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  1. Article: The effect of adjuvant transarterial chemoembolization for hepatocellular carcinoma after liver resection based on risk stratification.

    Zeng, Jin-Shu / Zeng, Jian-Xing / Huang, Yao / Liu, Jing-Feng / Zeng, Jin-Hua

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2022  Volume 22, Issue 5, Page(s) 482–489

    Abstract: Background: There is currently no standard adjuvant treatment proven to prevent hepatocellular carcinoma (HCC) recurrence. Recent studies suggest that postoperative adjuvant transarterial chemoembolization (PA-TACE) is beneficial for patients at high ... ...

    Abstract Background: There is currently no standard adjuvant treatment proven to prevent hepatocellular carcinoma (HCC) recurrence. Recent studies suggest that postoperative adjuvant transarterial chemoembolization (PA-TACE) is beneficial for patients at high risk of tumor recurrence. However, it is difficult to select the patients. The present study aimed to develop an easy-to-use score to identify these patients.
    Methods: A total of 4530 patients undergoing liver resection were recruited. Independent risk factors were identified by Cox regression model in the training cohort and the Primary liver cancer big data transarterial chemoembolization (PDTE) scoring system was established.
    Results: The scoring system was composed of ten risk factors including alpha-fetoprotein (AFP), albumin-bilirubin (ALBI) grade, operative bleeding loss, resection margin, tumor capsular, satellite nodules, tumor size and number, and microvascular and macrovascular invasion. Using 5 points as risk stratification, the patients with PA-TACE had higher recurrence-free survival (RFS) compared with non-TACE in > 5 points group (P < 0.001), whereas PA-TACE patients had lower RFS compared with non-TACE in ≤ 5 points group (P = 0.013). In the training and validation cohorts, the C-indexes of PDTE scoring system were 0.714 [standard errors (SE) = 0.010] and 0.716 (SE = 0.018), respectively.
    Conclusions: The model is a simple tool to identify PA-TACE for HCC patients after liver resection with a favorable performance. Patients with > 5 points may benefit from PA-TACE.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Chemoembolization, Therapeutic/adverse effects ; Neoplasm Recurrence, Local/pathology ; Hepatectomy/adverse effects ; Risk Assessment ; Retrospective Studies
    Language English
    Publishing date 2022-07-30
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/j.hbpd.2022.07.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6313: Show issues Location:
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  2. Article: [Genetic Testing for Alpha and Beta Thalassemia in Children in Quanzhou Region of Fujian Province in China].

    Huang, Shi-Jie / Chen, Wen-Li / Zhuang, Jian-Long / Zhuang, Qian-Mei / Zeng, Jian-Xing / Wang, Yuan-Bai

    Zhongguo shi yan xue ye xue za zhi

    2021  Volume 29, Issue 4, Page(s) 1266–1270

    Abstract: Objective: To analyze the genotypes and distribution of thalassemia in children in Quanzhou Region so as to provide reference for the prevention and control of thalassemia.: Methods: A total of 1 302 children with suspected thalassemia were collected ...

    Abstract Objective: To analyze the genotypes and distribution of thalassemia in children in Quanzhou Region so as to provide reference for the prevention and control of thalassemia.
    Methods: A total of 1 302 children with suspected thalassemia were collected from January 2014 to April 2020 in Quanzhou Region. The deletional α-thalassemia was detected by Gap-PCR, and DNA reverse dot blot (RDB) hybridization was used to detect α- and β-thalassemia mutations.
    Results: In the 1 302 cases, 667 cases were identified as thalassemia carriers, and the positive detection rate was about 51.23%. Among them, 380 cases of α-thalassemia gene were detected, and --
    Conclusion: There are various genotypes of thalassemia in children in Quanzhou Region, and many children with thalassemia major or intermedia. Therefore, further prevention and control of thalassemia need to be strengthened for reducing the birth of thalassemia major or intermedia.
    MeSH term(s) Child ; China ; Genetic Testing ; Genotype ; Heterozygote ; Humans ; Mutation ; alpha-Thalassemia/genetics ; beta-Thalassemia/genetics
    Language Chinese
    Publishing date 2021-08-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2021.04.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6603: Show issues Location:
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  3. Article: Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy.

