cross-sectional, case-control and cohort studies published in English or Chinese that reported the risk factors for PROM were eligible for inclusion. Data extraction and synthesis: Two reviewers independently extracted the data and evaluated the risk of bias using the Newcastle-Ottawa Scale and American Agency for Healthcare Research and Quality tools. Analyses were performed using RevMan 5.4 software, and heterogeneity was assessed using χ Results: A total of 21 studies involving 18 174 participants with 18 risk factors were included. The significant risk factors were low Body Mass Index (BMI) (OR 2.18, 95% CI 1.32 to 3.61), interpregnancy interval (IPI) <2 years (OR 2.99, 95% CI 1.98 to 4.50), previous abortion (OR 2.35, 95% CI 1.76 to 3.14), previous preterm birth (OR 5.72, 95% CI 3.44 to 9.50), prior PROM (OR 3.95, 95% CI 2.48 to 6.28), history of caesarean section (OR 3.06, 95% CI 1.72 to 5.43), gestational hypertension (OR 3.84, 95% CI 2.36 to 6.24), gestational diabetes mellitus (GDM) (OR 2.16, 95% CI 1.44 to 3.23), abnormal vaginal discharge (OR 2.17, 95% CI 1.45 to 3.27), reproductive tract infection (OR 2.16, 95% CI 1.70 to 2.75), malpresentation (OR 2.26, 95% CI 1.78 to 2.85) and increased abdominal pressure (OR 1.45, 95% CI 1.07 to 1.97). The sensitivity analysis showed that the pooled estimates were stable. Conclusions: This meta-analysis indicated that low BMI, IPI <2 years, previous abortion, previous preterm birth, prior PROM, history of caesarean section, gestational hypertension, GDM, abnormal vaginal discharge, reproductive tract infection, malpresentation and increased abdominal pressure might be associated with a greater risk of PROM. Associations between smoking status, short cervical length, fine particulate matter (PM Prospero registration number: CRD42022381485.
MeSH term(s)	Pregnancy ; Female ; Infant, Newborn ; Humans ; Pregnancy Outcome ; Pregnant Women ; Premature Birth/epidemiology ; Hypertension, Pregnancy-Induced ; Cesarean Section ; Cross-Sectional Studies ; Reproductive Tract Infections ; Diabetes, Gestational ; Risk Factors ; Vaginal Discharge
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-077727
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Article ; Online: Intestines-erythrocytes-mediated bio-disposition deciphers the hypolipidemic effect of berberine from Rhizoma Coptidis: A neglected insight.

Huang, Ziwei / Li, Minhua / Qin, Zehui / Ma, Xingdong / Huang, Ronglei / Liu, Yuhong / Xie, Jianhui / Zeng, Huifang / Zhan, Ruoting / Su, Ziren

Journal of ethnopharmacology

2023 Volume 314, Page(s) 116600

Abstract: Ethnopharmacological relevance: Rhizoma Coptidis (RC), the dried rhizome of Coptis Chinensis Franch., can dispel dampness and heat within the body and has been traditionally used for the treatment of cardiovascular disease (CVD)-associated problems ... ...

