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Article ; Online: Counteraction of ABI5-mediated inhibition of seed germination and postgerminative growth by RACK1 in Arabidopsis.

Li, Zhiyong / Zhang, Dayan / Liang, Xiaoju / Liang, Jiansheng

2024

Abstract: ABSCISIC ACID (ABA) INSENSITIVE5 (ABI5), the key regulator of abscisic acid (ABA) signaling pathway, plays a fundamental role in seed germination and postgerminative development. However, the detailed molecular mechanism underlying the repression ... ...

Abstract	ABSCISIC ACID (ABA) INSENSITIVE5 (ABI5), the key regulator of abscisic acid (ABA) signaling pathway, plays a fundamental role in seed germination and postgerminative development. However, the detailed molecular mechanism underlying the repression function of ABI5 in these processes remains to be elucidated. In this study, we demonstrate that the conserved eukaryotic WD40 repeat protein RACK1 is a novel negative regulator of ABI5 in Arabidopsis. The RACK1 loss-of-function mutant is hypersensitive to ABA, while this phenotype was rescued by the mutation of ABI5. Moreover, overexpression of RACK1 suppresses ABI5 transcriptional activation activity for ABI5-targeted genes. RACK1 could also physically interact with ABI5 and facilitate its degradation. Furthermore, we found that RACK1 and the two substrate receptors for CUL4-based E3 ligases (DWA1 and DWA2) function together to mediate the turnover of ABI5, thereby efficiently turning down ABA signaling for seed germination and postgerminative growth. On the other hand, a series of molecular analyses demonstrated that ABI5 could bind with the promoter of RACK1 to repress its expression. Collectively, our findings suggest that RACK1 and ABI5 might form a feedback loop to regulate the homeostasis of ABA signaling for acute seed germination and early plant development.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2976-2
ISSN	1460-2431 ; 0022-0957
ISSN (online)	1460-2431
ISSN	0022-0957
DOI	10.1093/jxb/erae153
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Article ; Online: RACK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis.

Fu, Yajuan / Zhu, Wei / Zhou, Yeling / Su, Yujing / Li, Zhiyong / Zhang, Dayan / Zhang, Dong / Shen, Jinyu / Liang, Jiansheng

Journal of integrative plant biology

2024

Abstract: Plants deploy versatile scaffold proteins to intricately modulate complex cell signaling. Among these, RACK1A (Receptors for Activated C Kinase 1A) stands out as a multifaceted scaffold protein functioning as a central integrative hub for diverse ... ...

Abstract	Plants deploy versatile scaffold proteins to intricately modulate complex cell signaling. Among these, RACK1A (Receptors for Activated C Kinase 1A) stands out as a multifaceted scaffold protein functioning as a central integrative hub for diverse signaling pathways. However, the precise mechanisms by which RACK1A orchestrates signal transduction to optimize seedling development remain largely unclear. Here, we demonstrate that RACK1A facilitates hypocotyl elongation by functioning as a flexible platform that connects multiple key components of light signaling pathways. RACK1A interacts with PHYTOCHROME INTERACTING FACTOR (PIF)3, enhances PIF3 binding to the promoter of BBX11 and down-regulates its transcription. Furthermore, RACK1A associates with ELONGATED HYPOCOTYL 5 (HY5) to repress HY5 biochemical activity toward target genes, ultimately contributing to hypocotyl elongation. In darkness, RACK1A is targeted by CONSTITUTIVELY PHOTOMORPHOGENIC (COP)1 upon phosphorylation and subjected to COP1-mediated degradation via the 26 S proteasome system. Our findings provide new insights into how plants utilize scaffold proteins to regulate hypocotyl elongation, ensuring proper skoto- and photo-morphogenic development.
Language	English
Publishing date	2024-04-01
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2130095-1
ISSN	1744-7909 ; 1672-9072
ISSN (online)	1744-7909
ISSN	1672-9072
DOI	10.1111/jipb.13651
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Article ; Online: Primary antibiotic resistance in Helicobacter pylori in China: a systematic review and meta-analysis.

Wang, Yuxiang / Du, Jinran / Zhang, Dayan / Jin, Cong / Chen, Jiangpo / Wang, Zeyuan / Mei, Tonglin / Fu, Kaili / Qian, Qingzeng / Pang, Tieliang

Journal of global antimicrobial resistance

2023 Volume 34, Page(s) 30–38

Abstract: Objectives: The incidence of Helicobacter pylori (HP) is 25-50% in developed countries and 80% in developing countries, including 56.2% in China. However, antibiotic resistance of HP is a threat to HP control. The purpose of this study was to ... ...