    Yu, Yang / Tian, Zhi-Qiang / Liang, Lei / Yang, Xue / Sheng, Dan-Dan / Zeng, Jian-Xing / Li, Xiao-Yong / Shi, Rong-Yu / Han, Zhi-Peng / Wei, Li-Xin

    Cell & bioscience

    2019  Volume 9, Page(s) 80

    Abstract: Background: Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on ethanol-induced liver injury and ... ...

    Abstract Background: Babao Dan (BBD), a traditional Chinese medicine, has been used as a complementary and alternative medicine to treat multifarious liver diseases. In this study, we aimed to observe its protective effect on ethanol-induced liver injury and explore potential mechanisms.
    Methods: Mice pretreated with BBD (0.125, 0.25 and 0.5 g/kg BW) were administrated by ethanol gavage (5 g/kg BW). Liver injury biomarkers and hepatic redox parameters were evaluated by histopathology as well as serum and hepatic content analysis. AML-12 cell was also utilized to determine the efficacy of BBD against ethanol-induced hepatotoxicity.
    Results: Drunkenness experiment showed that the latency was significantly increased and the drunken sleep time was decreased in mice pretreated with BBD. We then found that BBD could reduce hepatic lipid peroxidation and steatosis induced by ethanol exposure. BBD could also suppress ethanol-induced depletion of hepatic antioxidant enzyme. Besides that, BBD treatment lessened the induction of hepatic cytochrome P450 2E1, a major contributor to ethanol-mediated oxidative stress, and up-regulated the expression of nuclear factor erythroid 2-related factor 2 and its two transcriptional targets hemeoxygenase-1 and glutamate-cysteine ligase catalytic subunit. Furthermore, autophagy induced by BBD contributed to hepatoprotection activity.
    Conclusions: Our results suggest that BBD can markedly dispel acute ethanol-induced hepatotoxicity through multiple pathways including attenuation of ethanol-mediated oxidative stress, enhancement of the oxidative defense systems and activation of autophagy.
    Language English
    Publishing date 2019-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-019-0343-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: LPS-induced CXCR4-dependent migratory properties and a mesenchymal-like phenotype of colorectal cancer cells.

    Liu, Wen-Ting / Jing, Ying-Ying / Yan, Fei / Han, Zhi-Peng / Lai, Fo-Bao / Zeng, Jian-Xing / Yu, Guo-Feng / Fan, Qing-Min / Li, Rong / Zhao, Qiu-Dong / Wu, Meng-Chao / Wei, Li-Xin

    Cell adhesion & migration

    2016  Volume 11, Issue 1, Page(s) 13–23

    Abstract: Colorectal cancer (CRC) is the most commonly diagnosed cancer worldwide, and over 50% of patients will develop hepatic metastasis during the course of their disease. CXCR4 and its ligand, stromal cell-derived factor 1α (SDF-1α)/chemokine (C-X-C motif) ... ...

