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Article ; Online: Phytochemistry of Red Ginseng, a Steam-Processed

Wang, Chong-Zhi / Zhang, Chun-Feng / Zhang, Qi-Hui / Yuan, Chun-Su

The American journal of Chinese medicine

2024 Volume 52, Issue 1, Page(s) 35–55

Abstract: Asian ginseng, the root ... ...

Abstract	Asian ginseng, the root of
MeSH term(s)	Ginsenosides/therapeutic use ; Steam ; Panax/chemistry ; Complementary Therapies ; Phytochemicals
Chemical Substances	Ginsenosides ; Steam ; Phytochemicals
Language	English
Publishing date	2024-02-14
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X24500022
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Article: Book review: "how to understand the theory of traditional chinese medicine: open a window to the west" the theory of chinese medicine by Hong hai.

Zhang, Chun-Feng

The American journal of Chinese medicine

2014 Volume 42, Issue 6, Page(s) 1559–1560

Language	English
Publishing date	2014
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	0192-415X ; 0090-2942
ISSN	0192-415X ; 0090-2942
DOI	10.1142/S0192415X14800019
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Article ; Online: Hsp90-associated DNA replication checkpoint protein and proteasome-subunit components are involved in the age-related macular degeneration.

Xing, Chen / Liu, Xiao-Feng / Zhang, Chun-Feng / Yang, Liu

Chinese medical journal

2021 Volume 134, Issue 19, Page(s) 2322–2332

Abstract: Background: Age-related macular degeneration (AMD) is the leading cause of vision loss worldwide. However, the mechanisms involved in the development and progression of AMD are poorly delineated. We aimed to explore the critical genes involved in the ... ...

Abstract	Background: Age-related macular degeneration (AMD) is the leading cause of vision loss worldwide. However, the mechanisms involved in the development and progression of AMD are poorly delineated. We aimed to explore the critical genes involved in the progression of AMD. Methods: The differentially expressed genes (DEGs) in AMD retinal pigment epithelial (RPE)/choroid tissues were identified using the microarray datasets GSE99248 and GSE125564, which were downloaded from the gene expression omnibus database. The overlapping DEGs from the two datasets were screened to identify DEG-related biological pathways using gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses. The hub genes were identified from these DEGs through protein-protein interaction network analyses. The expression levels of hub genes were evaluated by quantitative real-time polymerase chain reaction following the induction of senescence in ARPE-19 with FK866. Following the identification of AMD-related key genes, the potential small molecule compounds targeting the key genes were predicted by PharmacoDB. Finally, a microRNA-gene interaction network was constructed. Results: Microarray analyses identified 174 DEGs in the AMD RPE compared to the healthy RPE samples. These DEGs were primarily enriched in the pathways involved in the regulation of DNA replication, cell cycle, and proteasome-mediated protein polyubiquitination. Among the top ten hub genes, HSP90AA1, CHEK1, PSMA4, PSMD4, and PSMD8 were upregulated in the senescent ARPE-19 cells. Additionally, the drugs targeting HSP90AA1, CHEK1, and PSMA4 were identified. We hypothesize that Hsa-miR-16-5p might target four out of the five key DEGs in the AMD RPE. Conclusions: Based on our findings, HSP90AA1 is likely to be a central gene controlling the DNA replication and proteasome-mediated polyubiquitination during the RPE senescence observed in the progression of AMD. Targeting HSP90AA1, CHEK1, PSMA4, PSMD4, and/or PSMD8 genes through specific miRNAs or small molecules might potentially alleviate the progression of AMD through attenuating RPE senescence.
MeSH term(s)	DNA Replication ; Gene Expression Profiling ; Gene Ontology ; Humans ; Macular Degeneration/genetics ; Proteasome Endopeptidase Complex
Chemical Substances	Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2021-09-20
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001773
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Article ; Online: Light-Quality-Adapted Carotenoid Photoprotection in the Photosystem of

Hao, Jin-Fang / Qi, Chen-Hui / Yu, Bu-Yang / Wang, Hao-Yi / Gao, Rong-Yao / Yamano, Nami / Ma, Fei / Wang, Peng / Xin, Yue-Yong / Zhang, Chun-Feng / Yu, Long-Jiang / Zhang, Jian-Ping

The journal of physical chemistry letters

2024 Volume 15, Issue 12, Page(s) 3470–3477

Abstract: The photosystem of filamentous anoxygenic ... ...

