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  1. Article: COVID-19-Impfstoffe für Kinder und Jugendliche.

    Zepp, Fred

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

    2021  Volume 169, Issue 5, Page(s) 393–394

    Title translation COVID-19 vaccines for children and adolescents.
    Language German
    Publishing date 2021-04-13
    Publishing country Germany
    Document type Editorial
    ZDB-ID 137102-2
    ISSN 1433-0474 ; 0026-9298
    ISSN (online) 1433-0474
    ISSN 0026-9298
    DOI 10.1007/s00112-021-01176-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 285: Show issues

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  2. Book ; Online ; E-Book: Pädiatrie

    Schaub, Jürgen / Schulte, Franz-Josef / Hoffmann, Georg F. / Lentze, Michael J. / Spranger, Jürgen W. / Zepp, Fred / Berner, Reinhard

    Grundlagen und Praxis

    (Springer Reference Medizin)

    2020  

    Author's details Georg F. Hoffmann, Michael J. Lentze, Jürgen Spranger, Fred Zepp, Reinhard Berner Hrsg. ; Begründet von Michael J. Lentze, Jürgen Schuab, Franz-Josef Schulte und Jürgen Spranger
    Series title Springer Reference Medizin
    Keywords Pediatrics ; Kinder ; Kinderkrankheiten ; Kinder- und Jugendheilkunde ; Kinderheilkunde ; Pädiatrisch ; Kinder- und Jugendmedizin
    Language German
    Size 1 Online-Ressource (XLIV, 3211 Seiten), Illustrationen, Diagramme
    Edition 5., vollständig überarbeitete Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020838038
    ISBN 978-3-662-60300-0 ; 9783662602997 ; 3-662-60300-4 ; 3662602997
    DOI 10.1007/978-3-662-60300-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Medizinische Versorgung in der Transition

    Reincke, Martin / Zepp, Fred

    spezielle Anforderungen beim Übergang vom Kindes- und Jugendalter zum Erwachsenenalter ; mit 28 Tabellen

    (Report Versorgungsforschung ; 5)

    2011  

    Title variant M. Reincke, F. Zepp (Hrsg.)
    Series title Report Versorgungsforschung ; 5
    Collection
    Keywords Jugend ; Chronische Krankheit ; Erwachsener ; Medizinische Versorgung
    Subject Jugend ; Jugendalter ; Jugendlicher ; Teenager ; Gesundheitsversorgung ; Gesundheitliche Versorgung ; Patientenversorgung ; Erwachsenenalter ; Erwachsener ; Erwachsene ; Krankheit ; Chronisches Leiden ; Chronische Krankheiten
    Language German
    Size VI, 209 S. : Ill., graf. Darst.
    Publisher Dt. Ärzte-Verl
    Publishing place Köln
    Publishing country Germany
    Document type Book
    HBZ-ID HT017253546
    ISBN 978-3-7691-3495-7 ; 3-7691-3495-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 2468 order for loan Magazin

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  4. Article: Liebe Leserinnen und Leser, liebe Kolleginnen und Kollegen,

    Zepp, Fred

    Pädiatrie up2date

    2022  Volume 17, Issue 04, Page(s) 271–272

    Language German
    Publishing date 2022-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2256194-8
    ISSN 1862-9393 ; 1611-6445
    ISSN (online) 1862-9393
    ISSN 1611-6445
    DOI 10.1055/a-1910-6094
    Database Thieme publisher's database

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  5. Book: Die neue Influenza A/H1N1 ("Schweinegrippe")

    Zepp, Fred

    [basiert auf dem Vortrag im Rahmen des 21. Consilium Live am 7. November 2009 in Hannover]

    (Consilium infectiorum : Pädiatrie : Sonderausgabe ; 2009,3)

    2009  

    Author's details Autor: Fred Zepp
    Series title Consilium infectiorum : Pädiatrie : Sonderausgabe ; 2009,3
    Consilium infectiorum
    Consilium infectiorum ; Pädiatrie
    Collection Consilium infectiorum
    Consilium infectiorum ; Pädiatrie
    Language German
    Size 8 S. : graph. Darst.
    Publisher Infectopharm
    Publishing place Heppenheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT016163145
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6832 -2009,3- verfügbar in Königswinter Königswinter

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  6. Article: Editorial

    Zepp, Fred

    Pädiatrie up2date

    2021  Volume 16, Issue 01, Page(s) 3–4

    Language German
    Publishing date 2021-03-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2256194-8
    ISSN 1862-9393 ; 1611-6445
    ISSN (online) 1862-9393
    ISSN 1611-6445
    DOI 10.1055/a-1255-6208
    Database Thieme publisher's database

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  7. Article: Aktuelle allgemeinpädiatrisch relevante Beiträge.

    Kerbl, Reinhold / Berner, Reinhard / Hansen, Gesine / Zepp, Fred

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

    2023  Volume 171, Issue 4, Page(s) 293–295

    Title translation Current articles relevant to general pediatrics.
    Language German
    Publishing date 2023-03-27
    Publishing country Germany
    Document type Editorial
    ZDB-ID 137102-2
    ISSN 1433-0474 ; 0026-9298
    ISSN (online) 1433-0474
    ISSN 0026-9298
    DOI 10.1007/s00112-023-01737-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Principles in Immunology for the Design and Development of Vaccines.

