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  1. Article ; Online: A commentary on 'Perioperative versus postoperative calcium and vitamin D supplementation to prevent symptomatic hypocalcemia after total thyroidectomy: a randomized placebo controlled trial'.

    Zhao, Zhe-Ming / Zhang, Chun-Dong

    International journal of surgery (London, England)

    2023  Volume 109, Issue 7, Page(s) 2133–2134

    MeSH term(s) Humans ; Calcium/therapeutic use ; Hypocalcemia/etiology ; Hypocalcemia/prevention & control ; Thyroidectomy/adverse effects ; Vitamin D/therapeutic use ; Parathyroid Hormone ; Dietary Supplements ; Postoperative Complications/etiology ; Postoperative Complications/prevention & control ; Postoperative Complications/drug therapy
    Chemical Substances Calcium (SY7Q814VUP) ; Vitamin D (1406-16-2) ; Parathyroid Hormone
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TNIK regulates actin cytoskeleton morphology via Rho/ROCK/LIMK1 pathway in lung adenocarcinoma A549 cells

    SUN Xuehua / ZHANG Lian / ZHANG Chundong / CHEN Quan

    陆军军医大学学报, Vol 45, Iss 7, Pp 659-

    2023  Volume 666

    Abstract: Objective To investigate the molecular mechanism of TNIK regulating actin cytoskeleton morphology in lung adenocarcinoma A549 cells, and determine its effects on the proliferation and apoptosis of the cancer cells when combined with mitosis-targeted drug. ...

    Abstract Objective To investigate the molecular mechanism of TNIK regulating actin cytoskeleton morphology in lung adenocarcinoma A549 cells, and determine its effects on the proliferation and apoptosis of the cancer cells when combined with mitosis-targeted drug. Methods RNA sequencing data were profiled to screen differentially expressed genes in the A549 cells with TNIK stable knockdown, and the expression of genes related to actin cytoskeleton assembly was subsequently detected. RT-PCR, Western blotting, and double immunofluorescence staining were preformed to analyze the molecular mechanism of TNIK regulating the assembly of actin-microtubule cytoskeleton system. Moreover, A549 cells with TNIK knockdown were treated with targeted antimitotic chemotherapeutic agent, paclitaxel, to observe the growth and apoptosis of the cancer cells. Results RNA-seq showed that the differentially expressed genes after TNIK knockdown were closely associated with mitotic progression. Further analysis revealed that TNIK knockdown significantly inhibited the expression of Rho pathway related genes including RhoA/B, ROCK1/2 and LIMK1 at the transcriptional level (P < 0.01), but had no obvious effect on the expression of Rac and CDC42 pathway related genes. Immunofluorescence assay indicated that TNIK knockdown resulted in abnormal mitosis and morphology in actin cytoskeleton system. As compared with the control cells, paclitaxel treatment decreased the proliferation (P < 0.01) while improved the apoptotic rate (P < 0.01) in TNIK knockdown cells. Conclusion TNIK regulates the morphology of actin-microtubule cytoskeleton system in lung adenocarcinoma A549 cells through the Rho/ROCK/LIMK1 pathway, and TNIK knockdown can enhance the efficiency of mitosis-targeted chemotherapeutic drug.
    Keywords lung adenocarcinoma cells ; actin cytoskeleton ; microtubule cytoskeleton ; chemotherapy ; tnik ; Medicine (General) ; R5-920
    Subject code 570
    Language Chinese
    Publishing date 2023-04-01T00:00:00Z
    Publisher Editorial Office of Journal of Army Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: The biological role of extracellular vesicles in gastric cancer metastasis.

    Lei, Yun / Cai, Shuang / Zhang, Chun-Dong / Li, Yong-Shuang

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1323348

    Abstract: Gastric cancer (GC) is a tumor characterized by high incidence and mortality, with metastasis being the primary cause of poor prognosis. Extracellular vesicles (EVs) are an important intercellular communication medium. They contain bioactive substances ... ...