    Abstract Colorectal cancer (CRC) is the most commonly diagnosed cancer worldwide, and over 50% of patients will develop hepatic metastasis during the course of their disease. CXCR4 and its ligand, stromal cell-derived factor 1α (SDF-1α)/chemokine (C-X-C motif) ligand 12 (CXCL12) have been revealed as regulatory molecules involved in the spreading and progression of a variety of tumors. Here we have shown that lipopolysaccharides (LPS) promoted the migratory capacity of colon cancer cells in vivo and in vitro, which correlated with the activation of SDF-1α/CXCR4 axis and epithelial-mesenchymal transition (EMT) occurrence. Additionally, we found that LPS-induced CXCR4 expression and EMT through NF-κB signaling pathway activation. And inhibition of NF-κB pathway, which recovered the epithelial phenotype and attenuated CXCR4 expression, inhibited cell migratory capacity. Clinically, high levels of CXCR4 always correlated with metastasis and poor prognosis of CRC patients. In conclusion, LPS participate in the whole process of hepatic metastasis of CRC, not only causing liver damage resulting in the production of SDF-1α, but also enhancing the invasive potential of CRC cells by promoting CXCR4 expression and EMT occurrence, which would contribute to the enhancement of cell migration and invasion.
    MeSH term(s) Animals ; Cell Line, Tumor ; Cell Movement/drug effects ; Chemokine CXCL12/metabolism ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Humans ; Lipopolysaccharides/pharmacology ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Male ; Mesoderm/drug effects ; Mesoderm/metabolism ; Mesoderm/pathology ; Mice, Inbred BALB C ; Middle Aged ; NF-kappa B/metabolism ; Phenotype ; Prognosis ; Receptors, CXCR4/metabolism ; Signal Transduction/drug effects ; Up-Regulation/drug effects
    Chemical Substances Chemokine CXCL12 ; Lipopolysaccharides ; NF-kappa B ; Receptors, CXCR4
    Language English
    Publishing date 2016-01-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1933-6926
    ISSN (online) 1933-6926
    DOI 10.1080/19336918.2015.1134404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-κB/HIF-1α pathway.

    Lai, Fo-Bao / Liu, Wen-Ting / Jing, Ying-Ying / Yu, Guo-Feng / Han, Zhi-Peng / Yang, Xue / Zeng, Jian-Xing / Zhang, Hang-Jie / Shi, Rong-Yu / Li, Xiao-Yong / Pan, Xiao-Rong / Li, Rong / Zhao, Qiu-Dong / Wu, Meng-Chao / Zhang, Ping / Liu, Jing-Feng / Wei, Li-Xin

    Cancer letters

    2016  Volume 378, Issue 2, Page(s) 131–141

    Abstract: Due to the existence of cancer stem cells (CSCs), persistence and relapse of human hepatocellular carcinoma (HCC) are common after treatment with existing anti-cancer therapies. Emerging evidence indicates that lipopolysaccharide (LPS) plays a crucial ... ...

    Abstract Due to the existence of cancer stem cells (CSCs), persistence and relapse of human hepatocellular carcinoma (HCC) are common after treatment with existing anti-cancer therapies. Emerging evidence indicates that lipopolysaccharide (LPS) plays a crucial role in aggravating HCC, but information about the effect of LPS on CSCs of HCC remains scant. Here, we report that the stemness of CD133(+) CSCs sorted from the human HCC cell line Huh7 was maintained well when cells were cultured with LPS. The reduction of CD133 expression was much lesser in cultured CSCs in the presence of LPS. In response to LPS stimulation, CSCs showed an increase in their activity of clonogenesis and tumorigenesis. LPS also supported maintaining CSC abilities of migration, invasion, and chemo-resistance. Treatment with HIF-1α-specific siRNA significantly reduced CD133 expression by CSCs at both mRNA and protein levels. Further, the expression of HIF-1α and CD133 was reduced in LPS-stimulated CSCs when the NF-κB inhibitor was added to the cell culture. HIF-1α-specific siRNA also effectively counteracted the effect of LPS on maintaining CSC abilities of migration and invasion. These data indicate that LPS, an important mediator in the liver tumor microenvironment, supports the maintenance of CSC stemness through signaling of the NF-κB/HIF-1α pathway. Our current study highlights LPS as a potential target for developing new therapeutic approaches to eliminate CSCs during the treatment of HCC.
    MeSH term(s) AC133 Antigen/genetics ; AC133 Antigen/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Lipopolysaccharides/pharmacology ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Male ; Mice, Inbred BALB C ; Mice, Nude ; NF-kappa B/metabolism ; Neoplasm Invasiveness ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Phenotype ; RNA Interference ; Signal Transduction/drug effects ; Time Factors ; Transfection ; Tumor Burden ; Tumor Microenvironment
    Chemical Substances AC133 Antigen ; Antineoplastic Agents ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; Lipopolysaccharides ; NF-kappa B ; PROM1 protein, human
    Language English
    Publishing date 2016--10
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2016.05.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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