Article ; Online: The role of cannabinoid receptor 2 in bone remodeling during orthodontic tooth movement.
2024 Volume 24, Issue 1, Page(s) 23
Abstract: Background: The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement.: Methods: Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2: ...
| Abstract | Background: The purpose of this study is to explore the effects of CB2 on bone regulation during orthodontic tooth movement. Methods: Thirty male mice were allocated into 2 groups (n = 15 in each group): wild type (WT) group and CB2 knockout (CB2 Results: The WT group exhibited the typical pattern of OTM, characterized by narrowed periodontal space and bone resorption on the compression area. In contrast, the accelerated tooth displacement, increased osteoclast number (P < 0.0001) and bone resorption on the compression area in CB2 Conclusions: CB2 modulated OTM and bone remodeling through regulating osteoclast activity and RANKL/OPG balance. |
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| MeSH term(s) | Animals ; Male ; Mice ; Bone Remodeling/physiology ; Bone Resorption ; Osteoclasts ; Tooth Movement Techniques ; Receptor, Cannabinoid, CB2/genetics |
| Chemical Substances | Cnr2 protein, mouse ; Receptor, Cannabinoid, CB2 |
| Language | English |
| Publishing date | 2024-01-04 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2091511-1 |
| ISSN | 1472-6831 ; 1472-6831 |
| ISSN (online) | 1472-6831 |
| ISSN | 1472-6831 |
| DOI | 10.1186/s12903-023-03810-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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