LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 65

Search options

  1. Article ; Online: Sensing and acting: Full circle in fat.

    Li, Qingqing / Zeng, Wenwen

    Cell metabolism

    2023  Volume 35, Issue 1, Page(s) 9–11

    Abstract: White adipose tissue (WAT) communicates with the CNS bidirectionally. In recent studies, aided by three-dimensional imaging, Wang et al. and Frei et al. have provided the organ-wide view of the afferent somatosensory network in the inguinal WAT (iWAT) ... ...

    Abstract White adipose tissue (WAT) communicates with the CNS bidirectionally. In recent studies, aided by three-dimensional imaging, Wang et al. and Frei et al. have provided the organ-wide view of the afferent somatosensory network in the inguinal WAT (iWAT) and have further delineated its critical involvement in energy balance.
    MeSH term(s) Adipose Tissue, White/metabolism ; Energy Metabolism
    Language English
    Publishing date 2023-01-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2022.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Antiviral immunity rewired for axon regeneration.

    Jiang, Meng / Zeng, Wenwen

    Cell reports. Medicine

    2022  Volume 4, Issue 1, Page(s) 100907

    Abstract: In Neuron's January ... ...

    Abstract In Neuron's January 18
    MeSH term(s) Antiviral Agents ; Axons ; Nerve Regeneration ; Immunity, Innate ; Signal Transduction
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-12-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2022.100907
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: The Sympathetic-Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues.

    Ren, Wenran / Hua, Meng / Cao, Fang / Zeng, Wenwen

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 11, Issue 8, Page(s) e2306128

    Abstract: Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important ... ...

    Abstract Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases.
    MeSH term(s) Liver ; Pancreas ; Adipose Tissue ; Intestines
    Language English
    Publishing date 2023-12-01
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202306128
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Fat mesenchyme closes the neural-ILC2 circuit.

    Meng, Xia / Zeng, Wenwen

    Immunity

    2021  Volume 54, Issue 10, Page(s) 2191–2193

    Abstract: The immune milieu and neuronal activity each impact adipose metabolic health, yet their interplay remains largely undefined. In a recent issue of Nature, Cardoso et al. uncover a sympathetic neuro-mesenchymal-ILC2s circuit from brain-to-fat controlling ... ...

    Abstract The immune milieu and neuronal activity each impact adipose metabolic health, yet their interplay remains largely undefined. In a recent issue of Nature, Cardoso et al. uncover a sympathetic neuro-mesenchymal-ILC2s circuit from brain-to-fat controlling obesity and glucose metabolism.
    MeSH term(s) Adipose Tissue ; Humans ; Immunity, Innate ; Lymphocytes ; Mesoderm ; Obesity
    Language English
    Publishing date 2021-10-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2021.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: RBP-J regulates homeostasis and function of circulating Ly6C

    Kou, Tiantian / Kang, Lan / Zhang, Bin / Li, Jiaqi / Zhao, Baohong / Zeng, Wenwen / Hu, Xiaoyu

    eLife

    2024  Volume 12

    Abstract: Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells ... ...

    Abstract Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6C
    MeSH term(s) Monocytes ; Myeloid Cells ; Macrophages ; Bone Marrow Transplantation ; Homeostasis ; Receptors, Chemokine
    Chemical Substances Receptors, Chemokine
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88135
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Stromal cell-derived NGF controls sympathetic innervation in subcutaneous fat.

    Meng, Xia / Chen, Jian / Zeng, Wenwen

    Journal of lipid research

    2022  Volume 64, Issue 2, Page(s) 100264

    MeSH term(s) Neurons ; Sympathetic Nervous System ; Subcutaneous Fat
    Language English
    Publishing date 2022-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2022.100264
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Neuroimmune regulation of white adipose tissues

    Qian, Xinmin / Meng, Xia / Zhang, Shan / Zeng, Wenwen

    The FEBS Journal. 2022 Dec., v. 289, no. 24 p.7830-7853

    2022  

    Abstract: The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. ... ...

    Abstract The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. Their activities are coordinated through intercellular communications among adipocytes and other cell types such as residential and infiltrating immune cells, which are collectively under neuronal control. The adipocytes and immune subtypes including macrophages/monocytes, eosinophils, neutrophils, group 2 innate lymphoid cells (ILC2s), T and B cells, dendritic cells (DCs), and natural killer (NK) cells display cellular and functional diversity in response to the energy states and contribute to metabolic homeostasis and pathological conditions. Accumulating evidence reveals that neuronal innervations control lipid deposition and mobilization via regulating lipolysis, adipocyte size, and cellularity. Vice versa, the neuronal innervations and activity are influenced by cellular factors in the WAT. Though the literature describing adipose tissue cells is too extensive to cover in detail, we strive to highlight a selected list of neuronal and immune components in this review. The cell‐to‐cell communications and the perspective of neuroimmune regulation are emphasized to enlighten the potential therapeutic opportunities for treating metabolic disorders.
    Keywords adipocytes ; adipose tissue ; energy ; eosinophils ; functional diversity ; homeostasis ; lipids ; lipolysis ; macrophages ; monocytes ; neurons ; neutrophils ; therapeutics
    Language English
    Dates of publication 2022-12
    Size p. 7830-7853.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note REVIEW
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16213
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article ; Online: MS4A4A Regulates Arginase 1 Induction during Macrophage Polarization and Lung Inflammation in Mice.

