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Article ; Online: Annual advances of integrative pharmacology in 2018

Zeng Ke-Wu

Traditional Medicine Research, Vol 4, Iss 2, Pp 56-

2019 Volume 67

Abstract: A number of researches concerning pharmacology of traditional medicine and active natural products over the past 12 months have outlined the importance of reviewing the progress. This annual integrative pharmacology review evaluates researches published ... ...

Abstract	A number of researches concerning pharmacology of traditional medicine and active natural products over the past 12 months have outlined the importance of reviewing the progress. This annual integrative pharmacology review evaluates researches published during 2018 in different diseases including cardiovascular and cerebrovascular diseases, cancers, diabetes and metabolic diseases, and so on. The emphasis is on bioactive compounds and extracts from traditional herbs, as well as the novel molecular targets and mechanisms. Moreover, some traditional prescriptions in China and other geographical locations have also been included.
Keywords	Traditional medicine ; Natural product ; Herb ; Cancer ; Inflammation ; Cardiovascular diseases ; Medicine ; R ; Miscellaneous systems and treatments ; RZ409.7-999
Language	English
Publishing date	2019-03-01T00:00:00Z
Publisher	Hong Kong Gold Orchid Science and Technology Co., Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of Three Ovulation Induction Therapies for Patients With Polycystic Ovary Syndrome and Infertility.

Xia, Ting-Ting / Zeng, Ke-Fei / Peng, Qing-Mei

Journal of clinical pharmacology

2023 Volume 63, Issue 12, Page(s) 1371–1376

Abstract: The purpose of this research was to evaluate the efficacy of 3 ovulation induction therapies for treating infertility in patients with polycystic ovary syndrome (PCOS). In this retrospective study, we compared the success rates of 90 patients who ... ...

Abstract	The purpose of this research was to evaluate the efficacy of 3 ovulation induction therapies for treating infertility in patients with polycystic ovary syndrome (PCOS). In this retrospective study, we compared the success rates of 90 patients who underwent intrauterine insemination, who were randomly assigned to 1 of 3 treatment groups: letrozole (LE) + urinary gonadotropin (human menopausal gonadotropin [HMG]), clomiphene (CC) + HMG, or HMG alone. Using ultrasound scanning, we examined the number of mature follicles, ovulation rate, clinical pregnancy rate, endometrial thickness, and blood flow. When compared to the other 2 groups, the LE + HMG group had significantly higher levels of mature follicles, ovulation rate, clinical pregnancy rate, estradiol, and luteinizing hormone on the day of the human chorionic gonadotropin injection and endometrial receptivity (P < .05). There was no statistically significant difference between the 3 groups in terms of abortion rate, ectopic pregnancy rate, or adverse reactions. In this research, we found that infertility in patients with PCOS could be effectively treated by combining LE with HMG. This protocol increased ovulation, boosted fertility, and enhanced endometrial receptivity with no increase in adverse reactions. Therefore, it may be a useful clinical approach for inducing ovulation and treating infertility in patients with PCOS.
MeSH term(s)	Pregnancy ; Female ; Humans ; Polycystic Ovary Syndrome/drug therapy ; Infertility, Female/drug therapy ; Fertility Agents, Female/therapeutic use ; Retrospective Studies ; Letrozole/therapeutic use ; Ovulation Induction/methods ; Menotropins/therapeutic use
Chemical Substances	Fertility Agents, Female ; Letrozole (7LKK855W8I) ; Menotropins (61489-71-2)
Language	English
Publishing date	2023-08-10
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.2318
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Article ; Online: Identification of Skp1 as a target of mercury sulfide for neuroprotection.

Zhao, Mei-Mei / Li, Lu-Di / Yang, Mi-Mi / Yao, Lu / Wang, Qi / Zeng, Ke-Wu

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 11, Page(s) 1464–1467

Abstract: Mercury sulfide (HgS) exerts extensive biological effects on neuronal function. To investigate the direct target of HgS in neuronal cells, we developed a biotin-tagged HgS probe (bio-HgS) and employed an affinity purification technique to capture its ... ...

