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Article ; Online: YKL-40 (chitinase-3-like protein 1) serum levels are associated with abdominal aortic calcification in hemodialysis patients.

Bi, Shu-Hong / Su, Chunyan / A, La-Ta / Wang, Yue / He, Lian / Zhang, Ai-Hua

2024

Abstract: Background: Vascular calcification (VC) is highly prevalent and predicts cardiovascular mortality in dialysis patients. The mechanisms are still unclear. Inflammation is a well-known inducer of VC. YKL-40 has been suggested as a novel biomarker of ... ...

Abstract	Background: Vascular calcification (VC) is highly prevalent and predicts cardiovascular mortality in dialysis patients. The mechanisms are still unclear. Inflammation is a well-known inducer of VC. YKL-40 has been suggested as a novel biomarker of inflammation and has been demonstrated to be associated with cardiovascular mortality in hemodialysis patients. This study aims to evaluate the relationship between serum YKL-40 and VC in hemodialysis (HD) patients. Methods: A total of 109 HD patients and 31 healthy controls were enrolled in the study from September 2014 to December 2014. We evaluated the abdominal aortic calcification (AAC) score by plain X-ray films of the abdomen and measured serum YKL-40 concentrations using enzyme-linked immunosorbent assay. We also examined the relationship between YKL-40 levels and AAC scores in HD patients. Results: Serum YKL-40 levels in HD patients were significantly higher than those in healthy controls [199.8 (144.8, 288.7) vs. 71.9 (52.8, 89.3) ng/ml; P < 0.001]. There was a tendency that YKL-40 levels in diabetic hemodialysis patients were higher than those in nondiabetic patients [217.8 (155.3, 335.8) vs. 192.9 (135.9, 274.4) ng/ml; P = 0.093]. A significant positive correlation was found between serum YKL-40 level and AAC score in these patients (r = 0.410, P = 0.003). Multiple regression analysis showed that Ln(YKL-40) was independently associated with AAC score in HD patients (P = 0.044). Conclusion: This study showed high serum YKL-40 concentrations in chronic HD patients and that YKL-40 was independently associated with increased AAC in hemodialysis patients.
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-024-03986-x
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Zs.A 733: Show issues

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Article ; Online: Phospholipase A2 Receptor Antibodies and Clinical Prognosis in Patients with Idiopathic Membranous Nephropathy: An Updated Systematic Review and Meta-Analysis.

Zhang, Jialing / Fan, Zhengjia / Wang, Peixin / Zhang, Ai-Hua

Kidney & blood pressure research

2023 Volume 48, Issue 1, Page(s) 102–113

Abstract: Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN.: Objective: Here, ... ...

Abstract	Background: Idiopathic membranous nephropathy (IMN) is the most common form of primary nephrotic syndrome in adults. Antibodies against the M-type phospholipase A2 receptor (PLA2R-ab) are considered as diagnostic biomarkers of IMN. Objective: Here, we performed an updated meta-analysis to assess the diagnostic value of PLA2R-ab for clinical remission in IMN patients. Method: PubMed, Embase, and Cochrane databases were searched for relevant studies published before September 2022. Odds ratios and corresponding 95% confidence intervals were determined using a fixed or random effects model. The heterogeneity among studies was explored by subgroup analysis. Results: Sixteen studies involving 1,761 IMN participants were included. There were significant differences between PLA2R-ab (+) and PLA2R-ab (-) patients in terms of complete remission (CR) and spontaneous remission. The rates of partial remission (PR) and relapse were similar between the two groups. Patients with PLA2R-ab (-) were at a higher CR rate when treated with a calcineurin inhibitor or a treatment course for 3 months and 6 months, while the spontaneous remission rate was higher in PLA2R-ab seronegative patients from Asia. However, the CR and spontaneous remission rate only significantly declined in IMN patients with the highest titer, but not a middle titer, when compared to those with the lowest titer. Conclusion: In contrast with previous meta-analyses, our results verified that PLA2R-ab can likely predict CR and spontaneous remission in IMN patients, instead of PR and relapse. Race, immunosuppressive agents, and duration of treatment may affect the prognostic value of PLA2R-ab. Considering that the remission rate of IMN patients with a middle level of PLA2R-ab was not different from that of patients with the lowest level, a proper cut-off value of PLA2R-ab for prognosis should be clarified.
MeSH term(s)	Adult ; Humans ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Receptors, Phospholipase A2 ; Remission, Spontaneous ; Antibodies ; Prognosis ; Pathologic Complete Response ; Recurrence
Chemical Substances	Receptors, Phospholipase A2 ; Antibodies
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Systematic Review ; Meta-Analysis
ZDB-ID	1326018-2
ISSN	1423-0143 ; 1420-4096
ISSN (online)	1423-0143
ISSN	1420-4096
DOI	10.1159/000529415
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Zs.A 1458: Show issues

