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  1. Article ; Online: The high expression of TOP2A and MELK induces the occurrence of psoriasis.

    Zhu, Xinhua / Zhang, Erjia / Qin, Li

    Aging

    2024  Volume 16, Issue 4, Page(s) 3185–3199

    Abstract: Background: Psoriasis is a chronic inflammatory skin disease. However, the influence of the TOP2A and MELK genes on psoriasis remains unclear.: Methods: Psoriasis datasets GSE166388 and GSE181318 were downloaded from the Gene Expression Omnibus (GEO) ...

    Abstract Background: Psoriasis is a chronic inflammatory skin disease. However, the influence of the TOP2A and MELK genes on psoriasis remains unclear.
    Methods: Psoriasis datasets GSE166388 and GSE181318 were downloaded from the Gene Expression Omnibus (GEO) database generated from GPL570 and GPL22120. Differential gene expression (DEGs) was identified. Functional enrichment analysis, gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), and immune infiltration analysis were conducted. The protein-protein interaction (PPI) network was constructed and analyzed. Gene expression heat map was generated. The most relevant diseases associated with core genes were determined through comparison with the Comparative Toxicogenomics Database (CTD) website. TargetScan was used to select miRNAs regulating central DEGs.
    Results: A total of 773 DEGs were identified. According to Gene Ontology (GO) analysis, they were mainly enriched in mitochondrial gene expression, oxidative phosphorylation, mitochondrial envelope, mitochondria and ribosome. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that target cells were mainly enriched in metabolic pathways, proteasome, and oxidative phosphorylation. Seven core genes (TOP2A, NUF2, MELK, ASPM, DLGAP5, CCNA2, DEPDC1B) were obtained. The gene expression heatmap showed high expression of core genes (TOP2A, MELK) in psoriasis samples, while DEPDC1B, CCNA2, DLGAP5, NUF2, ASPM were lowly expressed in psoriasis samples. CTD analysis found that TOP2A and MELK were related to skin neoplasms, skin diseases, psoriasis, erythema, dermatitis, and infections.
    Conclusion: TOP2A and MELK genes are highly expressed in psoriasis, and higher expression of TOP2A and MELK genes is associated with poorer prognosis.
    MeSH term(s) Humans ; Gene Regulatory Networks ; Gene Expression Regulation, Neoplastic ; Protein Interaction Maps/genetics ; Gene Expression Profiling ; Psoriasis/genetics ; Nerve Tissue Proteins/genetics ; Computational Biology ; Protein Serine-Threonine Kinases/genetics ; GTPase-Activating Proteins/genetics
    Chemical Substances Nerve Tissue Proteins ; MELK protein, human (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; DEPDC1B protein, human ; GTPase-Activating Proteins
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Narrow-Band Intense Pulsed Light as Treatment for Erythematotelangiectatic Rosacea: A Retrospective Study.

    Shi, Hualing / Zhang, Erjia / Zhang, Mengli / Lin, Tong

    Journal of drugs in dermatology : JDD

    2023  Volume 22, Issue 11, Page(s) 1095–1098

    Abstract: Background: Erythematotelangiectatic rosacea can be successfully treated using various laser and light-based devices. However, the use of narrow-band intense pulsed light for the treatment of erythematotelangiectatic rosacea has not been investigated in ...