Abstract	Ethnopharmacological relevance: Rhizoma Coptidis (RC), the dried rhizome of Coptis Chinensis Franch., can dispel dampness and heat within the body and has been traditionally used for the treatment of cardiovascular disease (CVD)-associated problems including hyperlipidemia in China. Berberine (BBR) is the main active component of RC, which has been shown to possess significant therapeutic potential. However, only 0.14% of BBR is metabolized in the liver, and the extremely low bioavailability (<1%) and blood concentration of BBR in experimental and clinical settings is insufficient to achieve the effects as observed under in vitro conditions, which imposes challenges to explain its excellent pharmacological actions. Intense efforts are currently being devoted to defining its specific pharmacological molecular targets, while the exploration from the perspective of its pharmacokinetic disposition has rarely been reported to date, which could hardly make a comprehensive understanding of its hypolipidemic enigma. Aim of the study: This study made a pioneering endeavor to unveil the hypolipidemic mechanism of BBR from RC focusing on its unique intestines-erythrocytes-mediated bio-disposition. Materials and methods: The fate of BBR in intestines and erythrocytes was probed by a rapid and sensitive LC/MS-IT-TOF method. To analyze the disposition of BBR, a reliable HPLC method was subsequently developed and validated for simultaneous determination of BBR and its key active metabolite oxyberberine (OBB) in whole blood, tissues, and excreta. Meanwhile, the enterohepatic circulation (BDC) of BBR and OBB was verified by bile duct catheterization rats. Finally, lipid overloading models of L02 and HepG2 cells were employed to probe the lipid-lowering activity of BBR and OBB at in vivo concentration. Results: The results showed that BBR underwent biotransformation in both intestines and erythrocytes, and converted into the major metabolite oxyberberine (OBB). The AUC Conclusions: Cumulatively, BBR underwent unique extrahepatic metabolism and disposition into OBB by virtue of intestines and erythrocytes. BBR and OBB were mainly presented and transported in the protein-bound form within the circulating erythrocytes, potentially resulting in hepatocyte targeting accompanied by obvious enterohepatic circulation. The unique extrahepatic disposition of BBR via intestines and erythrocytes conceivably contributed enormously to its hypolipidemic effect. OBB was the important material basis for the hypolipidemic effect of BBR and RC.
MeSH term(s)	Rats ; Animals ; Berberine/pharmacology ; Berberine/therapeutic use ; Plant Extracts/pharmacology ; Triglycerides/metabolism ; Intestines ; Erythrocytes/metabolism
Chemical Substances	Berberine (0I8Y3P32UF) ; Plant Extracts ; Triglycerides
Language	English
Publishing date	2023-05-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116600
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Article ; Online: Intestines-erythrocytes-mediated bio-disposition deciphers the hypolipidemic effect of berberine from Rhizoma Coptidis: A neglected insight

Huang, Ziwei / Li, Minhua / Qin, Zehui / Ma, Xingdong / Huang, Ronglei / Liu, Yuhong / Xie, Jianhui / Zeng, Huifang / Zhan, Ruoting / Su, Ziren

Journal of Ethnopharmacology. 2023 Oct., v. 314 p.116600-

2023

Abstract: Rhizoma Coptidis (RC), the dried rhizome of Coptis Chinensis Franch., can dispel dampness and heat within the body and has been traditionally used for the treatment of cardiovascular disease (CVD)-associated problems including hyperlipidemia in China. ... ...