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Article: [Evaluation of the efficacy of sodium fluoride dental protective agent combined with pit and fissure sealant in prevention of dental caries in preschool children].

Zhang, Ai-Hua / Li, Jing

Shanghai kou qiang yi xue = Shanghai journal of stomatology

2020 Volume 28, Issue 5, Page(s) 553–556

Abstract: Purpose: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children.: Methods: Two hundred preschool children who were treated with pit and fissure closure from January 2014 ... ...

Abstract	Purpose: To explore the effect of sodium fluoride tooth protector combined with pit and fissure sealing to prevent caries in preschool children. Methods: Two hundred preschool children who were treated with pit and fissure closure from January 2014 to September 2014 were selected as subjects. According to random number table method, 100 cases were divided into the combined group and the control group. Children in the control group were treated with pit and fissure sealant for prevention of caries, while children in the combined group were treated with sodium fluoride tooth protector combined with pit and fissure sealant for caries prevention. The incidence of dental caries, proximal caries, mean DMFT, and expulsion rate of the sealants were compared between the two groups at 1 year and 2 years. Data analysis was performed using SPSS 16.0 software package for data analysis. Results: At 1 year of follow-up, there was no significant difference in the incidence of dental caries, proximal caries, and mean DMFT between the two groups (P>0.05). The incidence of caries and mean DMFT in the combined group were significantly lower than those in the control group at 2 years of follow-up (P<0.05). The incidence of proximal caries in the combined group was not significantly different from that in the control group (P>0.05). The retension rate of the pit and fissure sealant in the combined group was significantly higher than that in the control group (P<0.05). There was no significant difference in the partial shedding rate and complete expulsion rate between the two groups (P>0.05). Conclusions: Sodium fluoride tooth protector combined with pit and fissure sealing has better anti-caries effect than the use of pit and fissure sealant alone in preschool children.
MeSH term(s)	Cariostatic Agents ; Child, Preschool ; Dental Caries ; Humans ; Pit and Fissure Sealants ; Research Design ; Sodium Fluoride
Chemical Substances	Cariostatic Agents ; Pit and Fissure Sealants ; Sodium Fluoride (8ZYQ1474W7)
Language	Chinese
Publishing date	2020-03-26
Publishing country	China
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2269714-7
ISSN	1006-7248
ISSN	1006-7248
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Zs.A 6471: Show issues

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Article: Alterations in the Gut Microbiota and Their Metabolites in Colorectal Cancer: Recent Progress and Future Prospects.

Li, Jing / Zhang, Ai-Hua / Wu, Fang-Fang / Wang, Xi-Jun

Frontiers in oncology

2022 Volume 12, Page(s) 841552

Abstract: Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide. The etiology and pathogenesis of CRC remain unclear. A growing body of evidence suggests dysbiosis of gut bacteria can contribute to the occurrence and development of ...

