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Article: Farmer Heterogeneity and Land Transfer Decisions Based on the Dual Perspectives of Economic Endowment and Land Endowment

Cheng, Ying / Hu, Yuan / Zeng, Weizhong / Liu, Zhongbao

Land. 2022 Feb. 27, v. 11, no. 3

2022

Abstract: Guiding qualified farmers to transfer their land is an important way to alleviate the problem of land abandonment, improve land use efficiency, and achieve moderately large-scale land management. Based on the dual perspectives of economic endowment and ... ...

Abstract	Guiding qualified farmers to transfer their land is an important way to alleviate the problem of land abandonment, improve land use efficiency, and achieve moderately large-scale land management. Based on the dual perspectives of economic endowment and land endowment, this paper uses the 2015 data of the China Household Finance Survey (CHFS), using the semilogarithmic ordinary least-squares method and the logit model, to explore differences in land transfer decisions under the effect of farmer heterogeneity. The circulation trading market was further improved to provide a reference. The heterogeneity of economic endowment and land endowment significantly affects the decision-making behavior of farmers in transferring land. The higher the land endowment is, the greater the probability that farmers transfer the land out and successfully trade, and they are more inclined to transfer the cultivated land to cooperatives, village collectives, and other institutions through formal channels, leading to a higher unit income of the transfer. Further research shows that land endowment has no significant difference in the impact of land endowment on whether farmers with different livelihood endowments transfer their land, but under the same land endowment, farmers with economic endowment advantages are more able to use their own endowment advantages to transfer their land out through formal channels and obtain higher gains income. Therefore, focusing on improving the conditions of land resources and increasing the endowment of farmers are important means to promote successful transactions in the land transfer market, ensure its sustainable operation, and promote further increase in the income of transfer farmers.
Keywords	abandoned land ; agricultural land ; decision making ; family resource management ; farmers ; income ; land use ; least squares ; livelihood ; logit analysis ; markets ; probability ; surveys ; trade ; villages ; China
Language	English
Dates of publication	2022-0227
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2682955-1
ISSN	2073-445X
ISSN	2073-445X
DOI	10.3390/land11030353
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Effectiveness of corticosteroids to treat coronavirus disease 2019 symptoms: A meta-analysis.

Zeng, Yiqian / Zeng, Weizhong / Yang, Bihui / Liu, Zhao

Medicina clinica

2022 Volume 159, Issue 12, Page(s) 575–583

Abstract: Objective: Currently, corticosteroids are widely used to treat coronavirus disease 2019 (COVID-19) symptoms. However, the therapeutic role of corticosteroids remains highly controversial. To that end, we aimed to assess the efficacy of corticosteroids ... ...

Abstract	Objective: Currently, corticosteroids are widely used to treat coronavirus disease 2019 (COVID-19) symptoms. However, the therapeutic role of corticosteroids remains highly controversial. To that end, we aimed to assess the efficacy of corticosteroids in treating COVID-19 patients. Method: We searched PubMed, Embase, and Cochrane Library to select suitable studies. Our primary study endpoint was all-cause mortality. The secondary study endpoint was the length of hospital stay. Results: A total of 9 randomized controlled trials (RCTs) with 7907 patients were assessed. The pooled result indicated that corticosteroids treatment could significantly reduce all-cause mortality in patients with COVID-19 (RR=0.88, 95% CI [0.82, 0.95], P=0.002). When subgroup analyses were performed, we found that corticosteroids were associated with decreased all-cause mortality in severe COVID-19 patients (RR=0.77, 95% CI [0.68, 0.88], P<0.0001), however no obvious difference was observed in all-cause mortality of non-severe COVID-19 patients between the corticosteroid and control group (RR=0.96, 95% CI [0.86, 1.06], P=0.41), meanwhile, a low dose (RR=0.89, 95% CI [0.82, 0.97], P=0.007) of dexamethasone (RR=0.9, 95% CI [0.83, 0.98], P=0.01) with a long treatment course (RR=0.89, 95% CI [0.82, 0.98], P=0.02) was beneficial for all-cause mortality in COVID-19 patients. Additionally, we found that corticosteroids might be associated with a longer length of hospital stay in non-severe COVID-19 patients (MD=3.83, 95% CI [1.11, 6.56], P=0.006). Conclusion: Our results showed that corticosteroid therapy was related to a reduction in all-cause mortality in severe COVID-19 patients. However, in patients with non-severe COVID-19, the use of corticosteroids did not decrease all-cause mortality and may prolong the duration of hospital stay. In addition, we revealed that a low dose of dexamethasone with a long treatment course could reduce all-cause mortality in COVID-19 patients.
MeSH term(s)	Humans ; COVID-19 ; Adrenal Cortex Hormones/therapeutic use ; Length of Stay ; Dexamethasone/therapeutic use ; Randomized Controlled Trials as Topic
Chemical Substances	Adrenal Cortex Hormones ; Dexamethasone (7S5I7G3JQL)
Language	Spanish
Publishing date	2022-05-03
Publishing country	Spain
Document type	Meta-Analysis ; Journal Article
ZDB-ID	411607-0
ISSN	1578-8989 ; 0025-7753
ISSN (online)	1578-8989
ISSN	0025-7753
DOI	10.1016/j.medcli.2022.03.013
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Article ; Online: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

