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Article ; Online: Reply to a letter to the Editor regarding the article "Sleep and Hypertension".

Zeng, Ziqian

2020 Volume 25, Issue 2, Page(s) 1169

MeSH term(s)	Humans ; Hypertension/epidemiology ; Sleep ; Sleep Apnea, Obstructive/therapy
Language	English
Publishing date	2020-09-24
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-020-02196-w
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Zs.A 5658: Show issues

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Article: Real-time tracking of fibrinolysis under constant wall shear and various pulsatile flows in an in-vitro thrombolysis model.

Zeng, Ziqian / Christodoulides, Alexei / Alves, Nathan J

Bioengineering & translational medicine

2023 Volume 8, Issue 3, Page(s) e10511

Abstract: A great need exists for the development of a more representative in-vitro model to efficiently screen novel thrombolytic therapies. We herein report the design, validation, and characterization of a highly reproducible, physiological scale, flowing clot ... ...

Abstract	A great need exists for the development of a more representative in-vitro model to efficiently screen novel thrombolytic therapies. We herein report the design, validation, and characterization of a highly reproducible, physiological scale, flowing clot lysis platform with real-time fibrinolysis monitoring to screen thrombolytic drugs utilizing a fluorescein isothiocyanate (FITC)-labeled clot analog. Using this Real-Time Fluorometric Flowing Fibrinolysis assay (RT-FluFF assay), a tPa-dependent degree of thrombolysis was observed both via clot mass loss as well as fluorometrically monitored release of FITC-labeled fibrin degradation products. Percent clot mass loss ranged from 33.6% to 85.9% with fluorescence release rates of 0.53 to 1.17 RFU/min in 40 and 1000 ng/mL tPa conditions, respectively. The platform is easily adapted to produce pulsatile flows. Hemodynamics of human main pulmonary artery were mimicked through matching dimensionless flow parameters calculated using clinical data. Increasing pressure amplitude range (4-40 mmHg) results in a 20% increase of fibrinolysis at 1000 ng/mL tPA. Increasing shear flow rate (205-913 s
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ISSN	2380-6761
ISSN	2380-6761
DOI	10.1002/btm2.10511
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Book ; Online: From Ultra-Fine to Fine

Dai, Hongliang / Zeng, Ziqian

Fine-tuning Ultra-Fine Entity Typing Models to Fine-grained

2023

Abstract: For the task of fine-grained entity typing (FET), due to the use of a large number of entity types, it is usually considered too costly to manually annotating a training dataset that contains an ample number of examples for each type. A common way to ... ...

Abstract	For the task of fine-grained entity typing (FET), due to the use of a large number of entity types, it is usually considered too costly to manually annotating a training dataset that contains an ample number of examples for each type. A common way to address this problem is to use distantly annotated training data that contains incorrect labels. However, the performance of models trained solely with such data can be limited by the errors in the automatic annotation. Recently, there are a few approaches that no longer follow this conventional way. But without using sufficient direct entity typing supervision may also cause them to yield inferior performance. In this paper, we propose a new approach that can avoid the need of creating distantly labeled data whenever there is a new type schema. We first train an entity typing model that have an extremely board type coverage by using the ultra-fine entity typing data. Then, when there is a need to produce a model for a newly designed fine-grained entity type schema. We can simply fine-tune the previously trained model with a small number of examples annotated under this schema. Experimental results show that our approach achieves outstanding performance for FET under the few-shot setting. It can also outperform state-of-the-art weak supervision based methods after fine-tuning the model with only a small size manually annotated training set. Comment: ACL 2023
Keywords	Computer Science - Computation and Language
Subject code	005
Publishing date	2023-12-11
Publishing country	us
Document type	Book ; Online
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Article ; Online: Reply to a letter to the editor regarding "The association between altitude and the prevalence of hypertension among permanent highlanders".

