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Article ; Online: Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine.

Zhang, Peng / Zhang, Dingfan / Zhou, Wuai / Wang, Lan / Wang, Boyang / Zhang, Tingyu / Li, Shao

2024 Volume 25, Issue 1

Abstract: Network pharmacology (NP) provides a new methodological perspective for understanding traditional medicine from a holistic perspective, giving rise to frontiers such as traditional Chinese medicine network pharmacology (TCM-NP). With the development of ... ...

Abstract	Network pharmacology (NP) provides a new methodological perspective for understanding traditional medicine from a holistic perspective, giving rise to frontiers such as traditional Chinese medicine network pharmacology (TCM-NP). With the development of artificial intelligence (AI) technology, it is key for NP to develop network-based AI methods to reveal the treatment mechanism of complex diseases from massive omics data. In this review, focusing on the TCM-NP, we summarize involved AI methods into three categories: network relationship mining, network target positioning and network target navigating, and present the typical application of TCM-NP in uncovering biological basis and clinical value of Cold/Hot syndromes. Collectively, our review provides researchers with an innovative overview of the methodological progress of NP and its application in TCM from the AI perspective.
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Artificial Intelligence ; Network Pharmacology ; Research Personnel
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbad518
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Article ; Online: Assessing life-cycle GHG emissions of recycled paper products under imported solid waste ban in China: A case study.

Deng, Huijing / Zhang, Dingfan / Yu, Huajun / Man, Yi / Wang, Yutao

The Science of the total environment

2023 Volume 891, Page(s) 164407

Abstract: Changes of raw materials in China's recycled paper industry after the imported solid waste ban affect products' life-cycle greenhouse gas (GHG) emissions as well. This paper presented a case study of newsprint production with prior- and post-ban ... ...

Abstract	Changes of raw materials in China's recycled paper industry after the imported solid waste ban affect products' life-cycle greenhouse gas (GHG) emissions as well. This paper presented a case study of newsprint production with prior- and post-ban scenarios with life cycle assessment, including using imported waste paper (P0) and its three substitutions, i.e., virgin pulp (P1), domestic waste paper (P2), and imported recycled pulp (P3). The function unit is 1 ton of newsprint produced in China, and the study is conducted from cradle to grave which consists pulping and papermaking process, from raw material acquisition to manufacturing, with associated energy production and wastewater treatment, transport, and chemicals production. Our results showed that P1 holds the highest life-cycle GHG emission of 2724.91, followed by 2400.88 from P3. P2 has the lowest emission of 1619.27, only slightly lower than 1742.39 before the ban using route P0 (unit: kgCO
Language	English
Publishing date	2023-05-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164407
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Article ; Online: Assessing life-cycle GHG emissions of recycled paper products under imported solid waste ban in China: A case study

Deng, Huijing / Zhang, Dingfan / Yu, Huajun / Man, Yi / Wang, Yutao

Science of the Total Environment. 2023 Sept., v. 891 p.164407-

2023

Abstract	Changes of raw materials in China's recycled paper industry after the imported solid waste ban affect products' life-cycle greenhouse gas (GHG) emissions as well. This paper presented a case study of newsprint production with prior- and post-ban scenarios with life cycle assessment, including using imported waste paper (P0) and its three substitutions, i.e., virgin pulp (P1), domestic waste paper (P2), and imported recycled pulp (P3). The function unit is 1 ton of newsprint produced in China, and the study is conducted from cradle to grave which consists pulping and papermaking process, from raw material acquisition to manufacturing, with associated energy production and wastewater treatment, transport, and chemicals production. Our results showed that P1 holds the highest life-cycle GHG emission of 2724.91, followed by 2400.88 from P3. P2 has the lowest emission of 1619.27, only slightly lower than 1742.39 before the ban using route P0 (unit: kgCO₂e/ton paper). Scenario analysis showed that current average life-cycle GHG emission for one ton of newsprint is 2049.33 kgCO₂e, increased by 17.62 % due to the ban, while this number could be reduced to 12.22 % or even −0.79 % if switching from P1 to P3 and P2. Our study highlighted the importance of domestic waste paper as a promising way to reduce GHG emissions, which still has great potential to increase if with an enhanced waste paper recycling system in China.
Keywords	case studies ; cradle-to-grave ; energy ; environment ; greenhouse gas emissions ; greenhouse gases ; newsprint ; papermaking ; pulp ; pulp and paper industry ; raw materials ; recycled paper ; solid wastes ; waste paper ; wastewater treatment ; China ; Ban on imported solid waste ; Life cycle assessment ; GHG emission
Language	English
Dates of publication	2023-09
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.164407
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Advancing Sustainability in China's Pulp and Paper Industry Requires Coordinated Raw Material Supply and Waste Paper Management

Dai, Min / Sun, Mingxing / Chen, Bin / Xie, Hongyi / Zhang, Dingfan / Han, Zhixiu / Yang, Lan / Wang, Yutao

Resources, Conservation & Recycling. 2023, p.107162-

2023 , Page(s) 107162–

Abstract: As the largest global producer and consumer of pulp and paper, China faces significant sustainability challenges in fiber supply and waste paper management. A comprehensive material flow analysis of China's pulp and paper industry (CPPI) is needed to ... ...

