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  1. Article: A case report of successful therapy for neonatal chylothorax with pneumothorax by conservative medical treatment.

    Zhang, Chunyan / Pang, Yun

    Translational pediatrics

    2023  Volume 12, Issue 3, Page(s) 521–527

    Abstract: Background: Neonatal chylothorax is a rare disease that causes breathing difficulties in newborns and is one of the most common causes of pleural effusion during the neonatal period. Neonatal chylothorax is often caused by lymph leakage into the chest ... ...

    Abstract Background: Neonatal chylothorax is a rare disease that causes breathing difficulties in newborns and is one of the most common causes of pleural effusion during the neonatal period. Neonatal chylothorax is often caused by lymph leakage into the chest and can be divided into the following 5 types: congenital chylothorax, traumatic chylothorax, postoperative chylothorax, embolic chylothorax, and spontaneous chylothorax. Among them, spontaneous chylothorax is the most common type of neonatal chylothorax and has unknown causes. The mortality rate of neonatal chylothorax is relatively high, but there are still no unified management guidelines or expert consensus on its treatment.
    Case description: In this article, we report the case of a child in whom a large amount of pleural effusion on both sides of the thorax was first found 3 days before delivery. During labor, extrauterine intrapartum treatment (EXIT) was administered to complete the pleural effusion puncture and drainage but was complicated by the right pneumothorax. After delivery, the patient was cured and discharged from the hospital, but required high-frequency oscillating respiratory support, continuous chest drainage, and nutritional management.
    Conclusions: The effective control of the pleural effusion suction speed may reduce pneumothorax complications. Infection is the most common complication of neonatal chylothorax. Thus, the multidisciplinary collaborative diagnosis and EXIT may pave a new way for the efficient treatment of neonatal chylothorax. This successful case may serve as a reference for the management of children with congenital chylothorax.
    Language English
    Publishing date 2023-03-27
    Publishing country China
    Document type Case Reports
    ZDB-ID 2901309-4
    ISSN 2224-4344 ; 2224-4344 ; 2224-4336
    ISSN (online) 2224-4344
    ISSN 2224-4344 ; 2224-4336
    DOI 10.21037/tp-23-49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: N6-methyladenosine-induced METTL1 promotes tumor proliferation via CDK4.

    Zhang, Chunyan / Cui, Yuanbo

    Biological chemistry

    2023  Volume 405, Issue 3, Page(s) 217–228

    Abstract: N6-methyladenosine (m6A) and N7-methylguanosine (m7G) modification of RNA represent two major intracellular post-transcriptional regulation modes of gene expression. However, the crosstalk of these two epigenetic modifications in tumorigenesis remain ... ...

    Abstract N6-methyladenosine (m6A) and N7-methylguanosine (m7G) modification of RNA represent two major intracellular post-transcriptional regulation modes of gene expression. However, the crosstalk of these two epigenetic modifications in tumorigenesis remain poorly understood. Here, we show that m6A methyltransferase METTL3-mediated METTL1 promotes cell proliferation of head and neck squamous cell carcinoma (HNSC) through m7G modification of the cell-cycle regulator CDK4. By mining the database GEPIA, METTL1 was shown to be up-regulated in a broad spectrum of human cancers and correlated with patient clinical outcomes, particularly in HNSC. Mechanistically, METTL3 methylates METTL1 mRNA and mediates its elevation in HNSC via m6A. Functionally, over-expression of METTL1 enhances HNSC cell growth and facilitates cell-cycle progress, while METTL1 knockdown represses these biological behaviors. Moreover, METTL1 physically binds to CDK4 transcript and regulates its m7G modification level to stabilize CDK4. Importantly, the inhibitory effects of METTL1 knockdown on the proliferation of HNSC, esophageal cancer (ESCA), stomach adenocarcinoma (STAD), and colon adenocarcinoma (COAD) were significantly mitigated by over-expression of CDK4. Taken together, this study expands the understanding of epigenetic mechanisms involved in tumorigenesis and identifies the METTL1/CDK4 axis as a potential therapeutic target for digestive system tumors.
    MeSH term(s) Humans ; Adenocarcinoma ; Colonic Neoplasms ; Carcinogenesis/genetics ; Cell Proliferation ; Methyltransferases/genetics ; Cyclin-Dependent Kinase 4/genetics
    Chemical Substances METTL3 protein, human (EC 2.1.1.62) ; Methyltransferases (EC 2.1.1.-) ; METTL1 protein, human (EC 2.1.1.-) ; CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22)
    Language English
    Publishing date 2023-09-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1334659-3
    ISSN 1437-4315 ; 1431-6730 ; 1432-0355
    ISSN (online) 1437-4315
    ISSN 1431-6730 ; 1432-0355
    DOI 10.1515/hsz-2023-0260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A sustainable metal-free and additive-free olefination route to

