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  1. Article ; Online: Prediction of musculoskeletal pain after the first intravenous zoledronic acid injection in patients with primary osteoporosis: development and evaluation of a new nomogram.

    Zheng, Xiaoxia / Ye, Jiangnan / Zhan, Qunzhang / Zhao, Weifeng / Liao, Zhongqin / Ye, Xiaolin / Qu, Chongzheng

    BMC musculoskeletal disorders

    2023  Volume 24, Issue 1, Page(s) 841

    Abstract: Objective: To construct a new prediction nomogram to predict the risk of musculoskeletal pain in patients with primary osteoporosis who receive zoledronic acid intravenously for the first time.: Method: Clinical data of 368 patients with primary ... ...

    Abstract Objective: To construct a new prediction nomogram to predict the risk of musculoskeletal pain in patients with primary osteoporosis who receive zoledronic acid intravenously for the first time.
    Method: Clinical data of 368 patients with primary osteoporosis who received the first intravenous injection of zoledronic acid in our hospital from December 2019 to December 2022 were studied. Patients were divided into a musculoskeletal pain group (n = 258) and a non-musculoskeletal pain group (n = 110) based on the presence or absence of musculoskeletal pain 3 days after injection. Statistically significant predictors were screened by logistic regression analysis and the minimum absolute contraction and selection operator (LASSO) to construct a nomogram. The nomogram was evaluated by the receiver operating characteristic (ROC) curve, the calibration curve, the C-index, and the decision curve analysis (DCA) and verified in a validation cohort.
    Results: The independent predictors of the nomogram were age, serum 25-hydroxyvitamin D, NSAIDs, prior Vitamin D intake, and BMI. The area under the ROC curve (AUC) was 0.980 (95% CI, 0.915-0.987), showing excellent predictive performance. The nomogram c index was 0.980, and the nomogram c index for internal verification remained high at 0.979. Moreover, calibration curves show that the nomogram has good consistency. Finally, the DCA showed that the net benefit of the nomogram was 0.20-0.49.
    Conclusion: Musculoskeletal pain is a common symptom of APR in OP patients treated with intravenous zoledronic acid. Risk factors for musculoskeletal pain after zoledronic acid injection in OP patients were: non-use of NSAIDs, youth (<80 years old), serum 25 (OH) D<30ng /mL, no prior intake of vitamin D, BMI<24 kg /m
    MeSH term(s) Adolescent ; Humans ; Aged, 80 and over ; Musculoskeletal Pain/chemically induced ; Musculoskeletal Pain/diagnosis ; Musculoskeletal Pain/drug therapy ; Nomograms ; Zoledronic Acid/adverse effects ; Vitamin D ; Anti-Inflammatory Agents, Non-Steroidal ; Osteoporosis/drug therapy
    Chemical Substances Zoledronic Acid (6XC1PAD3KF) ; Vitamin D (1406-16-2) ; Anti-Inflammatory Agents, Non-Steroidal
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-023-06965-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Therapeutic potential of a prominent dihydroxyflavanone pinocembrin for osteolytic bone disease:

    Hong, Guoju / Li, Shuqiang / Zheng, Guanqiang / Zheng, Xiaoxia / Zhan, Qunzhang / Zhou, Lin / Wei, Qiushi / He, Wei / Chen, Zhenqiu

    Journal of orthopaedic translation

    2024  Volume 45, Page(s) 197–210

    Abstract: Background/objective: As the pivotal cellular mediators of bone resorption and pathological bone remodeling, osteoclasts have emerged as a prominent target for anti-resorptive interventions. Pinocembrin (PIN), a predominant flavonoid found in damiana, ... ...

