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Article: Potential of ultraviolet laser pulse-induced current for characterizing the grain size of table sugar.

Liu, Xuecong / Zhao, Kun / Miao, Xinyang / Zhan, Honglei

2023 Volume 9, Issue 11, Page(s) e21195

Abstract: In this work, we proposed a laser-induced current (LIC) method to investigate the grain-size dependence of the plasma of table sugar induced by a nanosecond (ns) pulsed ultraviolet laser in the size range of ... 550 μm and achieve the lower power ... ...

Abstract	In this work, we proposed a laser-induced current (LIC) method to investigate the grain-size dependence of the plasma of table sugar induced by a nanosecond (ns) pulsed ultraviolet laser in the size range of <180 μm->550 μm and achieve the lower power consumption in measurement. Under multiple laser irradiations and an external electric field (V
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21195
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Article ; Online: Bimetallic Gold/Silver and Bioactive Camptothecin Hybrid Nanoparticles for Eradication of Cancer Stem Cells in a Combination Manner.

Zhan, Honglei / Lv, Yulong / Shen, Ruiyu / Li, Chaoyue / Li, Miao / Li, Yahong

Molecular pharmaceutics

2024 Volume 21, Issue 3, Page(s) 1450–1465

Abstract: The defeat of cancer is still a challenge due to the existence of cancer stem cells (CSCs) because they resist conventional chemotherapy via multifactor regulated mechanisms. Consequently, one-dimensional action toward CSCs cannot work. Herein, we used ... ...

Abstract	The defeat of cancer is still a challenge due to the existence of cancer stem cells (CSCs) because they resist conventional chemotherapy via multifactor regulated mechanisms. Consequently, one-dimensional action toward CSCs cannot work. Herein, we used rationally designed hybrid nanoparticles as a combined cancer therapy, hoping to form a multidimensional control network. In this paper, gold/silver alloy nanoparticle decorated camptothecin nanocrystals were formulated according to complementary anti-CSC mechanisms from gold, silver, and organic drug. This smart drug formulation could combine chemotherapy and thermotherapy, target different tumor sites, and demonstrate versatile toxicity profiles from each component. Major results indicated that this nanosystem demonstrated indiscriminately effective cytotoxic/proapoptotic/necrotic activity against bulk MCF-7 cells and their CSC subpopulation, in particular under laser ablation. Moreover, this nanosystem displayed enhanced antineoplastic activity against CSC spheroids, resulting in a significant reduction in their number and size, that is, their self-renewal capacity. All the results indicated that CSCs upon treatment of these new hybrid nanoparticles underwent reduced stemness and conversion from the original quiescent state and recovered their sensitivity toward chemotherapy. The relevant anticancer mechanism was ascribed to NIR-pH dual responsive drug release, synergistic/combined thermo-chemotherapy of organic drug and inorganic alloy nanoparticles, enhanced cellular uptake mediated by alloy nanoparticles, and Ag
MeSH term(s)	Humans ; Camptothecin/pharmacology ; Silver ; Gold/chemistry ; Antineoplastic Agents/pharmacology ; Nanoparticles/chemistry ; Neoplastic Stem Cells ; Alloys/pharmacology ; Cell Line, Tumor ; Neoplasms/pathology
Chemical Substances	Camptothecin (XT3Z54Z28A) ; Silver (3M4G523W1G) ; Gold (7440-57-5) ; Antineoplastic Agents ; Alloys
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c01100
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Article ; Online: Characterisation of a casein-/whey protein concentrate-Antarctic krill oil emulsion system and improvement of its storage stability.

Liu, Yujia / Wang, Ziyang / Lv, Lu / Wang, Liang / Li, Deyang / Miao, Xiao / Zhan, Honglei

Journal of microencapsulation

2024 Volume 41, Issue 3, Page(s) 190–203

Abstract: Aims: To develop Antarctic krill oil emulsions with casein and whey protein concentrate (WPC) and study their physicochemical properties and storage stability.: Methods: Emulsions were prepared by homogenisation and ultrasonication. The properties of ...

