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  1. Article: [Clinical efficacy of Manlyman Spray combined with biofeedback therapy on premature ejaculation].

    Zhang, Gao-Yue / Chen, Shan-Wen / Fang, Guang-Hong / Li, Jian-Ying / Li, Jian-Hui

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 7, Page(s) 630–633

    Abstract: Objective： To observe the clinical effect of Manlyman Spray combined with biofeedback therapy in the treatment of premature ejaculation (PE)．Methods： A total of 60 primary premature ejaculation patients with stable sexual partners and regular sexual ... ...

    Abstract Objective： To observe the clinical effect of Manlyman Spray combined with biofeedback therapy in the treatment of premature ejaculation (PE)．Methods： A total of 60 primary premature ejaculation patients with stable sexual partners and regular sexual activity (≥１ times per week) from April 2021 to October 2022 were involved in the clinical observation, The patients' age is (34.3 ± 4.9) years old, and the course of the disease is (112.5 ± 65.5) months, and Manlyman Spray combined with biofeedback therapy was used to treat patients for 8 weeks. Manlyman Spray was sprayed 3 times on the surface of the penisqd for 4 weeks, and Biofeedback therapy is treated twice a week according to the AI setting module, for a total of 8 weeks. Before and 8 weeks after medication and at 4 weeks after drug withdrawal, the Intravaginal Ejaculation Latency Time (IELT), Premature Ejaculation Diagnostic Tool (PEDT) scores and Clinical Global Impression of Change (CGIC) scores were Obtained and compared. Results： After 8 weeks of treatment, the IELT of the patients was significantly prolonged (［351.4 ± 76.7］ vs ［87 ± 16.8］,P<0.05) and at 4 weeks after drug withdrawal, the therapeutic effect still existed (［345.9 ± 80.3］ vs ［87 ± 16.8］,P<0.05), the PEDT scores were significantly improved after treatment (［18.2 ± 1.1］ vs ［9.0 ± 1.4］,P<0.05)and at 4 weeks after drug withdrawal(［18.0 ± 1.2］ vs ［9.0 ± 1.4］,P<0.05), and so were the CGIC scores (［13.4 ± 1.3］ vs ［3.3 ± 1.4］,P<0.05, and ［12.6 ± 1.6］ vs ［3.3 ± 1.4］,P<0.05). Conclusion： The combination of Manlyman Spray and biofeedback therapy can effectively treat primary premature ejaculation, with a long duration of treatment and good safety, and the specific mechanism needs further study.
    MeSH term(s) Male ; Humans ; Adult ; Premature Ejaculation/therapy ; Biofeedback, Psychology ; Treatment Outcome ; Ejaculation ; Sexual Behavior
    Language Chinese
    Publishing date 2024-04-15
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6577: Show issues Location:
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  2. Article: [Value of non-sexual penile erection for penile rehabilitation in men with erectile dysfunction].

    Lü, Bo-Dong / Wang, Wen-Zhi / Yan, Jun-Feng / Zhang, Gao-Yue

    Zhonghua nan ke xue = National journal of andrology

    2018  Volume 23, Issue 8, Page(s) 675–679

    Abstract: Erectile dysfunction (ED) is a common male disease. Some related studies show that the prevalence of ED is nearly 52% in men aged 40 to 70 years and is increasing among younger males. Hypoxia is now considered to be an independent risk factor for ED and ... ...

    Abstract Erectile dysfunction (ED) is a common male disease. Some related studies show that the prevalence of ED is nearly 52% in men aged 40 to 70 years and is increasing among younger males. Hypoxia is now considered to be an independent risk factor for ED and the mechanisms of hypoxia inducing ED are varied and complicated. Recently, an idea in penile rehabilitation has attracted much attention, which aims at improving erectile function by increasing oxygen supply to the cavernosum and reducing tissue fibrosis and apoptosis. The approaches to achieve non-sexual penile erection by increasing oxygen supply to the cavernosum, such as behavior therapy, medication, vacuum constriction device, and intracavernous injection, can simulate normal sexual erection and help patients with penile rehabilitation. This review focuses on the strategies for non-sexual penile erection in penile rehabilitation.
    MeSH term(s) Adult ; Aged ; Erectile Dysfunction/epidemiology ; Erectile Dysfunction/etiology ; Erectile Dysfunction/rehabilitation ; Humans ; Hypoxia/complications ; Hypoxia/therapy ; Male ; Middle Aged ; Oxygen/administration & dosage ; Penile Erection ; Penis/blood supply ; Risk Factors
    Chemical Substances Oxygen (S88TT14065)
    Language Chinese
    Publishing date 2018-05-03
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6577: Show issues Location:
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  3. Article ; Online: The platelet-derived growth factor receptor/STAT3 signaling pathway regulates the phenotypic transition of corpus cavernosum smooth muscle in rats.

    Yan, Jun-Feng / Huang, Wen-Jie / Zhao, Jian-Feng / Fu, Hui-Ying / Zhang, Gao-Yue / Huang, Xiao-Jun / Lv, Bo-Dong

    PloS one

    2017  Volume 12, Issue 2, Page(s) e0172191

    Abstract: Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus cavernosum smooth muscle cells (CCSMCs) in rats, but the underlying molecular mechanism is still ...