Abstract	As the largest global producer and consumer of pulp and paper, China faces significant sustainability challenges in fiber supply and waste paper management. A comprehensive material flow analysis of China's pulp and paper industry (CPPI) is needed to understand the interaction between raw material supply and waste paper management. Here, we construct a closed-loop material flow analysis model for CPPI, examine the evolution patterns of material metabolism from 1990 to 2019, and explore the demand for paper production, waste paper recycling, and virgin fiber supply in 2030 and 2050 under multiple scenarios considering critical factors. Results show that the industry has undergone rapid expansion, increased material use efficiency, and a shift towards recycled pulp from 1990 to 2019. China's paper demand will grow to 186 Mt in the next 30 years, resulting in a significant increase in both demands for fibers (175 Mt) and the generation of waste paper (138 Mt). To ensure a sustainable fiber supply for CPPI, domestic waste paper recycling needs to be prioritized. However, attention should also be paid to the availability of virgin pulp supply and proper disposal of organic solid waste. Proper management of these factors is crucial for achieving a circular economy in the industry and reducing its environmental impact. The findings highlight the importance of addressing both raw material supply and waste paper management for CPPI's sustainable development.
Keywords	circular economy ; environmental impact ; material flow analysis ; metabolism ; paper ; papermaking ; pulp ; pulp and paper industry ; raw materials ; solid wastes ; sustainable development ; waste paper ; China
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2023.107162
Database	NAL-Catalogue (AGRICOLA)

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Article: Uncovering the mechanisms of Yi Qi Tong Qiao Pill in the treatment of allergic rhinitis based on Network target analysis.

Wang, Boyang / Zhang, Dingfan / Zhang, Tingyu / Sutcharitchan, Chayanis / Hua, Jianlin / Hua, Dongfang / Zhang, Bo / Li, Shao

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 88

Abstract: Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from ... ...

Abstract	Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods: Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results: Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-γ, TNF-α and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion: A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Trial registration Name of the registry: Chinese Clinical Trial Registry: Trial registration number: ChiCTR-TRC-13,003,137: Date of registration: Registered 29 March 2013 - Retrospectively registered: URL of trial registry record: https://www.chictr.org.cn/showproj.html?proj=6422 .
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00781-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential impacts of Fukushima nuclear wastewater discharge on nutrient supply and greenhouse gas emissions of food systems

Zhang, Dingfan / Chen, Bin / Hubacek, Klaus / Meng, Jing / Sun, Mingxing / Mao, Jiafu / Jin, Mingzhou / Almeida, Cecilia Maria Villas Bôas de / Chiu, Anthony SF / Yang, Lan / Zhang, Linxiu / Ding, Chun / Wang, Yutao

Resources, Conservation & Recycling. 2023 June, v. 193 p.106985-

2023

Abstract: Seafood plays a critical role in promoting a nutritious and climate-friendly food system but faces challenges from marine contamination that pose food safety risks. To address these challenges, we developed a Marine Pollution-induced Food System Risk ... ...

Abstract	Seafood plays a critical role in promoting a nutritious and climate-friendly food system but faces challenges from marine contamination that pose food safety risks. To address these challenges, we developed a Marine Pollution-induced Food System Risk Assessment and Response (MP-FSRAR) model to assess the impact of consumer perceptions of marine pollution risk events on nutrient supply and greenhouse gas (GHG) emissions. Applying this model to the proposed Fukushima Nuclear Wastewater Discharge (FNWD) into the Pacific Ocean, we identified the potential variation in nutrient supply and GHG emissions resulting from changes in Chinese consumers' willingness to consume seafood under 12 scenarios. Our analysis revealed nutrient supply gaps in daily protein, minerals, vitamins, and fatty acids, ranging from 1.5 to 2.7 g/person, 2.5–4.5 mg/person, 5.6–10.3 mcg/person, and 0.08–0.14 g/person, respectively. Closing the protein gap in China would require an additional 3.2–15.8 billion kg yr⁻¹ protein-rich foods, including aquatic, livestock, dairy, and pulses. Additional food supply would increase extra GHG emissions by 1–79 billion kg CO₂e yr⁻¹, resulting in potential GHG emissions being transmitted to other countries through the trade chain. Furthermore, we found that the livestock-based food substitution pathway had 40 times higher GHG emissions than the plant-based one. Our MP-FSRAR model provides global stakeholders with new perspectives on the potential consequences of consumer perceptions of marine pollution risks and offers valuable insights for developing countermeasures to build a more resilient and low-carbon food system.
Keywords	Japan ; food availability ; food safety ; greenhouse gases ; livestock ; marine pollution ; models ; risk ; risk assessment ; seafoods ; stakeholders ; trade ; wastewater ; China ; Pacific Ocean ; Consumer perceptions ; Food security ; Nutrition supply ; GHG emissions
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1498716-8
ISSN	0921-3449
ISSN	0921-3449
DOI	10.1016/j.resconrec.2023.106985
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Network pharmacology on the mechanism of Yi Qi Tong Qiao Pill inhibiting allergic rhinitis