Zhang, Yuewen / Chen, Weizhong / Zeng, Ziqian

Hypertension research : official journal of the Japanese Society of Hypertension

2022 Volume 46, Issue 2, Page(s) 546–547

MeSH term(s)	Humans ; Altitude ; Prevalence ; Hypertension/epidemiology
Language	English
Publishing date	2022-11-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1175297-x
ISSN	1348-4214 ; 0916-9636
ISSN (online)	1348-4214
ISSN	0916-9636
DOI	10.1038/s41440-022-01102-z
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Zs.A 3898: Show issues

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Article ; Online: Multivalent Benzamidine Molecules for Plasmin Inhibition: Effect of Valency and Linker Length.

Nallan Chakravarthula, Tanmaye / Zeng, Ziqian / Alves, Nathan J

ChemMedChem

2022 Volume 17, Issue 22, Page(s) e202200364

Abstract: There is an emerging interest in utilizing synthetic multivalent inhibitors that comprise of multiple inhibitor moieties linked on a common scaffold to achieve strong and selective enzyme inhibition. As multivalent inhibition is impacted by valency and ... ...

Abstract	There is an emerging interest in utilizing synthetic multivalent inhibitors that comprise of multiple inhibitor moieties linked on a common scaffold to achieve strong and selective enzyme inhibition. As multivalent inhibition is impacted by valency and linker length, in this study, we explore the effect of multivalent benzamidine inhibitors of varying valency and linker length on plasmin inhibition. Plasmin is an endogenous enzyme responsible for digesting fibrin present in blood clots. Monovalent plasmin(ogen) inhibitors are utilized clinically to treat hyperfibrinolysis-associated bleeding events. Benzamidine is a reversible inhibitor that binds to plasmin's active site. Herein, multivalent benzamidine inhibitors of varying valencies (mono-, bi- and tri-valent) and linker lengths (∼1-12 nm) were synthesized to systematically study their effect on plasmin inhibition. Inhibition assays were performed using a plasmin substrate (S-2251) to determine inhibition constants (Ki). Pentamidine (shortest bivalent) and Tri-AMB (shortest trivalent) were the strongest inhibitors with Ki values of 2.1±0.8 and 3.9±1.7 μM, respectively. Overall, increasing valency and decreasing linker length, increases effective local concentration of the inhibitor and therefore, resulted in stronger inhibition of plasmin via statistical rebinding. This study aids in the design of multivalent inhibitors that can achieve desired enzyme inhibition by means of modulating valency and linker length.
MeSH term(s)	Fibrinolysin/chemistry ; Fibrinolysin/metabolism ; Benzamidines/pharmacology
Chemical Substances	Fibrinolysin (EC 3.4.21.7) ; benzamidine (KUE3ZY3J1F) ; Benzamidines
Language	English
Publishing date	2022-10-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202200364
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Zs.A 6280: Show issues

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Article ; Online: In-vitro thromboelastographic characterization of reconstituted whole blood utilizing cryopreserved platelets.

Christodoulides, Alexei / Zeng, Ziqian / Alves, Nathan J

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2021 Volume 32, Issue 8, Page(s) 556–563

Abstract: Conducting in-vitro thrombosis research presents numerous challenges, the primary of which is working with blood products, whether whole blood or fractionated whole blood, that have limited functional shelf-lives. As a result, being able to significantly ...

