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  1. Article: Study on the Characteristics of Traditional Chinese Medicine Syndromes in Patients with Erosive Gastritis Based on Metabolomics.

    Shixiong, Zhang / Shaowei, Liu / Zeqi, Yang / Miaochan, Xu / Pingping, Zhou / Haiyan, Bai / Jingjing, Lv / Yangang, Wang

    International journal of analytical chemistry

    2024  Volume 2024, Page(s) 6684677

    Abstract: According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in ...

    Abstract According to traditional Chinese medicine theory, tongue coatings reflect changes in the body. The goal of this study was to identify a metabolite or a set of metabolites capable of classifying characteristics of traditional Chinese medicine syndromes in erosive gastritis. In this study, we collected tongue coatings of patients with erosive gastritis with damp-heat syndrome (DHS), liver depression and qi stagnation syndrome (LDQSS), and healthy volunteers. Then, we analyzed the differences in metabolic characteristics between the two groups based on metabolomics. We identified 14 potential biomarkers related to the DHS group, and six metabolic pathways were enriched. The differential pathways included pyrimidine metabolism, pantothenate and CoA biosynthesis, citrate cycle (TCA cycle), pyruvate metabolism, glycolysis/gluconeogenesis, and purine metabolism. Similarly, in the LDQSS group, we identified 25 potential biomarkers and 18 metabolic pathways were enriched. The top five pathways were the TCA cycle, sphingolipid metabolism, fatty acid biosynthesis, pantothenate and CoA biosynthesis, and the pentose phosphate pathway. In conclusion, the DHS group and the LDQSS group have different characteristics.
    Language English
    Publishing date 2024-01-02
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2494714-3
    ISSN 1687-8779 ; 1687-8760
    ISSN (online) 1687-8779
    ISSN 1687-8760
    DOI 10.1155/2024/6684677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Position/Force Tracking Impedance Control for Robotic Systems with Uncertainties Based on Adaptive Jacobian and Neural Network

    Jinzhu Peng / Zeqi Yang / Tianlei Ma

    Complexity, Vol

    2019  Volume 2019

    Abstract: In this paper, an adaptive Jacobian and neural network based position/force tracking impedance control scheme is proposed for controlling robotic systems with uncertainties and external disturbances. To achieve precise force control performance ... ...

    Abstract In this paper, an adaptive Jacobian and neural network based position/force tracking impedance control scheme is proposed for controlling robotic systems with uncertainties and external disturbances. To achieve precise force control performance indirectly by using the position tracking, the control scheme is divided into two parts: the outer-loop force impedance control and the inner-loop position tracking control. In the outer-loop, an improved impedance controller, which combines the traditional impedance relationship with the PID-like scheme, is designed to eliminate the force tracking error quickly and to reduce the force overshoot effectively. In this way, the satisfied force tracking performance can be achieved when the manipulator contacts with environment. In the inner-loop, an adaptive Jacobian method is proposed to estimate the velocities and interaction torques of the end-effector due to the system kinematical uncertainties, and the system dynamical uncertainties and the uncertain term of adaptive Jacobian are compensated by an adaptive radial basis function neural network (RBFNN). Then, a robust term is designed to compensate the external disturbances and the approximation errors of RBFNN. In this way, the command position trajectories generated from the outer-loop force impedance controller can be then tracked so that the contact force tracking performance can be achieved indirectly in the forced direction. Based on the Lyapunov stability theorem, it is proved that all the signals in closed-loop system are bounded and the position and velocity errors are asymptotic convergence to zero. Finally, the validity of the control scheme is shown by computer simulation on a two-link robotic manipulator.
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 629
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Determination of the protective effects of Hua‐Zhuo‐Jie‐Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites

    Pingping Zhou / Xinyu Hao / Yu Liu / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Tianxiao Yang / Xiaomei Wang / Yangang Wang

    Chinese Medicine, Vol 16, Iss 1, Pp 1-

    combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing

    2021  Volume 19

    Abstract: Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes ...

