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  1. Article ; Online: Joint Depth and Defocus Estimation From a Single Image Using Physical Consistency.

    Zhang, Anmei / Sun, Jian

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2021  Volume 30, Page(s) 3419–3433

    Abstract: Estimating depth and defocus maps are two fundamental tasks in computer vision. Recently, many methods explore these two tasks separately with the help of the powerful feature learning ability of deep learning and these methods have achieved impressive ... ...

    Abstract Estimating depth and defocus maps are two fundamental tasks in computer vision. Recently, many methods explore these two tasks separately with the help of the powerful feature learning ability of deep learning and these methods have achieved impressive progress. However, due to the difficulty in densely labeling depth and defocus on real images, these methods are mostly based on synthetic training dataset, and the performance of learned network degrades significantly on real images. In this paper, we tackle a new task that jointly estimates depth and defocus from a single image. We design a dual network with two subnets respectively for estimating depth and defocus. The network is jointly trained on synthetic dataset with a physical constraint to enforce the physical consistency between depth and defocus. Moreover, we design a simple method to label depth and defocus order on real image dataset, and design two novel metrics to measure accuracies of depth and defocus estimation on real images. Comprehensive experiments demonstrate that joint training for depth and defocus estimation using physical consistency constraint enables these two subnets to guide each other, and effectively improves their depth and defocus estimation performance on real defocused image dataset.
    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2021.3061901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical efficacy of adjuvant chemotherapy for locally advanced nasopharyngeal carcinoma

    YANG Xiu / YANG Qiao / CHEN Guangpeng / ZHANG Anmei / CUI Tianxiang

    陆军军医大学学报, Vol 44, Iss 22, Pp 2307-

    2022  Volume 2316

    Abstract: Objective To evaluate the clinical efficacy of the concurrent chemoradiotherapy (CCRT) combined adjuvant chemotherapy (AC) for locally advanced nasopharyngeal carcinoma (NPC). Methods From April 2011 to January 2019, 318 patients with locally advanced ... ...

    Abstract Objective To evaluate the clinical efficacy of the concurrent chemoradiotherapy (CCRT) combined adjuvant chemotherapy (AC) for locally advanced nasopharyngeal carcinoma (NPC). Methods From April 2011 to January 2019, 318 patients with locally advanced NPC were collected from radiotherapy center of the Second Affiliated Hospital of Army Medical University. According to the results of CCRT, the patients were divided into the adjuvant group and the no-adjuvant group to comparatively analyze the survival outcome and adverse reaction of those patients received adjuvant chemotherapy. Stratification analysis was used to analyze the survival difference of different therapy plans (CCRT, CCRT+AC, IC+CCRT and IC+CCRT+AC) among 318 patients. The survival difference of 99 pairs of patients in the subgroup of clinical parameters was analyzed after the patients in the adjuvant group were paired with the patients in the no-adjuvant group. Results Compared with CCRT, CCRT combined with adjuvant chemotherapy could increase the overall survival(OS), progression-free survival(PFS), distant metastasis-free survival(DMFS)and recurrence-free survival(RFS); Compared with IC plus CCRT(IC+CCRT), IC+CCRT+AC showed a decreasing trend in OS, PFS, DMFS and RFS. According to the results of stratification analysis, for EBV positive, N3 stage and IVA stage patients, adjuvant chemotherapy had a tendency to increase OS, PFS, DMFS and RFS, and increase the RFS for the T4 stage patients. There was no difference in acute radiation mucositis, acute radiation pharyngitis and esophagitis between the two groups. The adjuvant group had higher incidence rate than the non-adjuvant group in ≥2 grade of myelosuppression(68% vs 55%, P=0.020). Conclusion Adjuvant chemotherapy after concurrent chemoradiotherapy cannot significantly increase the survival benefit for patients with locally advanced NPC; For EBV positive, stage N3 and stage ⅣA patients, there is a positive trend in OS, PFS, DMFS and RFS, and for stage T4 patients, they also obtain benefit in PFS.
    Keywords nasopharyngeal carcinoma ; concurrent chemoradiotherapy ; adjuvant chemotherapy ; survival outcome ; adverse events ; Medicine (General) ; R5-920
    Subject code 610
    Language Chinese
    Publishing date 2022-11-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer.

    Wang, Huilan / Cheng, Xinyu / Yang, Fan / Chen, Lu / Zhang, Anmei / Zhong, Liangzhi / Long, Haixia / Zhu, Bo / Wang, Zhongyu

    Chinese medical journal

    2024  Volume 137, Issue 7, Page(s) 880–882

    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Drug Resistance, Neoplasm ; B7-H1 Antigen ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Programmed Cell Death 1 Receptor ; Immune Checkpoint Inhibitors ; B7-H1 Antigen ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-03-15
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000003015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Endobronchial ultrasound-guided cryobiopsy-when it is indicated? - Authors' reply.

