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Article ; Online: Adverse perinatal outcomes complicated with gestational diabetes mellitus in preterm mothers and preterm infants.

Zhang, Cai-Hong / Zhang, Ping-Li

2023 Volume 26, Issue 3, Page(s) 425

Abstract: The incidence rate of gestational diabetes mellitus (GDM) in pregnancy is currently on the increase. GDM is associated with short and long-term adverse outcomes for mothers, fetuses and newborns. The aim of the present study was to compare the incidence ... ...

Abstract	The incidence rate of gestational diabetes mellitus (GDM) in pregnancy is currently on the increase. GDM is associated with short and long-term adverse outcomes for mothers, fetuses and newborns. The aim of the present study was to compare the incidence of adverse perinatal outcomes in women with and without GDM, in addition to comparing the morbidity and mortality rates of preterm infants born to women with and without GDM. A retrospective analysis of 640 preterm infants admitted to the Neonatal Intensive Care Unit of Qilu Hospital of Shandong University (Qingdao, China) between January 2019 and December 2020 was undertaken in the present study. According to mothers with or without GDM, the preterm infants were divided into the GDM group (n=217) and non-GDM group (n=423). Women with GDM were older (P<0.01) and more of advanced maternal age (≥35 years) or multipara (P<0.001), tended to have an increased risk of gestational hypertension (P<0.05), placenta previa (P<0.005) and polycystic ovarian syndrome (P<0.05). In infants born preterm, those born from mothers with GDM were associated with an increased risk of respiratory distress syndrome (P<0.001) and sepsis (P<0.05). In addition, very low birth weight infants born to mothers with GDM were found to have an increased risk of hypoglycemia (P<0.05) and sepsis (P<0.05). In the logistic regression analysis, RDS was the only condition independently associated with GDM [adjusted odds ratio: 1.699 (95% confidence interval: 1.699-1.699)]. However, there was no significant difference in the risk of mortality among the two groups. In conclusion, data from the present study suggested that GDM is associated with a higher risk of adverse perinatal outcomes in pregnant women and a higher risk of adverse neonatal outcomes in infants born preterm.
Language	English
Publishing date	2023-07-18
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2023.12124
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Carbon Sink Afforestation Projects on China’s Forest Product Export Trade: Empirical Evidence from Chinese Microenterprises

Gao, Xiaoxin / Zhang, Caihong

Forests. 2023 Aug. 18, v. 14, no. 8

2023

Abstract: Forestry carbon sinks are an important measure for enabling China to cope with global climate change and realize its “double carbon” goal. Carbon sink afforestation projects (CSAPs) are a type of forestry carbon sink projects, and the question of whether ...

Abstract	Forestry carbon sinks are an important measure for enabling China to cope with global climate change and realize its “double carbon” goal. Carbon sink afforestation projects (CSAPs) are a type of forestry carbon sink projects, and the question of whether China’s forest products with an export orientation can adapt to the requirements of high-quality development is important for balancing the relationship between emissions reduction and development. We use the micro-data of forest product export enterprises provided by the China Customs Database and construct a difference-in-difference (DID) model to investigate the impact of CSAPs on China’s forest product export and its heterogeneity. The results show that CSAPs significantly increase the export scale of China’s forest products. CSAPs lead to significant heterogeneity regarding the forest product export scale in relation to regions, production factor intensity, trade pattern, enterprise ownership, and export destination countries. We further find that although the implementation of CSAPs significantly reduces the export types of forest products, it significantly promotes an increase in the export price and the expansion of the export quantity of forest products, and it optimizes the export structure of forest products to some extent. The “Belt and Road” initiative (BRI) has played a significant positive role in regulating the expansion of the forest product export scale with CSAPs. The implementation of CSAPs reduces the risk of termination of trade relations among forest product export enterprises and extends the export duration. The conclusions provide implications for policy makers and managers of forest product enterprises.
Keywords	afforestation ; business enterprises ; carbon ; carbon sinks ; climate change ; databases ; exports ; forests ; issues and policy ; ownership ; prices ; China
Language	English
Dates of publication	2023-0818
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14081667
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: miR-192 family in breast cancer: Regulatory mechanisms and diagnostic value.

Yu, Mingxuan / Du, Hua / Zhang, Caihong / Shi, Yingxu

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 175, Page(s) 116620

Abstract: There is a growing interest in the role of the miRNA family in human cancer. The miRNA-192 family is a group of conserved small RNAs, including miR-192, miR-194, and miR-215. Recent studies have shown that the incidence and mortality of breast cancer ... ...

