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Article ; Online: Association between circulating betatrophin levels and T2DM: A meta-analysis.

Zhan, Yuquan

2024

Abstract: Introduction: The association between betatrophin level and type 2 diabetes mellitus (T2DM) is a subject of controversy, and the reasons for conflicting results have been poorly explained. To address this gap, we conducted a meta-analysis of relevant ... ...

Abstract	Introduction: The association between betatrophin level and type 2 diabetes mellitus (T2DM) is a subject of controversy, and the reasons for conflicting results have been poorly explained. To address this gap, we conducted a meta-analysis of relevant studies to obtain a more comprehensive estimate and draw a more accurate conclusion. Evidence acquisition: This study included literature published up to June 2023. We searched for relevant studies in the Web of Science and PubMed databases. We utilized STATA 12.0 software to calculate the standard mean difference (SMD) and 95% confidence interval (CI) to compare circulating betatrophin levels between individuals with T2DM and healthy controls (HCs). Evidence synthesis: The meta-analysis revealed a significantly higher circulating betatrophin level in individuals with T2DM compared to HC, using a random effects model [mean value of betatrophin level (T2DM vs. HC): 388,685.23 vs. 304,857.04 pg/mL; SMD=1.37; 95%CI: 1.01, 1.73]. Subgroup analysis indicated a higher circulating betatrophin level in T2DM compared to HC among Asian individuals, while no significant difference in circulating betatrophin level was observed between T2DM and HC among Caucasian individuals (Asian: SMD=1.65; 95%CI: 1.23, 2.06; Caucasian: SMD=0.50; 95%CI: -0.21, 1.20). Additionally, subgroup analysis revealed increased plasma and serum betatrophin levels in T2DM compared to HC (plasma: SMD=1.30; 95%CI: 0.72, 1.88; serum: SMD=1.47; 95%CI: 0.98, 1.96). Conclusions: This meta-analysis provides evidence of elevated levels of betatrophin in individuals with T2DM, suggesting that betatrophin may serve as a potential diagnostic biomarker for T2DM.
Language	English
Publishing date	2024-01-16
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062786-2
ISSN	2724-6116
ISSN (online)	2724-6116
DOI	10.23736/S2724-6507.23.04073-3
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Zs.A 2105: Show issues

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Article ; Online: Butylated hydroxyanisole induces vascular endothelial injury via TFEB-mediated degradation of GPX4 and FTH1.

Zhan, Yufei / Zhang, Yazhuo

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2024 Volume 188, Page(s) 114682

Abstract: Butylated hydroxyanisole (BHA) is one of the most commonly used antioxidants and is widely used in food, but whether it causes vascular damage has not been clearly studied. The present study demonstrated for the first time that BHA reduced the viability ... ...

Abstract	Butylated hydroxyanisole (BHA) is one of the most commonly used antioxidants and is widely used in food, but whether it causes vascular damage has not been clearly studied. The present study demonstrated for the first time that BHA reduced the viability of human umbilical vein endothelial cells (HUVECs) and mouse brain microvascular endothelial cells (BEND3) in a dose- and time-dependent manner. Moreover, BHA inhibited the migration and proliferation of vascular endothelial cells (ECs). Further analysis revealed that in ECs, the ferroptosis inhibitor ferrostatin-1 (Fer-1) reversed the BHA-induced increase in Fe
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2024.114682
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Zs.A 529: Show issues

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Article ; Online: Does internet use improve employment?--Empirical evidence from China.

Zhan, Yunqiu / Yang, Shuwen

PloS one

2024 Volume 19, Issue 4, Page(s) e0301465

Abstract: Achieving comprehensive and high-quality employment is essential to achieving new levels of people's well-being. The advancement of Internet technology not only affect the massiveness of employment, but also the quality of that. On the basis of ... ...

