LIVIVO - Search results -

Search results

Result 1 - 10 of total 41

Search options

Article ; Online: High-Precision Photoacoustic Nitrogen Dioxide Gas Analyzer for Fast Dynamic Measurement.

Qi, Hongchao / Zhang, Guangyin / Xu, Lin / Yang, Ling / Wang, Zhengzhi / Xu, Yufu / Chen, Ke

2024 Volume 96, Issue 3, Page(s) 1354–1361

Abstract: A high-precision photoacoustic (PA) gas analyzer for fast dynamic measurement of ambient nitrogen dioxide ( ... ...

Abstract	A high-precision photoacoustic (PA) gas analyzer for fast dynamic measurement of ambient nitrogen dioxide (NO
Language	English
Publishing date	2024-01-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c05084
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Efficacy of coenzyme Q10 supplementation for male infertility with high sperm DNA fragmentation index: a protocol for a systematic review and meta-analysis.

Zhao, Yu / Zhao, Xiaoli / Zhang, Guangyin / Ma, Ruihong / Geng, Qiang / Ouyang, Bin / Xia, Tian

BMJ open

2023 Volume 13, Issue 6, Page(s) e068368

Abstract: Introduction: Infertility is a focal issue in public health and affects human reproduction and survival. Notably, an increasing number of studies in recent decades have found that sperm DNA integrity plays a critical role in the development of healthy ... ...

Abstract	Introduction: Infertility is a focal issue in public health and affects human reproduction and survival. Notably, an increasing number of studies in recent decades have found that sperm DNA integrity plays a critical role in the development of healthy embryos. Among the multiple pathogenic factors of sperm DNA fragmentation, oxidative stress has proven to be predominant. Coenzyme Q10 supplementation, which has been used for the treatment of male infertility, has shown good clinical efficacy due to its oxidation resistance, but its efficacy as measured by the sperm DNA fragmentation index remains controversial. To address this issue, we will perform a systematic review and meta-analysis to evaluate the efficacy of coenzyme Q10 for male infertility patients with a high sperm DNA fragmentation index. Methods and analysis: The PubMed, Embase, Cochrane Central Register of Studies and Web of Science databases will be comprehensively searched from inception to 31 December 2022 to identify relevant studies published in the English language using appropriate search strategies. The search terms will be derived from the following concepts: sperm DNA fragmentation, coenzyme Q10 and randomised controlled trials. Two review stages, that is, title and abstract screening and full-text screening, will be performed by two reviewers. The risk of bias, publication bias and evidence grade of the included studies will be assessed using a standardised protocol. Data will be used to calculate effect sizes. Heterogeneity among the studies will be evaluated graphically. Subgroup analysis and sensitivity analysis will be performed if necessary to validate the results. Ethics and dissemination: No ethical approval will be needed, as there will be no participants in this study. We will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to disseminate the findings through publication and conference presentation. Prospero registration number: CRD42022293340.
MeSH term(s)	Humans ; Male ; Dietary Supplements ; DNA Fragmentation ; Infertility, Male/drug therapy ; Infertility, Male/genetics ; Meta-Analysis as Topic ; Semen ; Spermatozoa ; Systematic Reviews as Topic
Chemical Substances	coenzyme Q10 (EJ27X76M46)
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-068368
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Weighted Gene Coexpression Network Analysis Identifies Specific Modules and Hub Genes Related to Major Depression.

Zhang, Guangyin / Xu, Shixin / Yuan, Zhuo / Shen, Li

Neuropsychiatric disease and treatment

2020 Volume 16, Page(s) 703–713

Abstract: Purpose: Despite advances in characterizing the neurobiology of emotional disorders, there is still a significant lack of scientific understanding of the pathophysiological mechanisms governing major depressive disorder (MDD). This study attempted to ... ...