    Cui, Hongyi / Zhang, Chunyan / Ji, Yuqi / Zhang, Guoying

    RSC advances

    2024  Volume 14, Issue 7, Page(s) 4339–4344

    Abstract: A green and sustainable metal-free, additive-free olefination approach is proposed for the facile synthesis of various ... ...

    Abstract A green and sustainable metal-free, additive-free olefination approach is proposed for the facile synthesis of various unsaturated
    Language English
    Publishing date 2024-01-31
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d4ra00189c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Research on the suppression method of sensor impact vibration parasitic effects in surface reflection pressure measurement.

    Wang, Liangquan / Kong, Deren / Zhang, Chunyan

    The Review of scientific instruments

    2024  Volume 95, Issue 1

    Abstract: Ground reflection pressure plays a crucial role in evaluating the destructive power of ammunition explosions. Accurately measuring this pressure is essential for assessing ammunition's destructive capability and guiding ammunition design. In this study, ... ...

    Abstract Ground reflection pressure plays a crucial role in evaluating the destructive power of ammunition explosions. Accurately measuring this pressure is essential for assessing ammunition's destructive capability and guiding ammunition design. In this study, a theoretical analysis of the parasitic effect of shock and vibration was conducted and COMSOL was employed for performing a multi-physics finite element numerical simulation analysis to elucidate the attenuation characteristics of stress waves in commonly used shock- and vibration-resistant materials. Furthermore, a device was designed using aluminum foam and polytetrafluoroethylene to mitigate the parasitic effects on the ground reflection pressure sensor. Experimental testing was conducted to validate the device's effectiveness. The results demonstrated that the device successfully reduced the intensity of stress waves reaching the ground reflection pressure sensor, with a relative attenuation rate of 29.6% in peak stress values. The sensor measurements obtained with the suppression device exhibited smoother curves and higher signal-to-noise ratios, significantly improving the reliability of the measurement results. Our study holds considerable engineering application value in enhancing the accuracy of shock wave pressure measurements in explosive fields.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209865-9
    ISSN 1089-7623 ; 0034-6748
    ISSN (online) 1089-7623
    ISSN 0034-6748
    DOI 10.1063/5.0160576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Expression relationship and significance of NEAT1 and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer disease].

    He, Lijie / Zhang, Chunyan / Wang, Jing

    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

    2024  Volume 56, Issue 2, Page(s) 207–212

    Abstract: Objective: To explore the expression relationship and significance of long chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer disease (AD).: Methods: ... ...

    Abstract Objective: To explore the expression relationship and significance of long chain non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA NEAT1) and miR-27a-3p in serum and cerebrospinal fluid of patients with Alzheimer disease (AD).
    Methods: Sixty-six AD patients received by the department of neurology of our hospital from October 2019 to September 2021 were gathered, according to the clinical dementia rating scale score, they were grouped into mild group (≤1 point,
    Results: The MMSE score [21 (17, 25), 9(7, 11)
    Conclusion: The expression trends of NEAT1 and miR-27a-3p in the serum and cerebrospinal fluid of AD patients are consistent, the level of NEAT1 is increased, and the level of miR-27a-3p is decreased. The levels of the two are negatively correlated, which is related to the degree of Aβ deposition in the brain of AD patients and is involved in the progression of AD.
    MeSH term(s) Humans ; Alzheimer Disease/genetics ; Amyloid Precursor Protein Secretases ; Aspartic Acid Endopeptidases ; Peptide Fragments/cerebrospinal fluid ; RNA, Long Noncoding ; MicroRNAs/genetics
    Chemical Substances Amyloid Precursor Protein Secretases (EC 3.4.-) ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Peptide Fragments ; RNA, Long Noncoding ; MicroRNAs
    Language Chinese
    Publishing date 2024-04-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2452593-5
    ISSN 1671-167X
    ISSN 1671-167X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: De‐noising method of aquatic product image with foreign matters based on improved wavelet transform and bilateral filter

    Zhang, Chunyan / Li, Xinxing

    Journal of Food Process Engineering. 2023 Sept., v. 46, no. 9 p.e14412-

    2023  

    Abstract: Aiming at the strong spot noise caused by the reflection of meat slices in fish image with foreign matters that collected by ordinary camera or Single Lens Reflex (SLR) camera, we proposed an improved wavelet transform and bilateral filtering algorithm ... ...

