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  1. AU="Zhang, Fuhe"
  2. AU=Ensenauer Regina E
  3. AU=Finkelstein F O
  4. AU="Dolla, Chandra Kumar"
  5. AU=Grassmann Ralph AU=Grassmann Ralph
  6. AU="Kofi Adu-Boahen"
  7. AU="Christoph Kicker"
  8. AU="Daniella, J."
  9. AU="Wimperis, J"
  10. AU="Usán, Pablo"
  11. AU="Khan, Wasif A"
  12. AU="Kamei, Kaeko"
  13. AU="Sakamoto, Kyouichi"
  14. AU="Zhao, Bingqing"
  15. AU="Edwards, Margaret Sanchez" AU="Edwards, Margaret Sanchez"
  16. AU=Cozar J M
  17. AU="Hang-Lo Lee"
  18. AU="Pitner, Mary Kathryn"
  19. AU="Riemenschneider, Christina"
  20. AU="Diana Farah"
  21. AU="Laniyati Hamijoyo"
  22. AU=Fiedler S
  23. AU="Grzegorz Zaguła"
  24. AU="Ong, Pio"
  25. AU="Fefelova, Elena A"
  26. AU=Hamid Husnain
  27. AU=Joske David J L

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  1. Artikel ; Online: Transcriptomic analysis of mechanism of melanoma cell death induced by photothermal therapy.

    Yan, Guorong / Shi, Lei / Zhang, Fuhe / Luo, Min / Zhang, Guolong / Liu, Pei / Liu, Kaili / Chen, Wei R / Wang, Xiuli

    Journal of biophotonics

    2021  Band 14, Heft 8, Seite(n) e202100034

    Abstract: Melanoma is a malignancy with poor prognosis. Its incidence rate has been on the rise and it poses high health and economic challenges to different populations. Photothermal therapy (PTT) served as an effective local therapy in treating various tumors, ... ...

    Abstract Melanoma is a malignancy with poor prognosis. Its incidence rate has been on the rise and it poses high health and economic challenges to different populations. Photothermal therapy (PTT) served as an effective local therapy in treating various tumors, particularly cutaneous carcinoma like melanoma. To fully understand the mechanisms of tumor cell death induced by PTT, we investigated gene expression and immune cells compositions of B16-F10 tumors after PTT treatment. A total of 256 differentially expressed genes (DEGs) were identified, with 215 being downregulated and 41 upregulated by PTT. Functional annotation showed that most DEGs involved in immune response and inflammatory response. Immune cells compositions inference revealed changes in many immune cells including regulatory T cells, M2 macrophage and B cells after PTT treatment. Our results help delineate the mechanism of cell death at the transcriptional level triggered by non-invasive PTT treatment of melanoma without exogenous light absorbing agents.
    Mesh-Begriff(e) Cell Death ; Cell Line, Tumor ; Humans ; Melanoma/genetics ; Melanoma/therapy ; Phototherapy ; Photothermal Therapy ; Skin Neoplasms/genetics ; Skin Neoplasms/therapy ; Transcriptome
    Sprache Englisch
    Erscheinungsdatum 2021-05-26
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.202100034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: A novel cosmetic and clinically practicable laser immunotherapy for facial verruca plana: Intense pulsed light combined with BCG-PSN.

    Zhang, Fuhe / Shi, Lei / Liu, Pei / Zhang, Linglin / Wu, Qianqian / Wang, Bo / Zhang, Guolong / Wang, Peiru / Zhou, Feifan / Chen, Wei R / Wang, Xiuli

    Photodiagnosis and photodynamic therapy

    2018  Band 22, Seite(n) 86–90

    Abstract: Background: There is no standard method to remove facial verruca plana and achieve better cosmetic effects. The present study is the first study to use intense pulsed light (IPL) as photothermal therapy (PTT) combined with intra-gluteal injection of ... ...

