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  1. Article ; Online: Parenteral nutrition at home/long-term parenteral nutrition.

    Kumpf, Vanessa J / Gray, Brenda / Monczka, Jessica / Zeraschi, Sarah / Klek, Stanislaw

    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

    2024  

    Abstract: Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and ...

    Abstract Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
    Purpose: Some diseases require that patients receive parenteral nutrition (PN) over a prolonged time period. Long-term administration of PN can further complicate an already complex therapy, posing additional risk of potential complications. This article is based on presentations and discussions held at the International Safety and Quality of PN Summit, providing insights into aspects of home PN (HPN) and examples of good HPN practice.
    Summary: One critical step in the HPN process is when patients transition from a hospital to a home setting, and vice versa. Generally, electronic PN ordering is not feasible in an HPN setting, leading to potential difficulties in communication and coordination. HPN requires that patients (or their home caregivers) administer PN, and thus their education and competency are crucial. Likewise, the choice of PN formulation is of great importance. For example, using more modern intravenous lipid emulsions containing medium-chain triglycerides, olive oil, and/or fish oil can provide benefits in terms of liver function during long-term HPN. Internationally, there are wide variations in delivery of HPN, with compounded PN dominating in some countries while others make greater use of market-authorized multichamber bags (MCBs). Patient-related factors, institutional considerations, and the availability of different MCB formulations, are also contributing factors guiding formulation and delivery system preferences.
    Conclusion: Education and communication remain key components of a successful HPN process. The information shared here may help to motivate efforts to improve HPN processes and to consider the often-differing perspectives of patients and their healthcare professionals.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224627-x
    ISSN 1535-2900 ; 1079-2082
    ISSN (online) 1535-2900
    ISSN 1079-2082
    DOI 10.1093/ajhp/zxae081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey

    Pironi, Loris / Steiger, Ezra / Brandt, Chrisoffer / Joly, Francisca / Wanten, Geert / Chambrier, Cecile / Aimasso, Umberto / Sasdelli, Anna Simona / Zeraschi, Sarah / Kelly, Darlene / Szczepanek, Kinga / Jukes, Amelia / Di Caro, Simona / Theilla, Miriam / Kunecki, Marek / Daniels, Joanne / Serlie, Mireille / Poullenot, Florian / Wu, Jian /
    Cooper, Sheldon C / Rasmussen, Henrik H / Compher, Charlene / Seguy, David / Crivelli, Adriana / Pagano, Maria C / Hughes, Sarah-Jane / Guglielmi, Francesco W / Kozjek, Nada Rotovnik / Schneider, Stéphane M / Gillanders, Lyn / Ellegard, Lars / Thibault, Ronan / Matras, Przemysław / Zmarzly, Anna / Matysiak, Konrad / Van Gossum, Andrè / Forbes, Alastair / Wyer, Nicola / Taus, Marina / Virgili, Nuria M / O'Callaghan, Margie / Chapman, Brooke / Osland, Emma / Cuerda, Cristina / Sahin, Peter / Jones, Lynn / Won Lee, Andre Dong / Masconale, Luisa / Orlandoni, Paolo / Izbéki, Ferenc / Spaggiari, Corrado / Bueno, Marta / Doitchinova-Simeonova, Maryana / Garde, Carmen / Serralde-Zúñiga, Aurora E / Olveira, Gabriel / Krznaric, Zeljko / Czako, Laszlo / Kekstas, Gintautas / Sanz-Paris, Alejandro / Jáuregui, Estrella Petrina / Murillo, Ana Zugasti / Schafer, Eszter / Arends, Jann / Suárez-Llanos, José P / Lal, Simon

    Clinical nutrition. 2019 Mar. 09,

    2019  

    Abstract: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of ... ...

    Institution The Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN
    The European Society for Clinical Nutrition and Metabolism
    Abstract The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90.1%, malignant disease 9.9%), recording the patient, CIF and HPN characteristics in a structured database. The HPN-provider was categorized as health care system local pharmacy (LP) or independent home care company (HCC). The IVS-admixture was categorized as fluids and electrolytes alone (FE) or parenteral nutrition, either commercially premixed (PA) or customized to the individual patient (CA), alone or plus extra FE (PAFE or CAFE). Doctors of HPN centers were responsible for the IVS prescriptions.HCC (66%) was the most common HPN provider, with no difference noted between benign-CIF and malignant-CIF. LP was the main modality in 11 countries; HCC prevailed in 4 European countries: Israel, USA, South America and Oceania (p < 0.001). IVS-admixture comprised: FE 10%, PA 17%, PAFE 17%, CA 38%, CAFE 18%. PA and PAFE prevailed in malignant-CIF while CA and CAFE use was greater in benign-CIF (p < 0.001). PA + PAFE prevailed in those countries where LP was the main HPN-provider and CA + CAFE prevailed where the main HPN-provider was HCC (p < 0.001).This is the first study to demonstrate that HPN provision and the IVS-admixture differ greatly among countries, among HPN centers and between benign-CIF and cancer-CIF. As both HPN provider and IVS-admixture types may play a role in the safety and effectiveness of HPN therapy, criteria to homogenize HPN programs are needed so that patients can have equal access to optimal CIF care.
    Keywords adults ; databases ; digestive system diseases ; electrolytes ; health services ; intravenous injection ; parenteral feeding ; patients ; physicians ; surveys ; Europe ; Israel ; Pacific Ocean Islands ; South America ; United States
    Language English
    Dates of publication 2019-0309
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.03.010
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.