Abstract	There is a growing interest in the role of the miRNA family in human cancer. The miRNA-192 family is a group of conserved small RNAs, including miR-192, miR-194, and miR-215. Recent studies have shown that the incidence and mortality of breast cancer have been increasing epidemiologically year by year, and it is urgent to clarify the pathogenesis of breast cancer and seek new diagnostic and therapeutic methods. There is increasing evidence that miR-192 family members may be involved in the occurrence and development of breast cancer. This review describes the regulatory mechanism of the miRNA-192 family affecting the malignant behavior of breast cancer cells and evaluates the value of the miRNA-192 family as a diagnostic and prognostic biomarker for breast cancer. It is expected that summarizing and discussing the relationship between miRNA-192 family members and breast cancer, it will provide a new direction for the clinical diagnosis and treatment of breast cancer and basic medical research.
Language	English
Publishing date	2024-04-22
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116620
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Article ; Online: KCNQ1OT1 polymorphism rs35622507 and methylation status of KCNQ1OT1 promoter influence the drug resistance to L-OHP.

Zhang, Caihong / Wang, Yonglin

Aging

2022 Volume 14, Issue 4, Page(s) 1836–1847

Abstract: Background: LncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported to promote resistance to chemotherapy in colon cancer by inhibiting the expression of miR-34a. And the ... ...

Abstract	Background: LncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been reported to promote resistance to chemotherapy in colon cancer by inhibiting the expression of miR-34a. And the methylation of KCNQ1OT1 was also reported in the pathogenesis of various diseases. In this study, we aimed to study the combined effect of allele variation of KCNQ1OT1 polymorphism rs35622507 and methylation status of KCNQ1OT1 promoter in the treatment of colon cancer. Methods: The expression levels of KCNQ1OT1, miR-34a, and ATG4B mRNA were assessed by qRT-PCR. ATG4B protein expression was analyzed by Western blot analysis. TUNEL and MTT assay were performed to examine the cell apoptosis and viability. Luciferase assays revealed the relationship between KCNQ1OT1, miR-34a and ATG4B. Results: Carrier of allele 10 and methylated promoter in KCNQ1OT1 was associated with decreased KCNQ1OT1/ATG4B expression, increased miR-34a expression and enhanced apoptosis in colon cancer tissue samples. And subsequent luciferase assay showed that miR-34a could bind to KCNQ1OT1 and ATG4B at specific binding sites. The knockdown of KCNQ1OT1 significantly suppressed the KCNQ1OT1/ATG4B expression, improved the miR-34a expression and reduced the viability of HCT116 and SW480 cells. The over-expression of ATG4B notably restored the cell viability loss and apoptosis increase induced by the knockdown of KCNQ1OT1. Moreover, oxaliplatin (L-OHP) treatment elevated the apoptosis of HCT116 and SW480 cells. Conclusions: The drug resistance in the treatment of colon cancer is most reduced in patients carrying allele 10 and methylated in KCNQ1OT1 promoter. This function is accomplished by the signaling pathway of KCNQ1OT1/miR-34a/ATG4B.
MeSH term(s)	Apoptosis/genetics ; Cell Proliferation/genetics ; Colonic Neoplasms ; Drug Resistance ; Humans ; Methylation ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Oxaliplatin/pharmacology ; Oxaliplatin/therapeutic use ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism
Chemical Substances	MicroRNAs ; RNA, Long Noncoding ; Oxaliplatin (04ZR38536J)
Language	English
Publishing date	2022-02-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.203906
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Article ; Online: Comparative Mitochondrial Genomes between the Genera Amiota and Phortica (Diptera: Drosophilidae) with Evolutionary Insights into D-Loop Sequence Variability

Zhang, Caihong / Wang, Yalian / Chen, Hongwei / Huang, Jia

Genes (Basel). 2023 June 09, v. 14, no. 6

2023

Abstract: To address the limited number of mitochondrial genomes (mitogenomes) in the subfamily Steganinae (Diptera: Drosophilidae), we assembled 12 complete mitogenomes for six representative species in the genus Amiota and six representative species in the genus ...