Abstract	Achieving comprehensive and high-quality employment is essential to achieving new levels of people's well-being. The advancement of Internet technology not only affect the massiveness of employment, but also the quality of that. On the basis of constructing an employment quality evaluation index system, this article uses CLDS (China Labor-force Dynamics Survey) data to explore the impact of Internet use on the employment quality of workers and its underlying mechanisms. The results reveal that Internet use has a significant positive impact on improving the employment quality of workers. As the quantile of employment quality increases, internet use has a greater impact on workers with a lower employment quality quantile. In addition, the use of Internet has a more significant promoting effect on the employment quality of rural and female workers. From the perspective of mechanism, Internet use can increase workers' social capital and influence their employment quality through the accumulation of social capital. Based on this, countermeasures and suggestions are put forward from the aspects of increasing investment and construction of Internet infrastructure, further perfecting the reform of household registration system, promoting human capital investment and social capital construction.
MeSH term(s)	Female ; Humans ; Internet Use ; Employment ; China ; Rural Population ; Family Characteristics
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0301465
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Article: Neuronal Response and Behavioral Modulation in Social Interactions.

Zhan, Yang

Advances in experimental medicine and biology

2020 Volume 1284, Page(s) 43–48

Abstract: Social behavior is a complex behavior that requires processing of sensory cues and integration of internal states. Social interaction involves two or more individuals to approach each other and engage communications. Although sensory, motivational, ... ...

Abstract	Social behavior is a complex behavior that requires processing of sensory cues and integration of internal states. Social interaction involves two or more individuals to approach each other and engage communications. Although sensory, motivational, emotional, or reward cues may all play roles in directing the sociability and social preference during social interaction, how neural activities from different brain regions are modulated during the behavioral process of social interaction are only beginning to be studied. Multiple brain regions including prefrontal cortex, hippocampus, and amygdala contain active neurons during social interaction. This review examines the neural responses in behaving rodents during social behavior and discusses how manipulation of specific neural pathways can modulate social behavior. Neural activities during social interaction provide direct measurements about how social information is coded and are beneficial in understanding the neural mechanisms underlying social behavior.
MeSH term(s)	Amygdala/cytology ; Amygdala/physiology ; Animals ; Models, Animal ; Neurons/physiology ; Prefrontal Cortex/cytology ; Prefrontal Cortex/physiology ; Reward ; Social Behavior
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-15-7086-5_5
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Article: Tumor Stroma Content Regulates Penetration and Efficacy of Tumor-targeting Bacteria.

Zhan, Y / Burkel, B / Leaman, E J / Ponik, S M / Behkam, B

bioRxiv : the preprint server for biology

2024

Abstract: Bacteria-based cancer therapy (BBCT) strains grow selectively in primary tumors and metastases, colonize solid tumors independent of genetics, and kill cells resistant to standard molecular therapy. Clinical trials of BBCT in solid tumors have not ... ...

Abstract	Bacteria-based cancer therapy (BBCT) strains grow selectively in primary tumors and metastases, colonize solid tumors independent of genetics, and kill cells resistant to standard molecular therapy. Clinical trials of BBCT in solid tumors have not reported any survival advantage yet, partly due to the limited bacterial colonization. Collagen, abundant in primary and metastatic solid tumors, has a well-known role in hindering intratumoral penetration of therapeutics. Nevertheless, the effect of collagen content on the intratumoral penetration and antitumor efficacy of BBCT is rarely unexplored. We hypothesized that the presence of collagen limits the penetration and, thereby, the antitumor effects of tumor-selective
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.29.587035
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Article: Short-term restoration effects of ecological projects detected using the turning point method in the Three River Headwater Region, China.

Li, Yuzhe / Zhan, Yue

Frontiers in plant science

2023 Volume 14, Page(s) 1239417

Abstract: The Three River Headwater Region (TRHR) is an important river source area providing important ecological functions. Decades ago, climate change and human activities severely degraded the ecosystem in the TRHR. To restore vegetation, a series of ... ...

