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  1. Article ; Online: Chemical profiling and quality evaluation of Liuweizhiji Gegen-Sangshen oral liquid by UPLC-Q-TOF-MS and HPLC-diode array detector fingerprinting.

    Wei, Shulin / Jiang, Yu / Li, Mingxing / Zhao, Long / Wang, Tiangang / Wei, Mei / Zhao, Qianyun / Zeng, Jiuping / Zhao, Yueshui / Shen, Jing / Du, Fukuan / Chen, Yu / Deng, Shuai / Xiao, Zhangang / Li, Zhi / Wu, Xu

    Phytochemical analysis : PCA

    2024  

    Abstract: Introduction: Liuweizhiji Gegen-Sangshen (LGS) oral liquid is a Chinese patent medicine that is widely used for the prevention and treatment of alcoholic liver disease in clinical practice. However, the chemical complexity of LGS has not yet been ... ...

    Abstract Introduction: Liuweizhiji Gegen-Sangshen (LGS) oral liquid is a Chinese patent medicine that is widely used for the prevention and treatment of alcoholic liver disease in clinical practice. However, the chemical complexity of LGS has not yet been investigated.
    Objective: The aim of this study was to rapidly identify chemical constituents of LGS and establish a quality control method based on fingerprint and quantitative analysis.
    Methodology: A comprehensive strategy was used by combining qualitative analysis by ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and fingerprint analysis by high-performance liquid chromatography with diode array detection (HPLC-DAD).
    Results: A total of 162 chemical components in LGS, including 91 flavonoids, 31 organic acids, and 20 phenolic compounds, were identified or preliminarily characterized in both positive and negative ion modes based on the UPLC-Q-TOF-MS results. Of these, 37 were confirmed with the reference standards. In fingerprint analysis, 23 peaks were chosen as common peaks and used to evaluate the similarity of different batches of LGS. Subsequently, a rapid quantification method was optimized and validated for the simultaneous determination of multiple chemical markers in LGS. The validated quantitative method was successfully used to analyze different batches of LGS samples.
    Conclusion: The proposed comprehensive strategy combining HPLC-DAD fingerprinting and multi-component quantification demonstrated satisfactory results with high efficiency, accuracy, and reliability. This can be used as a reference for the overall quality consistency evaluation of Chinese patent medicines.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073576-8
    ISSN 1099-1565 ; 0958-0344
    ISSN (online) 1099-1565
    ISSN 0958-0344
    DOI 10.1002/pca.3333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4608: Show issues Location:
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  2. Article ; Online: Chinese herbal medicines for treating ulcerative colitis via regulating gut microbiota-intestinal immunity axis.

    Yang, Yifei / Wang, Yi / Zhao, Long / Wang, Fang / Li, Mingxing / Wang, Qin / Luo, Haoming / Zhao, Qianyun / Zeng, Jiuping / Zhao, Yueshui / Du, Fukuan / Chen, Yu / Shen, Jing / Wei, Shulin / Xiao, Zhangang / Wu, Xu

    Chinese herbal medicines

    2023  Volume 15, Issue 2, Page(s) 181–200

    Abstract: Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in ... ...

    Abstract Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC. Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC. Many Chinese herbal medicines including some of single herb, herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity. Some clinical trials have shown promising results. This review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut immunity. The existing clinical trials are also summarized.
    Language English
    Publishing date 2023-03-28
    Publishing country Singapore
    Document type Journal Article ; Review
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2023.03.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Pueraria lobata starch regulates gut microbiota and alleviates high-fat high-cholesterol diet induced non-alcoholic fatty liver disease in mice

    Yang, Yifei / Li, Mingxing / Wang, Qin / Huang, Huimin / Zhao, Yueshui / Du, Fukuan / Chen, Yu / Shen, Jing / Luo, Haoming / Zhao, Qianyun / Zeng, Jiuping / Li, Wanping / Chen, Meijuan / Li, Xiaobing / Wang, Fang / Sun, Yuhong / Gu, Li / Xiao, Zhangang / Wu, Xu

    Food Research International. 2022 July, v. 157 p.111401-

    2022  

    Abstract: The dried roots of Pueraria lobata (Willd.) Ohwi as an edible medicinal herb are enriched with starch. However, the structure, physiology, and biological bioactivity of P. lobata starch (PLS) has not yet been fully investigated. This study showed that ... ...