Abstract	Objectives: The incidence of Helicobacter pylori (HP) is 25-50% in developed countries and 80% in developing countries, including 56.2% in China. However, antibiotic resistance of HP is a threat to HP control. The purpose of this study was to comprehensively evaluate primary drug resistance of HP in China. Methods: The full text of reports of the primary antibiotic resistance prevalence of HP was obtained from multiple databases (PubMed, Web of Science, Evimed, Cochrane Library, and China National Knowledge Internet). Review Manager 5.2 was adopted for meta-analysis, sensitivity analysis, and bias analysis. The Newcastle-Ottawa Scale was used to assess the article quality. Results: In total, 38804 HP samples from 22 trials were extracted. The results suggested that the overall prevalence of amoxicillin, clarithromycin, metronidazole, and levofloxacin resistance among HP in adults was as follows: mean difference (MD) = 1.35%, 95% confidence interval (CI) [1.03%, 1.68%]; MD = 23.76%, 95% CI [20.23%, 27.3%]; MD = 69.32%, 95% CI [64.85%, 73.8%]; and MD = 29.45%, 95% CI [4.90, 176.96], respectively. From the results of sensitivity and publication bias, we find that these results are robust and had little publication bias. Conclusion: Our research showed that in China, the prevalence of HP resistance to primary antibiotics warrants attention, especially with regard to metronidazole, levofloxacin, and clarithromycin.
MeSH term(s)	Adult ; Humans ; Metronidazole/pharmacology ; Clarithromycin/pharmacology ; Levofloxacin/pharmacology ; Helicobacter pylori/genetics ; Helicobacter Infections/epidemiology ; Helicobacter Infections/drug therapy ; Drug Resistance, Bacterial ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; China/epidemiology
Chemical Substances	Metronidazole (140QMO216E) ; Clarithromycin (H1250JIK0A) ; Levofloxacin (6GNT3Y5LMF) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-06-12
Publishing country	Netherlands
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2023.05.014
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Article ; Online: Corrigendum to "Primary antibiotic resistance in Helicobacter pylori in China: a systematic review and meta-analysis" [Journal of Global Antimicrobial Resistance 34 (2023) 30-38].

Wang, Yuxiang / Du, Jinran / Zhang, Dayan / Jin, Cong / Chen, Jiangpo / Wang, Zeyuan / Mei, Tonglin / Fu, Kaili / Qian, Qingzeng / Pang, Tieliang

Journal of global antimicrobial resistance

2023 Volume 35, Page(s) 354

Language	English
Publishing date	2023-09-22
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2023.09.008
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Article ; Online: Production Inhibition and Excretion Promotion of Urate by Fucoidan from

Zhang, Dayan / Liu, Huazhong / Luo, Ping / Li, Yanqun

Marine drugs

2018 Volume 16, Issue 12

Abstract: This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of ... ...

Abstract	This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of the drugs. Serum uric acid, urea nitrogen, hepatorenal functions, activities of hepatic adenosine deaminase (ADA), xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and NF-κB p65 were assessed. As the serum uric acid, urea nitrogen, creatinine, glutamic oxalacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) data demonstrated, the adenine not only mediated hepatorenal function disorders, but also induced hyperuricemia in mice. Meanwhile, activities of hepatic ADA and XOD were markedly augmented by adenine, and the expression of URAT1 was promoted, which was conducive to the reabsorption of urate. However, exposure to fucoidan completely reversed those adenine-induced negative alternations in mice, and the activities of hepatic ADA and XOD were recovered to the normal level. It was obvious that hepatic and renal functions were protected by fucoidan treatment. The expression of URAT1 was returned to normal, resulting in an increase of renal urate excretion and consequent healing of adenine-induced hyperuricemia in mice. Expression and activation of NF-κB p65 was promoted in kidneys of adenine treated mice, but suppressed in kidneys of mice exposed to fucoidan from
MeSH term(s)	Adenine/toxicity ; Animals ; Blood Urea Nitrogen ; Creatinine/blood ; Creatinine/urine ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Humans ; Hyperuricemia/chemically induced ; Hyperuricemia/drug therapy ; Hyperuricemia/urine ; Kidney/metabolism ; Laminaria/chemistry ; Liver/drug effects ; Liver/metabolism ; Male ; Mice ; Polysaccharides/isolation & purification ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Renal Elimination/drug effects ; Treatment Outcome ; Uric Acid/blood ; Uric Acid/metabolism ; Uric Acid/urine
Chemical Substances	Polysaccharides ; Uric Acid (268B43MJ25) ; fucoidan (9072-19-9) ; Creatinine (AYI8EX34EU) ; Adenine (JAC85A2161)
Language	English
Publishing date	2018-11-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175190-0
ISSN	1660-3397 ; 1660-3397
ISSN (online)	1660-3397
ISSN	1660-3397
DOI	10.3390/md16120472
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Article: Pragmatic Comparison of Piperacillin/Tazobactam versus Carbapenems in Treating Patients with Nosocomial Pneumonia Caused by Extended-Spectrum β-Lactamase-Producing

Zha, Lei / Li, Xiang / Ren, Zhichu / Zhang, Dayan / Zou, Yi / Pan, Lingling / Li, Shirong / Chen, Shanghua / Tefsen, Boris

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 10

Abstract: The effectiveness of piperacillin/tazobactam for managing nosocomial pneumonia caused by extended-spectrum β-lactamase (ESBL)- ... ...

