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Article: Fabrication of nanoemulsion delivery system with high bioaccessibility of carotenoids from

Zhang, Chunlan / Li, Bin

2022 Volume 10, Issue 8, Page(s) 2582–2589

Abstract: The interest in incorporating carotenoids into foods and beverages is growing due to their potential health benefits. However, the poor water solubility and low bioavailability of carotenoids are still challenges in food application. This work aimed to ... ...

Abstract	The interest in incorporating carotenoids into foods and beverages is growing due to their potential health benefits. However, the poor water solubility and low bioavailability of carotenoids are still challenges in food application. This work aimed to study the influence of system composition and preparation conditions on the physical properties of carotenoids-loaded nanoemulsions prepared by spontaneous emulsification. Furthermore, the bioaccessibility of carotenoids in the nanoemulsions was evaluated. The nanoemulsions with the smallest droplet size were produced when the ratio of Span 80:Tween 80 was 1.5:8.5. The droplet size increased slightly with the increase of organic phase content (24%-40%). The droplet size decreased gradually with the increase of stirring speed (200-1000 rpm (revolutions per minute)). The ratio of mixed surfactants and surfactant-to-oil ratio (SOR) had an appreciable impact on the droplet size. Carotenoids-loaded nanoemulsions with small mean droplet size (d < 50 nm) could be prepared with the optimized conditions. The initial digestion rate decreased as the SOR increased. The bioaccessibility could reach up to about 80% at SOR=2-5 in vitro digestion. These results have important implications for the design of effective delivery systems to encapsulate carotenoids and other lipophilic bioactive components in food applications.
Language	English
Publishing date	2022-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.2863
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Long non-coding RNA MALAT1 in hematological malignancies and its clinical applications.

Zhang, Chunlan / Qin, Yun / Wu, Yu / Xu, Heng / Shu, Yang

Chinese medical journal

2024 Volume 137, Issue 10, Page(s) 1151–1159

Abstract: Abstract: Metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, ... ...

Abstract	Abstract: Metastasis-associated lung adenocarcinoma transcript 1 ( MALAT1 ) is a well-established oncogenic long non-coding RNA, the higher expression of which is strongly correlated with cancer events such as tumorigenesis, progression, metastasis, drug resistance, and treatment outcome in solid cancers. Recently, a series of studies has highlighted its potential role in hematological malignancies in terms of these events. Similar to solid cancers, MALAT1 can regulate various target genes via sponging and epigenetic mechanisms, but the miRNAs sponged by MALAT1 differ from those identified in solid cancers. In this review, we systematically describe the role and underlying mechanisms of MALAT1 in multiple types of hematological malignancies, including regulation of cell proliferation, metastasis, stress response, and glycolysis. Clinically, MALAT1 expression is related to poor treatment outcome and drug resistance, therefore exhibiting potential prognostic value in multiple myeloma, lymphoma, and leukemia. Finally, we discuss the evaluation of MALAT1 as a novel therapeutic target against cancer in preclinical studies.
MeSH term(s)	RNA, Long Noncoding/genetics ; Humans ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/metabolism ; Cell Proliferation/genetics ; MicroRNAs/genetics
Chemical Substances	MALAT1 long non-coding RNA, human
Language	English
Publishing date	2024-04-01
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000003090
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Article ; Online: The Effect of Acetylation on the Physicochemical Properties of Chickpea Starch

Zhang, Chunlan / Du, Mengyao / Cao, Tiantian / Xu, Wei

Foods. 2023 June 23, v. 12, no. 13

2023

Abstract: The effect of acetylation on the physicochemical properties of chickpea starch was studied. After the chickpea starch was acetylated, the basic properties were measured. When the degree of substitution (DS) was 0.1004 and the temperature was 95 °C, the ... ...

