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Article: [Exosomes derived from miR-133a-3p engineered mesenchymal stem cells promote myocardial repair in rats after acute myocardial infarction].

Sun, L / Zhu, W W / Zhang, J / Zhao, P C / Zhu, Y Q / Zhang, F X

2023 Volume 52, Issue 1, Page(s) 72–78

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Rats ; Humans ; Animals ; Exosomes/metabolism ; Stroke Volume ; Rats, Sprague-Dawley ; MicroRNAs/genetics ; Ventricular Function, Left ; Myocardial Infarction/genetics ; Cardiomyopathies/metabolism ; Fibrosis ; Mesenchymal Stem Cells/metabolism ; Apoptosis
Chemical Substances	MicroRNAs
Language	Chinese
Publishing date	2023-05-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20231008-00243
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Article ; Online: Variations in aggregate-associated organic carbon and polyester microfibers resulting from polyester microfibers addition in a clayey soil.

Zhang, G S / Zhang, F X

Environmental pollution (Barking, Essex : 1987)

2019 Volume 258, Page(s) 113716

Abstract: Organic carbon is an essential element for sustainable soil management. While the effects of microplastics on soil physical and biological properties are presenting, it remains unclear whether the organic carbon dynamics of soil are altered by increased ... ...

Abstract	Organic carbon is an essential element for sustainable soil management. While the effects of microplastics on soil physical and biological properties are presenting, it remains unclear whether the organic carbon dynamics of soil are altered by increased microplastic accumulation. The objectives of this study were to evaluate the influences of different polyester microfiber (PMF 0, 0.1% and 0.3% of soil dry weight) and organic material (OM 0, 1%, 2% and 3% of soil dry weight) addition levels on soil organic carbon and to determine the PMF distribution in aggregates from a pot experiment. After 75 days of incubation under 6 wet-dry cycles, the concentrations of soil total organic carbon did not differ significantly between the PMF (9.7 ± 6.6 g kg
MeSH term(s)	Carbon/analysis ; Clay ; Plastics/analysis ; Polyesters/analysis ; Soil/chemistry
Chemical Substances	Plastics ; Polyesters ; Soil ; Carbon (7440-44-0) ; Clay (T1FAD4SS2M)
Language	English
Publishing date	2019-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2019.113716
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Article: Variations in aggregate-associated organic carbon and polyester microfibers resulting from polyester microfibers addition in a clayey soil

Zhang, G.S / Zhang, F.X

Environmental pollution. 2020 Mar., v. 258

2020

Abstract	Organic carbon is an essential element for sustainable soil management. While the effects of microplastics on soil physical and biological properties are presenting, it remains unclear whether the organic carbon dynamics of soil are altered by increased microplastic accumulation. The objectives of this study were to evaluate the influences of different polyester microfiber (PMF 0, 0.1% and 0.3% of soil dry weight) and organic material (OM 0, 1%, 2% and 3% of soil dry weight) addition levels on soil organic carbon and to determine the PMF distribution in aggregates from a pot experiment. After 75 days of incubation under 6 wet-dry cycles, the concentrations of soil total organic carbon did not differ significantly between the PMF (9.7 ± 6.6 g kg−1) and control (9.7 ± 6.9 g kg−1) treatments. However, PMF addition significantly reduced the organic carbon concentration in the large (>2 mm) macro-aggregates compared to the control treatment (10.6 ± 4.8 g kg−1 vs. 11.7 ± 4.4 g kg−1), but the results were opposite in the small (2–0.25 mm)macro-aggregates (10.2 ± 4.9 g kg−1 vs. 8.4 ± 3.8 g kg−1). In this study, less than 30% of added PMFs were incorporated into soil aggregates. In addition, the abundance and average length of aggregate-associated PMF in the large (2210 ± 180 particles per g aggregate and 2.08 ± 0.17 mm) and small (1820 ± 150 particles per g aggregate and 1.68 ± 0.11 mm) macro-aggregates were significantly greater than those in the micro-aggregates (1010 ± 70 particles per g aggregate and 0.72 ± 0.05 mm). Our results demonstrate that the distribution of organic carbon in soil macro-aggregates is affected by PMFs addition. Thus, we propose that the behavior of microplastics inside soil aggregates should be further explored to clarify their effects on the physical protection of soil organic carbon.
Keywords	clay soils ; microplastics ; polyesters ; soil aggregates ; soil management ; soil organic carbon ; total organic carbon ; wet-dry cycles
Language	English
Dates of publication	2020-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2019.113716
Database	NAL-Catalogue (AGRICOLA)