    Meyer, Claudius U / Zepp, Fred

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2410, Page(s) 27–56

    Abstract: Vaccinology has come a long way from early, empirically developed vaccines to modern vaccines rationally designed and produced. Vaccines are meant to cooperate with the human immune system, the later largely unknown in the early years of vaccine ... ...

    Abstract Vaccinology has come a long way from early, empirically developed vaccines to modern vaccines rationally designed and produced. Vaccines are meant to cooperate with the human immune system, the later largely unknown in the early years of vaccine development. In the recent years, a tremendous depth of knowledge has been accumulated in the field of immunology that has provided an opportunity to understand the mechanisms of action of the vaccine components. In parallel, our knowledge in microbiology, molecular biology, infectiology, epidemiology, and furthermore in bioinformatics has fostered our understanding of the interaction of microorganisms with the human immune system. Strategies engaged by pathogens strongly determine the targets of a vaccine, which should be formulated to stimulate potent and efficiently protective immune responses. The improved knowledge of immune response mechanisms has facilitated the development of new vaccines with the capacity to selectively address the key pathogenic mechanisms. The primary goal of a vaccine design might no longer be to mimic the pathogen but to identify the relevant processes of the pathogenic mechanisms to be effectively interrupted by a highly specific immune response, eventually surpassing natural limitations. Vaccines have become complex sets of components meant to orchestrate the fine-tuning of the immune processes leading to a lasting and specific immune memory. In addition to antigenic materials, which are comprised of the most critical immunogenic epitopes, adjuvant components are frequently added to induce a favorable immunological activation. Furthermore, for reasons of production and product stability preservatives, stabilizers, inactivators, antibiotics, or diluents could be present, but need to be evaluated. While on the one hand vaccine effectiveness is a primary goal, on the other hand side effects need to be excluded due to safety and tolerability. Further challenges in vaccinology include variability of the vaccinees, the variability of the pathogen, the population-based settings of vaccine application, and the process technology in vaccine production. Vaccine design has become more tailored and in turn has opened up the potential of extending its application to hitherto not accessible complex microbial pathogens plus providing new immunotherapies to tackle diseases such as cancer, Alzheimer's disease, and autoimmune disease. This chapter gives an overview of the key considerations and processes involved in vaccine design and development. It also describes the basic principles of normal immune responses and in their function in defense of infectious agents by vaccination.
    MeSH term(s) Adjuvants, Immunologic ; Humans ; Vaccination ; Vaccine Development ; Vaccine Efficacy ; Vaccines
    Chemical Substances Adjuvants, Immunologic ; Vaccines
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1884-4_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: „Coronavirus disease 2019“.

    Kerbl, Reinhold / Zepp, Fred

    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

    2021  Volume 169, Issue 4, Page(s) 308–311

    Title translation Coronavirus disease 2019.
    Language German
    Publishing date 2021-03-29
    Publishing country Germany
    Document type Editorial
    ZDB-ID 137102-2
    ISSN 1433-0474 ; 0026-9298
    ISSN (online) 1433-0474
    ISSN 0026-9298
    DOI 10.1007/s00112-021-01158-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Principles of Vaccination.

    Zepp, Fred

    Methods in molecular biology (Clifton, N.J.)

    2016  Volume 1403, Page(s) 57–84

    Abstract: While many of the currently available vaccines have been developed empirically, with limited understanding on how they activate the immune system and elicit protective immunity, the recent progress in basic sciences like immunology, microbiology, ... ...

    Abstract While many of the currently available vaccines have been developed empirically, with limited understanding on how they activate the immune system and elicit protective immunity, the recent progress in basic sciences like immunology, microbiology, genetics, and molecular biology has fostered our understanding on the interaction of microorganisms with the human immune system. In consequence, modern vaccine development strongly builds on the precise knowledge of the biology of microbial pathogens, their interaction with the human immune system, as well as their capacity to counteract and evade innate and adaptive immune mechanisms. Strategies engaged by pathogens strongly determine how a vaccine should be formulated to evoke potent and efficient protective immune responses. The improved knowledge of immune response mechanisms has facilitated the development of new vaccines with the capacity to defend against challenging pathogens and can help to protect individuals particular at risk like immunocompromised and elderly populations. Modern vaccine development technologies include the production of highly purified antigens that provide a lower reactogenicity and higher safety profile than the traditional empirically developed vaccines. Attempts to improve vaccine antigen purity, however, may result in impaired vaccine immunogenicity. Some of such disadvantages related to highly purified and/or genetically engineered vaccines yet can be overcome by innovative technologies, such as live vector vaccines, and DNA or RNA vaccines. Moreover, recent years have witnessed the development of novel adjuvant formulations that specifically focus on the augmentation and/or control of the interplay between innate and adaptive immune systems as well as the function of antigen-presenting cells. Finally, vaccine design has become more tailored, and in turn has opened up the potential of extending its application to hitherto not accessible complex microbial pathogens plus providing new immunotherapies to tackle diseases such as cancer, Alzheimer's disease, and autoimmune disease. This chapter gives an overview of the key considerations and processes involved in vaccine development. It also describes the basic principles of normal immune respoinses and its their function in defense of infectious agents by vaccination.
    MeSH term(s) Adaptive Immunity ; Animals ; B-Lymphocytes/immunology ; Drug Design ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Immunologic Memory ; Infection/immunology ; Infection Control ; T-Lymphocytes/immunology ; Vaccines/immunology
    Chemical Substances Vaccines
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-3387-7_3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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