    Zhang, An-Mei / Huang, Zan-Sheng / Fan, Ye / Herth, Felix Jf

    The Lancet. Respiratory medicine

    2022  Volume 11, Issue 3, Page(s) e24

    MeSH term(s) Humans ; Lung ; Lung Neoplasms ; Ultrasonography, Interventional ; Bronchoscopy
    Language English
    Publishing date 2022-12-05
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00485-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Identification of the shared gene signatures and molecular mechanisms between multiple sclerosis and non-small cell lung cancer.

    Yang, Jingyun / Hu, Xiaofei / Wang, Yu / Liu, Wenying / Zhang, Mengjie / Zhang, Anmei / Ni, Bing

    Frontiers in immunology

    2023  Volume 14, Page(s) 1180449

    Abstract: Introduction: The association between multiple sclerosis (MS) and non-small cell lung cancer (NSCLC) has been the subject of investigation in clinical cohorts, yet the molecular mechanisms underpinning this relationship remain incompletely understood. ... ...

    Abstract Introduction: The association between multiple sclerosis (MS) and non-small cell lung cancer (NSCLC) has been the subject of investigation in clinical cohorts, yet the molecular mechanisms underpinning this relationship remain incompletely understood. To address this, our study aimed to identify shared genetic signatures, shared local immune microenvironment, and molecular mechanisms between MS and NSCLC.
    Methods: We selected multiple Gene Expression Omnibus (GEO) datasets, including GSE19188, GSE214334, GSE199460, and GSE148071, to obtain gene expression levels and clinical information from patients or mice with MS and NSCLC. We employed Weighted Gene Co-expression Network Analysis (WGCNA) to investigate co-expression networks linked to MS and NSCLC and used single-cell RNA sequencing (scRNA-seq) analysis to explore the local immune microenvironment of MS and NSCLC and identify possible shared components.
    Results: Our analysis identified the most significant shared gene in MS and NSCLC, phosphodiesterase 4A (PDE4A), and we analyzed its expression in NSCLC patients and its impact on patient prognosis, as well as its molecular mechanism. Our results demonstrated that high expression of PDE4A was associated with poor prognoses in NSCLC patients, and Gene Set Enrichment Analysis (GSEA) revealed that PDE4A is involved in immune-related pathways and has a significant regulatory effect on human immune responses. We further observed that PDE4A was closely linked to the sensitivity of several chemotherapy drugs.
    Conclusion: Given the limitation of studies investigating the molecular mechanisms underlying the correlation between MS and NSCLC, our findings suggest that there are shared pathogenic processes and molecular mechanisms between these two diseases and that PDE4A represents a potential therapeutic target and immune-related biomarker for patients with both MS and NSCLC.
    MeSH term(s) Humans ; Animals ; Mice ; Multiple Sclerosis/genetics ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 4 ; Gene Expression Profiling ; Tumor Microenvironment/genetics
    Chemical Substances Cyclic Nucleotide Phosphodiesterases, Type 4 (EC 3.1.4.17)
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1180449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A real-world retrospective study of incidence and associated factors of endocrine adverse events related to PD-1/PD-L1 inhibitors.

    Wang, Zhiyi / Hu, Chunyan / Zhang, Anmei / Wang, Xinxin / Zeng, Dong / Long, Tao / Zhu, Bo / Wang, Zhongyu

    Annals of translational medicine

    2023  Volume 11, Issue 4, Page(s) 164

    Abstract: Background: The adverse events (AEs) related to immune checkpoint inhibitors (ICIs) have been mostly described in clinical trials, however, such trials are restricted to selection criteria and the results cannot wholly represent the real-world setting. ... ...