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Article: [Validation of the Caprini risk assessment model for venous thromboembolism in Chinese hospitalized patients in a general hospital].

Luo, X Y / Zhang, F X

Zhonghua yi xue za zhi

2017 Volume 97, Issue 24, Page(s) 1875–1877

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Beijing ; Hospitals, General ; Humans ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Venous Thromboembolism/epidemiology
Language	Chinese
Publishing date	2017-06-27
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.issn.0376-2491.2017.24.007
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Article: [Comparison of three dimensional CT venography and ascending phlebography based on propensity score matching in the evaluation of recurrent varicose veins].

Huang, Y P / Wang, Z N / Jing, Z X / Li, X T / Zhang, H / Niu, L Y / Zhang, F X / Luo, X Y

Zhonghua wai ke za zhi [Chinese journal of surgery

2023 Volume 61, Issue 12, Page(s) 1065–1073

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Female ; Humans ; Phlebography/methods ; Retrospective Studies ; Propensity Score ; Quality of Life ; Varicose Veins/diagnostic imaging ; Varicose Veins/surgery ; Tomography, X-Ray Computed/methods ; Venous Insufficiency/diagnosis
Language	Chinese
Publishing date	2023-11-06
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604573-x
ISSN	0529-5815
ISSN	0529-5815
DOI	10.3760/cma.j.cn112139-20230917-00128
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Zs.B 2469: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 218: Show issues

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Article ; Online: Effects of polyester microfibers on soil physical properties: Perception from a field and a pot experiment.

Zhang, G S / Zhang, F X / Li, X T

The Science of the total environment

2019 Volume 670, Page(s) 1–7

Abstract: Understanding soil physical properties is essential for soil quality management and sustainable land use. With the growing accumulation of microplastics in soils, a better understanding of the impact of microplastics on soil physical properties is ... ...

Abstract	Understanding soil physical properties is essential for soil quality management and sustainable land use. With the growing accumulation of microplastics in soils, a better understanding of the impact of microplastics on soil physical properties is crucial to conserve and manage soil quality. This study explored the effects of polyester microfiber (PMF) concentrations (0, 0.1% and 0.3%) on bulk density, porosity, aggregation and hydraulic conductivity of a clayey soil from a field experiment (1 year) and a pot experiment (6 wet-dry cycles). Polyester microfibers significantly increased the volume of >30 μm pores and reduced the volume of <30 μm pores compared to the control treatment. However, there were no detectable changes in the soil bulk density and saturated hydraulic conductivity between the PMF treatments and the control treatment. Interestingly, we observed that polyester microfibers significantly increased the contents of water stable large macroaggregates (>2 mm) in the 0.3% PMF (44%) and 0.1% PMF (39%) treatments compared to the control treatment (31%) in the pot experiment, but this was not true in the field experiment. The efficient interaction between polyester microfibers and fine soil particles and the frequent wet-dry cycles enhanced the formation and stability of macro-aggregates induced by polyester microfibers in the pot experiment. Overall, our results provide valuable evidence for microplastic influences on soil physical properties. Because microplastics are long-term anthropogenic contaminants, it is necessary to further study the impacts of microplastics on soil quality for terrestrial ecosystem sustainability.
Language	English
Publishing date	2019-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2019.03.149
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Zs.A 949: Show issues

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Article ; Online: Neuroprotective effect of DUSP14 overexpression against isoflurane-induced inflammatory response, pyroptosis and cognitive impairment in aged rats through inhibiting the NLRP3 inflammasome.