    Abstract Abstract Background Hua-Zhuo-Jie-Du (HZJD), a Chinese herbal prescription consisting of 11 herbs, is commonly used in China to treat chronic atrophic gastritis (CAG). We aimed to determine the effect of HZJD on the microbiome-associated metabolic changes in CAG rats. Methods The CAG rat models were induced by 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) combined with irregular fasting and 2% sodium salicylate, which was intragastrically administrated in fasted animals for 24 weeks. The CAG rats in the Chinese medicine (CM) group were administered a daily dose of 14.81 g/kg/day HZJD, and the vitacoenzyme (V) group were administered a daily dose of 0.08 g/kg/day vitacoenzyme. All animals were treated for 10 consecutive weeks, consecutively. Hematoxylin and eosin (H&E) staining was used to assess the histopathological changes in the gastric tissues. An integrated approach based on liquid chromatograph mass spectrometer (LC-MS) metabolic profiling combined with 16S rRNA gene sequencing was carried out to assess the effects of HZJD on CAG rats. Spearman analysis was used to calculate the correlation coefficient between the different intestinal microbiota and the metabolites. Results The H&E results indicated that HZJD could improve the pathological condition of CAG rats. The LC–MS results indicated that HZJD could significantly improve 21 gastric mucosal tissue perturbed metabolites in CAG rats; the affected metabolites were found to be involved in multiple metabolic pathways, such as the central carbon metabolism in cancer. The results of 16S rRNA gene sequencing indicated that HZJD could regulate the diversity, microbial composition, and abundance of the intestinal microbiota of CAG rats. Following HZJD treatment, the relative abundance of Turicibacter was increased, and the relative abundance of Desulfococcus and Escherichia were decreased in the CM group when compared with the M group. Spearman analysis revealed that perturbed intestinal microbes had a strong correlation with differential metabolites, ...
    Keywords Hua‐Zhuo‐Jie‐Du ; Chronic atrophic gastritis ; LC–MS ; 16S rRNA gene sequencing ; Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Integrating Network Pharmacology and Experimental Validation to Investigate the Mechanisms of Huazhuojiedu Decoction to Treat Chronic Atrophic Gastritis

    Xinyu Hao / Yu Liu / Pingping Zhou / Qian Jiang / Zeqi Yang / Miaochan Xu / Shaowei Liu / Shixiong Zhang / Yangang Wang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2020  Volume 2020

    Abstract: Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few ... ...

    Abstract Background. Chronic atrophic gastritis (CAG) is an important stage in the normal gastric mucosa’s transformation into gastric cancer. Huazhuojiedu decoction (HZJD), a Chinese herbal preparation, has proven clinically effective to treat CAG. However, few studies have explored the mechanism of HZJD in CAG treatment. Purpose. This study aimed to shed light on the mechanisms underlying HZJD decoction CAG treatment using a network pharmacology approach and experimental validation. Methods. The active components of HZJD decoction were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. Their targets were predicted through the SwissTargetPrediction database. Disease targets were screened using the GeneCards database. The disease and drug prediction targets were intersected to select the common potential therapeutic targets, which then were input into the Search Tool for the Retrieval of Interacting Genes to build a protein-protein interaction network. The “herb-compound-target-disease” and the “herb-target-pathway” network diagrams were constructed in Cytoscape 3.3.0. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of effective targets were performed using the Database for Annotation, Visualization, and Integrated Discovery. Finally, the core targets were preliminarily verified by CAG rat model. The gastric mucosa’s histopathological changes were observed via hematoxylin-eosin staining. The expressions of MAPK1, AKT1, TNF, VEGFA, and EGFR were detected by western blot and quantitative real-time reverse transcription-polymerase chain reaction. Results. A total of 155 nodes, including 20 putative targets of HZJD decoction, were selected as core hubs based on topological importance and were closely associated with the regulation of cell proliferation, apoptotic process, and cancer-related pathways (AKT1, TNF, VEGFA, and EGFR) in CAG. Further animal experiments showed that the expression of AKT1 in CAG rats was significantly increased, ...
    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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