    Abstract Gastric cancer (GC) is a tumor characterized by high incidence and mortality, with metastasis being the primary cause of poor prognosis. Extracellular vesicles (EVs) are an important intercellular communication medium. They contain bioactive substances such as proteins, nucleic acids, and lipids. EVs play a crucial biological role in the process of GC metastasis. Through mechanisms such as remodeling the tumor microenvironment (TME), immune suppression, promoting angiogenesis, and facilitating epithelial-mesenchymal transition (EMT) and mesothelial-mesenchymal transition (MMT), EVs promote invasion and metastasis in GC. Further exploration of the biological roles of EVs will contribute to our understanding of the mechanisms underlying GC metastasis and may provide novel targets and strategies for the diagnosis and treatment of GC. In this review, we summarize the mechanisms by which EVs influence GC metastasis from four aspects: remodeling the TME, modulating the immune system, influencing angiogenesis, and modulating the processes of EMT and MMT. Finally, we briefly summarized the organotropism of GC metastasis as well as the potential and limitations of EVs in GC.
    Language English
    Publishing date 2024-01-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1323348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Brief Review of Recent Theoretical Advances in Fe-Based Catalysts for CO

    Tang, Haoxiang / Qiu, Tongyue / Wang, Xuerui / Zhang, Chundong / Zhang, Zunmin

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 6

    Abstract: Catalytic hydrogenation presents a promising approach for converting ... ...

    Abstract Catalytic hydrogenation presents a promising approach for converting CO
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29061194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Laboratory biomarker as an alternative to low-dose computed tomography for the diagnosis of suspected appendicitis? Circulating fibrocyte percentage and neutrophil-lymphocyte ratio are accurate biomarkers of uncomplicated and complicated appendicitis: a prospective cohort study.

    Zhang, Rui / Zhao, Zhe-Ming / Zhang, Chun-Dong

    International journal of surgery (London, England)

    2023  Volume 109, Issue 5, Page(s) 1524–1525

    MeSH term(s) Humans ; Neutrophils ; Appendicitis/diagnostic imaging ; Appendicitis/complications ; Prospective Studies ; Lymphocytes ; Biomarkers ; Tomography ; Acute Disease ; Retrospective Studies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How to reasonably deal with zero-events in meta-analysis of surgery-related outcomes? Oncologic outcomes of intersphincteric resection vs. abdominoperineal resection for lower rectal cancer: a systematic review and meta-analysis.

    Zhang, Rui / Ning, Fei-Long / Zhang, Chun-Dong

    International journal of surgery (London, England)

    2023  Volume 109, Issue 7, Page(s) 2137–2138

    MeSH term(s) Humans ; Rectal Neoplasms/surgery ; Proctectomy ; Treatment Outcome ; Anal Canal/surgery
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000000379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hospital volume-mortality association after esophagectomy for cancer: a systematic review and meta-analysis.

    Di, Jie / Lu, Xiao-Shi / Sun, Min / Zhao, Zhe-Ming / Zhang, Chun-Dong

    International journal of surgery (London, England)

    2024  Volume 110, Issue 5, Page(s) 3021–3029

    Abstract: Background: Postoperative mortality plays an important role in evaluating the surgical safety of esophagectomy. Although postoperative mortality after esophagectomy is partly influenced by the yearly hospital surgical case volume (hospital volume), this ...

    Abstract Background: Postoperative mortality plays an important role in evaluating the surgical safety of esophagectomy. Although postoperative mortality after esophagectomy is partly influenced by the yearly hospital surgical case volume (hospital volume), this association remains unclear.
    Methods: Studies assessing the association between hospital volume and postoperative mortality in patients who underwent esophagectomy for esophageal cancer were searched for eligibility. Odds ratios were pooled for the highest versus lowest categories of hospital volume using a random effects model. The dose-response association between hospital volume and the risk of postoperative mortality was analyzed. The study protocol was registered with PROSPERO.
    Results: Fifty-six studies including 385 469 participants were included. A higher-volume hospital significantly reduced the risk of postesophagectomy mortality by 53% compared with their lower-volume counterparts (odds ratio, 0.47; 95% CI: 0.42-0.53). Similar results were found in subgroup analyses. Volume-outcome analysis suggested that postesophagectomy mortality rates remained roughly stable after the hospital volume reached a plateau of 45 esophagectomies per year.
    Conclusions: Higher-volume hospitals had significantly lower postesophagectomy mortality rates in patients with esophageal cancer, with a threshold of 45 esophagectomies per year for a high-volume hospital. This remarkable negative correlation showed the benefit of a better safety in centralization of esophagectomy to a high-volume hospital.
    MeSH term(s) Humans ; Esophagectomy/mortality ; Esophagectomy/adverse effects ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/mortality ; Hospitals, High-Volume/statistics & numerical data ; Hospital Mortality ; Hospitals, Low-Volume/statistics & numerical data ; Postoperative Complications/mortality ; Postoperative Complications/epidemiology
    Language English
    Publishing date 2024-05-01
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Meta-Analysis
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1097/JS9.0000000000001185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Correction: DJ-1 promotes epithelial-to-mesenchymal transition via enhancing FGF9 expression in colorectal cancer.