Abstract	The effect of acetylation on the physicochemical properties of chickpea starch was studied. After the chickpea starch was acetylated, the basic properties were measured. When the degree of substitution (DS) was 0.1004 and the temperature was 95 °C, the solubility and swelling power of starch were 19.6% and 21.4 g/g, respectively. The freeze–thaw stability of acetylated starch paste increased with the increase in the degree of substitution. The surface morphology of starch granules changed, but the crystalline morphology did not change, and the C-type crystalline structure was still maintained. There are three new absorption peaks in the infrared spectroscopy of starch, and the -COCH₃ group was introduced. With the increase in DS, the viscosity of esterified chickpea starch decreased gradually. Compared with unmodified chickpea starch, the ability to form gel was poor.
Keywords	absorption ; acetylation ; chickpeas ; crystal structure ; esterification ; freeze-thaw cycles ; gels ; infrared spectroscopy ; solubility ; starch ; temperature ; viscosity
Language	English
Dates of publication	2023-0623
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12132462
Database	NAL-Catalogue (AGRICOLA)

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Article: The Effect of Acetylation on the Physicochemical Properties of Chickpea Starch.

Zhang, Chunlan / Du, Mengyao / Cao, Tiantian / Xu, Wei

Foods (Basel, Switzerland)

2023 Volume 12, Issue 13

Abstract	The effect of acetylation on the physicochemical properties of chickpea starch was studied. After the chickpea starch was acetylated, the basic properties were measured. When the degree of substitution (DS) was 0.1004 and the temperature was 95 °C, the solubility and swelling power of starch were 19.6% and 21.4 g/g, respectively. The freeze-thaw stability of acetylated starch paste increased with the increase in the degree of substitution. The surface morphology of starch granules changed, but the crystalline morphology did not change, and the C-type crystalline structure was still maintained. There are three new absorption peaks in the infrared spectroscopy of starch, and the -COCH
Language	English
Publishing date	2023-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12132462
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Article: Modulation of physicochemical properties of lipid droplets using soy protein isolate and lactoferrin interfacial coatings.

Zhang, Chunlan / Du, Mengyao / Li, Bin

Food science & nutrition

2023 Volume 11, Issue 12, Page(s) 8035–8042

Abstract: In order to improve the physicochemical stability of soy protein isolate (SPI) emulsion, lactoferrin (LF) was used to modify the interface layer. The stable multilayer emulsion can be formed when the content of lactoferrin is 0.5% at pH 5. The emulsion ... ...

Abstract	In order to improve the physicochemical stability of soy protein isolate (SPI) emulsion, lactoferrin (LF) was used to modify the interface layer. The stable multilayer emulsion can be formed when the content of lactoferrin is 0.5% at pH 5. The emulsion with good stability was at pH 3-7, and it was also stable to temperature change. The FFAs release of SPI emulsion and LF-SPI emulsion was 103.9% and 103.7%, respectively. The results showed that the lactoferrin layer did not hinder the digestion of oil and the bioaccessibility of carotenoids, but lactoferrin layer improved the physicochemical stability of SPI emulsions. This work provides information valuable in the design of emulsion formulations for applications in the food, pharmaceutical, and personal care industries.
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3723
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Article ; Online: Comparison of different drug for reducing testosterone levels in women with polycystic ovary syndrome: A systematic review and network meta-analysis.

Hao, Song-Li / Zhang, Chun-Lan / Meng, Xiao-Yu

Medicine

2023 Volume 102, Issue 41, Page(s) e35152

Abstract: Background: The optimal drug for treatment with polycystic ovary syndrome (PCOS) was in debate. We did this network meta-analysis to assess the efficacy and safety of different drugs for reducing testosterone levels in women with PCOS.: Methods: We ... ...