    Abstract Background: Erythematotelangiectatic rosacea can be successfully treated using various laser and light-based devices. However, the use of narrow-band intense pulsed light for the treatment of erythematotelangiectatic rosacea has not been investigated in detail. This retrospective study aimed to analyze the clinical efficacy of narrow-band intense pulsed light (500-600 nm) for the treatment of erythematotelangiectatic rosacea among Chinese individuals.  Methods: Patients with erythematotelangiectatic rosacea who had completed 3 sessions of treatment with narrow-band intense pulsed light and follow-up from July 2016 to December 2018 were retrospectively evaluated. Clinical improvement was assessed by 2 blinded dermatologists based on photographs obtained at each follow-up visit using the clinician erythema assessment scale and 5-grade scale.
    Results: Forty-five patients with erythematotelangiectatic rosacea treated with narrow-band intense pulsed light were included in this study. The effectiveness and excellent rates after 3 treatment sessions were 68.9% and 35.6%, respectively. An average of 2 treatment sessions was required among patients who achieved good or excellent clearance of erythema and telangiectasia. Except for transient erythema and edema, no severe adverse effects were observed.
    Conclusions: Narrow-band intense pulsed light is a safe and effective treatment for erythematotelangiectatic rosacea. Even with a small number of treatment sessions, narrow-band intense pulsed light can deliver a significant therapeutic effect, which may be applicable in clinical practice. J Drugs Dermatol. 2023;22(11):1095-1098     doi:10.36849/JDD.4920.
    MeSH term(s) Humans ; Asian People ; Erythema/diagnosis ; Erythema/therapy ; Retrospective Studies ; Rosacea/diagnosis ; Rosacea/therapy ; Intense Pulsed Light Therapy
    Language English
    Publishing date 2023-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2145090-0
    ISSN 1545-9616
    ISSN 1545-9616
    DOI 10.36849/JDD.4920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5931: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Ultrasound-Guided Superior Laryngeal Nerve Block Facilitates Anesthesia Management in Bariatric Surgery.

    Sun, Jiehao / Zhang, Erjia / Chen, Xiaodan / Gao, Wei

    The Journal of emergency medicine

    2022  Volume 62, Issue 4, Page(s) e85–e87

    Abstract: Background: Patients with obesity usually have a narrow pharyngeal cavity. They are prone to exposure difficulties and intubation failure during endotracheal intubation, and even face mask oxygen supply difficulties and hypoxemia in severe cases. We ... ...

    Abstract Background: Patients with obesity usually have a narrow pharyngeal cavity. They are prone to exposure difficulties and intubation failure during endotracheal intubation, and even face mask oxygen supply difficulties and hypoxemia in severe cases. We described the successful completion of conscious endotracheal intubation with superior laryngeal nerve internal branch block (SLNi) in a patient with pathologic obesity.
    Case report: A 29-year-old, nondiabetic man with severe obesity (weight 211 kg, height 186 cm, and body mass index [BMI] 60.99 kg/m
    MeSH term(s) Adult ; Bariatric Surgery ; Cough ; Humans ; Intubation, Intratracheal ; Laryngeal Masks ; Laryngeal Nerves ; Male ; Nerve Block ; Obesity, Morbid/surgery ; Ultrasonography, Interventional
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2021.12.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1895: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Histological Characteristics of Skin Treated With a Fractionated 1064-nm Nd: YAG Picosecond Laser With Holographic Optics.

    Zhang, Mengli / Guan, Yang / Huang, Yuqing / Zhang, Erjia / Lin, Tong / Wu, Qiuju

    Lasers in surgery and medicine

    2021  Volume 53, Issue 8, Page(s) 1073–1079

    Abstract: Background and objectives: Picosecond lasers (PSL) constitute a significant technological advancement and exert rejuvenating effects upon the skin. This study was conducted to investigate changes in the skin upon treatment with the fractionated 1064-nm ... ...