    Pironi, Loris / Steiger, Ezra / Brandt, Chrisoffer / Joly, Francisca / Wanten, Geert / Chambrier, Cecile / Aimasso, Umberto / Sasdelli, Anna Simona / Zeraschi, Sarah / Kelly, Darlene / Szczepanek, Kinga / Jukes, Amelia / Di Caro, Simona / Theilla, Miriam / Kunecki, Marek / Daniels, Joanne / Serlie, Mireille / Poullenot, Florian / Wu, Jian /
    Cooper, Sheldon C / Rasmussen, Henrik H / Compher, Charlene / Seguy, David / Crivelli, Adriana / Pagano, Maria C / Hughes, Sarah-Jane / Guglielmi, Francesco W / Kozjek, Nada Rotovnik / Schneider, Stéphane M / Gillanders, Lyn / Ellegard, Lars / Thibault, Ronan / Matras, Przemysław / Zmarzly, Anna / Matysiak, Konrad / Van Gossum, Andrè / Forbes, Alastair / Wyer, Nicola / Taus, Marina / Virgili, Nuria M / O'Callaghan, Margie / Chapman, Brooke / Osland, Emma / Cuerda, Cristina / Sahin, Peter / Jones, Lynn / Won Lee, Andre Dong / Masconale, Luisa / Orlandoni, Paolo / Izbéki, Ferenc / Spaggiari, Corrado / Bueno, Marta / Doitchinova-Simeonova, Maryana / Garde, Carmen / Serralde-Zúñiga, Aurora E / Olveira, Gabriel / Krznaric, Zeljko / Czako, Laszlo / Kekstas, Gintautas / Sanz-Paris, Alejandro / Jáuregui, Estrella Petrina / Murillo, Ana Zugasti / Schafer, Eszter / Arends, Jann / Suárez-Llanos, José P / Lal, Simon

    Clinical nutrition (Edinburgh, Scotland)

    2019  Volume 39, Issue 2, Page(s) 585–591

    Abstract: Background & aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in ... ...

    Abstract Background & aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).
    Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90.1%, malignant disease 9.9%), recording the patient, CIF and HPN characteristics in a structured database. The HPN-provider was categorized as health care system local pharmacy (LP) or independent home care company (HCC). The IVS-admixture was categorized as fluids and electrolytes alone (FE) or parenteral nutrition, either commercially premixed (PA) or customized to the individual patient (CA), alone or plus extra FE (PAFE or CAFE). Doctors of HPN centers were responsible for the IVS prescriptions.
    Results: HCC (66%) was the most common HPN provider, with no difference noted between benign-CIF and malignant-CIF. LP was the main modality in 11 countries; HCC prevailed in 4 European countries: Israel, USA, South America and Oceania (p < 0.001). IVS-admixture comprised: FE 10%, PA 17%, PAFE 17%, CA 38%, CAFE 18%. PA and PAFE prevailed in malignant-CIF while CA and CAFE use was greater in benign-CIF (p < 0.001). PA + PAFE prevailed in those countries where LP was the main HPN-provider and CA + CAFE prevailed where the main HPN-provider was HCC (p < 0.001).
    Conclusions: This is the first study to demonstrate that HPN provision and the IVS-admixture differ greatly among countries, among HPN centers and between benign-CIF and cancer-CIF. As both HPN provider and IVS-admixture types may play a role in the safety and effectiveness of HPN therapy, criteria to homogenize HPN programs are needed so that patients can have equal access to optimal CIF care.
    MeSH term(s) Chronic Disease ; Cross-Sectional Studies ; Female ; Health Surveys/methods ; Health Surveys/statistics & numerical data ; Humans ; Internationality ; Intestinal Diseases/diet therapy ; Intestinal Diseases/epidemiology ; Male ; Middle Aged ; Parenteral Nutrition, Home/methods ; Parenteral Nutrition, Home/statistics & numerical data ; Treatment Outcome
    Language English
    Publishing date 2019-03-25
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2019.03.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