Abstract	To address the limited number of mitochondrial genomes (mitogenomes) in the subfamily Steganinae (Diptera: Drosophilidae), we assembled 12 complete mitogenomes for six representative species in the genus Amiota and six representative species in the genus Phortica. We performed a series of comparative and phylogenetic analyses for these 12 Steganinae mitogenomes, paying special attention to the commonalities and differences in the D-loop sequences. Primarily determined by the lengths of the D-loop regions, the sizes of the Amiota and Phortica mitogenomes ranged from 16,143–16,803 bp and 15,933–16,290 bp, respectively. Our results indicated that the sizes of genes and intergenic nucleotides (IGNs), codon usage and amino acid usage, compositional skewness levels, evolutionary rates of protein-coding genes (PCGs), and D-loop sequence variability all showed unambiguous genus-specific characteristics and provided novel insights into the evolutionary implications between and within Amiota and Phortica. Most of the consensus motifs were found downstream of the D-loop regions, and some of them showed distinct genus-specific patterns. In addition, the D-loop sequences were phylogenetically informative as the data sets of PCGs and/or rRNAs, especially within the genus Phortica.
Keywords	Drosophilidae ; amino acids ; codon usage ; genetic variation ; mitochondrial genome ; nucleotides ; phylogeny ; statistical analysis
Language	English
Dates of publication	2023-0609
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061240
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: What Promotes Natural Forest Protection and Restoration? Insights from the Perspective of Multiple Parties

Ke, Jinkai / Sun, Ruolin / Ma, Yifei / Zhang, Caihong

Forests. 2023 Feb. 08, v. 14, no. 2

2023

Abstract: The natural forest protection and restoration (NFPR) system is imperfect due to contradictions between the objectives of natural forest protection and the reality of situations, outdated cultivation concepts, conflicting interests among participating ... ...

Abstract	The natural forest protection and restoration (NFPR) system is imperfect due to contradictions between the objectives of natural forest protection and the reality of situations, outdated cultivation concepts, conflicting interests among participating parties, and the lack of regulation guarantees and assessment criteria. These problems are not only common in China but also in international forest protection. As the NFPR system is more focused on the protection of natural forests, the level of natural forest restoration in China has been poor, with low natural forest quality and forest productivity. At the same time, the value of natural forest ecosystem services does not match the demand of farmers, forest management, and other multiple participating parties. As a result, except for the government, other multiple parties lack the intrinsic motivation to participate in NFPR, ultimately forming a sustainable management dilemma. Under the institutional analysis and development (IAD) framework, the objective of this research was to explore the influencing factors and outcomes of the participation of multiple parties in NFPR and to construct a multiple parties’ participation mechanism for solving this dilemma. This research found that among external variables, multiple parties’ characteristics, biophysical conditions, attributes of community, and rules-in-use jointly influence and constitute the driving mechanism of multiple parties’ participation in NFPR. The rules-in-use directly impact the participation action scenario and regulate the other three external variables. Various factors and mechanisms in NFPR interact in the action space and produce outcomes that create positive incentives for each external variable, thus promoting the whole mechanism to achieve a virtuous cycle of sustainable management. This study provides a theoretical contribution to understanding the behavior of multiple parties participating in NFPR.
Keywords	forest ecosystems ; forest management ; forest restoration ; forests ; motivation ; China
Language	English
Dates of publication	2023-0208
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f14020339
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Phylogenetic insights based on the first complete mitochondrial genome of

Ma, Ting / Zhang, Caihong / Huang, Jia

Mitochondrial DNA. Part B, Resources

2023 Volume 8, Issue 12, Page(s) 1320–1324

Abstract: To investigate the phylogenetic position ... ...

Abstract	To investigate the phylogenetic position of
Language	English
Publishing date	2023-12-04
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2023.2288916
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative Mitochondrial Genomes between the Genera

Zhang, Caihong / Wang, Yalian / Chen, Hongwei / Huang, Jia

Genes

2023 Volume 14, Issue 6

Abstract	To address the limited number of mitochondrial genomes (mitogenomes) in the subfamily Steganinae (Diptera: Drosophilidae), we assembled 12 complete mitogenomes for six representative species in the genus
MeSH term(s)	Animals ; Drosophilidae/genetics ; Phylogeny ; Genome, Mitochondrial/genetics ; Nucleotides/genetics ; Amino Acids/genetics
Chemical Substances	Nucleotides ; Amino Acids
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14061240
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Article ; Online: Dual-Functional AIE Fluorescent Probe for Visualization of Lipid Droplets and Photodynamic Therapy of Cancer.

Pei, Shizeng / Li, Haoyang / Chen, Linfeng / Nie, Gang / Wang, Huiling / Liu, Chunrong / Zhang, Caihong

Analytical chemistry

2024 Volume 96, Issue 14, Page(s) 5615–5624

Abstract: Abnormal lipid droplets (LDs) are known to be intimately bound with the occurrence and development of cancer, allowing LDs to be critical biomarkers for cancers. Aggregation-induced emission luminogens (AIEgens), with efficient reactive oxygen species ( ... ...