Abstract	Rhizoma Coptidis (RC), the dried rhizome of Coptis Chinensis Franch., can dispel dampness and heat within the body and has been traditionally used for the treatment of cardiovascular disease (CVD)-associated problems including hyperlipidemia in China. Berberine (BBR) is the main active component of RC, which has been shown to possess significant therapeutic potential. However, only 0.14% of BBR is metabolized in the liver, and the extremely low bioavailability (<1%) and blood concentration of BBR in experimental and clinical settings is insufficient to achieve the effects as observed under in vitro conditions, which imposes challenges to explain its excellent pharmacological actions. Intense efforts are currently being devoted to defining its specific pharmacological molecular targets, while the exploration from the perspective of its pharmacokinetic disposition has rarely been reported to date, which could hardly make a comprehensive understanding of its hypolipidemic enigma. This study made a pioneering endeavor to unveil the hypolipidemic mechanism of BBR from RC focusing on its unique intestines-erythrocytes-mediated bio-disposition. The fate of BBR in intestines and erythrocytes was probed by a rapid and sensitive LC/MS-IT-TOF method. To analyze the disposition of BBR, a reliable HPLC method was subsequently developed and validated for simultaneous determination of BBR and its key active metabolite oxyberberine (OBB) in whole blood, tissues, and excreta. Meanwhile, the enterohepatic circulation (BDC) of BBR and OBB was verified by bile duct catheterization rats. Finally, lipid overloading models of L02 and HepG2 cells were employed to probe the lipid-lowering activity of BBR and OBB at in vivo concentration. The results showed that BBR underwent biotransformation in both intestines and erythrocytes, and converted into the major metabolite oxyberberine (OBB). The AUC₀₋ₜ ratio of total BBR to OBB was approximately 2:1 after oral administration. Besides, the AUC₀₋ₜ ratio of bound BBR to its unbound counterpart was 4.6:1, and this ratio of OBB was 2.5:1, indicative of abundant binding-type form in the blood. Liver dominated over other organs in tissue distribution. BBR was excreted in bile, while the excretion of OBB in feces was significantly higher than that in bile. Furthermore, the bimodal phenomenon of both BBR and OBB disappeared in BDC rats and the AUC₀₋ₜ was significantly lower than that in the sham-operated control rats. Interestingly, OBB significantly decreased triglycerides and cholesterol levels in lipid overloading models of L02 and HepG2 cells at in vivo-like concentration, which was superior to the prodrug BBR. Cumulatively, BBR underwent unique extrahepatic metabolism and disposition into OBB by virtue of intestines and erythrocytes. BBR and OBB were mainly presented and transported in the protein-bound form within the circulating erythrocytes, potentially resulting in hepatocyte targeting accompanied by obvious enterohepatic circulation. The unique extrahepatic disposition of BBR via intestines and erythrocytes conceivably contributed enormously to its hypolipidemic effect. OBB was the important material basis for the hypolipidemic effect of BBR and RC.
Keywords	Coptis chinensis ; berberine ; bile ; bile ducts ; bioavailability ; biotransformation ; cardiovascular diseases ; catheters ; cholesterol ; erythrocytes ; excretion ; feces ; heat ; hyperlipidemia ; lipemic effect ; liver ; metabolites ; oral administration ; pharmacokinetics ; rhizomes ; tissue distribution ; traditional medicine ; China ; Extrahepatic metabolism ; Intestine microflora ; Erythrocyte ; Oxyberberine ; Hypolipidemic ; AST ; ALT ; BBR ; BDC ; BSA ; CD ; EHC ; FFAs ; HCl ; IS ; OA ; OBB ; PA ; TFA ; TG
Language	English
Dates of publication	2023-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116600
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Article ; Online: Hypouricemic effect of gallic acid, a bioactive compound from

Jiang, Linyun / Wu, Yulin / Qu, Chang / Lin, Yinsi / Yi, Xiaoqing / Gao, Changjun / Cai, Jian / Su, Ziren / Zeng, Huifang

Food & function

2022 Volume 13, Issue 19, Page(s) 10275–10290

Abstract: As a tropical medicinal plant, ...

Abstract	As a tropical medicinal plant,
MeSH term(s)	Adenosine Deaminase/adverse effects ; Adenosine Deaminase/metabolism ; Adenosine Triphosphatases/metabolism ; Animals ; Creatinine ; Cyclooxygenase 2/metabolism ; Cystatins/metabolism ; Cystatins/pharmacology ; Gallic Acid/metabolism ; Gallic Acid/pharmacology ; Hyperuricemia/chemically induced ; Interleukin-6/metabolism ; Kidney ; Lythraceae/metabolism ; Mice ; Oxonic Acid/adverse effects ; Superoxide Dismutase/metabolism ; Transforming Growth Factor beta1/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Uric Acid ; Water/metabolism ; Xanthine Oxidase/metabolism
Chemical Substances	Cystatins ; Interleukin-6 ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha ; Water (059QF0KO0R) ; Uric Acid (268B43MJ25) ; Oxonic Acid (5VT6420TIG) ; Gallic Acid (632XD903SP) ; Creatinine (AYI8EX34EU) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Xanthine Oxidase (EC 1.17.3.2) ; Adenosine Deaminase (EC 3.5.4.4) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2022-10-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d2fo02068h
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Article ; Online: Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.