    Abstract Background and objectives: Picosecond lasers (PSL) constitute a significant technological advancement and exert rejuvenating effects upon the skin. This study was conducted to investigate changes in the skin upon treatment with the fractionated 1064-nm Nd: YAG PSL through in vivo and ex vivo human histological analysis.
    Study design/materials and methods: In vivo back skin specimens were treated with a fractionated 1064-nm PSL at 1.3, 2.1, and 2.9 mJ fluence for two passes, and 2.9 mJ for 10 passes, and then stained with hematoxylin and eosin (H&E). Ex vivo foreskin specimens after circumcision surgery were treated with a PSL at 1.3, 2.1, and 2.9 mJ fluence for two and 10 passes, followed by H&E staining. Ex vivo skin tissue sections treated with a PSL at 2.9 mJ fluence for 10 passes were also immunostained for Melan-A and CD31.
    Results: Intraepidermal vacuoles were observed, along with pigment accumulation and inflammatory cell infiltration in the vacuoles at 24 hours after PSL treatment in the in vivo skin specimens. The vacuoles expanded as the fluence increased. Numerous intraepidermal vacuoles were observed, with dermal hemorrhage and inflammatory cell infiltration upon high-fluence, multi-pass PSL treatment in the in vivo skin specimens. PSL treatment yielded both epidermal and dermal vacuoles in ex vivo skin specimens. Melan-A-positive cells were seen in the cystic wall of vacuoles in the epidermal basal layer, whereas CD31-positive cells were detected in the cystic wall of some dermal vacuoles.
    Conclusions: The fractionated 1064-nm PSL produced epidermal vacuoles and dermal lesions, with histological differences between the in vivo and ex vivo skin specimens. Lasers Surg. Med. © 2021 Wiley Periodicals LLC.
    MeSH term(s) Dermis ; Epidermis ; Humans ; Lasers, Solid-State/therapeutic use ; Male ; Nipples ; Skin
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604493-1
    ISSN 1096-9101 ; 0196-8092
    ISSN (online) 1096-9101
    ISSN 0196-8092
    DOI 10.1002/lsm.23389
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    Zs.A 1603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: LDC7559 Exerts Neuroprotective Effects by Inhibiting GSDMD-Dependent Pyroptosis of Microglia in Mice with Traumatic Brain Injury.

    Yu, Enxing / Zhang, Erjia / Lv, Xinhuang / Yan, Lin / Lin, Zhongxiao / Siaw-Debrah, Felix / Zhang, Ying / Yang, Su / Ruan, Linhui / ZhuGe, Qichuan / Ni, Haoqi

    Journal of neurotrauma

    2022  Volume 40, Issue 7-8, Page(s) 742–757

    Abstract: ... ...

    Abstract Abstract
    MeSH term(s) Mice ; Animals ; Microglia/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/pharmacology ; Neuroprotective Agents/pharmacology ; Pyroptosis ; Inflammation/metabolism ; Brain Injuries, Traumatic/metabolism ; Brain Injuries/metabolism
    Chemical Substances Intracellular Signaling Peptides and Proteins ; Neuroprotective Agents
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2021.0318
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    Zs.A 2016: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Development and validation of two artificial intelligence models for diagnosing benign, pigmented facial skin lesions.

    Yang, Yin / Ge, Yiping / Guo, Lifang / Wu, Qiuju / Peng, Lin / Zhang, Erjia / Xie, Junxiang / Li, Yong / Lin, Tong

    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

    2020  Volume 27, Issue 1, Page(s) 74–79

    Abstract: Objective: This study used deep learning for diagnosing common, benign hyperpigmentation.: Method: In this study, two convolutional neural networks were used to identify six pigmentary diseases, and a disease diagnosis model was established. Because ... ...

    Abstract Objective: This study used deep learning for diagnosing common, benign hyperpigmentation.
    Method: In this study, two convolutional neural networks were used to identify six pigmentary diseases, and a disease diagnosis model was established. Because the distribution of lesions in the original training picture is very complex, we cropped the image around the lesions, trained the network on the extracted lesion images, and fused the verification results of the overall picture and the extracted picture to assess the model performance in identifying hyperpigmented dermatitis pictures. Finally, we evaluated the image recognition performance of the two convolutional neural networks and the converged networks in the test set through a comparison of the converged network and the physicians' assessments.
    Results: The AUC of DenseNet-96 for the overall picture was 0.98, whereas the AUC of ResNet-152 was 0.96; therefore, we concluded that DenseNet-96 performed better than ResNet-152. From the AUC, the converged network has the best performance. The converged network model achieved a comprehensive classification performance comparable to that of the doctors.
    Conclusions: The diagnostic model for benign, pigmented skin lesions based on convolutional neural networks had a slightly higher overall performance than the skin specialists.
    MeSH term(s) Artificial Intelligence ; Deep Learning ; Humans ; Neural Networks, Computer ; Skin ; Skin Diseases
    Language English
    Publishing date 2020-08-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1229160-2
    ISSN 1600-0846 ; 0909-752X ; 1397-1344
    ISSN (online) 1600-0846
    ISSN 0909-752X ; 1397-1344
    DOI 10.1111/srt.12911
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    Zs.A 4278: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