Que, Y-Y / Zhu, T / Zhang, F-X / Peng, J

European review for medical and pharmacological sciences

2020 Volume 24, Issue 12, Page(s) 7101–7113

Abstract: Objective: Postoperative cognitive dysfunction (POCD) is a common complication after general anesthesia in the elderly people. Dual-specificity phosphatase 14 (DUSP14, also known as MKP6) has been implicated in the pathogenesis of various inflammatory ... ...

Abstract	Objective: Postoperative cognitive dysfunction (POCD) is a common complication after general anesthesia in the elderly people. Dual-specificity phosphatase 14 (DUSP14, also known as MKP6) has been implicated in the pathogenesis of various inflammatory diseases. However, the exact role and mechanism of DUSP14 in POCD remains unclear. Materials and methods: An isoflurane exposure induced POCD aged rat model was successfully constructed. The pathological changes of hippocampal tissues of aged rats were detected by Nissl staining. Evaluation of learning and memory abilities in aged rats was measured using Morris water maze task test. The DUSP14 level was detected by immunohistochemistry (IHC) assay, quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) and Western blot, respectively. Levels of brain injury markers [S-100β and neuron specific enolase (NSE)] and inflammatory cytokines [interleukin (IL)-1β (tumor necrosis factor (TNF)-α and IL-6] were detected using Enzyme Linked Immunosorbent Assay (ELISA) or qRT-PCR. The apoptosis of hippocampal nerve cells was assessed by Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. Western blot assay was used to measure the expression of proteins related to apoptosis, pyroptosis and NOD-like receptor family pyrin domain-containing 3 (NLRP3)-Caspase-1 pathway. Results: Isoflurane exposure led to brain injury, inflammatory response, cognitive dysfunction in aged rats and decreased the expression of DUSP14. Overexpression of DUSP14 could inhibit apoptosis, inflammation, pyroptosis, brain tissue damage, and improve cognitive dysfunction of aged rats after isoflurane anesthesia. Further mechanism studies revealed that DUSP14 may play a neuroprotective effect on POCD by regulating NLRP3 inflammasome-mediated pyroptosis. Conclusions: DUSP14 may effectively protect against isoflurane-induced neuro-inflammation, brain damage and cognitive dysfunction, indicating that DUSP14 may be a potential predictor and therapeutic target for POCD.
MeSH term(s)	Aging ; Animals ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Cognitive Dysfunction/pathology ; Dual-Specificity Phosphatases/genetics ; Dual-Specificity Phosphatases/metabolism ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Isoflurane/antagonists & inhibitors ; Isoflurane/pharmacology ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Neuroprotective Agents/metabolism ; Neuroprotective Agents/pharmacology ; Pyroptosis/drug effects ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Neuroprotective Agents ; Nlrp3 protein, rat ; Isoflurane (CYS9AKD70P) ; Dual-Specificity Phosphatases (EC 3.1.3.48)
Language	English
Publishing date	2020-08-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202006_21704
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Zs.A 1887: Show issues

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Article: [Genetic screening for a pedigree of familial hypercholesterolemia].

Zhu, F / Zhong, Y C / Wang, C / Zhang, F X / Wang, M / Dong, S L / Wang, X / Cheng, X

Zhonghua xin xue guan bing za zhi

2022 Volume 50, Issue 2, Page(s) 185–188

MeSH term(s)	Genetic Testing ; Humans ; Hyperlipoproteinemia Type II/diagnosis ; Hyperlipoproteinemia Type II/genetics ; Pedigree ; Receptors, LDL/genetics
Chemical Substances	Receptors, LDL
Language	Chinese
Publishing date	2022-02-16
Publishing country	China
Document type	Journal Article
ZDB-ID	603425-1
ISSN	0253-3758
ISSN	0253-3758
DOI	10.3760/cma.j.cn112148-20210315-00225
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Article: [Recommendations for diagnosis and treatment of psoriatic arthritis in China].

