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  1. Article ; Online: Extending Hilbert-Schmidt Independence Criterion for Testing Conditional Independence.

    Zhang, Bingyuan / Suzuki, Joe

    Entropy (Basel, Switzerland)

    2023  Volume 25, Issue 3

    Abstract: The Conditional Independence (CI) test is a fundamental problem in statistics. Many nonparametric CI tests have been developed, but a common challenge exists: the current methods perform poorly with a high-dimensional conditioning set. In this paper, we ... ...

    Abstract The Conditional Independence (CI) test is a fundamental problem in statistics. Many nonparametric CI tests have been developed, but a common challenge exists: the current methods perform poorly with a high-dimensional conditioning set. In this paper, we considered a nonparametric CI test using a kernel-based test statistic, which can be viewed as an extension of the Hilbert-Schmidt Independence Criterion (HSIC). We propose a local bootstrap method to generate samples from the null distribution H0:X⫫Y∣Z. The experimental results showed that our proposed method led to a significant performance improvement compared with previous methods. In particular, our method performed well against the growth of the dimension of the conditioning set. Meanwhile, our method can be computed efficiently against the growth of the sample size and the dimension of the conditioning set.
    Language English
    Publishing date 2023-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e25030425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: High-precision sensor for glucose solution using active multidimensional feature THz spectroscopy.

    Zhang, Min / Liu, Jiarui / Wang, Nan / Zhang, Bingyuan / Gao, Feilong / Wang, Minghong / Song, Qi

    Biomedical optics express

    2024  Volume 15, Issue 3, Page(s) 1418–1427

    Abstract: Terahertz waves are known for their bio-safety and spectral fingerprinting features, and terahertz spectroscopy technology holds great potential for both qualitative and quantitative identification in the biomedical field. There has been a substantial ... ...

    Abstract Terahertz waves are known for their bio-safety and spectral fingerprinting features, and terahertz spectroscopy technology holds great potential for both qualitative and quantitative identification in the biomedical field. There has been a substantial amount of research utilizing this technology in conjunction with machine learning algorithms for substance identification. However, due to the strong absorption of water for terahertz waves, the single-dimensional features of the sample become indistinct, thereby diminishing the efficiency of the algorithmic recognition. Building upon this, we propose a method that employs terahertz time-domain spectroscopy (THz-TDS) in conjunction with multidimensional feature spectrum identification for the detection of blood sugar and glucose mixtures. Our research indicates that combining THz-TDS with multidimensional feature spectrum and linear discriminant analysis (LDA) algorithms can effectively identify glucose concentrations and detect adulteration. By integrating the multidimensional feature spectrum, the identification success rate increased from 68.9% to 96.0%. This method offers an economical, rapid, and safe alternative to traditional methods and can be applied in blood sugar monitoring, sweetness assessment, and food safety.
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.515588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: WaveFlex biosensor based on S-tapered and waist-expanded technique for detection of glycosylated hemoglobin.

    Zhang, Guiwei / Singh, Ragini / Zhang, Bingyuan / Kumar, Santosh / Li, Guoru

    Biomedical optics express

    2023  Volume 14, Issue 11, Page(s) 6100–6113

    Abstract: Glycosylated hemoglobin (HbA1c) is considered a new standard for the detection of diabetes mellitus because it is more accurate than regular blood sugar tests and there is no need to take blood on an empty stomach or at a specific time. In this work, we ... ...

    Abstract Glycosylated hemoglobin (HbA1c) is considered a new standard for the detection of diabetes mellitus because it is more accurate than regular blood sugar tests and there is no need to take blood on an empty stomach or at a specific time. In this work, we have developed a novel optical fiber biosensor, referred to as the "WaveFlex biosensor," which operates on the principles of localized surface plasmon resonance (LSPR) plasmonic wave. The sensor is fabricated using an innovative S-tapered and waist-expanded technique, enabling it to effectively detect HbA1c. Compared to the HbA1c sensors currently in use, HbA1c optical fiber sensors possess the characteristics of high sensitivity, low cost, and strong anti-interference ability. The gold nanoparticles (AuNPs), cerium oxide (CeO
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.505864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Humanoid-shaped WaveFlex biosensor for the detection of food contamination.