    Abstract Background/objective: As the pivotal cellular mediators of bone resorption and pathological bone remodeling, osteoclasts have emerged as a prominent target for anti-resorptive interventions. Pinocembrin (PIN), a predominant flavonoid found in damiana, honey, fingerroot, and propolis, has been recognized for its potential therapeutic effects in osteolysis. The purpose of our project is to investigate the potential of PIN to prevent bone resorption in ovariectomized (OVX) mice by suppressing osteoclast production through its underlying mechanisms.
    Methods: The study commenced by employing protein-ligand molecular docking to ascertain the specific interaction between PIN and nuclear factor-κB (NF-κB) ligand (RANKL). Subsequently, PIN was introduced to bone marrow macrophages (BMMs) under the stimulation of RANKL. The impact of PIN on osteoclastic activity was assessed through the utilization of a positive TRAcP staining kit and a hydroxyapatite resorption assay. Furthermore, the study investigated the generation of reactive oxygen species (ROS) in osteoclasts induced by RANKL using H
    Results: In this study, we elucidated the profound inhibitory effects of PIN on osteoclastogenesis and bone resorption, achieved through repression of NF-κB and NFATc1-mediated signaling pathways. Notably, PIN also exhibited potent anti-oxidative properties by mitigating RANKL-induced ROS generation and augmenting activities of ROS-scavenging enzymes, ultimately leading to a reduction in intracellular ROS levels. Moreover, PIN effectively abrogated the expression of osteoclast-specific marker genes (
    Conclusion: Our findings highlight the potent inhibitory effects of PIN on osteoclastogenesis, bone resorption, and RANKL-induced signaling pathways, thereby establishing PIN as a promising therapeutic candidate for the prevention and management of osteolytic bone diseases.
    The translational potential of this article: PIN serves as a promising therapeutic agent for the prevention and management of osteolytic bone diseases and holds promise for future clinical applications in addressing conditions characterized by excessive bone resorption. PIN is a natural compound found in various sources, including damiana, honey, fingerroot, and propolis. Its widespread availability and potential for therapeutic use make it an attractive candidate for further investigation and development as a clinical intervention.
    Language English
    Publishing date 2024-03-27
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2747531-1
    ISSN 2214-031X
    ISSN 2214-031X
    DOI 10.1016/j.jot.2023.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Study on active compounds of Yupingfeng San for prevention of coronavirus disease 2019 (COVID-19) based on network pharmacology and molecular docking/ 基于网络药理学和分子对接的玉屏风散预防新型冠状病毒肺炎（COVID-19）活性化合物的研究

    Zhan, Qun-Zhang / Huang, Ying-Jie / Lin, Shu-Hong / Chu, Qing-Min

    Chin. Trad. Herbal Drugs

    Abstract: Objective: To find out the active compounds of Yupingfeng San for the prevention and treatment of the coronavirus pneumoniadisease 2019 (COVID-19) using network pharmacology and molecular docking, with a purpose to find a better clinical use of ... ...

    Abstract Objective: To find out the active compounds of Yupingfeng San for the prevention and treatment of the coronavirus pneumoniadisease 2019 (COVID-19) using network pharmacology and molecular docking, with a purpose to find a better clinical use of Yupingfeng San. Methods: The effective ingredients and targets of Astragali Radix, Atractylodis Macrocephalae Rhizoma and Saposhnikoviae Radix were searched from the traditional Chinese medicine system pharmacology analysis platform (TCMSP) website, and the protein and protein interactive network of Yupingfeng San was established using the String database (PPI). Cytoscape 3.6.1 software was used for data analysis to extract the Hub network from the PPI network. The KEGG pathway analysis was performed using the String database and the molecular docking was performed using ChemOffice, PyMOL, and Auto Dock software. Results: A total of 45 effective ingredients were obtained with limited screening conditions [oral bioavailability (OB) ≥ 30%; drug-like (DL) ≥ 0.18], and 345 potential targets and 15 key targets of Yupingfeng San were screened. A total of 50 pathways were obtained by KEGG pathway analysis, among which 25 main pathways were selected, including PIK3R1 target regulation PI3K-Akt signaling pathway, Ras signaling pathway, HIF-1 signaling pathway, and MAPK signaling pathways and T cell receptor signaling pathways. Conclusion: The active compounds in Yupingfeng San can inhibit the combination between SARS-CoV-2 protein and angiotensin-converting enzyme II (ACE2), thus regulating multiple signal pathways (PIK3R1, IGF1R, etc), which plays a role in the prevention of COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #378831
    Database COVID19

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  4. Article ; Online: Integrating Network Pharmacology and Experimental Validation to Decipher the Mechanism of Action of Huanglian Jiedu Decoction in Treating Atherosclerosis.

    Liang, Jiahua / Huang, Yingjie / Mai, Zhexing / Zhan, Qunzhang / Lin, Hengchen / Xie, Yuxin / Wang, Haihao / Liu, Yan / Luo, Chuanjin

    Drug design, development and therapy

    2021  Volume 15, Page(s) 1779–1795

    Abstract: Background: This study used network pharmacology, molecular docking and experimental validation to assess the effects of Huanglian Jiedu Decoction (HLJDD) on atherosclerosis (AS).: Methods: The components and targets of HLJDD were analyzed using the ... ...