Abstract	The photosystem of filamentous anoxygenic phototroph
MeSH term(s)	Chloroflexi/chemistry ; Chloroflexi/metabolism ; Carotenoids ; Light-Harvesting Protein Complexes/chemistry ; Photosynthesis ; Bacteriochlorophylls/metabolism ; Bacterial Proteins/chemistry
Chemical Substances	Carotenoids (36-88-4) ; Light-Harvesting Protein Complexes ; Bacteriochlorophylls ; Bacterial Proteins
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.4c00593
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Article ; Online: Ruthenium-dihydroartemisinin complex: a promising new compound for colon cancer prevention via G1 cell cycle arrest, apoptotic induction, and adaptive immune regulation.

Wang, Chong-Zhi / Wan, Chunping / Li, Cang-Hai / Liang, Guo-Gang / Luo, Yun / Zhang, Chun-Feng / Zhang, Qi-Hui / Ma, Qinge / Wang, Angela H / Lager, Mallory / Jiang, Ting-Liang / Hou, Lifei / Yuan, Chun-Su

Cancer chemotherapy and pharmacology

2024 Volume 93, Issue 5, Page(s) 411–425

Abstract: Background: Artemisinin (ART) and its derivatives are important antimalaria agents and have received increased attention due to their broad biomedical effects, such as anticancer and anti-inflammation activities. Recently, ruthenium-derived complexes ... ...

Abstract	Background: Artemisinin (ART) and its derivatives are important antimalaria agents and have received increased attention due to their broad biomedical effects, such as anticancer and anti-inflammation activities. Recently, ruthenium-derived complexes have attracted considerable attention as their anticancer potentials were observed in preclinical and clinical studies. Methods: To explore an innovative approach in colorectal cancer (CRC) management, we synthesized ruthenium-dihydroartemisinin complex (D-Ru), a novel metal-based artemisinin derivative molecule, and investigated its anticancer, anti-inflammation, and adaptive immune regulatory properties. Results: Compared with its parent compound, ART, D-Ru showed stronger antiproliferative effects on the human CRC cell lines HCT-116 and HT-29. The cancer cell inhibition of D-Ru comprised G1 cell cycle arrest via the downregulation of cyclin A and the induction of apoptosis. ART and D-Ru downregulated the expressions of pro-inflammatory cytokines IL-1β, IL-6, and IL-8. Although ART and D-Ru did not suppress Treg cell differentiation, they significantly inhibited Th1 and Th17 cell differentiation. Conclusions: Our results demonstrated that D-Ru, a novel ruthenium complexation of ART, remarkably enhanced its parent compound's anticancer action, while the anti-inflammatory potential was not compromised. The molecular mechanisms of action of D-Ru include inhibition of cancer cell growth via cell cycle arrest, induction of apoptosis, and anti-inflammation via regulation of adaptive immunity.
MeSH term(s)	Humans ; Artemisinins/pharmacology ; Artemisinins/chemistry ; Apoptosis/drug effects ; Colonic Neoplasms/pathology ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/immunology ; G1 Phase Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Adaptive Immunity/drug effects ; Ruthenium/chemistry ; Ruthenium/pharmacology ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; HCT116 Cells ; HT29 Cells ; Animals ; Cytokines/metabolism ; Coordination Complexes/pharmacology ; Coordination Complexes/chemistry ; Mice
Chemical Substances	Artemisinins ; artenimol (6A9O50735X) ; Ruthenium (7UI0TKC3U5) ; Antineoplastic Agents ; Cytokines ; Coordination Complexes
Language	English
Publishing date	2024-01-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-023-04623-7
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Article ; Online: Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats.

Han, Bing-Jing / Cao, Gui-Yun / Jia, Li-Ying / Zheng, Guo / Zhang, Liang / Sheng, Ping / Xie, Ji-Zhen / Zhang, Chun-Feng

The American journal of Chinese medicine

2022 Volume 50, Issue 7, Page(s) 1887–1904

Abstract: Tetrahydropalmatine (THP) is an active component ... ...

Abstract	Tetrahydropalmatine (THP) is an active component of
MeSH term(s)	Rats ; Animals ; Molecular Docking Simulation ; Rats, Sprague-Dawley ; Myocardial Infarction/drug therapy ; Myocardial Infarction/metabolism ; Myocardial Infarction/pathology ; Myocardium/pathology ; Myocytes, Cardiac/pathology ; Apoptosis ; Myocardial Ischemia/pathology ; Superoxide Dismutase/metabolism
Chemical Substances	tetrahydropalmatine (3X69CO5I79) ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2022-09-04
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X2250080X
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Article ; Online: Effects of Curcuminoids and Surfactant-Formulated Curcumin on Chemo-Resistant Colorectal Cancer.