    Abstract Erectile dysfunction (ED) is a common clinical disease that is difficult to treat. We previously found that hypoxia modulates the phenotype of primary corpus cavernosum smooth muscle cells (CCSMCs) in rats, but the underlying molecular mechanism is still unknown. Platelet-derived growth factor receptor (PDGFR)-related signaling pathways are correlated with cell phenotypic transition, but research has been focused more on vascular smooth muscle and tracheal smooth muscle and less on CCSMCs. Here, we investigated the role of PDGFR-related signaling pathways in penile CCSMCs, which were successfully isolated from rats and cultured in vitro. PDGF-BB at 5, 10, or 20 ng/ml altered CCSMC morphology from the original elongated, spindle shape to a broader shape and promoted the synthetic phenotype and expression of the related proteins vimentin and collagen-I, while inhibiting the contractile phenotype and expression of the related proteins smooth muscle (SM) α-actin (α-SMA) and desmin. Inhibition of PDGFR activity via siRNA or the PDGFR inhibitor crenolanib inhibited vimentin and collagen-I expression, increased α-SMA and desmin expression, and considerably inhibited serine-threonine protein kinase (AKT) and signal transducer and activator of transcription 3 (STAT3) phosphorylation. STAT3 knockdown promoted the contractile phenotype, inhibited vimentin and collagen-I expression, and increased α-SMA and desmin expression, whereas AKT knockdown did not affect phenotype-associated proteins. STAT3 overexpression in CCSMC cells weakened the suppressive effect of PDGFR inhibition on the morphology and phenotypic transformation induced by PDGF-BB. Through activation of the PDGFR/STAT3 signaling pathway, PDGF promoted the synthetic phenotype transition; thus, regulation of this pathway might contribute to ED therapy.
    MeSH term(s) Actins/metabolism ; Animals ; Becaplermin ; Cell Hypoxia ; Cells, Cultured ; Collagen Type I/metabolism ; Dose-Response Relationship, Drug ; Erectile Dysfunction/drug therapy ; Male ; Muscle Contraction/drug effects ; Muscle, Smooth/metabolism ; Myocytes, Smooth Muscle/metabolism ; Penis/metabolism ; Phenotype ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-sis/pharmacology ; RNA Interference ; RNA, Small Interfering/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptors, Platelet-Derived Growth Factor/metabolism ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Vimentin/metabolism
    Chemical Substances Actins ; Collagen Type I ; Proto-Oncogene Proteins c-sis ; RNA, Small Interfering ; STAT3 Transcription Factor ; Stat3 protein, rat ; Vimentin ; Becaplermin (1B56C968OA) ; Receptors, Platelet-Derived Growth Factor (EC 2.7.10.1) ; Akt1 protein, rat (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2017-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0172191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Effect of salidroside on the expression of connexin43 in the corpus cavernosum smooth muscle cells of hypoxic rats].

    Yan, Jun-Feng / Zhao, Jian-Feng / Zhang, Gao-Yue / Huang, Xiao-Jun / Chen, Gang / Lü, Bo-Dong

    Zhonghua nan ke xue = National journal of andrology

    2017  Volume 22, Issue 8, Page(s) 725–729

    Abstract: Objective: To investigate the effect of salidroside on the expression of the connexin43 (Cx43) protein in the corpus cavernosum smooth muscle cells (CCSMCs) of hypoxic SD rats.: Methods: CCSMCs were cultured in vitro and identified by ... ...

    Abstract Objective: To investigate the effect of salidroside on the expression of the connexin43 (Cx43) protein in the corpus cavernosum smooth muscle cells (CCSMCs) of hypoxic SD rats.
    Methods: CCSMCs were cultured in vitro and identified by immunofluorescence staining. The cells were divided into six groups: normal control (21% O2), hypoxia (1% O2), hypoxia+salidroside (HS) 8 μg/ml,HS 16 μg/ml, HS 32 μg/ml, and HS 64 μg/ml, and cultured for 48 hours. Then the relative expression of Cx43 in different groups was detected by Western blot.
    Results: The in vitro cultured CCSMCs grew well and 90% of the cells showed positivity for α-SMA and desmin on immunohistochemistry. Salidroside ≤64 μg/ml produced no obvious toxicity on the CCSMCs. The expressions of Cx43 and phosphorylated proteins were dramatically increased in the hypoxia group as compared with the normal control (P<0.01 and P<0.05). The HS groups all showed significantly higher expression of Cx43 than the hypoxia group (P<0.01), but the phosphorylation rate of the Cx43 proteins was remarkably decreased (P<0.01).
    Conclusions: Hypoxia increases the expression of Cx43 in the CCSMCs of SD rats. Salidroside ≤64 μg/ml cannot reverse the hypoxia-induced change but can reduce the dephosphorylation of Cx43 in CCSMCs. It is deduced that salidroside can protect CCSMCs by decreasing the phosphorylation of Cx43 and suppressing hypoxia-induced formation of the gap junction channel.
    MeSH term(s) Actins/metabolism ; Animals ; Cell Hypoxia ; Cells, Cultured ; Connexin 43/metabolism ; Glucosides/pharmacology ; Male ; Myocytes, Smooth Muscle/drug effects ; Myocytes, Smooth Muscle/metabolism ; Penis/drug effects ; Penis/metabolism ; Phenols/pharmacology ; Phosphorylation/drug effects ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Acta2 protein, rat ; Actins ; Connexin 43 ; Gja1 protein, rat ; Glucosides ; Phenols ; rhodioloside (M983H6N1S9)
    Language Chinese
    Publishing date 2017-10-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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