    Abstract Background: There is no standard method to remove facial verruca plana and achieve better cosmetic effects. The present study is the first study to use intense pulsed light (IPL) as photothermal therapy (PTT) combined with intra-gluteal injection of bacillus calmette-guerin polysaccharide nucleic acid (BCG-PSN), which function as immunotherapy, contracting a new type of clinically available laser immunotherapy (LIT) for the treatment of facial verruca plana. The aim of this study was to evaluate the efficacy, cosmetic outcome, and adverse reactions of IPL combined with BCG-PSN for facial verruca plana.
    Methods: Twenty-three patients with facial verruca plana were treated with IPL (560-nm filter, 15-17 J/cm
    Results: A complete and excellent response was noted in 17 patients (74%). Of the 676 treated warts, 548 were eradicated and the overall clearance rate was 81%. No patient relapsed during the 20-week follow-up. No obvious adverse reactions was observed. Almost all patients showed an improvement in skin texture after IPL treatment CONCLUSION: We conclude that a novel LIT based on BCG-PSN and IPL for the treatment of facial verruca plana proved to be a well-tolerated and effective treatment modality. This novel LIT can clear skin lesions and achieve a very good cosmetic effect.
    Mesh-Begriff(e) Adjuvants, Immunologic ; Adolescent ; Adult ; Cosmetic Techniques ; Face ; Female ; Humans ; Immunomodulation ; Low-Level Light Therapy/methods ; Male ; Middle Aged ; Mycobacterium bovis ; Photochemotherapy/methods ; Photosensitizing Agents/therapeutic use ; Polysaccharides, Bacterial/administration & dosage ; Polysaccharides, Bacterial/therapeutic use ; Warts/drug therapy ; Warts/radiotherapy ; Warts/therapy ; Young Adult
    Chemische Substanzen Adjuvants, Immunologic ; Photosensitizing Agents ; Polysaccharides, Bacterial
    Sprache Englisch
    Erscheinungsdatum 2018-02-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2149918-4
    ISSN 1873-1597 ; 1572-1000
    ISSN (online) 1873-1597
    ISSN 1572-1000
    DOI 10.1016/j.pdpdt.2018.02.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Laser immunotherapy for cutaneous squamous cell carcinoma with optimal thermal effects to enhance tumour immunogenicity.

    Luo, Min / Shi, Lei / Zhang, Fuhe / Zhou, Feifan / Zhang, Linglin / Wang, Bo / Wang, Peiru / Zhang, Yunfeng / Zhang, Haiyan / Yang, Degang / Zhang, Guolong / Chen, Wei R / Wang, Xiuli

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

    2018  Band 34, Heft 8, Seite(n) 1337–1350

    Abstract: Background: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumours by damaging tumour cells directly and promoting the release of damage-associated molecular patterns (DAMPs) ... ...

    Abstract Background: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumours by damaging tumour cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumour immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC).
    Methods: The cell viability and the DAMPs productions of heat-treated cSCC A431 cells in different temperatures were investigated. Laser immunotherapy with the optimal thermal effect for DAMPs production was performed on SKH-1 mice bearing ultraviolet-induced cSCC and a patient suffering from a large refractory cSCC.
    Results: The temperature in the range of 45-50 °C killing half of A431 cells had an optimal thermal effect for the productions of DAMPs. The thermal effect could be further enhanced by local application of imiquimod, an immunoadjuvant. Laser immunotherapy eliminated most tumours and improved the survival rate of the ultraviolet-induced cSCC-bearing SKH-1 mice (p < 0.05). The patient with cSCC treated by laser immunotherapy experienced a significant tumour reduction after laser immunotherapy increased the amounts of infiltrating lymphocytes in the tumour. No obviously adverse effect was observed in the mice experiment or in the clinical application.
    Conclusions: Our results strongly indicate that laser immunotherapy with optimal thermal effects is an effective and safe treatment modality for cSCC.
    Mesh-Begriff(e) Adjuvants, Immunologic/therapeutic use ; Animals ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/therapy ; Cell Line, Tumor ; Combined Modality Therapy ; Female ; HMGB1 Protein/metabolism ; HSP70 Heat-Shock Proteins/metabolism ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Imiquimod/therapeutic use ; Immunotherapy ; Laser Therapy ; Mice ; Middle Aged ; Phototherapy ; Skin Neoplasms/metabolism ; Skin Neoplasms/therapy
    Chemische Substanzen Adjuvants, Immunologic ; HMGB1 Protein ; HSP70 Heat-Shock Proteins ; HSP90 Heat-Shock Proteins ; Imiquimod (P1QW714R7M)
    Sprache Englisch
    Erscheinungsdatum 2018-04-16
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 632526-9
    ISSN 1464-5157 ; 0265-6736
    ISSN (online) 1464-5157
    ISSN 0265-6736
    DOI 10.1080/02656736.2018.1446221
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Photothermal therapy enhanced the effectiveness of imiquimod against refractory cutaneous warts through boosting immune responses.

    Shi, Lei / Luo, Min / Zhang, Fuhe / Zhang, Linglin / Wang, Bo / Liu, Pei / Zhang, Yunfeng / Zhang, Haiyan / Yang, Degang / Zhang, Guolong / Zhou, Feifan / Stepp, Herbert / Sroka, Ronald / Chen, Wei R / Wang, Xiuli

    Journal of biophotonics

    2018  Band 12, Heft 2, Seite(n) e201800149

    Abstract: Refractory cutaneous warts are difficult to eliminate. In situ photo-immunotherapy (ISPI) is an innovative treatment concept combining local photothermal therapy (PTT) and topical immunotherapy using imiquimod. To compare the efficacy of ISPI vs topical ... ...