Abstract	The Three River Headwater Region (TRHR) is an important river source area providing important ecological functions. Decades ago, climate change and human activities severely degraded the ecosystem in the TRHR. To restore vegetation, a series of ecological projects have been implemented since 1989. Using net primary productivity (NPP) data from 1988 to 2012, a sequential Mann-Kendall trend test (SQ-MK) method was applied to identify the turning point of vegetation NPP. This approach was able to represent the critical response time of the vegetation to important disturbances. A 3-year time window was set after the implementation of one ecological project to detect and analyze its short-term effects. The ecological projects included the Yangtze River Basin Shelterbelt System Construction Project (YRCP), the TRHR Nature Reserve Construction Project (TNR), the Returning Grazing Land to Grassland Project (RGLGP), and the first phase of the Ecological Conservation and Restoration Project of the TRHR (ECRP). Our results showed that the vegetation in the TRHR responded positively to restoration: 89% of pixels showed an increasing trend and 54% of pixels underwent an abrupt change. The accelerated growth type accounted for the highest proportion among all types of detected turning points. In the ECRP's window, the positive turns rose rapidly, from 41% in 2005 to 86% in 2008, and it showed the most balanced restoration effects across grasslands. The alpine meadow and montane meadow restoration was largely influenced by the ECRP and the RGLGP (both >40%). The alpine steppe restoration was mainly attributed to the ECRP (68%). On the county scale, the positive turns in Yushu at the source of the Yangtze River mainly benefited from the RGLGP (56%), while the positive turns in Maduo at the source of the Yellow River benefited from the ECRP (77%). Nangqian, Tanggula and Zaduo County were still in need of intervention for restoration (< 3%). The results of the study can enhance our understanding of the spatio-temporal distribution of the short-term ecological benefits of different ecological projects, thus provide a scientific and timely reference for future planning and adjustment of the conservation and restoration projects.
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2023.1239417
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Article ; Online: Wearing different hats enriches "outside the box" thinking: Examining the relationship between personal life activity breadth and creativity at work.

Daniel, Victoria L / Zhan, Yujie

The Journal of applied psychology

2023 Volume 108, Issue 11, Page(s) 1881–1901

Abstract: People wear many salient hats across the different parts of their lives and recent advances in the work-life literature have called attention to the necessary addition of personal life activities to be studied as a unique facet of nonwork to better ... ...

Abstract	People wear many salient hats across the different parts of their lives and recent advances in the work-life literature have called attention to the necessary addition of personal life activities to be studied as a unique facet of nonwork to better understand interrole relationships. We therefore draw on enrichment theory to examine why and when employees' participation in personal life activities can positively influence creativity at work through nonwork cognitive developmental resources. Moreover, by integrating insights from construal level theory, this research sheds new light on the ways people think about their personal life activities as playing a discernible role in how people can generate and/or apply resources from their activities. Results of two multiwave studies revealed that people who tend to engage in a greater breadth of personal life activities can gain nonwork cognitive developmental resources (i.e., skills, knowledge, and perspectives) that, in turn, enhance their creativity at work. Personal life construal level also moderated the resource generation stage of enrichment, but not resource application to work; people who adopted lower construal level (i.e., more concretely:
MeSH term(s)	Humans ; Cognition ; Creativity ; Work Engagement
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	219157-x
ISSN	1939-1854 ; 0021-9010
ISSN (online)	1939-1854
ISSN	0021-9010
DOI	10.1037/apl0001098
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Zs.A 1238: Show issues

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Article ; Online: Correlation between catheter colonization of central venous catheters and clinical biochemical indicators: A retrospective analysis of the MIMIC‑IV database.

Zhan, Yefei / Xu, Zhaojun

American journal of infection control

2023 Volume 52, Issue 4, Page(s) 450–455

Abstract: Background: Clinical studies have not fully assessed the potential impact of patients' biochemical indicators on the rate of positive for central venous catheter-tip microorganism culture (PCMC).: Methods: Data were obtained from an online Medical ... ...