    Abstract Background: The adverse events (AEs) related to immune checkpoint inhibitors (ICIs) have been mostly described in clinical trials, however, such trials are restricted to selection criteria and the results cannot wholly represent the real-world setting. We aimed to evaluate the real-world endocrine AEs associated with programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1) inhibitors in Chinese population.
    Methods: This retrospective study included cancer patients who were treated with PD-1/PD-L1 inhibitors between January 2018 and December 2020 at Xinqiao Hospital, the Third Military Medical University. The information of 581 patients was reviewed, and data on clinical characteristics, PD-1/PD-L1 use, occurrence of endocrine AEs, and response to PD-1 blockade treatment were collated. The definition of endocrine AEs relied on diagnostic tests. Fisher's exact test or Pearson's chi-squared test was used to analyze the associations between endocrine variables and several categorical variables. Multivariate analyses were performed using a logistic regression model.
    Results: Endocrine AEs were observed in 116 of the 581 patients (20.0%). The median time to onset of endocrine AEs was approximately 12 weeks. Pembrolizumab was associated with a significantly higher incidence of endocrine AEs compared to other anti-PD-1 agents (38.5%; P=0.0002); PD-1/PD-L1 inhibitor treatment combined with antiangiogenic therapy or with two other therapies (chemotherapy and antiangiogenic therapy) was associated with a significantly increased occurrence of endocrine AEs, compared to PD-1 blockade treatment alone (41.2%; P=0.015), both based on multivariate analysis. Patients who developed endocrine AEs had significantly higher overall response rates (ORRs; 33.3%
    Conclusions: A real-world Chinese population receiving PD-1/PD-L1 treatment, pembrolizumab administrated and triple therapy treatment modalities had a higher incidence of endocrine AEs. Patients who developed endocrine AEs demonstrated a favorable response to PD-l blockade treatment.
    Language English
    Publishing date 2023-02-06
    Publishing country China
    Document type Journal Article
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm-22-5459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Feasibility of omitting the clinical target volume under PET-CT guidance in unresectable stage III non-small-cell lung cancer: A phase II clinical trial.

    Cui, Tianxiang / Zhang, Anmei / Cui, Jianxiong / Chen, Lu / Chen, Guangpeng / Dai, Hongya / Qin, Xianli / Li, Guanghui / Sun, Jianguo

    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

    2023  Volume 181, Page(s) 109505

    Abstract: Background: This clinical trial aims at investigate the feasibility of CTV-omitted, positron-emission tomography computed tomography (PET-CT) combined with intensity-modulated radiation therapy (IMRT) for unresectable stage III NSCLC.: Methods and ... ...

    Abstract Background: This clinical trial aims at investigate the feasibility of CTV-omitted, positron-emission tomography computed tomography (PET-CT) combined with intensity-modulated radiation therapy (IMRT) for unresectable stage III NSCLC.
    Methods and materials: This was a single-center, phase II clinical trial initiated in July 2016. Patients with unresectable stage III NSCLC undergoing routine IMRT were randomly enrolled into the study group (CTV-omitted under PET-CT guidance) and the control group (CTV-delineated). Patients received platinum-based dual-drug concurrent chemoradio therapy. In the study group, the PGTV dose was 60 Gy given in 30 daily 2 Gy fractions; in the control group, the PCTV dose was 54 Gy given in 30 daily 1.8 Gy fractions, and the PGTV dose was 60 Gy given in 30 daily 2 Gy fractions. The primary endpoint was the incidence of radiation respiratory events or esophagitis with grade 3 or higher. The secondary endpoints included objective response rate (ORR), locate control rate, progression-free survival (PFS), failure pattern and overall survival (OS).
    Results: A total of 90 patients were enrolled between July 2016 and March 2019. The incidence of radiation respiratory events or esophagitis with grade 3 or higher was 11.1 % in the study group, significantly lower than the rate of 28.9 % in the control group (P = 0.035), basically due to the reduced irradiated volumes of the lungs and esophagus in the study group. The median PFS was 9.0 months versus 10.0 months (P = 0.597), and the median OS 31.0 months versus 26.0 months (P = 0.489) in the study group and the control group, respectively. The failure pattern was not significantly different between the two groups (P = 0.826).
    Conclusion: Omitting the CTV under PET-CT guidance has high feasibility to reduce severe radiation associated toxicity in IMRT for unresectable stage III NSCLC, without compromising the efficacy.
    MeSH term(s) Humans ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/radiotherapy ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; Lung Neoplasms/drug therapy ; Positron Emission Tomography Computed Tomography/methods ; Feasibility Studies ; Esophagitis ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use
    Language English
    Publishing date 2023-02-09
    Publishing country Ireland
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605646-5
    ISSN 1879-0887 ; 0167-8140
    ISSN (online) 1879-0887
    ISSN 0167-8140
    DOI 10.1016/j.radonc.2023.109505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: NK cell transfer overcomes resistance to PD-(L)1 therapy in aged mice.

    Hou, Junlei / Xie, Shuanglong / Gao, Jianbao / Jiang, Tao / Zhu, Enjian / Yang, Xuezhi / Jin, Zheng / Long, Haixia / Zhang, Anmei / Yang, Fei / Wang, Lujing / Zha, Haoran / Jia, Qingzhu / Zhu, Bo / Wang, Xinxin

    Experimental hematology & oncology

    2024  Volume 13, Issue 1, Page(s) 48

    Abstract: Background: Cancer is the leading cause of death among older adults. Although the integration of immunotherapy has revolutionized the therapeutic landscape of cancer, the complex interactions between age and immunotherapy efficacy remain incompletely ... ...