    Singh, Ragini / Zhang, Wen / Liu, Xuecheng / Zhang, Bingyuan / Kumar, Santosh

    Biomedical optics express

    2023  Volume 14, Issue 9, Page(s) 4660–4676

    Abstract: High-toxicity secondary metabolites called aflatoxin are naturally produced by the ... ...

    Abstract High-toxicity secondary metabolites called aflatoxin are naturally produced by the fungus
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2572216-5
    ISSN 2156-7085
    ISSN 2156-7085
    DOI 10.1364/BOE.500311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Alanine aminotransferase detection using TIT assisted four tapered fiber structure-based LSPR sensor: From healthcare to marine life

    Singh, Ragini / Wang, Zhi / Marques, Carlos / Min, Rui / Zhang, Bingyuan / Kumar, Santosh

    Biosensors and Bioelectronics. 2023 Sept., v. 236 p.115424-

    2023  

    Abstract: Alanine aminotransferase (ALT), a type of inactive enzyme largely present in fish liver cells, is essential for the tricarboxylic acid (TCA) cycle. Monitoring ALT activity in the blood/hepatocellular layer has been demonstrated to be a sensitive sign of ... ...

    Abstract Alanine aminotransferase (ALT), a type of inactive enzyme largely present in fish liver cells, is essential for the tricarboxylic acid (TCA) cycle. Monitoring ALT activity in the blood/hepatocellular layer has been demonstrated to be a sensitive sign of liver dysfunction and an essential method for determining the health status of fish. This study details the development of a multi-layer material (hybrids of graphene oxide and multi-walled carbon nanotubes (GO/MWCNTs), gold nanoparticles (AuNPs), and glutamate oxidase (GluOx) enzyme) immobilized localized surface plasmon resonance based unique fiber structure biosensor for the quantitative determination of ALT biomolecules at concentrations ranging from 0 to 1000 U/L. For this kind of detection, a novel taper-in-taper with four tapered (TIT4T) structure based on single-mode fiber has been developed. In addition to AuNPs, GO/MWCNTs were immobilized in the probe's sensing region to increase its LSPR efficiency and sensitivity. Synthesis of AuNPs was carried out utilizing the Turkevich method. The selectivity of the sensor is ensured by the effective immobilization of GluOx on the surface treatment. The linearity of sensor is in the range of 0–1000 U/L, whereas the sensitivity, limit of detection, and detection time are individually found at 7.5 p.m./(U/L), 4.84 U/L and 20 min, respectively. After evaluating the prospective applications of the sensors, the sensors' reusability, reproducibility, stability, pH test, and selectivity have all been found to be satisfactory. Proposed fiber optic biosensors have high sensitivity, robustness, reliability, fast detection, no electromagnetic interference, low cost, real-time monitoring, and biocompatible.
    Keywords L-glutamate oxidase ; alanine transaminase ; biosensors ; blood ; carbon nanotubes ; detection limit ; electromagnetic interference ; fiber optics ; fish ; graphene oxide ; health services ; health status ; liver ; nanogold ; pH ; quantitative analysis ; surface plasmon resonance ; Alanine aminotransferase ; Fish health status ; Multi-walled carbon nanotubes ; Nanoparticles ; Localized surface plasmon resonance
    Language English
    Dates of publication 2023-09
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115424
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Facile degradation of chitosan-sodium alginate-chromium (III) gel in relation to leather re-tanning and filling

    Guan, Xiaoyu / Zhang, Bingyuan / Liu, Shiyong / An, Meng / Han, Qingxin / Li, Dongping / Rao, Ping

    International Journal of Biological Macromolecules. 2023 June, v. 240 p.124437-

    2023  

    Abstract: Natural polysaccharide hydrogel, exemplified by chitosan‑sodium alginate (CS-SA), has been prevailing in adsorption of chromium (III) (Cr(III)) containing contaminant. However, the traditional desorption of CS-SA-Cr(III) to recycle the adsorbent faces ... ...