Abstract	Aims: To develop Antarctic krill oil emulsions with casein and whey protein concentrate (WPC) and study their physicochemical properties and storage stability. Methods: Emulsions were prepared by homogenisation and ultrasonication. The properties of the emulsions were investigated via ultraviolet ray spectroscopy, dynamic light scattering, confocal laser scanning microscope, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, Fourier transform infra-red spectrometer, and fluorescence spectrum. Shelf life was predicted by the Arrhenius model. Results: Casein- and WPC-krill oil emulsions were well formed; the mean particle diameters were less than 128.19 ± 0.64 nm and 158 ± 1.56 nm, the polymer dispersity indices were less than 0.26 ± 0.01 and 0.27 ± 0.01, and the zeta potential were around -46.88 ± 5.02 mV and -33.51 ± 2.68 mV, respectively. Shelf life was predicted to be 32.67 ± 1.55 days and 29.62 ± 0.65 days (40 °C), 27.69 ± 1.15 days and 23.58 ± 0.14 days (50 °C), 24.02 ± 0.15 days and 20.1 ± 0.08 days (60 °C). Conclusion: The prepared krill oil emulsions have great potential to become a new krill oil supplement.
MeSH term(s)	Animals ; Emulsions/chemistry ; Whey Proteins/chemistry ; Caseins ; Euphausiacea ; Oils
Chemical Substances	Emulsions ; Whey Proteins ; Caseins ; Oils
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	843632-0
ISSN	1464-5246 ; 0265-2048
ISSN (online)	1464-5246
ISSN	0265-2048
DOI	10.1080/02652048.2024.2335152
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Article ; Online: A Green Synthesis of Au-Ag Alloy Nanoparticles using Polydopamine Chemistry: Evaluation of their Anticancer Potency Towards Both MCF-7 Cells and their Cancer Stem Cells Subgroup.

Zhan, Honglei / Ding, Shiyu / Shen, Ruiyu / Lv, Yulong / Tian, Xinran / Liu, Guie / Li, Chaoyue / Wang, Jihui

Anti-cancer agents in medicinal chemistry

2024

Abstract: Background: Limited chemotherapy efficacy and cancer stem cells (CSCs)-induced therapeutic resistance are major difficulties for tumour treatment. Adopting more efficient therapies to eliminate bulk-sensitive cancer cells and resistant CSCs is urgently ... ...

Abstract	Background: Limited chemotherapy efficacy and cancer stem cells (CSCs)-induced therapeutic resistance are major difficulties for tumour treatment. Adopting more efficient therapies to eliminate bulk-sensitive cancer cells and resistant CSCs is urgently needed. Methods: Based on the potential and functional complementarity of gold and silver nanoparticles (AuNPs or AgNPs) on tumour treatment, bimetallic NPs (alloy) have been synthesized to obtain improved or even newly emerging bioactivity from a combination effect. This study reported a facile, green and economical preparation of Au-Ag alloy NPs using biocompatible polydopamine (PDA) as a reductant, capping, stabilizing and hydrophilic agent. Results: These alloy NPs were quasi-spherical with rough surfaces and recorded in diameters of 80 nm. In addition, these alloy NPs showed good water dispersity, stability and photothermal effect. Compared with monometallic counterparts, these alloy NPs demonstrated a dramatically enhanced cytotoxic/pro-apoptotic/necrotic effect towards bulk-sensitive MCF-7 and MDA-MB-231 cells. The underlying mechanism regarding the apoptotic action was associated with a mitochondria-mediated pathway, as evidenced by Au3+/Ag+ mediated Mitochondria damage, ROS generation, DNA fragmentation and upregulation of certain apoptotic-related genes (Bax, P53 and Caspase 3). Attractively, these Au-Ag alloy NPs showed a remarkably improved inhibitory effect on the mammosphere formation capacity of MCF-7 CSCs. Conclusion: All the positive results were attributed to incorporated properties from Au, Ag and PDA, the combination effect of chemotherapy and photothermal therapy and the nano-scaled structure of Au-Ag alloy NPs. In addition, the high biocompatibility of Au-Ag alloy NPs supported them as a good candidate in cancer therapy.
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217610-X
ISSN	1875-5992 ; 1871-5206
ISSN (online)	1875-5992
ISSN	1871-5206
DOI	10.2174/0118715206296123240331050206
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Article: Sporosarcina aquimarina MS4 Regulates the Digestive Enzyme Activities, Body Wall Nutrients, Gut Microbiota, and Metabolites of Apostichopus japonicus

Yi, Hong / Bai, Qinglu / Li, Ying / Zhan, Honglei / Liu, Yujia / Liu, Bingnan / Wang, Jihui

Fishes. 2022 June 07, v. 7, no. 3

2022

Abstract: Sporosarcina aquimarina MS4 is a microecological preparation for overwintering Apostichopus japonicus, which has an immune regulation function, but its role in the nutritional regulation of A. japonicus is not clear. This study aimed to describe the ... ...

Abstract	Sporosarcina aquimarina MS4 is a microecological preparation for overwintering Apostichopus japonicus, which has an immune regulation function, but its role in the nutritional regulation of A. japonicus is not clear. This study aimed to describe the effects of S. aquimarina MS4 on the growth, digestion, and body wall nutrition of A. japonicus through feeding experiments and to discuss the potential mechanism of S. aquimarina MS4 regulating gut function through the detection of gut microbiota and metabolites. After 60 days of culture, the growth performance of A. japonicus fed S. aquimarina MS4 (10⁸ cfu/g) significantly improved, and the content of polysaccharide, leucine, phenylalanine, lysine, and docosahexaenoic acid in the body wall significantly increased. Gut microbiota analysis showed that although Proteobacteria, Verrucomicrobia, Firmicutes, and Bacteroidetes were the predominant phyla in all the sea cucumbers, Haloferula and Rubritalea showed significant difference between the group fed with or without S. aquimarina MS4. Metabolomics analysis showed that differential metabolites in the gut were mainly enriched in amino acid metabolism and lipid metabolism. The association analysis of differential metabolites and microbiota showed that the production of some differential metabolites was significantly related to differential microorganisms, which improved the understanding of the function of microorganisms and their roles in the gut of A. japonicus. This study reveals the life activities such as growth and metabolism of A. japonicus, and it provides support for the functional study of the gut microbiome of A. japonicus.
Keywords	Apostichopus japonicus ; Bacteroidetes ; Proteobacteria ; Sporosarcina aquimarina ; Verrucomicrobia ; amino acid metabolism ; digestion ; digestive enzymes ; docosahexaenoic acid ; growth performance ; integument ; intestinal microorganisms ; leucine ; lipid metabolism ; lysine ; metabolites ; metabolomics ; overwintering ; phenylalanine ; polysaccharides
Language	English
Dates of publication	2022-0607
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ISSN	2410-3888
DOI	10.3390/fishes7030134
Database	NAL-Catalogue (AGRICOLA)

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Article: Two-step pyrolysis degradation mechanism of oil shale through comprehensive analysis of pyrolysis semi-cokes and pyrolytic gases

Zhan, Honglei / Qin, Fankai / Chen, Sitong / Chen, Ru / Meng, Zhaohui / Miao, Xinyang / Zhao, Kun

Energy. 2022 Feb. 15, v. 241

2022

Abstract: Despite kerogen's importance as organic matter produced from oil shale, its pyrolytic degradation mechanism remains unexplored. As the potential demand for oil shale utilization increases, identifying the physical relationship between pyrolysis ... ...

Abstract	Despite kerogen's importance as organic matter produced from oil shale, its pyrolytic degradation mechanism remains unexplored. As the potential demand for oil shale utilization increases, identifying the physical relationship between pyrolysis degradation and temperature for kerogen becomes all the more important. Here, we determine the variation in the pyrolysis degradation of the Huadian oil shale through comprehensive analysis using terahertz spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy, infrared spectroscopy, and mass spectroscopy. Through the hybrid detection of pyrolysis semi-cokes and pyrolytic gases, we provide a detailed pyrolysis model for oil shale and show that it can be used to predict the essential characteristics that are amenable to experimental validation. Kerogen in oil shale was first depolymerized into asphalt monomer. The macromolecular organic matter (OM) began to decompose and produce CO₂, but the OM did not decompose into low-carbon oil and gas. As the temperature continued to rise, the asphalt monomer decomposed into shale oil and shale gas. The OM in the oil shale generated a large amount of oil and gas. Consequently, these results demonstrate the two-step pyrolysis degradation of oil shale, which provides theoretical support for underground in-situ pyrolysis technology and underground oil shale development.
Keywords	X-ray diffraction ; bitumen ; carbon dioxide ; energy ; hybrids ; infrared spectroscopy ; mass spectrometry ; models ; oil shale ; oils ; organic matter ; pyrolysis ; shale gas ; temperature ; thermogravimetry
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2019804-8
ISSN	0360-5442 ; 0360-5442
ISSN (online)	0360-5442
ISSN	0360-5442
DOI	10.1016/j.energy.2021.122871
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Article: Gibberellic acid‐induced fatty acid metabolism and ABC transporters promote astaxanthin production in Phaffia rhodozyma

Liu, Sijiao / Yi, Hong / Zhan, Honglei / Wang, Liang / Wang, Jihui / Li, Ying / Liu, Bingnan

Journal of applied microbiology. 2022 Jan., v. 132, no. 1

2022

Abstract: AIMS: Astaxanthin is an important natural antioxidant with various biological functions; however, the production of astaxanthin does not meet the requirements for industrialization. The aim of the present study was to identify an inducer that increases ... ...

Abstract	AIMS: Astaxanthin is an important natural antioxidant with various biological functions; however, the production of astaxanthin does not meet the requirements for industrialization. The aim of the present study was to identify an inducer that increases astaxanthin yield and to evaluate the regulatory mechanism of the induction of astaxanthin synthesis in Phaffia rhodozyma. METHODS AND RESULTS: The effects of indole‐3‐acetic acid (IAA), jasmonic acid (JA) and gibberellic acid (GA) on astaxanthin synthesis were studied by fermentation kinetics analysis. Then, combined transcriptomics and metabolomics approaches were used to analyse differential metabolites and expressed genes involved in astaxanthin synthesis induced by GA. The results indicated that GA significantly increased astaxanthin production; however, IAA and JA had no significant effect on astaxanthin synthesis. The induction by GA significantly enhanced fatty acid metabolism and ABC transporters, increased the expression of fatty acid desaturase and ABC transporter genes, and elevated the contents of unsaturated fatty acids. CONCLUSIONS: These results suggested that fatty acid saturation plays an important role in astaxanthin accumulation and that ABC transporters may be the efflux pumps for astaxanthin. SIGNIFICANCE AND IMPACT OF THE STUDY: The present study reveals metabolic mechanism of GA‐induced astaxanthin synthesis and proposes a new strategy of transporter engineering to improve astaxanthin production.
Keywords	ABC transporters ; antioxidants ; astaxanthin ; fatty acid desaturase ; fatty acid metabolism ; fermentation ; gibberellic acid ; indole acetic acid ; industrialization ; jasmonic acid ; metabolites ; metabolomics ; microbiology ; transcriptomics
Language	English
Dates of publication	2022-01
Size	p. 390-400.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1358023-1
ISSN	1365-2672 ; 1364-5072
ISSN (online)	1365-2672
ISSN	1364-5072
DOI	10.1111/jam.15187
Database	NAL-Catalogue (AGRICOLA)

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Article: A New Gold Nanoparticles and Paclitaxel Co-Delivery System for Enhanced Anti-Cancer Effect Through Chemo-Photothermal Combination.

Zhan, Honglei / Song, Wenjing / Gu, Mingyang / Zhao, He / Liu, Yujia / Liu, Bingnan / Wang, Jihui

Journal of biomedical nanotechnology

2022 Volume 18, Issue 4, Page(s) 957–975

Abstract: Limited chemotherapeutic efficiency, drug resistance and side effect are primary obstacles for cancer treatment. The development of co-delivery system with synergistic treatment modes should be a promising strategy. Here, we fabricated a multi- ... ...

Abstract	Limited chemotherapeutic efficiency, drug resistance and side effect are primary obstacles for cancer treatment. The development of co-delivery system with synergistic treatment modes should be a promising strategy. Here, we fabricated a multi-functionalized nanocarrier with a combination of chemotherapeutic agent and gold nanoparticles (AuNPs), which could integrate chemo-photothermal therapy and improve entire anti-cancer index. Particularly, Paclitaxel nanocrystals (PTX NC) were first fabricated as a platform, on surface of which AuNPs were decorated and polydopamine (PDA) layer act as capping, stabilizing and hydrophilic agents for PTX NC, providing a bridge connecting AuNPs to PTX. These AuNPs decorated PTX NC exhibited good physico-chemical properties like optimal sizes, stability and photothermal efficiency. Compared to other PTX formulations, they displayed considerably improved biocompatibility, selectivity, intracellular uptake, cytotoxicity, apoptosis induction activity and P-glycoprotein (Pgp) inhibitory capability, owing to a synergistic/ cooperative effect from AuNPs, PTX and NIR treatment, photothermal-triggered drug release and nano-scaled structure. Mitochondria-mediated signaling pathway is underlying mechanism for cytotoxic and apoptotic effect from AuNPs decorated PTX NC, in terms of Mitochondria damage, a loss of Mitochondrial membrane potential, intensified oxidative stress, DNA breakage, Caspase 3 activation, up-regulated expression in pro-apoptotic genes like
MeSH term(s)	Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Caspase 3 ; Cell Line, Tumor ; Drug Delivery Systems ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Nanoparticles/chemistry ; Paclitaxel ; Phototherapy
Chemical Substances	Antineoplastic Agents ; Gold (7440-57-5) ; Caspase 3 (EC 3.4.22.-) ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2022.3309
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Article: Green Synthesis of Gold Nanoparticles and Study of Their Inhibitory Effect on Bulk Cancer Cells and Cancer Stem Cells in Breast Carcinoma.

Wang, Jihui / Liu, Na / Su, Qing / Lv, Yulong / Yang, Chang / Zhan, Honglei

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 19

Abstract: Chemo-resistance from cancer stem cells (CSCs) subpopulation is a current issue in cancer treatment. It is important to select alternative therapies to efficiently eradicate both bulk cancer cells and CSCs. Here, gold nanoparticles (AuNPs) have been ... ...

Abstract	Chemo-resistance from cancer stem cells (CSCs) subpopulation is a current issue in cancer treatment. It is important to select alternative therapies to efficiently eradicate both bulk cancer cells and CSCs. Here, gold nanoparticles (AuNPs) have been selected regarding their biocompatibility, facile and controllable synthesis, potent anti-cancer activity and photothermal conversion performance. We reported a green synthesis of functionalized AuNPs using hyaluronic acid (HA) as a reductant, capping, stabilizing and hydrophilic substance. The resultant AuNPs were spherical-shaped with an average diameter of around 30 nm. These AuNPs displayed improved physico-chemical (yield, stability, photothermal effect) and biological properties (cellular uptake, cytotoxicity and apoptotic effect) against bulk MDA-MB-231 cells, in comparison with other organic anti-cancer drugs. The intensified bioactivity was dependent on a mitochondria-mediated cascade, reflected by the damage in mitochondria, oxidative stress, intensified Caspase 3 activity and increased/decreased expression of certain pro-apoptotic (
Language	English
Publishing date	2022-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12193324
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Article ; Online: Gold Nanoparticle-Decorated Drug Nanocrystals for Enhancing Anticancer Efficacy and Reversing Drug Resistance Through Chemo-/Photothermal Therapy.

Wang, Jihui / Zhao, He / Song, Wenjing / Gu, Mingyang / Liu, Yujia / Liu, Bingnan / Zhan, Honglei

Molecular pharmaceutics

2022 Volume 19, Issue 7, Page(s) 2518–2534

Abstract: Limited chemotherapeutic efficiency, drug resistance, and side effects are primary obstacles for cancer treatment. The development of co-delivery systems with synergistic treatment modes should be a promising strategy. Here, we fabricated a ... ...

Abstract	Limited chemotherapeutic efficiency, drug resistance, and side effects are primary obstacles for cancer treatment. The development of co-delivery systems with synergistic treatment modes should be a promising strategy. Here, we fabricated a multifunctionalized nanocarrier with a combination of chemotherapeutic agents and gold nanoparticles (AuNPs), which could integrate chemo-photothermal therapy, thus enhancing overall anticancer efficacy, sensitizing drug-resistant cancer cells, and diminishing cancer stem cells (CSCs). To be specific, camptothecin nanocrystals (CPT NCs) were prepared as a platform, on the surface of which AuNPs were decorated and a hyaluronic acid layer acted as capping, stabilizing, targeting, and hydrophilic agents for CPT NCs, and reducing agents for AuNPs, providing a bridge connecting AuNPs to CPT. These AuNP-decorated CPT NCs exhibited good physico-chemical properties such as optimal sizes, payload, stability, and photothermal efficiency. Compared to other CPT formulations, they displayed considerably improved biocompatibility, selectivity, intracellular uptake, cytotoxicity, apoptosis induction activity, Pgp inhibitory capability, and anti-CSC activity, owing to a synergistic/cooperative effect from AuNPs, CPT, near-infrared treatment, pH/photothermal-triggered drug release, and nanoscaled structure. A mitochondrial-mediated signaling pathway is the underlying mechanism for cytotoxic and apoptotic effects from AuNP-decorated CPT NCs, in terms of mitochondrial dysfunction, intensified oxidative stress, DNA fragmentation, caspase 3 activation, upregulation of proapoptotic genes such as
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Camptothecin/chemistry ; Camptothecin/pharmacology ; Caspase 3 ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Liberation ; Drug Resistance ; Gold/chemistry ; Metal Nanoparticles/chemistry ; Nanoparticles/chemistry ; Phototherapy ; Photothermal Therapy
Chemical Substances	Antineoplastic Agents ; Gold (7440-57-5) ; Caspase 3 (EC 3.4.22.-) ; Camptothecin (XT3Z54Z28A)
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.2c00150
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