Zhang, Jiyuan / Zeng, Weizhong / Han, Yan / Lee, Wan-Ru / Liou, Jen / Jiang, Youxing

Molecular Cell. 20232023 July 29, June 29, v. 83, no. 14 p.2524-2539.e7

2023

Abstract: Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to unravel a key biological function of human lysosome-associated membrane ... ...

Abstract	Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to unravel a key biological function of human lysosome-associated membrane proteins (LAMP-1 and LAMP-2) in regulating lysosomal pH homeostasis. Despite being widely used as a lysosomal marker, the physiological functions of the LAMP proteins have long been overlooked. We show that LAMP-1 and LAMP-2 directly interact with and inhibit the activity of the lysosomal cation channel TMEM175, a key player in lysosomal pH homeostasis implicated in Parkinson’s disease. This LAMP inhibition mitigates the proton conduction of TMEM175 and facilitates lysosomal acidification to a lower pH environment crucial for optimal hydrolase activity. Disrupting the LAMP-TMEM175 interaction alkalinizes the lysosomal pH and compromises the lysosomal hydrolytic function. In light of the ever-increasing importance of lysosomes to cellular physiology and diseases, our data have widespread implications for lysosomal biology.
Keywords	acidification ; electrophysiology ; homeostasis ; humans ; hydrolases ; ion channels ; lysosomes ; pH ; proteomics ; lysosomal LAMP proteins ; LAMP-1 and LAMP-2 ; TMEM175 ; lysosomal pH homeostasis ; lysosome acidification ; lysosomal hydrolytic function ; risk factor for Parkinson’s disease
Language	English
Dates of publication	2023-0629
Size	p. 2524-2539.e7.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.06.004
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1.

Xue, Jing / Zeng, Weizhong / Han, Yan / John, Scott / Ottolia, Michela / Jiang, Youxing

Nature communications

2023 Volume 14, Issue 1, Page(s) 6181

Abstract: ... ...

Abstract	Na
MeSH term(s)	Humans ; Sodium-Calcium Exchanger/metabolism ; Ion Transport ; Heart ; Cytosol/metabolism ; Calcium/metabolism
Chemical Substances	Sodium-Calcium Exchanger ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-10-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41885-4
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Article ; Online: Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.

Zhang, Jiyuan / Zeng, Weizhong / Han, Yan / Lee, Wan-Ru / Liou, Jen / Jiang, Youxing