Abstract	The effectiveness of piperacillin/tazobactam for managing nosocomial pneumonia caused by extended-spectrum β-lactamase (ESBL)-producing
Language	English
Publishing date	2022-10-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11101384
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Article: Genome-Wide Analysis of the

Shang, Xiaowen / Han, Zhaolan / Zhang, Dayan / Wang, Ya / Qin, Hao / Zou, Zhongwei / Zhou, Lin / Zhu, Xujun / Fang, Wanping / Ma, Yuanchun

Frontiers in plant science

2022 Volume 13, Page(s) 840350

Abstract: TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors TEOSINTE BRANCHED1/CYCLOIDEA/PCF have been suggested to control the cell growth and proliferation in meristems and lateral organs. A total of ... ...

Abstract	TEOSINTE BRANCHED1/CYCLOIDEA/PCF (TCP) transcription factors TEOSINTE BRANCHED1/CYCLOIDEA/PCF have been suggested to control the cell growth and proliferation in meristems and lateral organs. A total of 37
Language	English
Publishing date	2022-07-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.840350
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Article ; Online: Melatonin improves the removal and the reduction of Cr(VI) and alleviates the chromium toxicity by antioxidative machinery in Rhodobacter sphaeroides

Mao, Hao-Tian / Chen, Lun-Xing / Zhang, Meng-Ying / Shi, Qiu-Yun / Xu, Hong / Zhang, Da-Yan / Zhang, Zhong-Wei / Yuan, Ming / Yuan, Shu / Zhang, Huai-Yu / Su, Yan-Qiu / Chen, Yang-Er

Environmental Pollution. 2023 Feb., v. 319 p.120973-

2023

Abstract: Bioremediation with photosynthetic bacteria (PSB) is thought to be a promising removal method for hexavalent chromium [Cr(VI)]-containing wastewater. In the present study, Rhodobacter sphaeroides (R. sphaeroides) SC01 was used for the investigation of Cr( ...

Abstract	Bioremediation with photosynthetic bacteria (PSB) is thought to be a promising removal method for hexavalent chromium [Cr(VI)]-containing wastewater. In the present study, Rhodobacter sphaeroides (R. sphaeroides) SC01 was used for the investigation of Cr(VI) removal in Cr(VI)-contaminated solution in the presence of melatonin. It was found that exogenous melatonin alleviated oxidative damage to R. sphaeroides SC01, increased Cr (VI) absorption capacity of cell membrane, and improved the reduction efficiency of Cr(VI) via the activation of chromate reductants. The results showed that melatonin could further promote the increase in Cr(VI) removal efficiency, reaching up to 97.8%. Furthermore, melatonin application resulted in 296.9%, 44.4%, and 69.7% upregulation of ascorbic acid (AsA), glutathione (GSH), and cysteine (Cys) relative to non-melatioin treated R. sphaeroides SC01 at 48 h. In addition, the resting cells, cell-free supernatants (CFS), and cell-free extracts (CFE) with melatonin had a higher Cr(VI) removal rate of 18.6%, 82.0%, and 15.2% compared with non-melatonin treated R. sphaeroides SC01. Fourier transform infrared spectroscopy (FTIR) revealed that melatonin increased the binding of Cr(III) with PO4³⁻ and CO groups on cell membrane of R. sphaeroides SC01. X-ray diffractometer (XRD) analysis demonstrated that melatonin remarkably bioprecipitated the production of CrPO₄·6H₂O in R. sphaeroides SC01. Hence, these results indicated that melatonin plays the important role in the reduction and uptake of Cr(VI), demonstrating it is a great promising strategy for the management of Cr(VI) contaminated wastewater in photosynthetic bacteria.
Keywords	Fourier transform infrared spectroscopy ; Rhodobacter sphaeroides ; X-ray diffraction ; absorption ; ascorbic acid ; bioremediation ; cell membranes ; chromates ; chromium ; cysteine ; glutathione ; melatonin ; photosynthesis ; reducing agents ; toxicity ; wastewater ; water pollution ; Removal efficiency ; Bioreduction
Language	English
Dates of publication	2023-02
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.120973
Database	NAL-Catalogue (AGRICOLA)

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Article: A novel 4-1BB/HER2 bispecific antibody shows potent antitumor activities by increasing and activating tumor-infiltrating T cells.