Abstract	Conducting in-vitro thrombosis research presents numerous challenges, the primary of which is working with blood products, whether whole blood or fractionated whole blood, that have limited functional shelf-lives. As a result, being able to significantly prolong the clotting functionality of whole blood via fractionation and recombination promises greater accessibility via resource minimization in the realm of thrombosis research. Whole blood with CPDA1 from healthy volunteers was fractionated and stored as frozen platelet-free plasma (PFP, -20°C), refrigerated packed red blood cells (pRBCs, 4°C) and cryopreserved platelets (-80°C). Subsequent recombination of the above components into their native ratios were tested via thromboelastography (TEG) to capture clotting dynamics over a storage period of 13 weeks in comparison to refrigerated unfractionated WB+CPDA1. Reconstituted whole blood utilizing PFP, pRCBs and cryopreserved platelets were able to maintain clot strength (maximum amplitude) akin to day-0 whole blood even after 13 weeks of storage. Clots formed by reconstituted whole blood exhibited quicker clotting dynamics with nearly two-fold shorter R-times and nearly 1.3-fold increase in fibrin deposition rate as measured by TEG. Storage of fractionated whole blood components, in their respective ideal conditions, provides a means of prolonging the usable life of whole blood for in-vitro thrombosis research. Cryopreserved platelets, when recombined with frozen PFP and refrigerated pRBCs, are able to form clots that nearly mirror the overall clotting profile expected of freshly drawn WB.
MeSH term(s)	Blood Coagulation ; Blood Platelets ; Blood Preservation ; Cryopreservation ; Humans ; Thrombelastography
Language	English
Publishing date	2021-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001075
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Zs.A 2920: Show issues

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Article ; Online: Impact of baseline and longitudinal allostatic load changes on incident cardiovascular disease and all-cause mortality: A 7-year population-based cohort study in China.

Li, Yachao / Chen, Chu / Wen, Ying / Wang, Xiuli / Zeng, Ziqian / Shi, Hongying / Chen, Xiaofang / Sun, Ruichan / Xue, Qingping

Journal of affective disorders

2024 Volume 355, Page(s) 487–494

Abstract: Background: We aimed to prospectively examine the association of baseline allostatic load (AL) and longitudinal AL changes with incident cardiovascular disease (CVD) and all-cause mortality among middle-aged and elderly Chinese populations and evaluate ... ...

Abstract	Background: We aimed to prospectively examine the association of baseline allostatic load (AL) and longitudinal AL changes with incident cardiovascular disease (CVD) and all-cause mortality among middle-aged and elderly Chinese populations and evaluate the relative contributions of each physiological system of AL. Methods: Data from the China Health and Retirement Longitudinal Study (CHARLS) among adults aged 45 years or older were analyzed. Cox regression models were used to estimate the hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for the associations between baseline AL/longitudinal AL changes with incident CVD and all-cause mortality. Results: Compared with adults with AL 0-1, HRs of those with baseline AL 2-3 and AL ≥ 4 were 1.24 (95 % CI: 1.06, 1.45) and 1.51 (95 % CI: 1.27, 1.80) for incident CVD, and 1.39 (95 % CI: 1.11, 1.75) and 2.02 (95 % CI: 1.60, 2.54) for all-cause mortality. Similar results were found when we treated baseline AL as a continuous variable. We also found per AL score increase during 4 years of follow-up was related to a 11 % (HR, 1.11; 95 % CI: 1.03, 1.20) and 21 % (HR, 1.21; 95 % CI: 1.10, 1.34) increase in incident CVD and all-cause mortality, respectively. Limitations: Self-reported physician-diagnosed CVD was used to assess the incident CVD. Conclusions: Both baseline AL and longitudinal increases in AL were positively associated with incident CVD and all-cause mortality in middle-aged and elderly adults. Individuals with high AL need to be dynamically monitored for CVD and pre-mature mortality prevention.
MeSH term(s)	Aged ; Adult ; Middle Aged ; Humans ; Cardiovascular Diseases/epidemiology ; Longitudinal Studies ; Cohort Studies ; Allostasis ; Risk Factors
Language	English
Publishing date	2024-03-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2024.03.124
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Zs.A 1485: Show issues

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Article ; Online: New Pyranone Derivatives and Sesquiterpenoid Isolated from the Endophytic Fungus

Zhang, Yan / Jin, Yang / Yan, Wensi / Gu, Peishan / Zeng, Ziqian / Li, Ziying / Zhang, Guangtao / Wei, Mi / Xue, Yongbo

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: ... The ... ...