Wan, Chunping / Ma, Qinge / Anderson, Samantha / Zhang, Qi-Hui / Zhang, Chun-Feng / Wang, Angela H / Bell, Emma / Hou, Lifei / Yuan, Chun-Su / Wang, Chong-Zhi

The American journal of Chinese medicine

2023 Volume 51, Issue 6, Page(s) 1577–1594

Abstract: Colorectal cancer (CRC) is a leading cause of cancer-related death in the United States, and chronic gut inflammation is a risk factor for CRC initiation and development. ...

Abstract	Colorectal cancer (CRC) is a leading cause of cancer-related death in the United States, and chronic gut inflammation is a risk factor for CRC initiation and development.
MeSH term(s)	Humans ; Curcumin/pharmacology ; Diarylheptanoids ; Surface-Active Agents ; Curcuma ; Colorectal Neoplasms/drug therapy ; Water
Chemical Substances	Curcumin (IT942ZTH98) ; Diarylheptanoids ; Surface-Active Agents ; Water (059QF0KO0R)
Language	English
Publishing date	2023-07-19
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X23500714
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Article ; Online: Self-Nanoemulsifying Drug Delivery System of Genkwanin: A Novel Approach for Anti-Colitis-Associated Colorectal Cancer.

Yin, Hua-Feng / Yin, Chun-Ming / Ouyang, Ting / Sun, Shu-Ding / Chen, Wei-Guo / Yang, Xiao-Lin / He, Xin / Zhang, Chun-Feng

Drug design, development and therapy

2021 Volume 15, Page(s) 557–576

Abstract: Purpose: The aim of the present study was to develop an optimized Genkwanin (GKA)-loaded self-nanoemulsifying drug delivery system (SNEDDS) formulation to enhance the solubility, intestinal permeability, oral bioavailability and anti-colitis-associated ... ...

Abstract	Purpose: The aim of the present study was to develop an optimized Genkwanin (GKA)-loaded self-nanoemulsifying drug delivery system (SNEDDS) formulation to enhance the solubility, intestinal permeability, oral bioavailability and anti-colitis-associated colorectal cancer (CAC) activity of GKA. Methods: We designed a SNEDDS comprised oil phase, surfactants and co-surfactants for oral administration of GKA, the best of which were selected by investigating the saturation solubility, constructing pseudo-ternary phase diagrams, followed by optimizing thermodynamic stability, emulsification efficacy, self-nanoemulsification time, droplet size, transmission electron microscopy (TEM), drug release and intestinal permeability. In addition, the physicochemical properties and pharmacokinetics of GKA-SNEDDS were characterized, and its anti-colitis-associated colorectal cancer (CAC) activity and potential mechanisms were evaluated in AOM/DSS-induced C57BL/6J mice model. Results: The optimized nanoemulsion formula (OF) consists of Maisine CC, Labrasol ALF and Transcutol HP in a weight ratio of 20:60:20 (w/w/w), in which ratio the OF shows multiple improvements, specifically small mean droplet size, excellent stability, fast release properties as well as enhanced solubility and permeability. Pharmacokinetic studies demonstrated that compared with GKA suspension, the relative bioavailability of GKA-SNEDDS was increased by 353.28%. Moreover, GKA-SNEDDS not only significantly prevents weight loss and improves disease activity index (DAI) but also reduces the histological scores of inflammatory cytokine levels as well as inhibiting the formation of colon tumors via inducing tumor cell apoptosis in the AOM/DSS-induced CAC mice model. Conclusion: Our results show that the developed GKA-SNEDDS exhibited enhanced oral bioavailability and excellent anti-CAC efficacy. In summary, GKA-SNEDDS, using lipid nanoparticles as the drug delivery carrier, can be applied as a potential drug delivery system for improving the clinical application of GKA.
MeSH term(s)	Administration, Oral ; Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Cell Proliferation/drug effects ; Colitis/drug therapy ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Daphne/chemistry ; Dose-Response Relationship, Drug ; Drug Compounding ; Drug Delivery Systems ; Emulsions ; Flavones/administration & dosage ; Flavones/chemistry ; Flavones/pharmacology ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Nanoparticles/administration & dosage ; Nanoparticles/chemistry ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Rats ; Rats, Sprague-Dawley ; Solubility ; Structure-Activity Relationship
Chemical Substances	Antineoplastic Agents, Phytogenic ; Emulsions ; Flavones ; genkwanin (5K3I5D6B2B)
Language	English
Publishing date	2021-02-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S292417
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Article ; Online: Falcarindiol and dichloromethane fraction are bioactive components in

Wang, Chong-Zhi / Luo, Yun / Huang, Wei-Hua / Zeng, Jinxiang / Zhang, Chun-Feng / Lager, Mallory / Du, Wei / Xu, Ming / Yuan, Chun-Su

Journal of applied biomedicine

2021 Volume 19, Issue 2, Page(s) 113–124

Abstract: Oplopanax ... ...