Abstract	Purpose: Despite advances in characterizing the neurobiology of emotional disorders, there is still a significant lack of scientific understanding of the pathophysiological mechanisms governing major depressive disorder (MDD). This study attempted to elucidate the molecular circuitry of MDD and to identify more potential genes associated with the pathogenesis of the disease. Patients and methods: Microarray data from the GSE98793 dataset were downloaded from the NCBI Gene Expression Omnibus (GEO) database, including 128 patients with MDD and 64 healthy controls. Weighted gene coexpression network analysis (WGCNA) was performed to find modules of differentially expressed genes (DEGs) with high correlations followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to obtain further biological insight into the top three key modules. The protein-protein interaction (PPI) network, the modules from the PPI network, and the gene annotation enrichment of modules were analyzed, as well. Results: We filtered 3276 genes that were considered significant DEGs for further WGCNA analysis. By performing WGCNA, we found that the turquoise, blue and brown functional modules were all strongly correlated with MDD development, including immune response, neutrophil degranulation, ribosome biogenesis, T cell activation, glycosaminoglycan biosynthetic process, and protein serine/threonine kinase activator activity. Hub genes were identified in the key functional modules that might have a role in the progression of MDD. Functional annotation showed that these modules primarily enriched such KEGG pathways as the TNF signaling pathway, T cell receptor signaling pathway, primary immunodeficiency, Th1, Th2 and Th17 cell differentiation, autophagy and RNA degradation and oxidative phosphorylation. These results suggest that these genes are closely related to autophagy and cellular immune function. Conclusion: The results of this study may help to elucidate the pathophysiology of MDD development at the molecular level and explore the potential molecular mechanisms for new interventional strategies.
Language	English
Publishing date	2020-03-12
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S244452
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6068: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: A sentiment analysis driven method based on public and personal preferences with correlated attributes to select online doctors.

Wu, Jian / Zhang, Guangyin / Xing, Yumei / Liu, Yujia / Zhang, Zhen / Dong, Yucheng / Herrera-Viedma, Enrique

Applied intelligence (Dordrecht, Netherlands)

2023 , Page(s) 1–22

Abstract: This paper proposes a method to assist patients in finding the most appropriate doctor for online medical consultation. To do that, it constructs an online doctor selection decision-making method that considers the correlation attributes, in which the ... ...

Abstract	This paper proposes a method to assist patients in finding the most appropriate doctor for online medical consultation. To do that, it constructs an online doctor selection decision-making method that considers the correlation attributes, in which the measure of attribute correlation is derived from the history real decision data. To combine public and personal preference with correlated attributes, it proposes a Choquet integral based comprehensive online doctor ranking method. In detail, a two stage classification model based on BERT (Bidirectional Encoder Representations from Transformers) is used to extract service features from unstructured text reviews. Then, 2-additive fuzzy measure is adopted to represent the patient public group aggregated attribute preference. Next, a novel optimization model is proposed to combine the public preference and personal preference. Finally, a case study of dxy.com is carried out to illustrate the procedure of the method. The comparison result between proposed method and other traditional MADM (multi-attribute decision-making) methods prove its rationality.
Language	English
Publishing date	2023-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1479519-X
ISSN	1573-7497 ; 0924-669X
ISSN (online)	1573-7497
ISSN	0924-669X
DOI	10.1007/s10489-023-04485-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Details ▾
- Full text online
- Order with fees

Article: Multi-mechanism collaboration enhanced photoacoustic analyzer for trace H

Guo, Min / Zhao, Xinyu / Chen, Ke / Cui, Dongyu / Zhang, Guangyin / Li, Chenxi / Gong, Zhenfeng / Yu, Qingxu

Photoacoustics

2023 Volume 29, Page(s) 100449

Abstract: To realize the real-time highly sensitive detection of ... ...

Abstract	To realize the real-time highly sensitive detection of SF
Language	English
Publishing date	2023-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2716706-9
ISSN	2213-5979
ISSN	2213-5979
DOI	10.1016/j.pacs.2023.100449
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Multi-pass Differential Photoacoustic Sensor for Real-Time Measurement of SF

Zhao, Xinyu / Guo, Min / Cui, Dongyu / Li, Chenxi / Qi, Hongchao / Chen, Ke / Ma, Fengxiang / Huang, Jiayu / Zhang, Guangyin / Zhao, Jikuan

Analytical chemistry

2023 Volume 95, Issue 21, Page(s) 8214–8222

Abstract: We designed and implemented a photoacoustic (PA) sensor for ... ...