    Abstract Aiming at the strong spot noise caused by the reflection of meat slices in fish image with foreign matters that collected by ordinary camera or Single Lens Reflex (SLR) camera, we proposed an improved wavelet transform and bilateral filtering algorithm to reduce the noise of image. In this paper, our algorithm absorbed the advantages of wavelet threshold de‐noising algorithm and bilateral filtering algorithm, the wavelet threshold de‐noising algorithm being used for high frequency components and bilateral filtering being used for low frequency components, which not only achieved the effect of eliminating noise and weakening light spot, but also protected the details of the image. In the experiment, in order to verify the effectiveness of the proposed algorithm, we used the traditional bilateral filtering, Gaussian filtering and median filtering algorithms to process 500 salmon fish images which had residual fishbone, respectively. Since the original image itself was a noisy image, it was impossible to evaluate the noise reduction effect by using an algorithm that requires a noiseless image as a reference image, so we used five methods to evaluate the quality of the image processed by each algorithm, which were Blind/Referenceless Image Spatial QUality Evaluator (BRISQE), Cumulative Probability of Blur Detection (CPBD), variance, image entropy, and operation speed. Among them, BRISQE and CPBD could quantitatively reflect the overall quality of the image, the lower the BRISQE score or the higher the CPBD score, the better the quality of the image. Compared with other algorithms, the BRISQE score and CPBD score of the image processed by our algorithm were the best, with the average scores reaching 20.65 and .8421, respectively. Experimental results showed that the improved algorithm in this paper can effectively eliminate this kind of strong spot noise. The processed image has achieved better visual effect in both subjective and objective level.
    Keywords algorithms ; cameras ; entropy ; meat ; probability ; salmon ; variance ; wavelet
    Language English
    Dates of publication 2023-09
    Publishing place John Wiley & Sons, Inc.
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 752358-0
    ISSN 0145-8876
    ISSN 0145-8876
    DOI 10.1111/jfpe.14412
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Can the establishment of national sanitary cities better resist the impact of COVID-19?

    Gan Tianqi / Zhang Chunyan / Shen Renjun / Li Bo

    Frontiers in Public Health, Vol

    2023  Volume 11

    Abstract: The global spread of COVID-19 has led to profound reflection on building a global public health security system. This paper uses the urban data collected during the COVID-19 epidemic in China in 2020 to evaluate the effect of the National Sanitary City ( ... ...

    Abstract The global spread of COVID-19 has led to profound reflection on building a global public health security system. This paper uses the urban data collected during the COVID-19 epidemic in China in 2020 to evaluate the effect of the National Sanitary City (NSC) policy on the prevention and control of that epidemic at different stages. We found that the NSC policy was able to curb the occurrence and transmission of the epidemic the epidemic effectively after controlling a series of factors such as urban characteristics, population mobility and pathogen transmission. Compared with non-NSCs, the NSCs were better able to control the number of infected people and the infection rate and transmission rate, and this performance was even more impressive when the epidemic gradually entered the sporadic distribution stage. The heterogeneity analysis shows that the impact of the NSC policy on the prevention and control of COVID-19 differs according to the economic development level and population size. To a certain extent, the NSC policy has blocked the spread of viruses by continuously improving the urban medical and health system and strengthening the publicity concerning infectious disease prevention and control knowledge.
    Keywords COVID-19 ; National Sanitary City ; public health ; public health management ; urban policy ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: The types of tumor infiltrating lymphocytes are valuable for the diagnosis and prognosis of breast cancer.

    Sun, Ying / Zhang, Chunyan

    Frontiers in genetics

    2022  Volume 13, Page(s) 1019062

    Abstract: This study aimed at constructing a diagnostic immune risk score (dIRS) system and a prognostic immune risk score (pIRS) system for diagnose and prognosis of breast cancer (BC). The gene expression data of BC were downloaded from TCGA dataset (training ... ...