Molecular cell

2023 Volume 83, Issue 14, Page(s) 2524–2539.e7

Abstract	Maintaining a highly acidic lysosomal pH is central to cellular physiology. Here, we use functional proteomics, single-particle cryo-EM, electrophysiology, and in vivo imaging to unravel a key biological function of human lysosome-associated membrane proteins (LAMP-1 and LAMP-2) in regulating lysosomal pH homeostasis. Despite being widely used as a lysosomal marker, the physiological functions of the LAMP proteins have long been overlooked. We show that LAMP-1 and LAMP-2 directly interact with and inhibit the activity of the lysosomal cation channel TMEM175, a key player in lysosomal pH homeostasis implicated in Parkinson's disease. This LAMP inhibition mitigates the proton conduction of TMEM175 and facilitates lysosomal acidification to a lower pH environment crucial for optimal hydrolase activity. Disrupting the LAMP-TMEM175 interaction alkalinizes the lysosomal pH and compromises the lysosomal hydrolytic function. In light of the ever-increasing importance of lysosomes to cellular physiology and diseases, our data have widespread implications for lysosomal biology.
MeSH term(s)	Humans ; Hydrogen-Ion Concentration ; Lysosomal Membrane Proteins/genetics ; Lysosomal Membrane Proteins/metabolism ; Lysosomes/metabolism ; Parkinson Disease/metabolism ; Potassium Channels/metabolism
Chemical Substances	Lysosomal Membrane Proteins ; Potassium Channels ; TMEM175 protein, human ; LAMP1 protein, human ; LAMP2 protein, human
Language	English
Publishing date	2023-06-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.06.004
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Article ; Online: Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.

Xue, Jing / Han, Yan / Zeng, Weizhong / Jiang, Youxing

Neuron

2021 Volume 110, Issue 1, Page(s) 86–95.e5

Abstract: Mammalian cyclic nucleotide-gated (CNG) channels are nonselective cation channels activated by cGMP or cAMP and play essential roles in the signal transduction of the visual and olfactory sensory systems. CNGA1, the principal component of the CNG channel ...

Abstract	Mammalian cyclic nucleotide-gated (CNG) channels are nonselective cation channels activated by cGMP or cAMP and play essential roles in the signal transduction of the visual and olfactory sensory systems. CNGA1, the principal component of the CNG channel from rod photoreceptors, can by itself form a functional homotetrameric channel and has been used as the model system in the majority of rod CNG studies. However, the native rod CNG functions as a heterotetramer consisting of three A1 and one B1 subunits and exhibits different functional properties than the CNGA1 homomer. Here we present the functional analysis of human rod CNGA1/B1 heterotetramer and its cryo-EM structures in apo, cGMP-bound, cAMP-bound, and L-cis-Diltiazem-blocked states. These structures, with resolution ranging from 2.6 to 3.3 Å, elucidate the structural mechanisms underlying the 3:1 subunit stoichiometry, the asymmetrical gating upon cGMP activation, and the unique pharmacological property of the native rod CNG channel.
MeSH term(s)	Animals ; Cyclic GMP ; Cyclic Nucleotide-Gated Cation Channels ; Humans ; Mammals
Chemical Substances	Cyclic Nucleotide-Gated Cation Channels ; Cyclic GMP (H2D2X058MU)
Language	English
Publishing date	2021-10-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2021.10.006
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Article ; Online: Farmer heterogeneity and land transfer decisions based on the dual perspectives of economic endowment and land endowment

Cheng, Ying / Hu, Yuan / Zeng, Weizhong / Liu, Zhongbao

2022

Abstract	Guiding qualified farmers to transfer their land is an important way to alleviate the problem of land abandonment, improve land use efficiency, and achieve moderately large-scale land management. Based on the dual perspectives of economic endowment and land endowment, this paper uses the 2015 data of the China Household Finance Survey (CHFS), using the semilogarithmic ordinary least-squares method and the logit model, to explore differences in land transfer decisions under the effect of farmer heterogeneity. The circulation trading market was further improved to provide a reference. The heterogeneity of economic endowment and land endowment significantly affects the decision-making behavior of farmers in transferring land. The higher the land endowment is, the greater the probability that farmers transfer the land out and successfully trade, and they are more inclined to transfer the cultivated land to cooperatives, village collectives, and other institutions through formal channels, leading to a higher unit income of the transfer. Further research shows that land endowment has no significant difference in the impact of land endowment on whether farmers with different livelihood endowments transfer their land, but under the same land endowment, farmers with economic endowment advantages are more able to use their own endowment advantages to transfer their land out through formal channels and obtain higher gains income. Therefore, focusing on improving the conditions of land resources and increasing the endowment of farmers are important means to promote successful transactions in the land transfer market, ensure its sustainable operation, and promote further increase in the income of transfer farmers.
Keywords	ddc:330 ; land endowment ; economic endowment ; farmer heterogeneity ; land transfer out
Subject code	910
Language	English
Publisher	Basel: MDPI
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural mechanisms of gating and selectivity of human rod CNGA1 channel.