Li, Qiaoping / Huang, Ziwei / Liu, Defu / Zheng, Jingna / Xie, Jianhui / Chen, Jiannan / Zeng, Huifang / Su, Ziren / Li, Yucui

Drug design, development and therapy

2021 Volume 15, Page(s) 3241–3254

Abstract: Purpose: Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years. Many studies reported the anti-inflammatory and ... ...

Abstract	Purpose: Berberine (BBR) is an active component of Phellodendri Cortex (PC), which is a traditional Chinese medicine that has been prescribed clinically for hyperuricemia (HUA) for hundreds of years. Many studies reported the anti-inflammatory and nephroprotective properties of BBR and PC; however, the therapeutic effects of BBR on HUA have not been explored. This study aims to investigate the efficacy and mechanism of BBR for treating HUA. Methods: The mechanism of BBR in the treatment of HUA were predicted by network pharmacology. A mouse model of HUA established by potassium oxonate and hypoxanthine was used to verify the prediction. The levels of serum uric acid (UA), urea nitrogen (BUN) and creatinine (CRE) were determined by biochemical test kits. Hematoxylin and eosin staining of kidney tissues was used to observe the kidney damage. ELISA kits were applied to detect the levels of interleukin (IL)-1β and IL-18 in serum and kidney tissues. Quantitative real-time PCR and Western blotting were adopted to analyze the expression of NLRP3, ASC, Caspase1, IL-1β and URAT1. The expressions of URAT1 in the kidney tubules were visualized by immunohistochemical staining. Molecular docking was used to assess the interaction between URAT1 and BBR. Results: The network pharmacology screened out 82 genes and several inflammation-related signaling pathways related to the anti-hyperuricemia effect of BBR. In the in vivo experiment, BBR substantially decreased the level of UA, BUN and CRE, and alleviated the kidney damage in mice with HUA. BBR reduced IL-1β and IL-18, and downregulated expressions of NLRP3, ASC, Caspase1 and IL-1β. BBR also inhibited expression of URAT1 and exhibited strong affinity with this target in silico docking. Conclusion: BBR exerts anti-HUA and nephroprotective effects via inhibiting activation of NLRP3 inflammasome and correcting the aberrant expression of URAT1 in kidney. BBR might be a novel therapeutic agent for treating HUA.
MeSH term(s)	Animals ; Berberine/pharmacology ; Berberine/therapeutic use ; Disease Models, Animal ; Hyperuricemia/drug therapy ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/drug therapy ; Male ; Mice ; Molecular Docking Simulation ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; Network Pharmacology ; Organic Anion Transporters/analysis ; Organic Anion Transporters/antagonists & inhibitors ; Uric Acid/blood
Chemical Substances	NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Organic Anion Transporters ; Slc22a12 protein, mouse ; Berberine (0I8Y3P32UF) ; Uric Acid (268B43MJ25)
Language	English
Publishing date	2021-07-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S317776
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Article: Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect.

Ai, Gaoxiang / Huang, Ziwei / Cheng, Juanjuan / Xie, Jianhui / Zeng, Huifang / Liu, Yuhong / Li, Yucui / Huang, Xiaoqi / Chen, Jiannan / Su, Ziren

Frontiers in pharmacology

2021 Volume 12, Page(s) 639020

Abstract: Coptisine (COP) is a bioactive isoquinoline alkaloid derived ... ...