    Abstract This study aimed at constructing a diagnostic immune risk score (dIRS) system and a prognostic immune risk score (pIRS) system for diagnose and prognosis of breast cancer (BC). The gene expression data of BC were downloaded from TCGA dataset (training set), and from GSE65194, GSE29044, GSE42568, and GSE20685 (validation sets). Then, the immune cell type proportions in each dataset were assessed using EPIC tool, and the dIRS system was built based on the SVM-RFE and RF-VIMP algorithms. Subsequently, the pIRS system and the nomogram survival model were established separately using penalized and rms packages. Finally, the differential expressed genes (DEGs) between low and high pIRS groups were screened, and submitted for functional analysis. The dIRS system consisted of B cells, CD8 + T cells, endothelial cells, NK cells, and other cells had high accuracy in distinguishing BC patients from the healthy controls (AUROC >0.7). Subsequently, the pIRS system with the five prognosis-associated immune-infiltrating cell was constructed, and Kaplan-Meier analysis demonstrated that the survival rate of low pIRS group was significantly higher than that of high pIRS group (
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.1019062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Electronic structure modulation of Mo sites in anion and cation co-doped MoO

    Zhang, Chunyan / Wang, Ling / Cao, Zhuwei / Li, Rui / Ye, Sheng

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 20, Page(s) 2744–2747

    Abstract: Herein, we synthesized a type of anion/cation co-doped ... ...

    Abstract Herein, we synthesized a type of anion/cation co-doped MoO
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc06039j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Penehyclidine hydrochloride alleviates LPS-induced inflammatory responses and oxidative stress via ROS/Nrf2/HO-1 activation in RAW264.7 cells.

    Guo, Qiongmei / Zhang, Chunyan / Gao, Jingui / Shi, Wenjing / Liu, Xiaozhi

    Advances in clinical and experimental medicine : official organ Wroclaw Medical University

    2024  

    Abstract: Background: Inflammation is a biological response of the immune system to harmful stimuli. Penehyclidine hydrochloride (PCH) can alleviate inflammation and oxidative stress by activating reactive oxygen species (ROS), nuclear factor erythroid 2-related ... ...

    Abstract Background: Inflammation is a biological response of the immune system to harmful stimuli. Penehyclidine hydrochloride (PCH) can alleviate inflammation and oxidative stress by activating reactive oxygen species (ROS), nuclear factor erythroid 2-related factor (Nrf2) and heme oxygenase 1 (HO-1) in animal models, but there is a lack of cellular evidence.
    Objectives: This study investigated the effects of PHC on lipopolysaccharide (LPS)-induced inflammation response and oxidative stress in RAW264.7 cells.
    Material and methods: RAW264.7 cells were treated with 1 μg/mL or 5 μg/mL of PHC, with interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α), IL-1β, and prostaglandin E2 (PGE2) levels measured with enzyme-linked immunosorbent assay (ELISA) and nitric oxide (NO) measured using the Griess test. Reactive oxygen species were examined with flow cytometry and immunofluorescence, and b-related factor 2 (BRF-2) and NAD(P)H-quinone oxidoreductase 1 (NQO1) using western blot.
    Results: Penehyclidine hydrochloride partly, but substantially, reversed LPS-related NO and PGE2 production by RAW264.7 cells in a dose-dependent manner and suppressed LPS-induced expression of IL-6, TNF-α and IL-1β messenger ribonucleic acid (mRNA), secretion of IL-6, TNF-α and IL-1β, and ROS production. Lipopolysaccharide stimulation did not affect Nrf2, heme oxygenase 1 (HO-1) or NQO1 protein expression in RWA264.7 cells not treated with PHC. However, PHC treatment significantly elevated Nrf2, HO-1 and NQO1 protein in LPS-treated RWA264.7 cells, an effect that was dose-dependent. The ROS scavenging using N-acetyl-L-cysteine abolished the PHC-induced upregulation of Nrf2 and HO-1.
    Conclusions: Penehyclidine hydrochloride may alleviate LPS-induced inflammation and oxidative stress by activating Nrf2 signaling in RAW264.7 macrophages. These findings suggest that PHC could alleviate inflammation by targeting activated macrophages.
    Language English
    Publishing date 2024-03-26
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2270257-X
    ISSN 1899-5276 ; 1230-025X
    ISSN 1899-5276 ; 1230-025X
    DOI 10.17219/acem/183883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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