    Shi, Hao-Ze / Xiong, Jing-Shu / Gan, Lu / Zhang, Ying / Zhang, Cong-Cong / Kong, Ying-Qi / Miao, Qiu-Ju / Tian, Cui-Cui / Li, Rong / Liu, Jin-Quan / Zhang, Er-Jia / Bu, Wen-Bo / Wang, Yan / Cheng, Xian-Feng / Sun, Jian-Fang / Chen, Hao

    Clinical and translational medicine

    2022  Volume 12, Issue 11, Page(s) e1075

    Abstract: Background: A number of studies have demonstrated that N6-methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma. However, the ... ...

    Abstract Background: A number of studies have demonstrated that N6-methyladenosine (m6A) plays a vital role in the pathological process of various tumours. Recently, it was found that m6A writers or erasers affect the tumourigenesis of melanoma. However, the relationship between m6A readers such as YTH domain family (YTHDF) proteins and melanoma was still elusive.
    Methods: RT-qPCR, Western blot and immunohistochemistry were conducted to measure the expression level of YTH N6-methyladenosine RNA binding protein 3 (YTHDF3) and lysyl oxidase-like 3 (LOXL3) in melanoma tissues and cells. The effects of YTHDF3 and LOXL3 on melanoma were verified in vitro and in vivo. Multi-omics analysis including RNA-seq, MeRIP-seq, RIP-seq and mass spectrometry analyses was performed to identify the target. The interaction between YTHDF3 and LOXL3 was verified by RT-PCR, Western blot, MeRIP-qPCR, RIP-qPCR and CRISPR-Cas13b-based epitranscriptome engineering.
    Results: In this study, we found that m6A reader YTHDF3 could affect the metastasis of melanoma both in vitro and in vivo. The downstream targets of YTHDF3, such as LOXL3, phosphodiesterase 3A (PDE3A) and chromodomain helicase DNA-binding protein 7 (CHD7) were identified by means of RNA-seq, MeRIP-seq, RIP-seq and mass spectrometry analyses. Besides, RT-qPCR, Western blot, RIP-qPCR and MeRIP-qPCR were performed for subsequent validation. Among various targets of YTHDF3, LOXL3 was found to be the optimal target of YTHDF3. With the application of CRISPR-Cas13b-based epitranscriptome engineering, we further confirmed that the transcript of LOXL3 was captured and regulated by YTHDF3 via m6A binding sites. YTHDF3 augmented the protein expression of LOXL3 without affecting its mRNA level via the enrichment of eukaryotic translation initiation factor 3 subunit A (eIF3A) on the transcript of LOXL3. LOXL3 downregulation inhibited the metastatic ability of melanoma cells, and overexpression of LOXL3 ameliorated the inhibition of melanoma metastasis caused by YTHDF3 downregulation.
    Conclusions: The YTHDF3-LOXL3 axis could serve as a promising target to be interfered with to inhibit the metastasis of melanoma.
    MeSH term(s) Humans ; RNA-Binding Proteins/genetics ; Adenosine/metabolism ; Melanoma/genetics ; RNA, Messenger/genetics ; Amino Acid Oxidoreductases/metabolism
    Chemical Substances RNA-Binding Proteins ; Adenosine (K72T3FS567) ; RNA, Messenger ; LOXL3 protein, human (EC 1.4.3.-) ; Amino Acid Oxidoreductases (EC 1.4.-)
    Language English
    Publishing date 2022-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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