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  1. Article: Chromosome 7 to the rescue: overcoming chromosome 10 loss in gliomas.

    Nair, Nishanth Ulhas / Schäffer, Alejandro A / Gertz, E Michael / Cheng, Kuoyuan / Zerbib, Johanna / Sahu, Avinash Das / Leor, Gil / Shulman, Eldad D / Aldape, Kenneth D / Ben-David, Uri / Ruppin, Eytan

    bioRxiv : the preprint server for biology

    2024  

    Abstract: The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers, a phenomenon that has been investigated without resolution since the late 1980s. Expanding beyond previous gene- ... ...

    Abstract The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers, a phenomenon that has been investigated without resolution since the late 1980s. Expanding beyond previous gene-centric studies, we investigate the co-occurrence in a genome-wide manner taking an evolutionary perspective. First, by mining large tumor aneuploidy data, we predict that the more likely order is 10 loss followed by 7 gain. Second, by analyzing extensive genomic and transcriptomic data from both patients and cell lines, we find that this co-occurrence can be explained by functional rescue interactions that are highly enriched on 7, which can possibly compensate for any detrimental consequences arising from the loss of 10. Finally, by analyzing transcriptomic data from normal, non-cancerous, human brain tissues, we provide a plausible reason why this co-occurrence happens preferentially in cancers originating in certain regions of the brain.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.17.576103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model.

    Oved, Keren / Zennaro, Léa / Dorot, Orly / Zerbib, Johanna / Frank, Elie / Roux, Lauriane N / Bremond-Gignac, Dominique / Pichinuk, Edward / Aberdam, Daniel

    Biochemical and biophysical research communications

    2021  Volume 582, Page(s) 100–104

    Abstract: Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-related ... ...

    Abstract Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-related keratopathy, a progressive opacification of the cornea. There is no effective treatment for this blinding disease. Here we screen for small compounds and identified Ritanserin, a serotonin 2A receptor antagonist, that can rescue PAX6 haploinsufficiency of mutant limbal cells, defective cell migration and PAX6-target gene expression. We further demonstrated that Ritanserin activates PAX6 production through the selective inactivation of the MEK/ERK signaling pathway. Our data strongly suggest that repurposing this therapeutic molecule could be effective in preventing or treating existing blindness by restoring corneal transparency.
    MeSH term(s) Aniridia/drug therapy ; Aniridia/genetics ; Aniridia/metabolism ; Aniridia/pathology ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Repositioning/methods ; Epithelium, Corneal/drug effects ; Epithelium, Corneal/metabolism ; Epithelium, Corneal/pathology ; Gene Expression Regulation ; HEK293 Cells ; Haploinsufficiency ; Humans ; Limbus Corneae/drug effects ; Limbus Corneae/metabolism ; Limbus Corneae/pathology ; Mitogen-Activated Protein Kinase 1/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/antagonists & inhibitors ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Models, Biological ; Ophthalmic Solutions/pharmacology ; PAX6 Transcription Factor/agonists ; PAX6 Transcription Factor/genetics ; PAX6 Transcription Factor/metabolism ; Receptor, Serotonin, 5-HT2A/genetics ; Receptor, Serotonin, 5-HT2A/metabolism ; Ritanserin/pharmacology ; Serotonin Antagonists/pharmacology ; Signal Transduction/drug effects ; Stem Cells/drug effects ; Stem Cells/metabolism ; Stem Cells/pathology
    Chemical Substances HTR2A protein, human ; Ophthalmic Solutions ; PAX6 Transcription Factor ; Receptor, Serotonin, 5-HT2A ; Serotonin Antagonists ; Ritanserin (145TFV465S) ; MAPK1 protein, human (EC 2.7.11.24) ; MAPK3 protein, human (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
    Language English
    Publishing date 2021-10-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2021.10.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article: Ritanserin, a potent serotonin 2A receptor antagonist, represses MEK/ERK signalling pathway to restore PAX6 production and function in aniridia-like cellular model

    Oved, Keren / Zennaro, Léa / Dorot, Orly / Zerbib, Johanna / Frank, Elie / Roux, Lauriane N. / Bremond-Gignac, Dominique / Pichinuk, Edward / Aberdam, Daniel

    Biochemical and biophysical research communications. 2021 Dec. 10, v. 582

    2021  

    Abstract: Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-related ... ...