Abstract	Oplopanax elatus
MeSH term(s)	Apoptosis ; Cell Cycle Checkpoints ; Chemoprevention ; Colonic Neoplasms ; Cyclin A/pharmacology ; Cyclins/pharmacology ; Diynes ; Fatty Alcohols ; Humans ; Methylene Chloride/pharmacology ; Oplopanax/chemistry ; Up-Regulation
Chemical Substances	Cyclin A ; Cyclins ; Diynes ; Fatty Alcohols ; falcarindiol (55297-87-5) ; Methylene Chloride (588X2YUY0A)
Language	English
Publishing date	2021-11-04
Publishing country	Poland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2171142-2
ISSN	1214-0287 ; 1214-0287
ISSN (online)	1214-0287
ISSN	1214-0287
DOI	10.32725/jab.2021.013
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Article: Chinese medicine GeGen-DanShen extract protects from myocardial ischemic injury through promoting angiogenesis via up-regulation of VEGF/VEGFR2 signaling pathway

Zhai, Shuo / Zhang, Xiao-Fan / Lu, Fang / Chen, Wei-Guo / He, Xin / Zhang, Chun-Feng / Wang, Chong-Zhi / Yuan, Chun-Su

Journal of ethnopharmacology. 2021 Mar. 01, v. 267

2021

Abstract: Coronary heart disease (CHD) usually refers to myocardial ischemia or myocardial necrosis caused by coronary artery stenosis. GeGen and DanShen (GD) are popular Chinese herbs for the treatment of angina pectoris and myocardial infarction (MI). This ... ...

Abstract	Coronary heart disease (CHD) usually refers to myocardial ischemia or myocardial necrosis caused by coronary artery stenosis. GeGen and DanShen (GD) are popular Chinese herbs for the treatment of angina pectoris and myocardial infarction (MI). This sentence needs to be a separate paragraph.Aim of the study: This study was to investigate the role of GD extract in promoting ischemic myocardial angiogenesis, and to explore its signaling mechanism, so as to provide a more reliable scientific basis for the clinical treatment of ischemic cardiovascular disease.GD extract was initially analyzed by HPLC-Q-TOF MS. In vitro, migration assay and tube formation assay were subsequently used to detect the angiogenesis activity of GD extract in human umbilical vein endothelial cells (HUVECs). Following the in vitro study, an MI rat model was established by ligating the left anterior descending coronary artery (LAD), immediately followed by a 4-week daily GD extract treatment by intragastric administration. After the animal sacrifice, hematoxylin-eosin (HE) staining was conducted to observe the pathological changes of the infarct margin. Besides, the MI area was measured by 2,3,5-triphenyltetrazoliumchloride (TTC) staining. The microvascular density (MVD) was also quantified through CD31 immunohistochemistry. Moreover, the levels of VEGF, TXB2 and 6-keto-PGF1α in serum were detected by enzyme-linked immunosorbent assay. The expression of VEGFR2 and ERK were detected by immunohistochemistry as well.In vitro study, GD extract was found to induce significant angiogenesis in HUVECs. In vivo, smaller infarct size was found in treatment groups than that of the model group, and the protein expression of VEGFR2 as well as ERK in the marginal zone of MI in treatment groups were significantly increased. The morphological changes of myocardium were observed with a significant growth in the number of new blood vessels. Regarding the effect of GD extract, the serum levels of CK, LDH and TXB2 were consequently reduced, whereas the levels of VEGF, 6-keto-PGF1α were significantly increased.Based on the findings of this study, GD extract had a protective effect against MI in rats. The possible mechanism is to promote angiogenesis by regulating the VEGF/VEGFR2 signaling pathway after MI occurrence.
Keywords	Oriental traditional medicine ; angiogenesis ; animal models ; blood serum ; coronary disease ; coronary vessels ; enzyme-linked immunosorbent assay ; immunohistochemistry ; infarction ; intragastric administration ; myocardial infarction ; myocardium ; protective effect ; protein synthesis ; vascular endothelial growth factor receptor-2
Language	English
Dates of publication	2021-0301
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113475
Database	NAL-Catalogue (AGRICOLA)

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