Abstract	Coptisine (COP) is a bioactive isoquinoline alkaloid derived from
Language	English
Publishing date	2021-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.639020
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Article ; Online: Brusatol-Enriched Brucea javanica Oil Ameliorated Dextran Sulfate Sodium-Induced Colitis in Mice: Involvement of NF-

Zheng, Xinghan / Mai, Liting / Wang, Tongtong / Xu, Ying / Su, Zireng / Chen, Jiannan / Zeng, Huifang / Xie, Youliang

BioMed research international

2021 Volume 2021, Page(s) 5561221

Abstract: Brucea javanica oil (BJO) is beneficial for the treatment of ulcerative colitis (UC), and that quassinoids in particular brusatol are bioactive components. However, it is still uncertain whether or not other components in BJO, such as oleic acid and ... ...

Abstract	Brucea javanica oil (BJO) is beneficial for the treatment of ulcerative colitis (UC), and that quassinoids in particular brusatol are bioactive components. However, it is still uncertain whether or not other components in BJO, such as oleic acid and fatty acids, have an anti-UC effect. The present study is aimed at comparing the anti-UC effects between brusatol-enriched BJO (BE-BJO) and brusatol-free BJO (BF-BJO) and at exploring the effects and mechanisms of BE-BJO on colon inflammation and intestinal epithelial barrier function. Balb/C mice received 3% (wt/vol) DSS for one week to establish the UC model. Different doses of BE-BJO, BF-BJO, or BJO were treated. The result illustrated that BE-BJO alleviated DSS-induced loss of body weight, an increase of disease activity index (DAI), and a shortening of colon, whereas BF-BJO did not have these protective effects. BE-BJO treatment improved the morphology of colon tissue, inhibited the production and release of TNF-
MeSH term(s)	Animals ; Body Weight/drug effects ; Brucea/chemistry ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Gene Expression Regulation/drug effects ; Male ; Mice ; NF-kappa B/metabolism ; Phosphorylation/drug effects ; Plant Oils/administration & dosage ; Plant Oils/chemistry ; Plant Oils/pharmacology ; Quassins/administration & dosage ; Quassins/pharmacology ; Signal Transduction/drug effects ; Treatment Outcome ; rho-Associated Kinases/metabolism ; rhoA GTP-Binding Protein/metabolism
Chemical Substances	NF-kappa B ; Plant Oils ; Quassins ; brusatol (14907-98-3) ; Dextran Sulfate (9042-14-2) ; rho-Associated Kinases (EC 2.7.11.1) ; RhoA protein, mouse (EC 3.6.5.2) ; rhoA GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2021-08-09
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/5561221
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Therapeutic effect of oxyberberine on obese non-alcoholic fatty liver disease rats

Li, Qiao-Ping / Dou, Yao-Xing / Huang, Zi-Wei / Chen, Han-Bin / Li, Yu-Cui / Chen, Jian-Nan / Liu, Yu-Hong / Huang, Xiao-Qi / Zeng, Hui-Fang / Yang, Xiao-Bo / Su, Zi-Ren / Xie, Jian-Hui

Phytomedicine. 2021 May, v. 85

2021

Abstract: Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD). The metabolites of BBR were believed to contribute significantly to its pharmacological effects. Oxyberberine (OBB), a gut microbiota-mediated oxidative metabolite ... ...