Abstract	Abnormal lipid droplets (LDs) are known to be intimately bound with the occurrence and development of cancer, allowing LDs to be critical biomarkers for cancers. Aggregation-induced emission luminogens (AIEgens), with efficient reactive oxygen species (ROS) production performance, are prime photosensitizers (PSs) for photodynamic therapy (PDT) with imaging. Therefore, the development of dual-functional fluorescent probes with aggregation-induced emission (AIE) characteristics that enable both simultaneous LD monitoring and imaging-guided PDT is essential for concurrent cancer diagnosis and treatment. Herein, we reported the development of a novel LD-targeting fluorescent probe (TDTI) with AIE performance, which was expected to realize the integration of cancer diagnosis through LD visualization and cancer treatment via PDT. We demonstrated that TDTI, with typical AIE characteristics and excellent photostability, could target LDs with high specificity, which enables the dynamic tracking of LDs in living cells, specific imaging of LDs in zebrafish, and the differentiation of cancer cells from normal cells for cancer diagnosis. Meanwhile, TDTI exhibited fast ROS generation ability (achieving equilibrium within 60 s) under white light irradiation (10 mW/cm
MeSH term(s)	Humans ; Animals ; Mice ; HeLa Cells ; Fluorescent Dyes ; Lipid Droplets/metabolism ; Photochemotherapy/methods ; Reactive Oxygen Species/metabolism ; Zebrafish/metabolism ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy
Chemical Substances	Fluorescent Dyes ; Reactive Oxygen Species ; Photosensitizing Agents
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.4c00227
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Article ; Online: Effect of olive leaf (Olea europaea L.) extract addition to broiler diets on the growth performance, breast meat quality, antioxidant capacity and caecal bacterial populations

Xie, Pujun / Deng, Yejun / Huang, Lixin / Zhang, Caihong

Italian Journal of Animal Science. 2022 Dec. 31, v. 21, no. 1 p.1246-1258

2022

Abstract: This study aims to evaluate the effect of olive leaf extract (OLE) on growth performance, breast meat quality, antioxidant capacity and caecal microbiota regulation. OLE containing 51.5% oleuropein, 25.6% polyphenols and 6.2% flavonoids, was designed to ... ...

Abstract	This study aims to evaluate the effect of olive leaf extract (OLE) on growth performance, breast meat quality, antioxidant capacity and caecal microbiota regulation. OLE containing 51.5% oleuropein, 25.6% polyphenols and 6.2% flavonoids, was designed to different supplement levels ranging from 0.1% OLE (OLE0.1) to 0.5% OLE (OLE0.5) into a basal diet, separately. The whole feeding period lasts for 35 days after 7-day hatching from the egg. 720 1-day-age healthy Arbour Acres male broilers were thus divided into five experimental groups and one control group, consist of 20 broilers per group for six parallel experiments in triplicate. The results showed that the levels of average daily feed intake (ADFI) and average daily weight gain (ADG) of the broilers were decreased (p < 0.05) after the addition of 0.3% OLE. Moreover, the breast meat shear force was decreased by 34.4% (p < 0.05). The glutathione (GSH) levels in the meat were increased by 76.64% (p < 0.05); the levels of total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) were increased by 50.4% and 120%, respectively. And the malondialdehyde (MDA) levels in the meat were reduced by 34.2% (p < 0.05). Additionally, a decreased intensity of Escherichia coli (p < 0.05) and an increased intensity of Lactobacillus and Bifidobacterium (p < 0.05) were observed. Overall, supplementing 0.3% OLE into daily diet enables enhancing breast meat antioxidation, amplifying the abundance of Lactobacillus and Bifidobacterium as well as diminishing the abundance of E. coli in the caecum.HIGHLIGHTSOLE contains 51.5% oleuropein, 25.6% of TP and 6.2% TF levels. OLE addition at 0.3% lowers shear force and raises the GSH’s level of the meat. OLE causes a decrease in E. coli and an increase in Lactobacillus and Bifidobacterium.
Keywords	Bifidobacterium ; Escherichia coli ; Lactobacillus ; Olea europaea ; antioxidant activity ; breast meat ; cecum ; diet ; eggs ; feed intake ; flavonoids ; glutathione ; glutathione peroxidase ; growth performance ; leaf extracts ; leaves ; males ; malondialdehyde ; meat quality ; microorganisms ; oleuropein ; olives ; polyphenols ; superoxide dismutase ; weight gain ; shear force ; GSH and MDA ; microbiota intensity
Language	English
Dates of publication	2022-1231
Size	p. 1246-1258.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2408994-1
ISSN	1828-051X
ISSN	1828-051X
DOI	10.1080/1828051X.2022.2105265
Database	NAL-Catalogue (AGRICOLA)

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