Abstract	We designed and implemented a photoacoustic (PA) sensor for H
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c00003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: An In Situ Generated Prussian Blue Nanoparticle-Mediated Multimode Nanozyme-Linked Immunosorbent Assay for the Detection of Aflatoxin B1

Lu, Dai / Jiang, Hao / Zhang, Guangyin / Luo, Qian / Zhao, Qian / Shi, Xingbo

ACS applied materials & interfaces. 2021 May 27, v. 13, no. 22

2021

Abstract: This work aims to develop a novel multimode (photothermal/colorimetric/fluorescent) nanozyme-linked immunosorbent assay (NLISA) based on the in situ generation of Prussian blue nanoparticles (PBNPs) on the surface of magnetic nanoparticles (MNPs). Being ... ...

Abstract	This work aims to develop a novel multimode (photothermal/colorimetric/fluorescent) nanozyme-linked immunosorbent assay (NLISA) based on the in situ generation of Prussian blue nanoparticles (PBNPs) on the surface of magnetic nanoparticles (MNPs). Being considered the most toxic among the mycotoxins, aflatoxin B1 (AFB1) was chosen as the proof-of-concept target. In this strategy, MNPs, on which an AFB1 aptamer was previously assembled via streptavidin-biotin linkage, are anchored to 96-well plates by AFB1 and antibody. In the presence of HCl and K₄Fe(CN)₆, PBNPs formed in situ on the MNP surface, thereby achieving photothermal and colorimetric signal readout due to their photothermal effect and intrinsic peroxidase-like activity. Based on fluorescence quenching by MNPs, Cy5 fluorescence was recovered by the in situ generation of PBNPs to facilitate ultrasensitive fluorescence detection. Photothermal and colorimetric signals allow portable/visual point-of-care testing, and fluorescent signals enable accurate determination with a detection limit of 0.54 fg/mL, which is 6333 and 28 times lower than those of photothermal and colorimetric analyses, respectively. We expect that this proposed multimode NLISA can not only reduce the false-positive/negative rates through the multisignal crossdetection in AFB1 monitoring but also provide a universal way of sophisticated instrumentation-free, easy-to-use, cost-effective, and highly sensitive detection of other food hazards.
Keywords	aflatoxin B1 ; antibodies ; colorimetry ; cost effectiveness ; detection limit ; fluorescence ; magnetism ; oligonucleotides ; toxicity
Language	English
Dates of publication	2021-0527
Size	p. 25738-25747.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1944-8252
DOI	10.1021/acsami.1c04751
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Recent improvements in enzyme-linked immunosorbent assays based on nanomaterials

Zhao, Qian / Lu, Dai / Zhang, Guangyin / Zhang, Dong / Shi, Xingbo

Talanta. 2021 Feb. 01, v. 223

2021

Abstract: As a gold standard technique, enzyme-linked immunosorbent assay (ELISA) organically combines immunoreactions between antigens and antibodies with enzyme catalysis. The use of ELISA has contributed to advances in applications such as clinical diagnosis, ... ...

Abstract	As a gold standard technique, enzyme-linked immunosorbent assay (ELISA) organically combines immunoreactions between antigens and antibodies with enzyme catalysis. The use of ELISA has contributed to advances in applications such as clinical diagnosis, food quality control, and environmental monitoring. However, conventional ELISA suffer from the moderate sensitivity and reliance on enzyme activity, which make it impossible to reliably and inexpensively detect trace targets. The nanotechnology boom has yielded exciting developments in designing nanomaterial-based improved ELISA in recent years. In this review, we attempt to comprehensively describe the improvements in ELISA methodology based on nanomaterials, with a focus on the mode of signal detection, such as colorimetric, fluorescent, electrochemical, photothermal, and Raman scattering sensing. We particularly emphasized on how nanomaterials are used as loading carriers, enzyme mimics, and signal reporters. This review concerns on partially representative examples and describes novel concepts and promising applications, rather than being exhaustive. Finally, we outline the challenges and perspectives, hopefully provide brief guideline to develop neotype improved ELISA.
Keywords	Raman spectroscopy ; antibodies ; antigens ; catalytic activity ; colorimetry ; detection ; electrochemistry ; environmental monitoring ; enzyme activity ; enzyme-linked immunosorbent assay ; enzymes ; fluorescence ; food quality ; gold ; guidelines ; nanomaterials ; neotypes ; quality control
Language	English
Dates of publication	2021-0201
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-light
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121722
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: Multi-pass Differential Photoacoustic Sensor for Real-Time Measurement of SF₆ Decomposition Component H₂S at the ppb Level