    Abstract Background: Cancer is the leading cause of death among older adults. Although the integration of immunotherapy has revolutionized the therapeutic landscape of cancer, the complex interactions between age and immunotherapy efficacy remain incompletely defined. Here, we aimed to elucidate the relationship between aging and immunotherapy resistance.
    Methods: Flow cytometry was performed to evaluate the infiltration of immune cells in the tumor microenvironment (TME). In vivo T cell proliferation, cytotoxicity and migration assays were performed to evaluate the antitumor capacity of tumor antigen-specific CD8
    Results: We found that elderly patients with advanced non-small cell lung cancer (aNSCLC) aged ≥ 75 years exhibited poorer progression-free survival (PFS), overall survival (OS) and a lower clinical response rate after immunotherapy. Mechanistically, we showed that the infiltration of NK cells was significantly reduced in aged mice compared to younger mice. Furthermore, the aged NK cells could also suppress the activation of tumor antigen-specific CD8
    Conclusion: Our findings revealed the decreased sensitivity of elderly patients to immunotherapy, as well as in aged mice. This may be attributed to the reduction of NK cells in aged mice, which inhibits CD103
    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-024-00511-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Endobronchial Ultrasound-Guided Transbronchial Incision and Drainage in the Treatment of Mediastinal Abscess.

    Huang, Zan-Sheng / Xiang, Qing / Wu, Xian-Li / Zhang, An-Mei / Liu, Shuang-Lin / Wang, Jing / Herth, Felix J F / Fan, Ye

    Respiration; international review of thoracic diseases

    2022  Volume 101, Issue 10, Page(s) 948–952

    Abstract: Mediastinal abscess, mostly resulting from esophageal perforation or cardiothoracic surgery, is a serious condition carrying high morbidity and mortality. Antibiotic therapy alone normally did not achieve a satisfactory outcome, due to poor circulation ... ...

    Abstract Mediastinal abscess, mostly resulting from esophageal perforation or cardiothoracic surgery, is a serious condition carrying high morbidity and mortality. Antibiotic therapy alone normally did not achieve a satisfactory outcome, due to poor circulation of abscess that hampers drug delivery. Surgical intervention for debridement and drainage is recommended, but it poses a high risk in patients with poor health status and could lead to various complications. Recent studies proposed endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an effective alternative to surgery; however, repeated TBNA procedures are usually needed for complete clearance of the lesion, thus causing increased patient suffering and medical expenses. Here, we present the first case of successful application of EBUS-guided transbronchial incision and drainage, which provides a novel, safe, and effective treatment for patient with mediastinal abscess unwilling or unsuitable to undergo surgical intervention.
    MeSH term(s) Abscess/diagnostic imaging ; Abscess/drug therapy ; Abscess/surgery ; Anti-Bacterial Agents/therapeutic use ; Bronchoscopy/methods ; Drainage ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Humans ; Lung Neoplasms/pathology ; Mediastinal Diseases/diagnostic imaging ; Mediastinal Diseases/surgery
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000525773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Primary Mediastinal Large B-Cell Lymphoma Achieved by Non-Cautery Assisted Transbronchial Mediastinal Cryobiopsy.

    Zhang, Jing / Huang, Zan-Sheng / Wu, Xian-Li / Zhang, An-Mei / Fu, Wan-Lei / Liu, Gang / Herth, Felix J F / Fan, Ye

    Respiration; international review of thoracic diseases

    2022  Volume 101, Issue 7, Page(s) 683–687

    Abstract: Transbronchial mediastinal cryobiopsy is a novel sampling strategy that shows improved diagnostic utility for mediastinal lesions, particularly in rare tumors and benign disorders, as compared to standard endobronchial ultrasound-guided transbronchial ... ...

    Abstract Transbronchial mediastinal cryobiopsy is a novel sampling strategy that shows improved diagnostic utility for mediastinal lesions, particularly in rare tumors and benign disorders, as compared to standard endobronchial ultrasound-guided transbronchial needle aspiration. During this procedure, electrocautery incision is frequently needed to advance the cryoprobe through the airway into the mediastinal lesion, which however results in increased operative difficulty and prolonged procedural time. Here we present a case of mediastinal large B-cell lymphoma successfully diagnosed by transbronchial mediastinal cryobiopsy without cautery-induced airway incision.
    MeSH term(s) Bronchoscopy/methods ; Electrocoagulation ; Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods ; Humans ; Lymph Nodes/pathology ; Lymphoma, B-Cell/diagnosis ; Lymphoma, B-Cell/surgery ; Mediastinum/diagnostic imaging
    Language English
    Publishing date 2022-05-16
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 206674-9
    ISSN 1423-0356 ; 0025-7931
    ISSN (online) 1423-0356
    ISSN 0025-7931
    DOI 10.1159/000524768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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