Shen, Aolin / Liu, Wenting / Wang, Huizhen / Zeng, Xiaoli / Wang, Mengli / Zhang, Dayan / Zhao, Qun / Fang, Qing / Wang, Fengrong / Cheng, Liansheng / Shen, Guodong / Li, Yongxiang

American journal of cancer research

2023 Volume 13, Issue 7, Page(s) 3246–3256

Abstract: Resistance to HER2-targeted therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB/CD137 is a promising drug target as a costimulatory molecule of immune cells, no therapeutic drug has been approved in the clinic because of systemic ... ...

Abstract	Resistance to HER2-targeted therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB/CD137 is a promising drug target as a costimulatory molecule of immune cells, no therapeutic drug has been approved in the clinic because of systemic toxicity or limited efficacy. Previously, we developed a humanized anti-HER2 monoclonal antibody (mAb) HuA21 and anti-4-1BB mAb HuB6 with distinct antigen epitopes for cancer therapy. Here, we generated an Fc-muted IgG4 HER2/4-1BB bispecific antibody (BsAb) HK006 by the fusion of HuB6 scFv and HuA21 Fab. HK006 exhibited synergistic antitumor activity by blocking HER2 signal transduction and stimulating the 4-1BB signaling pathway simultaneously and strictly dependent on HER2 expression
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
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Article ; Online: An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity.

Cheng, Lian-Sheng / Zhu, Min / Gao, Yan / Liu, Wen-Ting / Yin, Wu / Zhou, Pengfei / Zhu, Zhongliang / Niu, Liwen / Zeng, Xiaoli / Zhang, Dayan / Fang, Qing / Wang, Fengrong / Zhao, Qun / Zhang, Yan / Shen, Guodong

Cellular & molecular biology letters

2023 Volume 28, Issue 1, Page(s) 47

Abstract: Background: Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has been given clinical approval ... ...

Abstract	Background: Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has been given clinical approval because of severe liver toxicity or limited efficacy. Therefore, a safe and efficient immunostimulatory molecule is urgently needed for cancer immunotherapy. Methods: HK010 was generated by antibody engineering, and the Fab/antigen complex structure was analyzed using crystallography. The affinity and activity of HK010 were detected by multiple in vitro bioassays, including enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance (SPR), flow cytometry, and luciferase-reporter assays. Humanized mice bearing human PD-L1-expressing MC38 (MC38/hPDL1) or CT26 (CT26/hPDL1) tumor transplants were established to assess the in vivo antitumor activity of HK010. The pharmacokinetics (PK) and toxicity of HK010 were evaluated in cynomolgus monkeys. Results: HK010 was generated as an Fc-muted immunoglobulin (Ig)G4 PD-L1x4-1BB bispecific antibody (BsAb) with a distinguished Fab/antigen complex structure, and maintained a high affinity for human PD-L1 (KD: 2.27 nM) and low affinity for human 4-1BB (KD: 493 nM) to achieve potent PD-1/PD-L1 blockade and appropriate 4-1BB agonism. HK010 exhibited synergistic antitumor activity by blocking the PD-1/PD-L1 signaling pathway and stimulating the 4-1BB signaling pathway simultaneously, and being strictly dependent on the PD-L1 receptor in vitro and in vivo. In particular, when the dose was decreased to 0.3 mg/kg, HK010 still showed a strong antitumor effect in a humanized mouse model bearing MC38/hPDL1 tumors. Strikingly, HK010 treatment enhanced antitumor immunity and induced durable antigen-specific immune memory to prevent rechallenged tumor growth by recruiting CD8+ T cells and other lymphocytes into tumor tissue and activating tumor-infiltrating lymphocytes. Moreover, HK010 not only did not induce nonspecific production of proinflammatory cytokines but was also observed to be well tolerated in cynomolgus monkeys in 5 week repeated-dose (5, 15, or 50 mg/kg) and single-dose (75 or 150 mg/kg) toxicity studies. Conclusion: We generated an Fc-muted anti-PD-L1x4-1BB BsAb, HK010, with a distinguished structural interaction with PD-L1 and 4-1BB that exhibits a synergistic antitumor effect by blocking the PD-1/PD-L1 signaling pathway and stimulating the 4-1BB signaling pathway simultaneously. It is strictly dependent on the PD-L1 receptor with no systemic toxicity, which may offer a new option for cancer immunotherapy.
MeSH term(s)	Animals ; Humans ; Mice ; CD8-Positive T-Lymphocytes/metabolism ; Cell Line, Tumor ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Immunotherapy ; Macaca fascicularis ; Programmed Cell Death 1 Receptor ; Antibodies, Bispecific/pharmacology
Chemical Substances	Programmed Cell Death 1 Receptor ; Antibodies, Bispecific
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2108724-6
ISSN	1689-1392 ; 1689-1392
ISSN (online)	1689-1392
ISSN	1689-1392
DOI	10.1186/s11658-023-00461-w
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