Abstract	Background: The optimal drug for treatment with polycystic ovary syndrome (PCOS) was in debate. We did this network meta-analysis to assess the efficacy and safety of different drugs for reducing testosterone levels in women with PCOS. Methods: We searched studies from inception until January 10, 2023, through PubMed, Embase, and Cochrane Library database. All studies comparing different drugs for reducing testosterone levels in women with polycystic ovary syndrome were included in this network meta-analysis. Outcomes were total testosterone levels, free testosterone levels, and withdraw due to adverse events. We calculated the surface under the cumulative ranking curve (SUCRA) for each treatment. Results: Finally, a total of 13 studies were finally included in this network meta-analysis. In head-to-head comparison, atorvastatin (WMD -3.1, 95% CrI: -3.7 to -2.5), metformin (WMD -2.6, 95% CrI: -3.5 to -1.6), metformin + simvastatin (WMD -2.8, 95% CrI: -4.1 to -1.5), simvastatin (WMD -2.7, 95% CrI: -4.2 to -1.3), spironolactone (WMD -3.1, 95% CrI: -4.3 to -1.9), spironolactone + metformin (WMD -3.2, 95% CrI: -4.5 to -2.0) were all more effective than the placebo, and the difference was statistically significant (P < .05). The SUCRA shows that spironolactone + metformin ranked first (SUCRA, 85.0%), Atorvastatin ranked second (SUCRA, 77.7%), Spironolactone ranked third (SUCRA, 77.2%), and metformin + simvastatin ranked the fourth. The SUCRA of different drugs for free testosterone levels shows that atorvastatin ranked first (SUCRA, 75.0%), spironolactone + metformin ranked second (SUCRA, 5.3%), metformin + simvastain ranked third (SUCRA, 62.6%), and spironolactone ranked the fourth (SUCRA, 56.4%). No statistically significant differences were found between the 2 treatment groups for withdrawn due to adverse events (P > .05). Conclusions: Considering the network meta-analysis and rankings, atorvastatin was recommended to be the optimal drug for treatment PCOS. However, the optimal dose of atorvastatin was unknown and should be verified by more randomized controlled trials.
MeSH term(s)	Humans ; Female ; Spironolactone/therapeutic use ; Atorvastatin/therapeutic use ; Network Meta-Analysis ; Polycystic Ovary Syndrome/drug therapy ; Metformin/therapeutic use ; Simvastatin/therapeutic use ; Testosterone/therapeutic use
Chemical Substances	Spironolactone (27O7W4T232) ; Atorvastatin (A0JWA85V8F) ; Metformin (9100L32L2N) ; Simvastatin (AGG2FN16EV) ; Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-10-13
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035152
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Article: Transcriptome analysis of

Wang, Tiantian / Li, Xiaobin / Zhang, Chunlan / Xu, Jize

Frontiers in microbiology

2023 Volume 14, Page(s) 1131599

Abstract: Green mold caused ... ...

Abstract	Green mold caused by
Language	English
Publishing date	2023-02-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1131599
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Article ; Online: Genome-wide analysis of LOG family genes in castor and RcLOG5 enhances drought, salt, and cold stress tolerance in Arabidopsis thaliana.

Li, Yanxiao / Zhu, Guishuang / Sun, Haonan / Xiang, Dianjun / Zhang, Chunlan / Li, Zhigang / Liu, Peng

Gene

2024 Volume 913, Page(s) 148398

Abstract: The gene encoding the specific phosphohydrolase LONELY GUY (LOG) plays an important role in the activation of cytokinin and the stress response in plant cells. However, the role of LOG genes in castor bean (Ricinus communis) has not been reported. In ... ...

Abstract	The gene encoding the specific phosphohydrolase LONELY GUY (LOG) plays an important role in the activation of cytokinin and the stress response in plant cells. However, the role of LOG genes in castor bean (Ricinus communis) has not been reported. In this study, we identified a total of nine members of the LOG gene family in the castor bean genome and investigated the upregulated expression of the RcLOG5 gene using transcriptome data analysis. We found that the RcLOG5 gene exhibited tissue-specific expression and was activated by polyethylene glycol, NaCl, low temperature, and abscisic acid stress. The subcellular localization results showed that the RcLOG5 gene is mainly located in the cytoplasm. Based on phenotypic and physiological indicators, namely root length, peroxidase activity, and malondialdehyde content, overexpression of the RcLOG5 gene not only improved the drought resistance, salt tolerance, and cold tolerance of transgenic Arabidopsis, but also shortened the dormancy period of the transgenic plants. Transcriptomic sequencing revealed that the overexpression of the RcLOG5 gene led to the enrichment of differentially expressed genes in the glutathione metabolism pathway in transgenic Arabidopsis. Moreover, the overexpression plants had higher levels of glutathione and a higher GSH/GSSG ratio under stress compared to the wild type. Therefore, we inferred that the RcLOG5 gene may be responsible for regulating cell membrane homeostasis by reducing the accumulation of reactive oxygen species through the glutathione pathway. Overall, the overexpression of the RcLOG5 gene positively regulated the stress resistance of transgenic Arabidopsis. This study provides valuable gene resources for breeding stress-tolerant castor bean varieties.
MeSH term(s)	Arabidopsis/metabolism ; Cold-Shock Response/genetics ; Droughts ; Stress, Physiological/genetics ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plant Breeding ; Plants, Genetically Modified/genetics ; Plants, Genetically Modified/metabolism ; Glutathione/genetics
Chemical Substances	Plant Proteins ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2024-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148398
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Article ; Online: MEG3 in hematologic malignancies: from the role of disease biomarker to therapeutic target.