    Li, Longhao / Zhang, Chundong / Li, Yi / Zhang, Ying / Lei, Yunlong

    Biology open

    2023  Volume 12, Issue 1

    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2632264-X
    ISSN 2046-6390 ; 2046-6390
    ISSN (online) 2046-6390
    ISSN 2046-6390
    DOI 10.1242/bio.059782
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  9. Article ; Online: Optimization and Control for Separation of Ethyl Benzene from C 8 Aromatic Hydrocarbons with Extractive Distillation

    Pan Jincheng / Ding Jiahai / Zhang Chundong / Wan Hui / Guan Guofeng

    Processes, Vol 10, Iss 2237, p

    2022  Volume 2237

    Abstract: Extractive distillation has great significance for the separation of ethylbenzene from C 8 aromatic hydrocarbons. Herein, a distillation process for the separation of ethylbenzene was designed using methyl phenylacetate as an extractant. A genetic ... ...

    Abstract Extractive distillation has great significance for the separation of ethylbenzene from C 8 aromatic hydrocarbons. Herein, a distillation process for the separation of ethylbenzene was designed using methyl phenylacetate as an extractant. A genetic algorithm (GA) was used to evaluate the economic and environmental factors of the process, and Aspen Dynamic was used to assess the dynamic performance. The sequential optimization method was used to obtain the initial process parameters. Then, the total annual cost and CO 2 emissions were minimized by NSGA-III to increase the economic and environmental benefits. To enhance the search performance of GA, the mutation probability and crossover probability were studied and adjusted. The optimal total annual cost and CO 2 emissions were 11.7% and 23.7% lower than those of the initial process. Based on a steady process, two control strategies, which were the flow rate of the recycling solvent controlled by entrainer makeup flow rate (CS1) and the bottom flow rate of the extractant recovery column (CS2), were designed. The results showed that the temperature deviation of CS2 was smaller than that of CS1, and the temperature of the process was more stable under the control of CS2.
    Keywords C 8 aromatic hydrocarbons ; extractive distillation ; genetic algorithm ; TAC ; dynamic simulation ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
    Subject code 660
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Association of hospital volume and long-term survival after esophagectomy: A systematic review and meta-analysis.

    Wang, Qing / Mine, Shinji / Nasu, Motomi / Fukunaga, Tetsu / Nojiri, Shuko / Zhang, Chun-Dong

    Frontiers in surgery

    2023  Volume 10, Page(s) 1161938

    Abstract: Background: It remains controversial whether esophageal cancer patients may benefit from esophagectomy in specialized high-volume hospitals. Here, the effect of hospital volume on overall survival (OS) of esophageal cancer patients post esophagectomy ... ...

    Abstract Background: It remains controversial whether esophageal cancer patients may benefit from esophagectomy in specialized high-volume hospitals. Here, the effect of hospital volume on overall survival (OS) of esophageal cancer patients post esophagectomy was assessed.
    Methods: PubMed, Embase, and Cochrane Library were systematically searched for relevant published articles between January 1990 and May 2022. The primary outcome was OS after esophagectomy in high- vs. low-volume hospitals. Random effect models were applied for all meta-analyses. Subgroup analysis were performed based on volume grouping, sample size, study country, year of publication, follow-up or study quality. Sensitivity analyses were conducted using the leave-one-out method. The Newcastle-Ottawa Scale was used to assess the study quality. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidance, and was registered (identifier: INPLASY202270023).
    Results: A total of twenty-four studies with 113,014 patients were finally included in the meta-analysis. A significant improvement in OS after esophagectomy was observed in high-volume hospitals as compared to that in their low-volume counterparts (HR: 0.77; 95% CI: 0.71-0.84,
    Conclusions: Esophageal cancer should be centralized in high-volume hospitals.
    Language English
    Publishing date 2023-04-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1161938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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