Zhao, Xinyu / Guo, Min / Cui, Dongyu / Li, Chenxi / Qi, Hongchao / Chen, Ke / Ma, Fengxiang / Huang, Jiayu / Zhang, Guangyin / Zhao, Jikuan

Analytical Chemistry. 2023 May 16, v. 95, no. 21 p.8214-8222

2023

Abstract: We designed and implemented a photoacoustic (PA) sensor for H₂S detection in SF₆ background gas based on a multi-pass differential photoacoustic cell (MDPC) and a near-infrared distributed feedback (DFB) laser. In the MDPC apparatus, two resonators with ... ...

Abstract	We designed and implemented a photoacoustic (PA) sensor for H₂S detection in SF₆ background gas based on a multi-pass differential photoacoustic cell (MDPC) and a near-infrared distributed feedback (DFB) laser. In the MDPC apparatus, two resonators with identical geometric parameters were vertically and symmetrically embedded. The differential processing algorithm of two phase-reversed signals realized the effective enhancement of the PA signal and suppressed the flow noise in the dynamic sampling process. In addition, the λ/4 buffer chamber in the MDPC was utilized as a muffler to further reduce the flow noise and realize the dynamic detection of H₂S. The collimated excitation light was reflected 30 times in a multi-pass structure constituted of two gold-plated concave mirrors, and an absorption path length of 4.92 m was achieved. Due to the high gas density of SF₆, the relationship between the signal-to-noise ratio (SNR) and the gas flow was different between SF₆ and N₂ background gases. The maximum flow rate of the characteristic gas components detected in the SF₆ background is 150 standard cubic centimeters per minute (SCCM), which is lower than 350 SCCM in N₂. The linearity property was analyzed, and the results show that the sensitivity of the sensor to H₂S in the SF₆ background was 27.3 μV/ppm. With the structure, parameters, temperature, gas flow, and natural frequency of the MDPC been optimized, a minimum detection limit (MDL) of 11 ppb was reached with an averaging time of 1000 s, which furnished an effective preventive implement for the safe operation of gas insulation equipment.
Keywords	absorption ; algorithms ; analytical chemistry ; detection limit ; equipment ; geometry ; insulating materials ; signal-to-noise ratio ; temperature
Language	English
Dates of publication	2023-0516
Size	p. 8214-8222.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c00003
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 52/94: Show issues
Z 2.9: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Recent improvements in enzyme-linked immunosorbent assays based on nanomaterials.

Zhao, Qian / Lu, Dai / Zhang, Guangyin / Zhang, Dong / Shi, Xingbo

Talanta

2020 Volume 223, Issue Pt 1, Page(s) 121722

Abstract	As a gold standard technique, enzyme-linked immunosorbent assay (ELISA) organically combines immunoreactions between antigens and antibodies with enzyme catalysis. The use of ELISA has contributed to advances in applications such as clinical diagnosis, food quality control, and environmental monitoring. However, conventional ELISA suffer from the moderate sensitivity and reliance on enzyme activity, which make it impossible to reliably and inexpensively detect trace targets. The nanotechnology boom has yielded exciting developments in designing nanomaterial-based improved ELISA in recent years. In this review, we attempt to comprehensively describe the improvements in ELISA methodology based on nanomaterials, with a focus on the mode of signal detection, such as colorimetric, fluorescent, electrochemical, photothermal, and Raman scattering sensing. We particularly emphasized on how nanomaterials are used as loading carriers, enzyme mimics, and signal reporters. This review concerns on partially representative examples and describes novel concepts and promising applications, rather than being exhaustive. Finally, we outline the challenges and perspectives, hopefully provide brief guideline to develop neotype improved ELISA.
MeSH term(s)	Catalysis ; Colorimetry ; Enzyme-Linked Immunosorbent Assay ; Nanostructures ; Nanotechnology
Language	English
Publishing date	2020-09-30
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2020.121722
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito