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Article ; Online: Current application status and attitude of depth of anesthesia monitoring devices in Chinese anesthesiologists

WANG Lu / GUO Yang / LI Hon / ZHAN Jian

陆军军医大学学报, Vol 45, Iss 1, Pp 67-

2023 Volume 72

Abstract: Objective To understand the current status of application of depth of anesthesia (DoA) monitors used by anesthesiologists in China and evaluated its validity. Methods Chinese anesthesiologists who have been licensed as medical practitioners were selected ...

Abstract	Objective To understand the current status of application of depth of anesthesia (DoA) monitors used by anesthesiologists in China and evaluated its validity. Methods Chinese anesthesiologists who have been licensed as medical practitioners were selected as the research objects. A nationwide online survey was carried out by sending a WeChat survey form to 12 750 anesthesiologists during July and September 2020, and the data of DoA monitor usage and effectiveness were collected. Finally, 4 037 valid questionnaires were obtained. The survey data were analyzed using SPSS 26.0 software. The data were expressed as proportions with 95% confidence interval (CI), and Chi-square test was conducted for statistical analysis. Results ① Only 9.1% of anesthesiologists routinely used DoA monitors in clinical anesthesia. Anesthesiologists in teaching hospitals [proportion of very familiar: 30.3% (28.3%~32.3%)] and grade-A tertiary hospitals [proportion of very familiar: 28.8% (27.1%~30.6%)] were more familiar with DoA monitors than those in non-teaching hospitals [proportion of very familiar: 14.8% (13.2%~16.4%)] and non-grade-A tertiary hospitals [proportion of very familiar: 11.8% (10.1%~13.5%)], respectively. Among the participants, 65.4% of them considered that the 3 electroencephalogram parameters of DoA monitors were equally important, with the proportion of anesthesiologists in teaching hospitals [66.7%(64.7%~68.7%)] higher than that in non-teaching hospitals [64.1%(62.0%~66.2%)], though no statistical difference due to 95%CI overlapping. ② 96.5% of anesthesiologists believed that the DoA monitors could effectively monitor DoA. However, there was no significant difference in anesthesiologists' evaluation of the effectiveness of different DoA monitors. ③ Anesthesiologists with different titles believed that DoA monitors were indispensable for different general anesthesia methods, but statistical difference was seen in whether DoA monitors were required for general anesthesia preserving spontaneous respiration (P < ...
Keywords	depth of anesthesia monitors ; anesthesiologists ; general anesthesia ; spontaneous respiration ; Medicine (General) ; R5-920
Subject code	310
Language	Chinese
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Army Medical University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Examining the correlates of cigarette smoking, e-cigarette use and dual use among Canadian post-secondary students.

Fagan, Matthew James / Zhan, Jian Kun / Wunderlich, Kelly B / Faulkner, Guy

Tobacco use insights

2024 Volume 17, Page(s) 1179173X241247414

Abstract: Many Canadians use nicotine products such as cigarettes and e-cigarettes. A particular subpopulation of concern is post-secondary students given they have a higher prevalence of use. Many correlates of cigarette smoking and e-cigarette use have been ... ...

Abstract	Many Canadians use nicotine products such as cigarettes and e-cigarettes. A particular subpopulation of concern is post-secondary students given they have a higher prevalence of use. Many correlates of cigarette smoking and e-cigarette use have been identified. However, less focus has been on examining the correlates of cigarette smoking, e-cigarette use and dual use. This study explores the correlates of different nicotine modality use in post-secondary students. Using data from the Canadian Campus Wellbeing Survey (CCWS;
Language	English
Publishing date	2024-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2532401-9
ISSN	1179-173X
ISSN	1179-173X
DOI	10.1177/1179173X241247414
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: 3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next?

Zhou, Yaoqi / Litfin, Thomas / Zhan, Jian

National science review

2023 Volume 10, Issue 12, Page(s) nwad259

Language	English
Publishing date	2023-10-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad259
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Article ; Online: SPIN-CGNN: Improved fixed backbone protein design with contact map-based graph construction and contact graph neural network.

Zhang, Xing / Yin, Hongmei / Ling, Fei / Zhan, Jian / Zhou, Yaoqi

PLoS computational biology

2023 Volume 19, Issue 12, Page(s) e1011330

Abstract: Recent advances in deep learning have significantly improved the ability to infer protein sequences directly from protein structures for the fix-backbone design. The methods have evolved from the early use of multi-layer perceptrons to convolutional ... ...

Abstract	Recent advances in deep learning have significantly improved the ability to infer protein sequences directly from protein structures for the fix-backbone design. The methods have evolved from the early use of multi-layer perceptrons to convolutional neural networks, transformers, and graph neural networks (GNN). However, the conventional approach of constructing K-nearest-neighbors (KNN) graph for GNN has limited the utilization of edge information, which plays a critical role in network performance. Here we introduced SPIN-CGNN based on protein contact maps for nearest neighbors. Together with auxiliary edge updates and selective kernels, we found that SPIN-CGNN provided a comparable performance in refolding ability by AlphaFold2 to the current state-of-the-art techniques but a significant improvement over them in term of sequence recovery, perplexity, deviation from amino-acid compositions of native sequences, conservation of hydrophobic positions, and low complexity regions, according to the test by unseen structures, "hallucinated" structures and diffusion models. Results suggest that low complexity regions in the sequences designed by deep learning, for generated structures in particular, remain to be improved, when compared to the native sequences.
MeSH term(s)	Amino Acids ; Amino Acid Sequence ; Cluster Analysis ; Diffusion ; Neural Networks, Computer
Chemical Substances	Amino Acids
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011330
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Article ; Online: HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.

Zhan, Jian / Zhang, Qian / Tong, Xu / Liu, Xu / Zhao, Chunbo

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2023 Volume 25, Issue 5, Page(s) 1472–1481

Abstract: Objective: Pancreatic cancer is a devastating and lethal malignancy. Our study investigated the effective mechanism of HNF4G on pancreatic cancer cell functions through the IGF2BP2 transcription.: Methods: HNF4G and IGF2BP2 expressions in pancreatic ... ...

Abstract	Objective: Pancreatic cancer is a devastating and lethal malignancy. Our study investigated the effective mechanism of HNF4G on pancreatic cancer cell functions through the IGF2BP2 transcription. Methods: HNF4G and IGF2BP2 expressions in pancreatic cancer were examined. The relationship between HNF4G expression and pancreatic cancer patients' clinicopathological characteristics was evaluated. After interfering with HNF4G expression in pancreatic cancer cells, the cell proliferative, migratory, and invasive capabilities were evaluated. Also, the expression of proliferation-related gene PCNA and migration and invasion-related gene MMP2 was determined. The binding relation between HNF4G and HNF4G promoter was forecasted and testified. A tumorigenesis assay in nude mice was performed to detect the HNF4G interference's effect on the subcutaneous tumorigenic capacity of pancreatic cancer cells. Results: HNF4G and IGF2BP2 expressions were up-regulated in pancreatic cancer. Specifically, interfering with HNF4G inhibited PANC-1 cell proliferative, invasive and migratory behaviors, and decreased PCNA and MMP2 expression. Mechanistically, HNF4G as a transcription factor could specifically bind to IGF2BP2 and promote its expression. Rescue assay findings showed that IGF2BP2 overexpression could reverse the inhibiting effect of HNF4G interference on pancreatic cancer cells. For the in vivo finding, interfering HNF4G expression retarded the subcutaneous tumorigenic ability of pancreatic cancer cells. Conclusion: We summarize that HNF4G as a transcription factor regulates IGF2BP2 expression to promote pancreatic cancer cell proliferation and migration capacities.
MeSH term(s)	Animals ; Humans ; Mice ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Matrix Metalloproteinase 2/genetics ; Matrix Metalloproteinase 2/metabolism ; Mice, Nude ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Proliferating Cell Nuclear Antigen/genetics ; Proliferating Cell Nuclear Antigen/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Pancreatic Neoplasms
Chemical Substances	Hnf4a protein, mouse ; HNF4G protein, human ; IGF2BP2 protein, human ; IGF2BP2 protein, mouse ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; MMP2 protein, human (EC 3.4.24.24) ; Mmp2 protein, mouse (EC 3.4.24.24) ; PCNA protein, human ; Proliferating Cell Nuclear Antigen ; Transcription Factors
Language	English
Publishing date	2023-01-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-022-03048-7
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Article ; Online: Nutrient leaching in extensive green roof substrate layers with different configurations.

Xu, Chen / Liu, Zaohong / Cai, Guanjun / Zhan, Jian

Environmental science and pollution research international

2022 Volume 29, Issue 23, Page(s) 34278–34287

Abstract: Due to substrate layers with different substrate configurations, extensive green roofs (EGRs) exhibit different rainfall runoff retention and pollution interception effects. In the rainfall runoff scouring process, nutrient leaching often occurs in the ... ...

Abstract	Due to substrate layers with different substrate configurations, extensive green roofs (EGRs) exhibit different rainfall runoff retention and pollution interception effects. In the rainfall runoff scouring process, nutrient leaching often occurs in the substrate layer, which becomes a pollution source for rainwater runoff. In this study, six EGR devices with different substrate layer configurations were fabricated. Then, the cumulative leaching quantity (CLQ) and total leaching rate (TLR) of NH
MeSH term(s)	Conservation of Natural Resources/methods ; Nitrogen ; Nutrients ; Phosphorus ; Rain ; Water Movements
Chemical Substances	Phosphorus (27YLU75U4W) ; Nitrogen (N762921K75)
Language	English
Publishing date	2022-01-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17969-3
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Article ; Online: High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5'-OH-end linker and unique 3'-P-end fragments from hydroxyl radical cleavage.

Solayman, Md / Litfin, Thomas / Zhou, Yaoqi / Zhan, Jian

RNA biology

2022 Volume 19, Issue 1, Page(s) 1179–1189

Abstract: Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights. Among various chemical probes developed, backbone-cleaving hydroxyl radical ... ...

Abstract	Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights. Among various chemical probes developed, backbone-cleaving hydroxyl radical is the only one that can provide unbiased detection of all accessible nucleotides. However, the readouts have been based on reverse transcription (RT) stop at the cleaving sites, which are prone to false positives due to PCR amplification bias, early drop-off of reverse transcriptase, and the use of random primers in RT reaction. Here, we introduced a fixed-primer method called RL-Seq by performing RtcB Ligation (RL) between a fixed 5'-OH-end linker and unique 3'-P-end fragments from hydroxyl radical cleavage prior to high-throughput sequencing. The application of this method to
MeSH term(s)	RNA/genetics ; RNA/chemistry ; Hydroxyl Radical/chemistry ; Nucleic Acid Conformation ; Nucleotides ; Solvents/chemistry ; Escherichia coli/genetics ; High-Throughput Nucleotide Sequencing/methods ; Amino Acyl-tRNA Synthetases/genetics ; Escherichia coli Proteins/genetics
Chemical Substances	RNA (63231-63-0) ; Hydroxyl Radical (3352-57-6) ; Nucleotides ; Solvents ; RtcB protein, E coli (EC 6.1.1.-) ; Amino Acyl-tRNA Synthetases (EC 6.1.1.-) ; Escherichia coli Proteins
Language	English
Publishing date	2022-11-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2159587-2
ISSN	1555-8584 ; 1555-8584
ISSN (online)	1555-8584
ISSN	1555-8584
DOI	10.1080/15476286.2022.2145098
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Article ; Online: Superficial Siderosis of the Central Nervous System with Sexual Dysfunction as the First Symptom and a Method Preventing Worsening: A Case with 11 Years of Follow-ups.

Zhan, Jian / Yu, Changyin / Zuo, Hao

Neurology India

2022 Volume 70, Issue 5, Page(s) 2275–2276

MeSH term(s)	Humans ; Siderosis/complications ; Follow-Up Studies ; Central Nervous System ; Central Nervous System Diseases/complications ; Central Nervous System Diseases/diagnosis ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-11-09
Publishing country	India
Document type	Letter
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.359295
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Article ; Online: Identification of the Immune Status of Hypertrophic Cardiomyopathy by Integrated Analysis of Bulk- and Single-Cell RNA Sequencing Data.

Zhao, Wei / Wu, Tianyu / Zhan, Jian / Dong, Zishuang

publication RETRACTED

Computational and mathematical methods in medicine

2022 Volume 2022, Page(s) 7153491

Abstract: Objectives: Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy and immune infiltration is considered an indispensable factor involved in its pathogenesis. In this study, we attempted to combine bulk sequencing and single-cell ...

Abstract	Objectives: Hypertrophic cardiomyopathy (HCM) is the most common hereditary cardiomyopathy and immune infiltration is considered an indispensable factor involved in its pathogenesis. In this study, we attempted to combine bulk sequencing and single-cell sequencing to map the immune infiltration-related genes in hypertrophic cardiomyopathy. Methods: The GSE36961, GSE160997, and GSE122930 datasets were obtained from the Gene Expression Omnibus database. The compositional patterns of the 18 types of immune cell fraction and pathway enrichment score in control and HCM patients were estimated based on the GSE36961 cohort using xCell algorithm. The Weighted Gene Coexpression Network Analysis (WGCNA) was performed to identify genes associated with immune infiltration for hypertrophic cardiomyopathy. The area under the curve (AUC) value was obtained and used to evaluate the discriminatory ability of common immune-related DEGs. "NetworkAnalyst" platform was used to identify TF-gene and TF-miRNA interaction with identified common genes. Heat map was used to determine the association between common DEGs and various immune cells. Results: Immune infiltration analysis by the xCell algorithm showed a higher level of CD8+ naive T cells, CD8+ T cells, as well as a lower level of activated dendritic cells (aDC), dendritic cells (DC), immature dendritic cells (iDC), conventional dendritic cells (cDC), macrophages, M1 macrophages, monocytes, and NKT cell in HCM compared with the control group in GSE36961 dataset. aDC, macrophages, and M1 macrophages were the top three discriminators between HCM and control groups with the area under the curve (AUC) of 0.907, 0.867, and 0.941. WGCNA analysis showed that 1258 immune-related genes were included in four different modules. Of these modules, the turquoise module showed a pivotal correlation with HCM. 13 common immune-related DEGs were found by intersecting common DEGs in GSE36961 and GSE160997 datasets with genes from the genes in turquoise module. 5 hub immune-related genes (S100A9, TYROBP, FCER1G, CD14, and S100A8) were identified by protein interaction network. Through analysis of single-cell sequencing data, S100a9, TYROBP, FCER1G, and S100a8 were mainly expressed by infiltrated M1 proinflammatory cells, especially Ccr2-M1 proinflammatory macrophage cells in the heart immune microenvironment while Cd14 was expressed by infiltrated M1 proinflammatory macrophage cells and M2 macrophages in transverse aortic constriction (TAC) mice at 1 week. Higher M2 macrophage and M1 proinflammatory macrophage infiltration as well as lower Ccr2-M1 proinflammatory macrophage and dendritic cells were shown in TAC 1week mice compared with sham mice. Conclusions: There was a difference in immune infiltration between HCM patients and normal groups. aDC, macrophages, and M1 macrophages were the top three discriminator immune cell subsets between HCM and control groups. S100A9, TYROBP, FCER1G, CD14, and S100A8 were identified as potential biomarkers to discriminate HCM from the control group. S100a9, TYROBP, FCER1G, and S100a8 were mainly expressed by infiltrated M1 proinflammatory cells, especially Ccr2-M1 proinflammatory cells in the heart immune microenvironment while Cd14 was expressed by M2 macrophages in transverse aortic constriction (TAC) mice at 1 week.
MeSH term(s)	Animals ; Biomarkers ; Cardiomyopathy, Hypertrophic/genetics ; Cardiomyopathy, Hypertrophic/metabolism ; Gene Regulatory Networks ; Mice ; MicroRNAs ; Sequence Analysis, RNA
Chemical Substances	Biomarkers ; MicroRNAs
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2252430-7
ISSN	1748-6718 ; 1748-670X ; 1027-3662
ISSN (online)	1748-6718
ISSN	1748-670X ; 1027-3662
DOI	10.1155/2022/7153491
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Article ; Online: High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage

Solayman, Md / Litfin, Thomas / Zhou, Yaoqi / Zhan, Jian

RNA Biology. 2022 Dec. 31, v. 19, no. 1 p.1179-1189

2022

Abstract	Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights. Among various chemical probes developed, backbone-cleaving hydroxyl radical is the only one that can provide unbiased detection of all accessible nucleotides. However, the readouts have been based on reverse transcription (RT) stop at the cleaving sites, which are prone to false positives due to PCR amplification bias, early drop-off of reverse transcriptase, and the use of random primers in RT reaction. Here, we introduced a fixed-primer method called RL-Seq by performing RtcB Ligation (RL) between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage prior to high-throughput sequencing. The application of this method to E. coli ribosomes confirmed its ability to accurately probe solvent accessibility with high sensitivity (low required sequencing depth) and accuracy (strong correlation to structure-derived values) at the single-nucleotide resolution. Moreover, a near-perfect correlation was found between the experiments with and without using unique molecular identifiers, indicating negligible PCR biases in RL-Seq. Further improvement of RL-Seq and its potential transcriptome-wide applications are discussed.
Keywords	Escherichia coli ; RNA ; RNA-directed DNA polymerase ; hydroxyl radicals ; nucleotides ; reverse transcription ; ribosomes ; solvents ; SASA ; hydroxyl radical ; probing ; RL-Seq ; solvent accessibility
Language	English
Dates of publication	2022-1231
Size	p. 1179-1189.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2159587-2
ISSN	1555-8584
ISSN	1555-8584
DOI	10.1080/15476286.2022.2145098
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