    Abstract Background: This study used network pharmacology, molecular docking and experimental validation to assess the effects of Huanglian Jiedu Decoction (HLJDD) on atherosclerosis (AS).
    Methods: The components and targets of HLJDD were analyzed using the Traditional Chinese Medicine Systems Pharmacology database, and information on the genes associated with AS was retrieved from the GeneCards and OMIM platforms. Protein-protein interactions were analyzed using the STRING platform. A component-target-disease network was constructed using Cytoscape. GO and KEGG analyses were performed to identify molecular biological processes and signaling pathways, and the predictions were verified experimentally. Molecular docking was conducted with ChemOffice software, PyMOL software and Vina to verify the correlation of targets and compounds.
    Results: HLJDD contained 31 active compounds, with quercetin, kaempferol, moupinamide and 5-hydroxy-7-methoxy-2-(3,4,5-trimethoxyphenyl)chromone as the core compounds. The most important biotargets of HLJDD in AS were ICAM-1, CD31 and RAM-11. The molecular docking results showed that the molecular docking interaction energy between the 3 key targets and the 4 high-degree components were much less than -5 kJ∙mol
    Conclusion: Based on network pharmacology and experimental validation, our study indicated that HLJDD exerted anti-AS effect through upregulating CD31 expression and reducing the expression of ICAM-1 and RAM-11. HLJDD may be a potential therapeutic drug to the prevention of AS.
    MeSH term(s) Animals ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Male ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Rabbits
    Chemical Substances Drugs, Chinese Herbal ; huanglian-jie-du decoction
    Language English
    Publishing date 2021-04-30
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S304911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Huang-Lian-Jie-Du Decoction Attenuates Atherosclerosis and Increases Plaque Stability in High-Fat Diet-Induced ApoE

    Cai, Yinhe / Wen, Junmao / Ma, Siwen / Mai, Zhexing / Zhan, Qunzhang / Wang, Yijun / Zhang, Yueyao / Chen, He / Li, Haiyi / Wu, Wei / Li, Rong / Luo, Chuanjin

    Frontiers in physiology

    2021  Volume 12, Page(s) 666449

    Abstract: Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in ... ...

    Abstract Macrophage polarization plays a vital impact in triggering atherosclerosis (AS) progression and regression. Huang-Lian-Jie-Du Decoction (HLJDD), a famous traditional Chinese decoction, displays notable anti-inflammatory and lipid-lowering effects in different animal models. However, its effects and mechanisms on AS have not been clearly defined. We determined whether HLJDD attenuated atherosclerosis and plaques vulnerability by regulating macrophage polarization in ApoE
    Language English
    Publishing date 2021-09-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.666449
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  6. Article ; Online: Total flavonoids of rhizoma drynariae ameliorates bone formation and mineralization in BMP-Smad signaling pathway induced large tibial defect rats.

    Sun, Weipeng / Li, Minying / Zhang, Yan / Huang, Yingjie / Zhan, Qunzhang / Ren, Yueyi / Dong, Hang / Chen, Jiena / Li, Zige / Fan, Chun / Huang, Feng / Shen, Zhen / Jiang, Ziwei

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2021  Volume 138, Page(s) 111480

    Abstract: Osteogenesis and angiogenesis acts as an essential role in repairing large tibial defects (LTDs). Total flavonoids of rhizoma drynariae (TFRD), a traditional Chinese medicinal herb, is reported to show anabolic effects on fracture healing. However, ... ...

    Abstract Osteogenesis and angiogenesis acts as an essential role in repairing large tibial defects (LTDs). Total flavonoids of rhizoma drynariae (TFRD), a traditional Chinese medicinal herb, is reported to show anabolic effects on fracture healing. However, whether TFRD could improve the bone formation and angiogenesis in LTDs remains unknown. The purpose of this study was to evaluate the effect of TFRD on bone formation and angiogenesis in LTDs in distraction osteogenesis (DO). Using a previously established fracture model, LTD rats was established with circular external fixator (CEF). All rats then randomly divided into TFRD low dosage group (with DO), TFRD medium dosage group (with DO), TFRD high dosage group (with DO), model group (with DO) and blank group (without DO). Twelve weeks after treatment, according to X-ray and Micro-CT, TFRD groups (especially in medium dosage group) can significantly promote the formation of a large number of epiphyses and improve new bone mineralization compared with model group, and the results of HE and Masson staining and in vitro ALP level of BMSC also demonstrated the formation of bone matrix and mineralization in the TFRD groups. Also, angiographic imaging suggested that total flavonoids of TFRD was able to promote angiogenesis in the defect area. Consistently, TFRD significantly increased the levels of BMP-2, SMAD1, SMAD4, RUNX-2, OSX and VEGF in LTD rats based on ELISA and Real-Time PCR. In addition, we found that ALP activity of TFRD medium dosage group reached a peak after 10 days of induction through BMSC cell culture in vitro experiment. TFRD promoted bone formation in LTD through activation of BMP-Smad signaling pathway, which provides a promising new strategy for repairing bone defects in DO surgeries.
    MeSH term(s) Animals ; Bone Density/drug effects ; Bone Density/physiology ; Bone Morphogenetic Protein 2/metabolism ; Flavonoids/isolation & purification ; Flavonoids/pharmacology ; Male ; Polypodiaceae ; Rats ; Rats, Sprague-Dawley ; Rhizome ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Smad Proteins/metabolism ; Tibia/diagnostic imaging ; Tibia/drug effects ; Tibia/metabolism ; X-Ray Microtomography/methods
    Chemical Substances Bmp2 protein, mouse ; Bone Morphogenetic Protein 2 ; Flavonoids ; Smad Proteins
    Language English
    Publishing date 2021-03-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2021.111480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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