Su, Y / Wang, C H / Gao, J F / Zhang, F X / Lin, J Y / Zhang, L Y / Zhao, Yan

Zhonghua nei ke za zhi

2022 Volume 61, Issue 8, Page(s) 883–892

Abstract: Psoriatic arthritis is a chronic systemic autoimmune disease, characterized by psoriasis skin lesions and inflammation of the spine and joint. It has complicated clinical manifestations and individual variations. Nearly half of the patients will have ... ...

Abstract	Psoriatic arthritis is a chronic systemic autoimmune disease, characterized by psoriasis skin lesions and inflammation of the spine and joint. It has complicated clinical manifestations and individual variations. Nearly half of the patients will have joints erosion in two years, which is crippling. The severity of the skin and joint disease frequently do not correlate with each other. Currently, the understanding of the disease is insufficient in China with the lack of standardized diagnosis and treatment. Therefore, researchers from the Chinese Rheumatology Association formulated this specification based on the diagnosis and management experience together with guidelines at home and abroad. The specification summarizes the present situation of domestic diagnosis and treatment, aiming to standardize the diagnosis process and treatment protocols of psoriatic arthritis. Furthermore, it can reduce misdiagnosis and missed diagnosis, as well as improve the prognosis.
MeSH term(s)	Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/therapy ; China ; Humans ; Prognosis ; Psoriasis/diagnosis ; Rheumatology ; Skin
Language	Chinese
Publishing date	2022-08-03
Publishing country	China
Document type	Journal Article
ZDB-ID	754223-9
ISSN	0578-1426
ISSN	0578-1426
DOI	10.3760/cma.j.cn112138-20220103-00003
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Article ; Online: CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form.

Yang, C-Y / Zhang, F-X / He, J-N / Wang, S-Q

European review for medical and pharmacological sciences

2019 Volume 23, Issue 16, Page(s) 6962–6970

Abstract: Objective: This study was designed to investigate the expression level of circRNA_100876 in breast cancer (BC) tissues or cells, and to further explore whether it can promote cell metastasis and proliferative capacity via targeting microRNA- 361-3 p.: ...

Abstract	Objective: This study was designed to investigate the expression level of circRNA_100876 in breast cancer (BC) tissues or cells, and to further explore whether it can promote cell metastasis and proliferative capacity via targeting microRNA- 361-3 p. Patients and methods: Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was performed to examine the expression of circRNA_100876 in 50 pairs of BC tissue specimens and corresponding adjacent ones, and the correlation between circRNA_100876 expression and prognosis of patients with BC was analyzed. Meanwhile, qRT-PCR was further performed to verify circRNA_100876 level in BC cell lines. In addition, circRNA_100876 knockdown model was constructed using lentivirus and transfected in BC cells. Subsequently, the impact of circRNA_100876 on BC cell function was analyzed using Cell Counting Kit-8 (CCK-8), transwell and clone formation assays. The interplay between circRNA_100876 and microRNA- 361-3 p was verified using the Luciferase reporter gene assay and cell reverse experiment. Results: QRT-PCR results showed that circRNA_100876 level in BC tissues was conspicuously higher than that in the adjacent tissues, and the patients with distant metastasis had higher expression than those without. Moreover, patients with a high expression of circRNA_100876 had a relatively lower overall survival rate. Compared with the NC group, the cell proliferation and invasion ability of circRNA_100876 knockdown group was conspicuously decreased. QRT-PCR revealed that microRNA-361-3p and circRNA_100876 showed a negative correlation in the expression level of genes in BC tissues. In addition, the results of the Luciferase reporter gene assay confirmed that circRNA_100876 can be targeted by microRNA-361-3p through their binding site. Conclusions: High expression of circRNA_100876 is conspicuously positively relevant to poor prognosis of BC patients. Additionally, circRNA_100876 is able to promote BC metastasis as well as proliferative capacity by modulating microRNA-361-3p expression.
MeSH term(s)	Adsorption ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line ; Cell Proliferation/genetics ; Female ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism
Chemical Substances	MIRN361 microRNA, human ; MicroRNAs ; RNA, Circular
Language	English
Publishing date	2019-09-05
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_201908_18736
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