Abstract	The fungus
MeSH term(s)	Mice ; Animals ; RAW 264.7 Cells ; Xylariales/chemistry ; Sesquiterpenes/chemistry ; Sesquiterpenes/pharmacology ; Sesquiterpenes/isolation & purification ; Nitric Oxide/biosynthesis ; Nitric Oxide/metabolism ; Glycoside Hydrolase Inhibitors/chemistry ; Glycoside Hydrolase Inhibitors/pharmacology ; Glycoside Hydrolase Inhibitors/isolation & purification ; Molecular Structure ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/isolation & purification ; Lipopolysaccharides ; Microbial Sensitivity Tests ; Macrophages/drug effects ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification
Chemical Substances	Sesquiterpenes ; Nitric Oxide (31C4KY9ESH) ; Glycoside Hydrolase Inhibitors ; Anti-Inflammatory Agents ; Lipopolysaccharides ; Anti-Infective Agents
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081728
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Article: Speckle rheological spectroscopy reveals wideband viscoelastic spectra of biological tissues.

Leartprapun, Nichaluk / Zeng, Ziqian / Hajjarian, Zeinab / Bossuyt, Veerle / Nadkarni, Seemantini K

bioRxiv : the preprint server for biology

2023

Abstract: Mechanical transformation of tissue is not merely a symptom but a decisive driver in pathological processes. Comprising intricate network of cells, fibrillar proteins, and interstitial fluid, tissues exhibit distinct solid-(elastic) and liquid-like ( ... ...

Abstract	Mechanical transformation of tissue is not merely a symptom but a decisive driver in pathological processes. Comprising intricate network of cells, fibrillar proteins, and interstitial fluid, tissues exhibit distinct solid-(elastic) and liquid-like (viscous) behaviours that span a wide band of frequencies. Yet, characterization of wideband viscoelastic behaviour in whole tissue has not been investigated, leaving a vast knowledge gap in the higher frequency range that is linked to fundamental intracellular processes and microstructural dynamics. Here, we present wideband Speckle rHEologicAl spectRoScopy (SHEARS) to address this need. We demonstrate, for the first time, analysis of frequency-dependent elastic and viscous moduli up to the sub-MHz regime in biomimetic scaffolds and tissue specimens of blood clots, breast tumours, and bone. By capturing previously inaccessible viscoelastic behaviour across the wide frequency spectrum, our approach provides distinct and comprehensive mechanical signatures of tissues that may provide new mechanobiological insights and inform novel disease prognostication.
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.08.544037
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Article ; Online: Effect of Chandler loop shear and tubing size on thrombus architecture.

Zeng, Ziqian / Nallan Chakravarthula, Tanmaye / Christodoulides, Alexei / Hall, Abigail / Alves, Nathan J

Journal of materials science. Materials in medicine

2023 Volume 34, Issue 5, Page(s) 24

Abstract: Thrombosis can lead to a wide variety of life-threatening circumstances. As current thrombolytic drug screening models often poorly predict drug profiles, leading to failure of thrombolytic therapy or clinical translation, more representative clot ... ...

Abstract	Thrombosis can lead to a wide variety of life-threatening circumstances. As current thrombolytic drug screening models often poorly predict drug profiles, leading to failure of thrombolytic therapy or clinical translation, more representative clot substrates are necessary for drug evaluation. Utilizing a Chandler loop device to form clot analogs at high shear has gained popularity in stroke societies. However, shear-dependent clot microstructure has not been fully addressed and low shear conditions are often overlooked. We herein characterized the impact of wall shear rate (126 to 951 s
MeSH term(s)	Humans ; Thrombosis ; Blood Platelets ; Stroke/pathology ; Stroke/therapy ; Fibrinolytic Agents ; Fibrin
Chemical Substances	Fibrinolytic Agents ; Fibrin (9001-31-4)
Language	English
Publishing date	2023-05-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1031752-1
ISSN	1573-4838 ; 0957-4530
ISSN (online)	1573-4838
ISSN	0957-4530
DOI	10.1007/s10856-023-06721-7
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