    Abstract Aniridia is a panocular inherited rare eye disease linked to heterozygous mutations on the PAX6 gene, which fail to properly produce sufficient protein essential for normal eye development and function. Most of the patients suffer from aniridia-related keratopathy, a progressive opacification of the cornea. There is no effective treatment for this blinding disease. Here we screen for small compounds and identified Ritanserin, a serotonin 2A receptor antagonist, that can rescue PAX6 haploinsufficiency of mutant limbal cells, defective cell migration and PAX6-target gene expression. We further demonstrated that Ritanserin activates PAX6 production through the selective inactivation of the MEK/ERK signaling pathway. Our data strongly suggest that repurposing this therapeutic molecule could be effective in preventing or treating existing blindness by restoring corneal transparency.
    Keywords antagonists ; blindness ; cell movement ; cornea ; eye diseases ; gene expression ; genes ; haploinsufficiency ; heterozygosity ; models ; mutants ; research ; serotonin ; therapeutics
    Language English
    Dates of publication 2021-1210
    Size p. 100-104.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2021.10.036
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 71/706: Show issues
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  4. Article ; Online: Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy.

    Ippolito, Marica Rosaria / Martis, Valentino / Martin, Sara / Tijhuis, Andréa E / Hong, Christy / Wardenaar, René / Dumont, Marie / Zerbib, Johanna / Spierings, Diana C J / Fachinetti, Daniele / Ben-David, Uri / Foijer, Floris / Santaguida, Stefano

    Developmental cell

    2021  Volume 56, Issue 17, Page(s) 2440–2454.e6

    Abstract: Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells might ...

    Abstract Mitotic errors lead to aneuploidy, a condition of karyotype imbalance, frequently found in cancer cells. Alterations in chromosome copy number induce a wide variety of cellular stresses, including genome instability. Here, we show that cancer cells might exploit aneuploidy-induced genome instability and the resulting gene copy-number changes to survive under conditions of selective pressure, such as chemotherapy. Resistance to chemotherapeutic drugs was dictated by the acquisition of recurrent karyotypes, indicating that gene dosage might play a role in driving chemoresistance. Thus, our study establishes a causal link between aneuploidy-driven changes in gene copy number and chemoresistance and might explain why some chemotherapies fail to succeed.
    MeSH term(s) Aneuploidy ; Chromosomal Instability/genetics ; Drug Resistance/genetics ; Drug Therapy/methods ; Gene Dosage/genetics ; Genomic Instability/genetics ; Humans ; Karyotype
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2054967-2
    ISSN 1878-1551 ; 1534-5807
    ISSN (online) 1878-1551
    ISSN 1534-5807
    DOI 10.1016/j.devcel.2021.07.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5742: Show issues Location:
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    Zs.MG 76: Show issues

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  5. Article ; Online: Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition.

    Cohen-Sharir, Yael / McFarland, James M / Abdusamad, Mai / Marquis, Carolyn / Bernhard, Sara V / Kazachkova, Mariya / Tang, Helen / Ippolito, Marica R / Laue, Kathrin / Zerbib, Johanna / Malaby, Heidi L H / Jones, Andrew / Stautmeister, Lisa-Marie / Bockaj, Irena / Wardenaar, René / Lyons, Nicholas / Nagaraja, Ankur / Bass, Adam J / Spierings, Diana C J /
    Foijer, Floris / Beroukhim, Rameen / Santaguida, Stefano / Golub, Todd R / Stumpff, Jason / Storchová, Zuzana / Ben-David, Uri

    Nature

    2021  Volume 590, Issue 7846, Page(s) 486–491

    Abstract: Selective targeting of aneuploid cells is an attractive strategy for cancer ... ...

    Abstract Selective targeting of aneuploid cells is an attractive strategy for cancer treatment
    MeSH term(s) Abnormal Karyotype/drug effects ; Aneuploidy ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromosome Segregation/drug effects ; Diploidy ; Genes, Lethal ; Humans ; Kinesins/deficiency ; Kinesins/genetics ; Kinesins/metabolism ; M Phase Cell Cycle Checkpoints/drug effects ; Neoplasms/genetics ; Neoplasms/pathology ; Spindle Apparatus/drug effects ; Synthetic Lethal Mutations/drug effects ; Synthetic Lethal Mutations/genetics ; Time Factors
    Chemical Substances KIF18A protein, human (EC 3.6.1.-) ; Kinesins (EC 3.6.4.4)
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-03114-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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