    Pironi, Loris / Steiger, Ezra / Joly, Francisca / Jeppesen, Palle B. / Wanten, Geert / Sasdelli, Anna S. / Chambrier, Cecile / Aimasso, Umberto / Mundi, Manpreet S. / Szczepanek, Kinga / Jukes, Amelia / Theilla, Miriam / Kunecki, Marek / Daniels, Joanne / Serlie, Mireille / Poullenot, Florian / Cooper, Sheldon C. / Rasmussen, Henrik H. / Compher, Charlene /
    Seguy, David / Crivelli, Adriana / Santarpia, Lidia / Guglielmi, Francesco W. / Kozjek, Nada Rotovnik / Schneider, Stéphane M. / Ellegard, Lars / Thibault, Ronan / Matras, Przemysław / Matysiak, Konrad / Van Gossum, Andrè / Forbes, Alastair / Wyer, Nicola / Taus, Marina / Virgili, Nuria M. / O'Callaghan, Margie / Chapman, Brooke / Osland, Emma / Cuerda, Cristina / Udvarhelyi, Gábor / Jones, Lynn / Won Lee, Andre D. / Masconale, Luisa / Orlandoni, Paolo / Spaggiari, Corrado / Díez, Marta Bueno / Doitchinova-Simeonova, Maryana / Serralde-Zúñiga, Aurora E. / Olveira, Gabriel / Krznaric, Zeljko / Czako, Laszlo / Kekstas, Gintautas / Sanz-Paris, Alejandro / Jáuregui, Mª Estrella Petrina / Murillo, Ana Zugasti / Schafer, Eszter / Arends, Jann / Suárez-Llanos, José P. / Youssef, Nader N. / Brillanti, Giorgia / Nardi, Elena / Lal, Simon / Crivelli, Adriana N. / Muñiz, Hector Solar / Chapman, Brooke R. / Hodgson, Ruth / Wallin, Siobhan / Lasenby, Kay / Van Gossum, Andre / Won Lee, Andre Dong / Rasmussen, Henrik Højgaard / Brandt, Chrisoffer / Boehm, Vanessa / Bataille, Julie / Billiauws, Lore / Molnar, Tomas / Zsilak-Urban, Mihaly / Izbéki, Ferenc / Sahin, Peter / Sasdelli, Anna Simona / Dario, Merlo F. / Bertasi, Valentino / Regano, Nunzia / Lidia, Santarpia / Alfonsi, Lucia / Busni, Debora / Gillanders, Lyn / Zmarzly, Anna / Bueno, Marta / Garde, Carmen / Jáuregui, Ma Estrella Petrina / Jonker, Cora / Di Caro, Simona / Keane, Niamh / Patel, Pinal / Nelson Hughes, Sarah-Jane / Lloyd, Rachel / Abraham, Arun / Garside, Gerda / Taylor, Michael / Wu, Jian / Smith, Trevor / Pither, Charlotte / Stroud, Michael / Parmar, Reena / Burch, Nicola / Zeraschi, Sarah / Mundi, Manpreet / Jezerski, Denise

    European Society for Clinical Nutrition and Metabolism Clinical nutrition ESPEN. 2021 Oct., v. 45

    2021  

    Abstract: The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was ... ...

    Institution The Home Artificial Nutrition and Chronic Intestinal Failure Special Interest Group of ESPEN
    The European Society for Clinical Nutrition and Metabolism
    Abstract The case-mix of patients with intestinal failure due to short bowel syndrome (SBS-IF) can differ among centres and may also be affected by the timeframe of data collection. Therefore, the ESPEN international multicenter cross-sectional survey was analyzed to compare the characteristics of SBS-IF cohorts collected within the same timeframe in different countries.The study included 1880 adult SBS-IF patients collected in 2015 by 65 centres from 22 countries. The demographic, nutritional, SBS type (end jejunostomy, SBS-J; jejuno-colic anastomosis, SBS-JC; jejunoileal anastomosis with an intact colon and ileocecal valve, SBS-JIC), underlying disease and intravenous supplementation (IVS) characteristics were analyzed. IVS was classified as fluid and electrolyte alone (FE) or parenteral nutrition admixture (PN). The mean daily IVS volume, calculated on a weekly basis, was categorized as <1, 1–2, 2–3 and >3 L/day.In the entire group: 60.7% were females and SBS-J comprised 60% of cases, while mesenteric ischaemia (MI) and Crohn’ disease (CD) were the main underlying diseases. IVS dependency was longer than 3 years in around 50% of cases; IVS was infused ≥5 days/week in 75% and FE in 10% of cases. Within the SBS-IF cohort: CD was twice and thrice more frequent in SBS-J than SBS-JC and SBS-JIC, respectively, while MI was more frequent in SBS-JC and SBS-JIC. Within countries: SBS-J represented 75% or more of patients in UK and Denmark and 50-60% in the other countries, except Poland where SBS-JC prevailed. CD was the main underlying disease in UK, USA, Denmark and The Netherlands, while MI prevailed in France, Italy and Poland.SBS-IF type is primarily determined by the underlying disease, with significant variation between countries. These novel data will be useful for planning and managing both clinical activity and research studies on SBS.
    Keywords adults ; clinical nutrition ; colon ; cross-sectional studies ; data collection ; electrolytes ; intravenous injection ; ischemia ; parenteral feeding ; surveys ; Denmark ; France ; Italy ; Netherlands ; Poland
    Language English
    Dates of publication 2021-10
    Size p. 433-441.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 2405-4577
    DOI 10.1016/j.clnesp.2021.07.004
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey.