    Abstract Refractory cutaneous warts are difficult to eliminate. In situ photo-immunotherapy (ISPI) is an innovative treatment concept combining local photothermal therapy (PTT) and topical immunotherapy using imiquimod. To compare the efficacy of ISPI vs topical imiquimod alone, a prospective randomized controlled trial was performed with patients suffering from refractory cutaneous warts. In both groups, approximately 50% of the skin surface containing warts was treated for 6 weeks. On the basis of topical imiquimod, ISPI includes an additional 808 nm laser irradiation. Treatment response, temperatures during irradiation and histopathologic examination were evaluated. The complete response rate in the ISPI-group (22/36, 61.1%) was significantly higher than in the imiquimod alone group (11/34, 32.4%). In the ISPI-group, the mean maximum temperature was 44.5 ± 5.1°C, and obvious lymphocytic infiltration was found in the perivasculature of the dermis. There was no recurrence or worsening in both groups during the 12-month follow-up. No obvious adverse reaction was observed. This study demonstrates that ISPI can be used as an effective and safe treatment modality for refractory cutaneous warts.
    Mesh-Begriff(e) Adolescent ; Adult ; Aged ; Child ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Humans ; Imiquimod/pharmacology ; Imiquimod/therapeutic use ; Immunotherapy ; Male ; Middle Aged ; Phototherapy ; Skin Diseases/drug therapy ; Skin Diseases/immunology ; Skin Diseases/pathology ; Temperature ; Treatment Outcome ; Warts/drug therapy ; Warts/immunology ; Warts/pathology ; Young Adult
    Chemische Substanzen Imiquimod (P1QW714R7M)
    Sprache Englisch
    Erscheinungsdatum 2018-10-08
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2390063-5
    ISSN 1864-0648 ; 1864-063X
    ISSN (online) 1864-0648
    ISSN 1864-063X
    DOI 10.1002/jbio.201800149
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: [Study on clinical treatment of acute bromoxynil poisoning].

    Zhang, Wan-li / Zhang, Fu-he / Wang, Li-min

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2005  Band 23, Heft 5, Seite(n) 387–388

    Mesh-Begriff(e) Adult ; Cause of Death ; Humans ; Male ; Nitriles/poisoning ; Poisoning/mortality ; Poisoning/therapy ; Young Adult
    Chemische Substanzen Nitriles ; bromoxynil (J46EK95K0P)
    Sprache Chinesisch
    Erscheinungsdatum 2005-10
    Erscheinungsland China
    Dokumenttyp Journal Article
    ISSN 1001-9391
    ISSN 1001-9391
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Successful treatment of Rosai-Dorfman disease using

    Li, Meng / Shi, Lei / Luo, Min / Chen, Jia / Wang, Bo / Zhang, Fuhe / Keyal, Uma / Bhatta, Anil Kumar / Chen, Wei R / Wang, Xiuli

    Indian journal of dermatology, venereology and leprology

    2017  Band 83, Heft 3, Seite(n) 332–336

    Abstract: Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left ... ...

    Abstract Rosai-Dorfman disease is difficult to cure. In situ photoimmunotherapy combines local photothermal therapy with immunoadjuvant. In the present case report, a 39-year-old Chinese man with Rosai-Dorfman disease lesions below the left nostril and left preauricular region was treated with in situ photoimmunotherapy. The patient was treated with daily application of topical imiquimod (5%) and laser irradiations every 2 weeks for 8 weeks. After three cycles of treatment, the lesions improved markedly without adverse effects. Our results showed that in situ photoimmunotherapy can be used as an effective treatment for Rosai-Dorfman disease.
    Sprache Englisch
    Erscheinungsdatum 2017-05
    Erscheinungsland India
    Dokumenttyp Case Reports
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.4103/ijdvl.IJDVL_356_16
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy.

    Yang, Weitao / Guo, Weisheng / Le, Wenjun / Lv, Guoxian / Zhang, Fuhe / Shi, Lei / Wang, Xiuli / Wang, Jun / Wang, Sheng / Chang, Jin / Zhang, Bingbo

    ACS nano

    2016  Band 10, Heft 11, Seite(n) 10245–10257

    Abstract: Photothermal therapy (PTT) is attracting increasing interest and becoming more widely used for skin cancer therapy in the clinic, as a result of its noninvasiveness and low systemic adverse effects. However, there is an urgent need to develop ... ...