Abstract	Mercury sulfide (HgS) exerts extensive biological effects on neuronal function. To investigate the direct target of HgS in neuronal cells, we developed a biotin-tagged HgS probe (bio-HgS) and employed an affinity purification technique to capture its target proteins. Then, we identified S-phase kinase-associated protein 1 (Skp1) as a potential target of HgS. Unexpectedly, we discovered that HgS covalently binds to Skp1 through a "Cys62-HgS-Cys120" mode. Moreover, our findings revealed that HgS inhibits the ubiquitin-protease system through Skp1 to up-regulate SNAP-25 expression, thereby triggering synaptic vesicle exocytosis to regulate locomotion ability in
MeSH term(s)	Animals ; Mercury/metabolism ; S-Phase Kinase-Associated Proteins ; Caenorhabditis elegans/metabolism ; Neuroprotection ; Sulfides/metabolism ; Mercury Compounds
Chemical Substances	Mercury (FXS1BY2PGL) ; S-Phase Kinase-Associated Proteins ; cinnabar (ZI0T668SF1) ; Sulfides ; Mercury Compounds
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc05141b
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Article: Is Allium Ureteral Stent Feasible for the Treatment of Ileal-Ureteral Anastomotic Stenosis? A Case Report.

Ye, Junbing / Deng, Kefei / Zeng, Ke / Huang, Guishu / Weng, Yusong / Yang, Kunru / Chen, Qian

Archivos espanoles de urologia

2024 Volume 77, Issue 1, Page(s) 113–118

Abstract: Background: The conventional approach for managing ureteral stenosis involves the placement of a double-J stent. In recent years, the utilisation of Allium ureteral stent (URS) has emerged as a novel treatment alternative for ureteral stenosis. Allium ... ...

Abstract	Background: The conventional approach for managing ureteral stenosis involves the placement of a double-J stent. In recent years, the utilisation of Allium ureteral stent (URS) has emerged as a novel treatment alternative for ureteral stenosis. Allium URS has several advantages over traditional stents, including an extended indwelling time and reduced incidence of complications. The number of cases reported worldwide on the use of Allium URS in the treatment of ureteral stenosis is currently limited. In this paper, we present the details of a case involving the use of an Allium URS to treat ileal-ureteral anastomotic stenosis in a 67-year-old patient. We aim to assess the feasibility of using Allium URS in such cases. Case presentation: A 67-year-old Chinese woman was referred to our hospital for the treatment of left lumbago. Urography showed left ileal-ureteral anastomotic stenosis. Computed tomography (CT) revealed severe hydronephrosis in the left kidney. Subsequently, an Allium URS was implanted via ureteroscopy. We found no instances of haematuria, lumbago or urinary tract irritation during the follow-up period. After 8 months, the patient was readmitted because of left lumbago. CT re-examination revealed that the left hydronephrosis had modestly improved. The Allium URS had detached and showed stone formation on its surface. For further treatment, ureteroscopy was performed and a new Allium URS was implanted. At 3-month follow-up, CT re-examination demonstrated that the stent had dislodged again but that the hydronephrosis in the left kidney had remarkably improved. Cystoscopy revealed that the stent had completely detached and that wall stones had attached on this surface. The stent was removed via cystoscopy. After 1 month, CT scanning showed that the left hydronephrosis of the patient had almost disappeared. Conclusion: Allium URS is effective in the treatment of hydronephrosis caused by ileal-ureteral anastomotic stenosis. Although complications, such as haematuria, lumbago and urinary tract irritation, are rare, complications, such as stent displacement and stone formation, may occur. Hence, caution must be exercised when considering the use of Allium URSs in the treatment of patients with ileal-ureteral anastomotic stenosis.
MeSH term(s)	Female ; Humans ; Aged ; Hematuria/etiology ; Constriction, Pathologic/surgery ; Constriction, Pathologic/complications ; Allium ; Low Back Pain/complications ; Ureteral Obstruction/surgery ; Ureteral Obstruction/etiology ; Ureteroscopy/methods ; Hydronephrosis/complications ; Stents/adverse effects ; Ureteral Calculi/complications ; Treatment Outcome
Language	English
Publishing date	2024-02-19
Publishing country	Spain
Document type	Case Reports
ZDB-ID	211673-x
ISSN	0004-0614
ISSN	0004-0614
DOI	10.56434/j.arch.esp.urol.20247701.15
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Article: Effect of WeChat-Based Medication Guidance on Symptoms and Serological Parameters in Children with Mycoplasma Pneumoniae.

Gao, Ke / Zeng, Ke / Yu, Xiping / Zhao, Wu / Qiu, Yanyan / Li, Yuyang / Li, Zhifei

Alternative therapies in health and medicine

2024

Abstract: Objective: The aim of this study was to assess the effect of microsoft-based medication guidance on the level of symptoms and serological indicators in children receiving budesonide nebulisation combined with terbutaline for the treatment of Mycoplasma ... ...