    Abstract The dried roots of Pueraria lobata (Willd.) Ohwi as an edible medicinal herb are enriched with starch. However, the structure, physiology, and biological bioactivity of P. lobata starch (PLS) has not yet been fully investigated. This study showed that PLS consisted of mixed population of granules with polyhedral or spherical surface. The apparent content of resistant starch was 23.14%, and the molecular weight was 1.93 × 10⁷ Da. PLS showed a branching degree and an average polymerization rate of 2.06% and 20.74%, respectively, with fairly high proportion of B1 short chains. The solubility and swelling power of PLS were 38.51% and 28.10 g/g, respectively, showing high hot stability of the viscosity. In vitro fermentation of PLS resulted in specifically altered composition of gut microbiota and increased production of SCFAs, showing a potential prebiotic effect. Moreover, PLS remarkably alleviated inflammation, hepatic steatosis and dyslipidemia in mice with high-fat high-cholesterol diet induced non-alcoholic fatty liver disease (NAFLD). The protective effect of PLS was associated with amelioration of NAFLD-associated gut dysbiosis through specifically increasing the abundance of Lactobacillus, Bifidobacterium and Turicibacter, and decreasing Desulfovibrio. The results would support the use of PLS as a functional prebiotic for protecting against NAFLD.
    Keywords Bifidobacterium ; Desulfovibrio ; Lactobacillus ; Pueraria montana var. lobata ; digestive system ; dysbiosis ; fatty liver ; fermentation ; food research ; high fat diet ; hyperlipidemia ; inflammation ; intestinal microorganisms ; medicinal plants ; molecular weight ; polymerization ; prebiotics ; protective effect ; resistant starch ; solubility ; viscosity ; Pueraria lobata ; Starch ; Gut microbiota ; ALT ; AST ; ASV ; DB ; db-RDA ; FT-IR ; GAM ; HDL-C ; HPAEC ; IL ; LDA ; LDL-C ; NAFLD ; NMDS ; PCoA ; PLS ; RS ; SCFA ; SEM ; TC ; TG ; TNF-α
    Language English
    Dates of publication 2022-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111401
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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  4. Article ; Online: Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases.

    Zeng, Jiuping / Li, Mingxing / Zhao, Qianyun / Chen, Meijuan / Zhao, Long / Wei, Shulin / Yang, Huan / Zhao, Yueshui / Wang, Anqi / Shen, Jing / Du, Fukuan / Chen, Yu / Deng, Shuai / Wang, Fang / Zhang, Zhuo / Li, Zhi / Wang, Tiangang / Wang, Shengpeng / Xiao, Zhangang /
    Wu, Xu

    Journal of pharmaceutical analysis

    2023  Volume 13, Issue 6, Page(s) 545–562

    Abstract: As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt) that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a critical role in the progression of several inflammatory and ... ...

    Abstract As a ligand-dependent transcription factor, retinoid-associated orphan receptor γt (RORγt) that controls T helper (Th) 17 cell differentiation and interleukin (IL)-17 expression plays a critical role in the progression of several inflammatory and autoimmune conditions. An emerging novel approach to the therapy of these diseases thus involves controlling the transcriptional capacity of RORγt to decrease Th17 cell development and IL-17 production. Several RORγt inhibitors including both antagonists and inverse agonists have been discovered to regulate the transcriptional activity of RORγt by binding to orthosteric- or allosteric-binding sites in the ligand-binding domain. Some of small-molecule inhibitors have entered clinical evaluations. Therefore, in current review, the role of RORγt in Th17 regulation and Th17-related inflammatory and autoimmune diseases was highlighted. Notably, the recently developed RORγt inhibitors were summarized, with an emphasis on their optimization from lead compounds, efficacy, toxicity, mechanisms of action, and clinical trials. The limitations of current development in this area were also discussed to facilitate future research.
    Language English
    Publishing date 2023-05-20
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2630174-X
    ISSN 2214-0883 ; 2095-1779
    ISSN (online) 2214-0883
    ISSN 2095-1779
    DOI 10.1016/j.jpha.2023.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways.