    Abstract Photothermal therapy (PTT) is attracting increasing interest and becoming more widely used for skin cancer therapy in the clinic, as a result of its noninvasiveness and low systemic adverse effects. However, there is an urgent need to develop biocompatible PTT agents, which enable accurate imaging, monitoring, and diagnosis. Herein, a biocompatible Gd-integrated CuS nanotheranostic agent (Gd:CuS@BSA) was synthesized via a facile and environmentally friendly biomimetic strategy, using bovine serum albumin (BSA) as a biotemplate at physiological temperature. The as-prepared Gd:CuS@BSA nanoparticles (NPs) with ultrasmall sizes (ca. 9 nm) exhibited high photothermal conversion efficiency and good photostability under near-infrared (NIR) laser irradiation. With doped Gd species and strong tunable NIR absorbance, Gd:CuS@BSA NPs demonstrate prominent tumor-contrasted imaging performance both on the photoacoustic and magnetic resonance imaging modalities. The subsequent Gd:CuS@BSA-mediated PTT result shows high therapy efficacy as a result of their potent NIR absorption and high photothermal conversion efficiency. The immune response triggered by Gd:CuS@BSA-mediated PTT is preliminarily explored. In addition, toxicity studies in vitro and in vivo verify that Gd:CuS@BSA NPs qualify as biocompatible agents. A biodistribution study demonstrated that the NPs can undergo hepatic clearance from the body. This study highlights the practicality and versatility of albumin-mediated biomimetic mineralization of a nanotheranostic agent and also suggests that bioinspired Gd:CuS@BSA NPs possess promising imaging guidance and effective tumor ablation properties, with high spatial resolution and deep tissue penetration.
    Mesh-Begriff(e) Copper/chemistry ; Magnetic Resonance Imaging ; Materials Testing ; Nanocomposites ; Neoplasms ; Phototherapy ; Tissue Distribution
    Chemische Substanzen Copper (789U1901C5) ; cupric sulfide (KL4YU612X7)
    Sprache Englisch
    Erscheinungsdatum 2016--22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.6b05760
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: In situ photoimmunotherapy for cutaneous granuloma caused by itraconazole-resistant Candida guilliermondii.

    Shi, Lei / Luo, Min / Chen, Wei R / Hu, Chan / Zhang, Guolong / Zhang, Fuhe / Chen, Jia / Mo, Xiaohui / Cai, Qing / Yang, Lianjuan / Wang, Xiuli

    Dermatologic therapy

    2016  Band 29, Heft 5, Seite(n) 353–357

    Abstract: Cutaneous granulomas caused by Candida guilliermondii are difficult to cure. In situ photoimmunotherapy (ISPI) is a novel method composed of local photothermal therapy and immunoadjuvant. In this study, ISPI was used the first time clinically for ... ...

    Abstract Cutaneous granulomas caused by Candida guilliermondii are difficult to cure. In situ photoimmunotherapy (ISPI) is a novel method composed of local photothermal therapy and immunoadjuvant. In this study, ISPI was used the first time clinically for cutaneous granuloma caused by itraconazole-resistant C.guilliermondii. A 10-week cycle of ISPI was composed of (1) 5% imiquimod applied topically every other day and (2) irradiation of lesions with an 808-nm diode laser at Days 14, 28, 42, and 56. Here we report our first case. A patient was treated with ISPI for four cycles. After the treatment, the lesions were eliminated without recurrence during a 12-month follow-up. Our results demonstrate that ISPI can be used as an effective treatment modality for cutaneous fungal granuloma.
    Mesh-Begriff(e) Adjuvants, Immunologic/administration & dosage ; Aged, 80 and over ; Aminoquinolines/administration & dosage ; Antifungal Agents/therapeutic use ; Biopsy ; Candidiasis, Cutaneous/diagnosis ; Candidiasis, Cutaneous/immunology ; Candidiasis, Cutaneous/microbiology ; Candidiasis, Cutaneous/therapy ; Drug Resistance, Fungal ; Granuloma/diagnosis ; Granuloma/immunology ; Granuloma/microbiology ; Granuloma/therapy ; Humans ; Immunotherapy/methods ; Itraconazole/therapeutic use ; Lasers, Semiconductor/therapeutic use ; Male ; Phototherapy/methods ; Treatment Outcome
    Chemische Substanzen Adjuvants, Immunologic ; Aminoquinolines ; Antifungal Agents ; Itraconazole (304NUG5GF4) ; imiquimod (P1QW714R7M)
    Sprache Englisch
    Erscheinungsdatum 2016-09
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.12376
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5181: Hefte anzeigen Standort:
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  9. Buch: Zhongguo jin dai jian zhu zong lan

    Xu, Feipeng / Zhang, Fuhe / Cun, Songshen

    Qingdao pian

    1992  

    Verfasserangabe Xu Feipeng, Zhang Fuhe, Cun Songshen bian
    Sprache Chinesisch
    Umfang 91 p, Ill
    Ausgabenhinweis Di 1 ban
    Verlag Zhongguo jianzhu gongye chubanshe
    Erscheinungsort Beijing
    Dokumenttyp Buch
    ISBN 7112014832 ; 9787112014835
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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