    Sui, Yinqiang / Zeng, Wenwen

    European journal of immunology

    2020  Volume 50, Issue 10, Page(s) 1602–1605

    Abstract: MS4A4A regulates the expression of arginase 1 in macrophages under IL4 stimulation. Also, MS4A4A regulates eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite. ...

    Abstract MS4A4A regulates the expression of arginase 1 in macrophages under IL4 stimulation. Also, MS4A4A regulates eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite.
    MeSH term(s) Animals ; Antigens, Dermatophagoides/immunology ; Arginase/genetics ; Arginase/metabolism ; Cell Differentiation ; Eosinophils/immunology ; Hypersensitivity/immunology ; Lung/immunology ; Macrophage Activation ; Macrophages/physiology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Pneumonia/immunology ; Pyroglyphidae ; Up-Regulation
    Chemical Substances Antigens, Dermatophagoides ; Membrane Proteins ; Ms4a4b protein, mouse ; Arg1 protein, mouse (EC 3.5.3.1) ; Arginase (EC 3.5.3.1)
    Language English
    Publishing date 2020-07-29
    Publishing country Germany
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 120108-6
    ISSN 1521-4141 ; 0014-2980
    ISSN (online) 1521-4141
    ISSN 0014-2980
    DOI 10.1002/eji.202048585
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Neuroimmune regulation of white adipose tissues.

    Qian, Xinmin / Meng, Xia / Zhang, Shan / Zeng, Wenwen

    The FEBS journal

    2021  

    Abstract: The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. ... ...

    Abstract The white adipose tissues (WAT) are located in distinct depots throughout the body. They serve as an energy reserve, providing fatty acids for other tissues via lipolysis when needed, and function as an endocrine organ to regulate systemic metabolism. Their activities are coordinated through intercellular communications among adipocytes and other cell types such as residential and infiltrating immune cells, which are collectively under neuronal control. The adipocytes and immune subtypes including macrophages/monocytes, eosinophils, neutrophils, group 2 innate lymphoid cells (ILC2s), T and B cells, dendritic cells (DCs), and natural killer (NK) cells display cellular and functional diversity in response to the energy states and contribute to metabolic homeostasis and pathological conditions. Accumulating evidence reveals that neuronal innervations control lipid deposition and mobilization via regulating lipolysis, adipocyte size, and cellularity. Vice versa, the neuronal innervations and activity are influenced by cellular factors in the WAT. Though the literature describing adipose tissue cells is too extensive to cover in detail, we strive to highlight a selected list of neuronal and immune components in this review. The cell-to-cell communications and the perspective of neuroimmune regulation are emphasized to enlighten the potential therapeutic opportunities for treating metabolic disorders.
    Language English
    Publishing date 2021-09-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16213
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Anti-melanization effects and inhibitory kinetics of tyrosinase of bird's nest fern (Asplenium australasicum) frond extracts on melanoma and human skin.

    Zeng, Wen-Wen / Lai, Lih-Shiuh

    Journal of bioscience and bioengineering

    2019  Volume 127, Issue 6, Page(s) 738–743

    Abstract: Some bioactive properties of p-coumaric acid and fucose-rich polysaccharide in skin health have been studied, including melanogenesis inhibition of the phenolic acid and growth inhibitory effects of the polysaccharide on melanoma. The dermatological ... ...

    Abstract Some bioactive properties of p-coumaric acid and fucose-rich polysaccharide in skin health have been studied, including melanogenesis inhibition of the phenolic acid and growth inhibitory effects of the polysaccharide on melanoma. The dermatological benefits of bird's nest fern extracts (BNFE), containing both substantial fucose-rich polysaccharide and p-coumaric acid, like promoting collagen production and growth of fibroblast cell and further improving the elasticity and dryness of human skins have been demonstrated in our previous study. Besides, the anti-melanization effects of various BNFE on B16-F10 melanoma and human skin were first studied here. The promising extracts revealed that the main phenolic acid, p-coumaric acid, in BNFE resulted in suppression against tyrosinase activity from melanogenesis. The inhibitory kinetics on the diphenolase activity indicated that AE40 was a noncompetitive inhibitor of mushroom tyrosinase. On the other hand, the fucose-rich mucilage of BNFE showed pronouncedly suppressing effect on B16-F10 melanoma viability. Clinical trial was performed by recruiting 46 female volunteers and the results indicated that the lotions with 1% of BNFE was non-irritant and reduced effectively the pigmentation on human skin after 7-14 days of continuous application. It was suggested that the fucose-rich mucilage and p-coumaric acid in BNFE may have potential for nutricosmetics and phytotherapy applications as a natural hypopigmenting agent.
    MeSH term(s) Enzyme Inhibitors/pharmacology ; Female ; Ferns/enzymology ; Humans ; Kinetics ; Melanins/biosynthesis ; Melanoma, Experimental/metabolism ; Monophenol Monooxygenase/antagonists & inhibitors ; Pigmentation/drug effects ; Plant Extracts/pharmacology ; Skin/drug effects ; Skin/metabolism
    Chemical Substances Enzyme Inhibitors ; Melanins ; Plant Extracts ; Monophenol Monooxygenase (EC 1.14.18.1)
    Language English
    Publishing date 2019-01-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1465387-4
    ISSN 1347-4421 ; 1389-1723
    ISSN (online) 1347-4421
    ISSN 1389-1723
    DOI 10.1016/j.jbiosc.2018.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top