Abstract	Objective: The aim of this study was to assess the effect of microsoft-based medication guidance on the level of symptoms and serological indicators in children receiving budesonide nebulisation combined with terbutaline for the treatment of Mycoplasma pneumoniae pneumoniae (MPP). Methods: A total of 109 children with MPP treated in The First Affiliated Hospital of Ningbo University of China between October 2022 and April 2023 were divided into the conventional group (n=54, with medication guidance by telephone follow-up) and the WeChat group (n=55, with medication guidance based on the WeChat platform) using a randomized number table. The time to resolution of symptoms, serological index levels, incidence of adverse drug events, medication adherence scores and satisfaction rate of family guidance were compared between the two groups. Results: The disappearance time of symptoms such as wheezing and cough in the WeChat group was shorter than that in the conventional group (P < .05). After treatment, the C-reactive protein (CRP), interleukin-6 (IL-6) and calcitoninogen (PCT) levels and the incidence of adverse drug events were lower in the WeChat group than in the conventional group (P < .05). After treatment, the levels of forceful spirometry (FVC), 1st-second expiratory volume (FEV1), peak expiratory flow rate (PEF), medication compliance score and family guidance satisfaction rate were higher in the WeChat group than in the conventional group (P < .05). Conclusion: WeChat-based medication guidance can optimize the therapeutic effect of MPP, improve children's medication compliance and satisfaction rate of family guidance, and reduce the occurrence of adverse drug events.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
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Article ; Online: Recent advances in neuroinflammation prevention and therapy: the role of natural products and underlying mechanisms based on molecular targets.

Zhao, Mei-Mei / Duan, Jun-Yu / Shen, Yue / Liu, Yang / Zeng, Ke-Wu

British journal of pharmacology

2024

Abstract: Neuroinflammation is initiated in response to a variety of endogenous and exogenous sources. As the resident macrophages of the central nervous system, the polarization of microglia into either the M1 pro-inflammatory phenotype or the M2 anti- ... ...

Abstract	Neuroinflammation is initiated in response to a variety of endogenous and exogenous sources. As the resident macrophages of the central nervous system, the polarization of microglia into either the M1 pro-inflammatory phenotype or the M2 anti-inflammatory phenotype holds great promise as a therapeutic strategy for neuroinflammation. Natural products, comprising a vital chemical library with distinctive structures and diverse functions, have been extensively employed to modulate microglial polarization for the treatment of neuroinflammation. In this review, we present up-to-date and extensive insights into the therapeutic effects and underlying mechanisms of natural products in the context of neuroinflammation. Furthermore, the review aims to present a new perspective by focusing on the targets of natural compounds, elucidating the molecular mechanisms and guiding the transition from natural-derived lead compounds to potential anti-neuroinflammatory drugs. Additionally, we provide a comprehensive overview of the challenges and limitations associated with the utilization of natural products for neuroinflammation therapy.
Language	English
Publishing date	2024-05-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16404
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Article ; Online: Effects of different sonication parameters of theta burst transcranial ultrasound stimulation on human motor cortex.

Zeng, Ke / Li, Zhiwei / Xia, Xue / Wang, Zhen / Darmani, Ghazaleh / Li, Xiaoli / Chen, Robert

Brain stimulation

2024 Volume 17, Issue 2, Page(s) 258–268

Abstract: Background: Theta burst TUS (tbTUS) can induce increased cortical excitability in human, but how different sonication parameters influence the effects are still unknown.: Objective: To examine how a range of sonication parameters, including acoustic ... ...

Abstract	Background: Theta burst TUS (tbTUS) can induce increased cortical excitability in human, but how different sonication parameters influence the effects are still unknown. Objective: To examine how a range of sonication parameters, including acoustic intensity, pulse repetition frequency, duty cycle and sonication duration, influence the effects of tbTUS on human motor cortical excitability. Methods: 14 right-handed healthy subjects underwent 8 sessions with different tbTUS parameters in a randomized, cross-over design on separate days. The original tbTUS protocol was studied in one session and one parameter was changed in each of the seven sessions. To examine changes in cortical excitability induced by tbTUS, we measured the motor-evoked potential (MEP) amplitude, resting motor threshold, short-interval intracortical inhibition and intracortical facilitation, as well as short-interval intracortical facilitation before and up to 90 min after tbTUS. Results: All conditions increased MEP amplitudes except the condition with low acoustic intensity of 10 W/cm Conclusions: Ultrasound bursts repeated at theta (∼5 Hz) frequency is optimal to produce increased cortical excitability with the range of 2-10 Hz. Furthermore, there was a dose-response effect regarding duty cycle and sonication duration in tbTUS for plasticity induction. The aftereffects of tbTUS were associated with a shift of the inhibition/excitation balance toward less inhibition and more excitation in the motor cortex. These findings can be used to determine the optimal tbTUS parameters in neuroscience research and treatment of neurological and psychiatric disorders.
MeSH term(s)	Humans ; Motor Cortex/physiology ; Male ; Evoked Potentials, Motor/physiology ; Female ; Adult ; Theta Rhythm/physiology ; Cross-Over Studies ; Young Adult ; Transcranial Magnetic Stimulation/methods ; Sonication/methods
Language	English
Publishing date	2024-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Randomized Controlled Trial
ZDB-ID	2394410-9
ISSN	1876-4754 ; 1935-861X
ISSN (online)	1876-4754
ISSN	1935-861X
DOI	10.1016/j.brs.2024.03.001
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Article: Effects of interpretation bias modification on hostile attribution bias and reactive cyber-aggression in Chinese adolescents: a randomized controlled trial.