Zhang, Chunlan / Qin, Yun / Tang, Yun / Gu, Mingyu / Li, Zhengyan / Xu, Heng

Pharmacogenetics and genomics

2024

Abstract: Maternally expressed gene 3 (MEG3) is a noncoding RNA that is known as a tumor suppressor in solid cancers. Recently, a line of studies has emphasized its potential role in hematological malignancies in terms of tumorigenesis, metastasis, and drug ... ...

Abstract	Maternally expressed gene 3 (MEG3) is a noncoding RNA that is known as a tumor suppressor in solid cancers. Recently, a line of studies has emphasized its potential role in hematological malignancies in terms of tumorigenesis, metastasis, and drug resistance. Similar to solid cancers, MEG3 can regulate various cancer hallmarks via sponging miRNA, transcriptional, or posttranslational regulation mechanisms, but may regulate different key elements. In contrast with solid cancers, in some subtypes of leukemia, MEG3 has been found to be upregulated and oncogenic. In this review, we systematically describe the role and underlying mechanisms of MEG3 in multiple types of hematological malignancies. Particularly, we highlight the role of MEG3 in drug resistance and as a novel therapeutic target.
Language	English
Publishing date	2024-05-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2175826-8
ISSN	1744-6880 ; 0960-314X ; 1744-6872
ISSN (online)	1744-6880
ISSN	0960-314X ; 1744-6872
DOI	10.1097/FPC.0000000000000534
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Article: Resistance mechanisms of immune checkpoint inhibition in lymphoma: Focusing on the tumor microenvironment.

Zhang, Chunlan / Wang, Leiming / Xu, Caigang / Xu, Heng / Wu, Yu

Frontiers in pharmacology

2023 Volume 14, Page(s) 1079924

Abstract: Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic strategies of multiple types of malignancies including lymphoma. However, efficiency of ICIs varies dramatically among different lymphoma subtypes, and durable response can only be ... ...

Abstract	Immune checkpoint inhibitors (ICIs) have revolutionized the therapeutic strategies of multiple types of malignancies including lymphoma. However, efficiency of ICIs varies dramatically among different lymphoma subtypes, and durable response can only be achieved in a minority of patients, thus requiring unveiling the underlying mechanisms of ICI resistance to optimize the individualized regimens and improve the treatment outcomes. Recently, accumulating evidence has identified potential prognostic factors for ICI therapy, including tumor mutation burden and tumor microenvironment (TME). Given the distinction between solid tumors and hematological malignancies in terms of TME, we here review the clinical updates of ICIs for lymphoma, and focus on the underlying mechanisms for resistance induced by TME, which play important roles in lymphoma and remarkably influence its sensitivity to ICIs. Particularly, we highlight the value of multiple cell populations (e.g., tumor infiltrating lymphocytes, M2 tumor-associated macrophages, and myeloid-derived suppressor cells) and metabolites (e.g., indoleamine 2, 3-dioxygenase and adenosine) in the TME as prognostic biomarkers for ICI response, and also underline additional potential targets in immunotherapy, such as EZH2, LAG-3, TIM-3, adenosine, and PI3Kδ/γ.
Language	English
Publishing date	2023-03-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1079924
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