Abstract	Background: Clinical studies have not fully assessed the potential impact of patients' biochemical indicators on the rate of positive for central venous catheter-tip microorganism culture (PCMC). Methods: Data were obtained from an online Medical Information Mart for Intensive Care IV database. Patients who were ≥18 years old and had central venous catheter-tip culture results without continuous renal replacement therapy were included in the study. A comparison of patient characteristics and their biochemical indicators was made between negative and positive culture results. Results: A total of 5,323 patients were included in the analysis, including 612 positive (PCMC group) and 4,711 negative culture results (negative for central venous catheter tip catheter-tip microorganism culture [NCMC] group). The only influence factor on PCMC in this study was the serum creatinine (Scr) (odds ratio: 1.312, 95% confidence interval: 1.084-1.590, P = .005), according to a binary logistic regression analysis. The cut-off value of Scr was 3.25 mg/dL. The prevalence of PCMC (27.1% vs 9.1%, P < .001) and Staphylococcus aureus (43.0% vs 18.6%, P < .001) for central venous catheter-tip culture results was much higher in patients with Scr ≥ 3.25 mg/dL than those Scr < 3.25 mg/dL. Conclusions: We used the large dataset collected from Medical Information Mart for Intensive Care IV to show that patients with Scr ≥ 3.25 mg/dL had an increased risk for PCMC.
MeSH term(s)	Humans ; Adolescent ; Central Venous Catheters/adverse effects ; Catheterization, Central Venous/adverse effects ; Catheterization, Central Venous/methods ; Retrospective Studies ; Intensive Care Units ; Staphylococcal Infections ; Catheters, Indwelling
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2023.11.002
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Article ; Online: Theta frequency prefrontal-hippocampal driving relationship during free exploration in mice.

Zhan, Y

Neuroscience

2015 Volume 300, Page(s) 554–565

Abstract: Inter-connected brain areas coordinate to process information and synchronized neural activities engage in learning and memory processes. Recent electrophysiological studies in rodents have implicated hippocampal-prefrontal connectivity in anxiety, ... ...

Abstract	Inter-connected brain areas coordinate to process information and synchronized neural activities engage in learning and memory processes. Recent electrophysiological studies in rodents have implicated hippocampal-prefrontal connectivity in anxiety, spatial learning and memory-related tasks. In human patients with schizophrenia and autism, robust reduced connectivity between the hippocampus (HPC) and prefrontal cortex (PFC) has been reported. However little is known about the directionality of these oscillations and their roles during active behaviors remain unclear. Here the directional information processing in mice was measured by Granger causality, a mathematical tool that has been used in neuroscience to quantify the oscillatory driving relationship between the ventral HPC (vHPC) and the PFC in two anxiety tests and between the dorsal HPC (dHPC) and the PFC in social interaction test. In the open field test, stronger vHPC driving to the PFC was found in the center compartment than in the wall area. In the light-dark box test, PFC to vHPC causality was higher than vHPC to PFC causality although no difference was found between the light and dark areas for the causality in both directions. In the social interaction test using Cx3cr1 knockout mice which model for deficient microglia-dependent synaptic pruning, higher PFC driving to the dHPC was found than driving from the dHPC to the PFC in both knockout mice and wild-type mice. Cx3cr1 knockout mice showed reduced baseline PFC driving to the dHPC compared to their wild-type littermates. PFC to dHPC causality could predict the actual time spent interacting with the social stimuli. The current findings indicate that directed oscillatory activities between the PFC and the HPC have task-dependent roles during exploration in the anxiety test and in the social interaction test.
MeSH term(s)	Animals ; CX3C Chemokine Receptor 1 ; Cohort Studies ; Exploratory Behavior/physiology ; Hippocampus/physiology ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Motor Activity/physiology ; Neural Pathways/physiology ; Neuropsychological Tests ; Prefrontal Cortex/physiology ; Receptors, Chemokine/genetics ; Receptors, Chemokine/metabolism ; Social Behavior ; Theta Rhythm/physiology
Chemical Substances	CX3C Chemokine Receptor 1 ; Cx3cr1 protein, mouse ; Receptors, Chemokine
Language	English
Publishing date	2015-08-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2015.05.063
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Article ; Online: Carbon dioxide emissions and environmental risks: Long term and short term.

Boubaker, Sabri / Liu, Zhenya / Mu, Yuhao / Zhan, Yaosong

Risk analysis : an official publication of the Society for Risk Analysis

2024

Abstract: The world is currently experiencing the environmental challenge of global warming, necessitating careful planning of carbon dioxide ( ... ...

Abstract	The world is currently experiencing the environmental challenge of global warming, necessitating careful planning of carbon dioxide (CO
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	778660-8
ISSN	1539-6924 ; 0272-4332
ISSN (online)	1539-6924
ISSN	0272-4332
DOI	10.1111/risa.14281
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