Abstract	Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide. The etiology and pathogenesis of CRC remain unclear. A growing body of evidence suggests dysbiosis of gut bacteria can contribute to the occurrence and development of CRC by generating harmful metabolites and changing host physiological processes. Metabolomics, a systems biology method, will systematically study the changes in metabolites in the physiological processes of the body, eventually playing a significant role in the detection of metabolic biomarkers and improving disease diagnosis and treatment. Metabolomics, in particular, has been highly beneficial in tracking microbially derived metabolites, which has substantially advanced our comprehension of host-microbiota metabolic interactions in CRC. This paper has briefly compiled recent research progress of the alterations of intestinal flora and its metabolites associated with CRC and the application of association analysis of metabolomics and gut microbiome in the diagnosis, prevention, and treatment of CRC; furthermore, we discuss the prospects for the problems and development direction of this association analysis in the study of CRC. Gut microbiota and their metabolites influence the progression and causation of CRC, and the association analysis of metabolomics and gut microbiome will provide novel strategies for the prevention, diagnosis, and therapy of CRC.
Language	English
Publishing date	2022-02-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2022.841552
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Article: The confused puzzles in antineutrophil cytoplasmic antibody-associated vasculitis activity evaluation: A case report.

Zhang, Ai-Hua / Yao, Wei-Long / Liu, Wen-Hu

Clinical case reports

2021 Volume 9, Issue 7, Page(s) e04497

Abstract: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of chronic multisystem autoimmune diseases with substantial mortality and morbidity and frequent relapses. The complexity of the disease condition and treatment-related ... ...

Abstract	Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of chronic multisystem autoimmune diseases with substantial mortality and morbidity and frequent relapses. The complexity of the disease condition and treatment-related adverse reactions as well as infections play important roles in the poor outcomes. Unfortunately, the subjective symptoms and objective indicators are not fully parallel, and manifestations between disease activity and treatment-related adverse reactions are often similar. Here, we describe a case of pulmonary mucormycosis in an old female patient with AAV to highlight these challenges.
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4497
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Article ; Online: Ruegeria marisflavi

He, Wei / Wang, Hong-Chuan / Wang, Lu / Xue, Hua-Peng / Li, Yong-Fu / Zhang, Ai Hua / Zhang, Dao-Feng

International journal of systematic and evolutionary microbiology

2024 Volume 74, Issue 4

Abstract: Two novel Gram-stain-negative, aerobic, non-motile and rod-shaped bacteria, designated as ... ...

Abstract	Two novel Gram-stain-negative, aerobic, non-motile and rod-shaped bacteria, designated as WL0004
MeSH term(s)	Base Composition ; Fatty Acids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Bacterial Typing Techniques ; Seawater
Chemical Substances	Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006323
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Zs.A 409: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Actomonas aquatica

Zhang, Ai Hua / Tang, Hao / Wang, Lu / He, Wei / Gao, Tian Heng / Gao, Zhi Gang / Zhang, Dao-Feng

International journal of systematic and evolutionary microbiology

2024 Volume 74, Issue 4

Abstract: A novel bacterial strain, designated ... ...

Abstract	A novel bacterial strain, designated WL0086
MeSH term(s)	Carbon ; Nitrogen Fixation ; Base Composition ; Fatty Acids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Bacterial Typing Techniques
Chemical Substances	Carbon (7440-44-0) ; Fatty Acids ; RNA, Ribosomal, 16S ; DNA, Bacterial
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2002336-4
ISSN	1466-5034 ; 1466-5026
ISSN (online)	1466-5034
ISSN	1466-5026
DOI	10.1099/ijsem.0.006314
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Zs.A 409: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Maximizing Polysaccharides and Phycoerythrin in

Yi, Sanjiong / Zhang, Ai-Hua / Huang, Jianke / Yao, Ting / Feng, Bo / Zhou, Xinghu / Hu, Yadong / Pan, Mingxuan

Marine drugs

2024 Volume 22, Issue 3

Abstract: Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides ... ...