    Pironi, Loris / Konrad, Denise / Brandt, Chrisoffer / Joly, Francisca / Wanten, Geert / Agostini, Federica / Chambrier, Cecile / Aimasso, Umberto / Zeraschi, Sarah / Kelly, Darlene / Szczepanek, Kinga / Jukes, Amelia / Di Caro, Simona / Theilla, Miriam / Kunecki, Marek / Daniels, Joanne / Serlie, Mireille / Poullenot, Florian / Wu, Jian /
    Cooper, Sheldon C / Rasmussen, Henrik H / Compher, Charlene / Seguy, David / Crivelli, Adriana / Pagano, Maria C / Hughes, Sarah-Jane / Guglielmi, Francesco W / Kozjek, Nada Rotovnik / Schneider, Stéphane M / Gillanders, Lyn / Ellegard, Lars / Thibault, Ronan / Matras, Przemysław / Zmarzly, Anna / Matysiak, Konrad / Van Gossum, Andrè / Forbes, Alastair / Wyer, Nicola / Taus, Marina / Virgili, Nuria M / O'Callaghan, Margie / Chapman, Brooke / Osland, Emma / Cuerda, Cristina / Sahin, Peter / Jones, Lynn / Lee, Andre D W / Bertasi, Valentino / Orlandoni, Paolo / Izbéki, Ferenc / Spaggiari, Corrado / Díez, Marta Bueno / Doitchinova-Simeonova, Maryana / Garde, Carmen / Serralde-Zúñiga, Aurora E / Olveira, Gabriel / Krznaric, Zeljko / Czako, Laszlo / Kekstas, Gintautas / Sanz-Paris, Alejandro / Jáuregui, Estrella Petrina / Murillo, Ana Zugasti / Schafer, Eszter / Arends, Jann / Suárez-Llanos, José P / Shaffer, Jon / Lal, Simon

    Clinical nutrition (Edinburgh, Scotland)

    2017  Volume 37, Issue 2, Page(s) 728–738

    Abstract: Background & aims: The aim of the study was to evaluate the applicability of the ESPEN 16-category clinical classification of chronic intestinal failure, based on patients' intravenous supplementation (IVS) requirements for energy and fluids, and to ... ...

    Abstract Background & aims: The aim of the study was to evaluate the applicability of the ESPEN 16-category clinical classification of chronic intestinal failure, based on patients' intravenous supplementation (IVS) requirements for energy and fluids, and to evaluate factors associated with those requirements.
    Methods: ESPEN members were invited to participate through ESPEN Council representatives. Participating centers enrolled adult patients requiring home parenteral nutrition for chronic intestinal failure on March 1st 2015. The following patient data were recorded though a structured database: sex, age, body weight and height, intestinal failure mechanism, underlying disease, IVS volume and energy need.
    Results: Sixty-five centers from 22 countries enrolled 2919 patients with benign disease. One half of the patients were distributed in 3 categories of the ESPEN clinical classification. 9% of patients required only fluid and electrolyte supplementation. IVS requirement varied considerably according to the pathophysiological mechanism of intestinal failure. Notably, IVS volume requirement represented loss of intestinal function better than IVS energy requirement. A simplified 8 category classification of chronic intestinal failure was devised, based on two types of IVS (either fluid and electrolyte alone or parenteral nutrition admixture containing energy) and four categories of volume.
    Conclusions: Patients' IVS requirements varied widely, supporting the need for a tool to homogenize patient categorization. This study has devised a novel, simplified eight category IVS classification for chronic intestinal failure that will prove useful in both the clinical and research setting when applied together with the underlying pathophysiological mechanism of the patient's intestinal failure.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Australasia ; Chronic Disease ; Cross-Sectional Studies ; Europe ; Female ; Humans ; Intestinal Diseases/diet therapy ; Intestinal Diseases/pathology ; Intestines/pathology ; Israel ; Male ; Middle Aged ; Parenteral Nutrition, Home/methods ; South America ; United States ; Young Adult
    Language English
    Publishing date 2017-04-19
    Publishing country England
    Document type Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2017.04.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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