Wang, Boyang / Zhang, DingFan / Zhang, Tingyu / Sutcharitchan, Chayanis / Hua, Jianlin / Hua, Dongfang / Zhang, Bo / Li, Shao

2023

Abstract	Objective: The purpose of this study is to reveal the mechanism of action of Yi Qi Tong Qiao Pill (YQTQP) in the treatment of allergic rhinitis (AR), as well as establish a paradigm for the researches on traditional Chinese medicine (TCM) from systematic perspective. Methods: Based on the data collected from TCM-related and disease-related databases, target profiles of compounds in YQTQP were calculated through network-based algorithms and holistic targets of TQTQP was constructed. Network target analysis was performed to explore the potential mechanisms of YQTQP in the treatment of AR and the mechanisms were classified into different modules according to their biological functions. Besides, animal and clinical experiments were conducted to validate our findings inferred from Network target analysis. Results: Network target analysis showed that YQTQP targeted 12 main pathways or biological processes related to AR, represented by those related to IL-4, IFN-{\gamma}, TNF-{\alpha} and IL-13. These results could be classified into 3 biological modules, including regulation of immune and inflammation, epithelial barrier disorder and cell adhesion. Finally, a series of experiments composed of animal and clinical experiments, proved our findings and confirmed that YQTQP could improve related symptoms of AR, like permeability of nasal mucosa epithelium. Conclusion: A combination of Network target analysis and the experimental validation indicated that YQTQP was effective in the treatment of AR and might provide a new insight on revealing the mechanism of TCM against diseases. Comment: 25 pages, 6 figures
Keywords	Quantitative Biology - Quantitative Methods ; None
Subject code	610
Publishing date	2023-05-06
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Development of a New IFOG-Based 3C Rotational Seismometer.

Cao, Yuwen / Chen, Yanjun / Zhou, Tong / Yang, Chunxia / Zhu, Lanxin / Zhang, Dingfan / Cao, Yujia / Zeng, Weiyi / He, Dong / Li, Zhengbin

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 11

Abstract: For many years, seismological research mainly focuses on translational ground motions due to the lack of appropriate sensors. However, because of the development of devices based on Sagnac effect, measuring rotational waves directly comes available. In ... ...

Abstract	For many years, seismological research mainly focuses on translational ground motions due to the lack of appropriate sensors. However, because of the development of devices based on Sagnac effect, measuring rotational waves directly comes available. In this work, a portable three-component broadband rotational seismometer named RotSensor3C based on open loop interferometric fiber optic gyroscope (IFOG) is designed and demonstrated. Laboratory tests and results are illustrated in detail. The self-noise ranging from 0.005 Hz to 125 Hz is about 1.2×10-7rads-1/Hz, and with the harmonics compensation the scale factor variation over ±250∘/s is lower than 10 ppm (parts per million). The misalignment matrix method is adopted to revise the output rotation rate. In a special near field experiment using the explosive source, the back-azimuths and phase velocity are estimated by the recorded acceleration and rotation rate. All the results prove the practicability of this new rotational sensor.
Language	English
Publishing date	2021-06-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21113899
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Tetrathiafulvalene derivatives as cation sensor: density functional theory investigation of the hyper-Rayleigh scattering first hyperpolarizability

Liu, Chun-Guang / Gao, Ming-Li / Liu, Shuang / Zhang, Ding-Fan

RSC advances. 2015 May 11, v. 5, no. 53

2015

Abstract: The hyper-Rayleigh scattering (HRS) first hyperpolarizability of a series of extended (ex) tetrathiafulvalene (TTF) and TTF derivatives have been theoretically investigated using density functional theory (DFT) with the CAM-B3LYP functional to explore ... ...

Abstract	The hyper-Rayleigh scattering (HRS) first hyperpolarizability of a series of extended (ex) tetrathiafulvalene (TTF) and TTF derivatives have been theoretically investigated using density functional theory (DFT) with the CAM-B3LYP functional to explore their use as potential cation sensor. Among these exTTF and TTF derivatives, a compound containing the redox-active TTF unit and chelating functional group pyridine is a an effective sensor for all five kinds of metal cation (Ni2+, Cu2+, Mg2+, Zn2+, and Cd2+) studied here according to our DFT calculations. Compared with the traditional linear optical detection technology, the nonlinear optical property (HRS first hyperpolarizability) has rarely been considered to detect metal cation. Towards such goals, this compound would be useful to guide the search for potential cation sensor in new directions.
Keywords	cadmium ; cations ; copper ; density functional theory ; magnesium ; metal ions ; moieties ; nickel ; pyridines ; zinc
Language	English
Dates of publication	2015-0511
Size	p. 42311-42321.
Publishing place	The Royal Society of Chemistry
Document type	Article
ISSN	2046-2069
DOI	10.1039/c5ra00554j
Database	NAL-Catalogue (AGRICOLA)

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