Zeng, Ke / Cao, Feizhen / Wu, Yajun / Zhang, Manhua / Ding, Xinfang

Current psychology (New Brunswick, N.J.)

2023 , Page(s) 1–14

Abstract: Highly aggressive individuals tend to interpret others' motives and intentions as hostile in both offline and online social situations. The current study examined whether hostile interpretation bias can be modified to influence cyber-aggression in ... ...

Abstract	Highly aggressive individuals tend to interpret others' motives and intentions as hostile in both offline and online social situations. The current study examined whether hostile interpretation bias can be modified to influence cyber-aggression in Chinese middle school students using an interpretation bias modification program. Gender differences and the heterogeneity of cyber-aggression were also investigated since previous studies suggest that they play important roles in determining the intervention effect. One hundred and twenty-one middle school students were randomized to receive either an eight-session interpretation bias modification task (CBM-I; Supplementary information: The online version contains supplementary material available at 10.1007/s12144-023-04433-3.
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2021598-8
ISSN	1936-4733 ; 1046-1310
ISSN (online)	1936-4733
ISSN	1046-1310
DOI	10.1007/s12144-023-04433-3
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Article ; Online: Preparation of g-C3N4/AgIn(MoO4)2 and its photocatalytic degradation of tetracycline hydrochloride

Jia Lijun / Zhang Qianqian / Yan Xu / Zeng Ke

E3S Web of Conferences, Vol 252, p

2021 Volume 02076

Abstract: Graphite phased carbon nitride and indium silver molybdate [g-C3N4 / AgIn(MoO4)2]photocatalytic materials were prepared by hydrothermal method. X-ray diffraction, transmission electron microscope, scanning electron microscope, X-ray photoelectric ... ...

Abstract	Graphite phased carbon nitride and indium silver molybdate [g-C3N4 / AgIn(MoO4)2]photocatalytic materials were prepared by hydrothermal method. X-ray diffraction, transmission electron microscope, scanning electron microscope, X-ray photoelectric spectrum, UV-vis diffuse reflection spectrum and solid fluorescence were used to analyze its structure and morphology. The results showed that the catalytic activity of g-C3N4 / AgIn(MoO4)2 was significantly higher than that of pure g-C3N4 and AgIn(MoO4)2 under visible light irradiation. Under the conditions of g-C3N4 and AgIn(MoO4)2 with a compound ratio of 2:1 and hydrothermal reaction at 120℃ for 6 hours, the degradation efficiency of tetracycline hydrochloride was the best. After 1 hour of light reaction, the degradation rate of tetracycline hydrochloride could reach 75.3%. g-C3N4/AgIn(MoO4)2 is expected to be a promising photocatalyst for wastewater treatment.
Keywords	Environmental sciences ; GE1-350
Subject code	540
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Rapid in situ determination of ClO2 in drinking water by improved solid DPD spectrophotometry

Zhang Qianqian / Jia Lijun / Hao Tianli / Zeng Ke

E3S Web of Conferences, Vol 252, p

2021 Volume 02063

Abstract: This research aims to realize the rapid detection of ClO2 content in drinking water by adopting improved solid DPD. This method is fast and convenient with low cost and less waste liquid. The results show that this method has good precision and ... ...

Abstract	This research aims to realize the rapid detection of ClO2 content in drinking water by adopting improved solid DPD. This method is fast and convenient with low cost and less waste liquid. The results show that this method has good precision and sensitivity. The linear correlation coefficients of the cubic regression equation were all greater than 0.999. The detection limit of the method was 0.002mg/L ClO2. The relative standard deviations (RSD) of seven parallel tests were between 1.37% and 8.87%, and the relative errors were small. The recovery rate was 96.67~110%. The method could be used for the direct determination of water samples with a mass concentration of 0.02mg/L~2.00mg/L in drinking water after ClO2 disinfection.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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