Abstract	Phycoerythrin and polysaccharides have significant commercial value in medicine, cosmetics, and food industries due to their excellent bioactive functions. To maximize the production of biomass, phycoerythrin, and polysaccharides in
MeSH term(s)	Porphyridium ; Phycoerythrin ; Calcium Gluconate ; Polysaccharides ; Gluconates
Chemical Substances	Phycoerythrin (11016-17-4) ; gluconic acid (R4R8J0Q44B) ; Calcium Gluconate (SQE6VB453K) ; Polysaccharides ; Gluconates
Language	English
Publishing date	2024-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md22030138
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Article: A Three-Dimensional Vibration Theory for Ultralight Cellular Sandwich Plates Subjected to Linearly Varying In-Plane Distributed Loads.

Li, Fei-Hao / Han, Bin / Zhang, Ai-Hua / Liu, Kai / Wang, Ying / Lu, Tian-Jian

Materials (Basel, Switzerland)

2023 Volume 16, Issue 11

Abstract: Thin structural elements such as large-scale covering plates of aerospace protection structures and vertical stabilizers of aircraft are strongly influenced by gravity (and/or acceleration); thus, exploring how the mechanical behaviors of such structures ...

Abstract	Thin structural elements such as large-scale covering plates of aerospace protection structures and vertical stabilizers of aircraft are strongly influenced by gravity (and/or acceleration); thus, exploring how the mechanical behaviors of such structures are affected by gravitational field is necessary. Built upon a zigzag displacement model, this study establishes a three-dimensional vibration theory for ultralight cellular-cored sandwich plates subjected to linearly varying in-plane distributed loads (due to, e.g., hyper gravity or acceleration), with the cross-section rotation angle induced by face sheet shearing accounted for. For selected boundary conditions, the theory enables quantifying the influence of core type (e.g., close-celled metal foams, triangular corrugated metal plates, and metal hexagonal honeycombs) on fundamental frequencies of the sandwich plates. For validation, three-dimensional finite element simulations are carried out, with good agreement achieved between theoretical predictions and simulation results. The validated theory is subsequently employed to evaluate how the geometric parameters of metal sandwich core and the mixture of metal cores and composite face sheets influence the fundamental frequencies. Triangular corrugated sandwich plate possesses the highest fundamental frequency, irrespective of boundary conditions. For each type of sandwich plate considered, the presence of in-plane distributed loads significantly affects its fundamental frequencies and modal shapes.
Language	English
Publishing date	2023-05-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16114086
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Article: The Value of Peripheral Blood Cell Ratios in Primary Membranous Nephropathy: A Single Center Retrospective Study.

Zhang, Ai-Hua / Dai, Guang-Xia / Zhang, Qi-Dong / Huang, Hong-Dong / Liu, Wen-Hu

Journal of inflammation research

2023 Volume 16, Page(s) 1017–1025

Abstract: Background: Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients continue to progress and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the ... ...

Abstract	Background: Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients continue to progress and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the major antigen of PMN, the clinical features do not often parallel with the antibody titers. Therefore, it is significant to find relative credible markers to predict the treatment response. Methods: One hundred and eighteen PMN patients were recruited. The response to treatment was defined as ALB≥30g/L at 6 months and complete remission (CR) or not at the end of the follow-up. Renal outcome endpoint was defined as 50% or more Cr increase at the end. Results: The patients with poor treatment effects had numerically higher platelet-lymphocytes ratio (PLR). For patients with CR or not, the difference was near to statistic significant ( Conclusion: PMN patients with poor treatment response tended to have higher PLR at the time of renal biopsy, and a higher MLR was associated with poor renal outcomes. Our findings suggested that PLR and MLR might be used to predict treatment efficacy and prognosis for PMN patients, respectively.
Language	English
Publishing date	2023-03-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S404591
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