    Abstract Natural polysaccharide hydrogel, exemplified by chitosan‑sodium alginate (CS-SA), has been prevailing in adsorption of chromium (III) (Cr(III)) containing contaminant. However, the traditional desorption of CS-SA-Cr(III) to recycle the adsorbent faces the problems including chemical desorbents secondary pollution, resource waste of the terminal CS-SA adsorbents, and tedious work of reusing the desorbed Cr(III). Herein, the adsorption product, CS-SA-Cr(III) gel, was degraded to CS/SA/Cr(III) sol and applied in leather re-tanning and filling processes directly. To achieve this goal, three degradation methods were used to transform the gel to sol. Due to the excellent overall performance of the CS/SA/Cr(III)-HMD₄ sol (obtained by the hydrothermal-mechanical degradation method for 4 h (HMD₄)), including wide size and distribution range, moderate viscosity (54 ± 3.1 mPa·s), high electronegativity (−38.6 ± 5.8 mV), and good stability, the resultant leather after re-tanning and filling by the sol achieved fascinating properties such as good thermal stability (Tₛ, 116.8 ± 1.8 °C; Td, 94.2 ± 1.7 °C), mechanical performance (tensile strength, 6.9 ± 0.52 MPa; elongation at break, 95 ± 3.0 %), and superduper thickening rate (31.8 %). Moreover, the mechanism of good re-tanning and filling effects was deciphered. Therefore, this work intends to overcome the limitation of traditional desorption technology and further realizes the high-valued application of the exhausted CS-SA-Cr(III) in leather re-tanning and filling processes.
    Keywords adsorbents ; adsorption ; alginates ; chromium ; desorption ; hydrogels ; leather ; pollution ; tensile strength ; thermal stability ; viscosity ; wastes ; Chitosan-sodium alginate (CS-SA) ; Leather re-tanning and filling
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124437
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Fascinating Pathway to Facilitate the Photoisomerization of Spiropyran-Based Nanocomposites.

    Guan, Xiaoyu / Zhang, Bingyuan / Zhu, Yanxia / Zheng, Sai / Li, Dongping / Liu, Shiyong / Han, Qingxin

    ACS applied materials & interfaces

    2023  Volume 15, Issue 33, Page(s) 39827–39836

    Abstract: Recently, spiropyran-based composites have gained more attention on account of their stimuli-responsive essence, especially of the fascinating and green photo stimulus. However, the great dipole moment change between the ring-opened merocyanine and ring- ... ...

    Abstract Recently, spiropyran-based composites have gained more attention on account of their stimuli-responsive essence, especially of the fascinating and green photo stimulus. However, the great dipole moment change between the ring-opened merocyanine and ring-closed spiropyran requires a large free volume available for isomerization, which significantly restrains the photoisomerization of spiropyran-based nanocomposites. Herein, a fascinating pathway by regulating the states both of spiropyran and the immobilized nanoparticle supports was put forward to facilitate the photoisomerization. The results demonstrated that the spiropyran grafting percentage of 5.18% and immobilized supports with less aggregation, high specific surface area, large pore size, and noncrystalline structure were suitable to fabricate spiropyran-based nanocomposites, which showed a significant improvement for Pb
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c06774
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Facile degradation of chitosan-sodium alginate-chromium (III) gel in relation to leather re-tanning and filling.