Xue, Jing / Han, Yan / Zeng, Weizhong / Wang, Yan / Jiang, Youxing

Neuron

2021 Volume 109, Issue 8, Page(s) 1302–1313.e4

Abstract: Mammalian cyclic nucleotide-gated (CNG) channels play an essential role in the signal transduction of the visual and olfactory sensory systems. Here we reveal the structural mechanism of ligand gating in human rod CNGA1 channel by determining its cryo-EM ...

Abstract	Mammalian cyclic nucleotide-gated (CNG) channels play an essential role in the signal transduction of the visual and olfactory sensory systems. Here we reveal the structural mechanism of ligand gating in human rod CNGA1 channel by determining its cryo-EM structures in both the apo closed and cGMP-bound open states. Distinct from most other members of voltage-gated tetrameric cation channels, CNGA1 forms a central channel gate in the middle of the membrane, occluding the central cavity. Structural analyses of ion binding profiles in the selectivity filters of the wild-type channel and the E365Q filter mutant allow us to unambiguously define the two Ca
MeSH term(s)	Binding Sites ; Calcium/metabolism ; Cyclic GMP/metabolism ; Cyclic Nucleotide-Gated Cation Channels/metabolism ; HEK293 Cells ; Humans ; Ion Channel Gating/physiology ; Protein Conformation
Chemical Substances	CNGA1 protein, human ; Cyclic Nucleotide-Gated Cation Channels ; Cyclic GMP (H2D2X058MU) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2021-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2021.02.007
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Article ; Online: Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P

Gan, Ninghai / Han, Yan / Zeng, Weizhong / Wang, Yan / Xue, Jing / Jiang, Youxing

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 7

Abstract: Transient receptor potential mucolipin 1 (TRPML1) is a ... ...

Abstract	Transient receptor potential mucolipin 1 (TRPML1) is a Ca
MeSH term(s)	Gene Expression Regulation/drug effects ; HEK293 Cells ; Humans ; Phosphatidylinositol Phosphates/pharmacology ; Sirolimus/pharmacology ; Transient Receptor Potential Channels/genetics ; Transient Receptor Potential Channels/metabolism
Chemical Substances	Mcoln1 protein, mouse ; Phosphatidylinositol Phosphates ; Transient Receptor Potential Channels ; phosphatidylinositol 3,5-diphosphate ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2022-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2120404119
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Article: [Electroacupuncture protects septic rats from acute lung injury through the JAK1/STAT3 pathway].

Xie, Cancan / Wu, Shuanghua / Li, Zhengrong / Huang, Bing / Zeng, Weizhong

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

2020 Volume 40, Issue 11, Page(s) 1662–1667

Abstract: Objective: To explore the protective effect of electroacupuncture against acute lung injury (ALI) in septic rats and explore the mechanism.: Methods: Sixty male SD rats were randomly divided into cecal ligation and puncture (CLP)-induced sepsis group ...

Abstract	Objective: To explore the protective effect of electroacupuncture against acute lung injury (ALI) in septic rats and explore the mechanism. Methods: Sixty male SD rats were randomly divided into cecal ligation and puncture (CLP)-induced sepsis group ( Results: Compared with those in the sham operation group, the rats in ALI group showed obvious lung pathologies with significantly increased lung W/D ratio ( Conclusions: Electroacupuncture can inhibit the release of inflammatory mediators and cell apoptosis via the JAK1/STAT3 pathway to reduce lung injuries in septic rats.
MeSH term(s)	Acute Lung Injury/therapy ; Animals ; Electroacupuncture ; Lung ; Male ; Rats ; Rats, Sprague-Dawley ; Sepsis/therapy ; Tumor Necrosis Factor-alpha
Chemical Substances	Tumor Necrosis Factor-alpha
Language	Chinese
Publishing date	2020-11-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2250951-3
ISSN	1673-4254
ISSN	1673-4254
DOI	10.12122/j.issn.1673-4254.2020.11.20
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