    Luo, Haoming / Li, Mingxing / Wang, Fang / Yang, Yifei / Wang, Qin / Zhao, Yueshui / Du, Fukuan / Chen, Yu / Shen, Jing / Zhao, Qianyun / Zeng, Jiuping / Wang, Shengpeng / Chen, Meijuan / Li, Xiaobing / Li, Wanping / Sun, Yuhong / Gu, Li / Wen, Qinglian / Xiao, Zhangang /
    Wu, Xu

    International journal of biological sciences

    2022  Volume 18, Issue 13, Page(s) 5185–5206

    Abstract: Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the crosstalk of dietary influence and host response has been identified as ... ...

    Abstract Intestinal stem cells (ISCs) play an important role in maintaining intestinal homeostasis via promoting a healthy gut barrier. Within the stem cell niche, gut microbiota linking the crosstalk of dietary influence and host response has been identified as a key regulator of ISCs. Emerging insights from recent research reveal that ISC and gut microbiota interplay regulates epithelial self-renewal. This article reviews the recent knowledge on the key role of ISC in their local environment (stem cell niche) associating with gut microbiota and their metabolites as well as the signaling pathways. The current progress of intestinal organoid culture is further summarized. Subsequently, the key challenges and future directions are discussed.
    MeSH term(s) Gastrointestinal Microbiome ; Homeostasis ; Intestinal Mucosa/metabolism ; Signal Transduction ; Stem Cell Niche ; Stem Cells/metabolism
    Language English
    Publishing date 2022-08-08
    Publishing country Australia
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2179208-2
    ISSN 1449-2288 ; 1449-2288
    ISSN (online) 1449-2288
    ISSN 1449-2288
    DOI 10.7150/ijbs.72600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Pueraria lobata starch regulates gut microbiota and alleviates high-fat high-cholesterol diet induced non-alcoholic fatty liver disease in mice.

    Yang, Yifei / Li, Mingxing / Wang, Qin / Huang, Huimin / Zhao, Yueshui / Du, Fukuan / Chen, Yu / Shen, Jing / Luo, Haoming / Zhao, Qianyun / Zeng, Jiuping / Li, Wanping / Chen, Meijuan / Li, Xiaobing / Wang, Fang / Sun, Yuhong / Gu, Li / Xiao, Zhangang / Wu, Xu

    Food research international (Ottawa, Ont.)

    2022  Volume 157, Page(s) 111401

    Abstract: The dried roots of Pueraria lobata (Willd.) Ohwi as an edible medicinal herb are enriched with starch. However, the structure, physiology, and biological bioactivity of P. lobata starch (PLS) has not yet been fully investigated. This study showed that ... ...

    Abstract The dried roots of Pueraria lobata (Willd.) Ohwi as an edible medicinal herb are enriched with starch. However, the structure, physiology, and biological bioactivity of P. lobata starch (PLS) has not yet been fully investigated. This study showed that PLS consisted of mixed population of granules with polyhedral or spherical surface. The apparent content of resistant starch was 23.14%, and the molecular weight was 1.93 × 10
    MeSH term(s) Animals ; Cholesterol ; Diet, High-Fat/adverse effects ; Gastrointestinal Microbiome ; Mice ; Non-alcoholic Fatty Liver Disease/prevention & control ; Pueraria/chemistry ; Starch
    Chemical Substances Starch (9005-25-8) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2022-05-26
    Publishing country Canada
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2022.111401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2972: Show issues

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