Abstract	Berberine (BBR) has been widely used to treat non-alcoholic fatty liver disease (NAFLD). The metabolites of BBR were believed to contribute significantly to its pharmacological effects. Oxyberberine (OBB), a gut microbiota-mediated oxidative metabolite of BBR, has been firstly identified in our recent work.Here, we aimed to comparatively investigate the anti-NAFLD properties of OBB and BBR.The anti-NAFLD effect was evaluated in high-fat diet-induced obese NAFLD rats with biochemical/ELISA tests and histological staining. The related gene and protein expressions were detected by qRT-PCR and Western blotting respectively. Molecular docking and dynamic simulation were also performed to provide further insight.Results indicated OBB remarkably and dose-dependently attenuated the clinical manifestations of NAFLD, which (100 mg/kg) achieved similar therapeutic effect to metformin (300 mg/kg) and was superior to BBR of the same dose. OBB significantly inhibited aberrant phosphorylation of IRS-1 and up-regulated the downstream protein expression and phosphorylation (PI3K, p-Akt/Akt and p-GSK-3β/GSK-3β) to improve hepatic insulin signal transduction. Meanwhile, OBB treatment remarkably alleviated inflammation via down-regulating the mRNA expression of MCP-1, Cd68, Nos2, Cd11c, while enhancing Arg1 mRNA expression in white adipose tissue. Moreover, OBB exhibited closer affinity with AMPK in silicon and superior hyperphosphorylation of AMPK in vivo, leading to increased ACC mRNA expression in liver and UCP-1 protein expression in adipose tissue.Taken together, compared with BBR, OBB was more capable of maintaining lipid homeostasis between liver and WAT via attenuating hepatic insulin pathway and adipocyte inflammation, which was associated with its property of superior AMPK activator.
Keywords	adipocytes ; berberine ; fatty liver ; gene expression ; genes ; high fat diet ; histology ; homeostasis ; inflammation ; insulin ; lipids ; liver ; metabolites ; metformin ; phosphatidylinositol 3-kinase ; phosphorylation ; protein synthesis ; signal transduction ; silicon ; therapeutics ; white adipose tissue
Language	English
Dates of publication	2021-05
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-light
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2021.153550
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Article ; Online: Dihydroberberine, a hydrogenated derivative of berberine firstly identified in Phellodendri Chinese Cortex, exerts anti-inflammatory effect via dual modulation of NF-κB and MAPK signaling pathways.

Tan, Lihua / Wang, Yongfu / Ai, Gaoxiang / Luo, Chaodan / Chen, Hanbin / Li, Cailan / Zeng, Huifang / Xie, Jianhui / Chen, Jiannan / Su, Ziren

International immunopharmacology

2019 Volume 75, Page(s) 105802

Abstract: Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. Nowadays most researches on PC focus on its main components like BBR, however, the role of its ... ...

Abstract	Dihydroberberine (DHB), a hydrogenated derivative of berberine (BBR), has been firstly identified in Phellodendri Chinese Cortex (PC) by HPLC-ESI-MS/MS. Nowadays most researches on PC focus on its main components like BBR, however, the role of its naturally-occurring derivatives remains poorly defined heretofore. The present work aimed to comparatively evaluate the in vivo anti-inflammatory properties and mechanisms of DHB and BBR in three typical inflammatory murine models. The results showed that DHB effectively mitigated acetic acid-induced vascular permeability, xylene-elicited ear edema and carrageenan-caused paw edema. Meanwhile, DHB markedly attenuated the inflammatory cell infiltration in pathological sections of ears and paws. DHB was also observed to significantly decrease the production and mRNA expression levels of IL-6, IL-1β, TNF-α, NO (iNOS) and PGE2 (COX-2), increase the release of IL-10, and inhibit the activation of NF-κB and MAPK signaling pathways. The anti-inflammatory effect of DHB was weaker than that of BBR. The results might further contribute to unraveling the pharmacodynamic basis of PC and support its ethnomedical use in the treatment of inflammatory diseases. DHB possesses good potential to be further developed into a promising anti-inflammatory alternative, and can serve as a lead template for novel anti-inflammatory candidate.
MeSH term(s)	Acetic Acid ; Animals ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Berberine/analogs & derivatives ; Berberine/pharmacology ; Berberine/therapeutic use ; Capillary Permeability/drug effects ; Carrageenan ; Cytokines/genetics ; Edema/chemically induced ; Edema/drug therapy ; Edema/immunology ; Edema/metabolism ; Female ; Foot/pathology ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; NF-kappa B/metabolism ; Phellodendron ; Plant Bark ; Xylenes
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; NF-kappa B ; Xylenes ; Berberine (0I8Y3P32UF) ; dihydroberberine (483-15-8) ; Carrageenan (9000-07-1) ; Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2019-08-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2019.105802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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