    Guan, Xiaoyu / Zhang, Bingyuan / Liu, Shiyong / An, Meng / Han, Qingxin / Li, Dongping / Rao, Ping

    International journal of biological macromolecules

    2023  Volume 240, Page(s) 124437

    Abstract: Natural polysaccharide hydrogel, exemplified by chitosan‑sodium alginate (CS-SA), has been prevailing in adsorption of chromium (III) (Cr(III)) containing contaminant. However, the traditional desorption of CS-SA-Cr(III) to recycle the adsorbent faces ... ...

    Abstract Natural polysaccharide hydrogel, exemplified by chitosan‑sodium alginate (CS-SA), has been prevailing in adsorption of chromium (III) (Cr(III)) containing contaminant. However, the traditional desorption of CS-SA-Cr(III) to recycle the adsorbent faces the problems including chemical desorbents secondary pollution, resource waste of the terminal CS-SA adsorbents, and tedious work of reusing the desorbed Cr(III). Herein, the adsorption product, CS-SA-Cr(III) gel, was degraded to CS/SA/Cr(III) sol and applied in leather re-tanning and filling processes directly. To achieve this goal, three degradation methods were used to transform the gel to sol. Due to the excellent overall performance of the CS/SA/Cr(III)-HMD
    MeSH term(s) Chromium/chemistry ; Chitosan ; Alginates ; Tanning ; Environmental Pollution
    Chemical Substances Chromium (0R0008Q3JB) ; Chitosan (9012-76-4) ; Alginates
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.124437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Natural polyphenol tannin-immobilized composites: rational design and versatile applications.

    Guan, Xiaoyu / Zhang, Bingyuan / Wang, Zequn / Han, Qingxin / An, Meng / Ueda, Motoki / Ito, Yoshihiro

    Journal of materials chemistry. B

    2023  Volume 11, Issue 21, Page(s) 4619–4660

    Abstract: Tannins, which are natural plant polyphenols, are widely used in different fields, especially in biomedical applications due to their unique properties, including high abundance, low cost, structural diversity, protein precipitation, biocompatibility, ... ...

    Abstract Tannins, which are natural plant polyphenols, are widely used in different fields, especially in biomedical applications due to their unique properties, including high abundance, low cost, structural diversity, protein precipitation, biocompatibility, and biodegradability. However, they fail to satisfy the requirements in some specific applications (
    MeSH term(s) Tannins/chemistry ; Polyphenols ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Polymers/chemistry ; Tissue Engineering
    Chemical Substances Tannins ; Polyphenols ; Anti-Bacterial Agents ; Polymers
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d3tb00661a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Slide-type waveflex biosensor based on signal enhancement technology for alpha-fetoprotein detection.

    Li, Guoru / Li, Xiangshan / Singh, Ragini / Zhang, Guiwei / Zhang, Bingyuan / Kumar, Santosh

    Optics letters

    2023  Volume 48, Issue 18, Page(s) 4745–4748

    Abstract: The development of signal enhancement technology in optical fiber biosensors is beneficial for the accurate measurement of low-concentration samples. Here, a localized surface plasmon resonance (LSPR)-based fiber biosensor combining a slide-type fiber ... ...

    Abstract The development of signal enhancement technology in optical fiber biosensors is beneficial for the accurate measurement of low-concentration samples. Here, a localized surface plasmon resonance (LSPR)-based fiber biosensor combining a slide-type fiber structure (thus named WaveFlex Biosensor) and low-dimensional materials is proposed for alpha-fetoprotein (AFP) detection. A symmetric transverse offset splicing technology was used to fabricate the multi-mode fiber (MMF-multi-core fiber (MCF)-MMF structure. Furthermore, the MMF on one side was prepared into an S-taper, forming a slide-type fiber structure to generate more energy leakage. The LSPR signal generated by gold nanoparticles (AuNPs) was enhanced by the CeO
    MeSH term(s) alpha-Fetoproteins ; Gold ; Metal Nanoparticles ; Surface Plasmon Resonance ; Biomedical Enhancement
    Chemical Substances alpha-Fetoproteins ; Gold (7440-57-5)
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.501864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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