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Article: [Annual review of clinical research on extracorporeal life support in 2023].

Zhang, Hongling / Yu, Yuan / Chen, Dechang / Shang, You

Zhonghua wei zhong bing ji jiu yi xue

2024 Volume 36, Issue 2, Page(s) 118–123

Abstract: The clinical research in the field of extracorporeal life support (ECLS) in 2023 has focused on the efficacy of veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with infarct-related cardiogenic shock. Additionally, the research also ... ...

Abstract	The clinical research in the field of extracorporeal life support (ECLS) in 2023 has focused on the efficacy of veno-arterial extracorporeal membrane oxygenation (ECMO) in patients with infarct-related cardiogenic shock. Additionally, the research also explored the efficacy of prone positioning during veno-venous ECMO, transfusion strategies, and the impact of obesity on outcomes. Awake veno-venous ECMO has shown novel therapeutic potential, but its optimal practice methods and management strategies remain to be determined. In in-hospital cardiac arrest patients, extracorporeal cardiopulmonary resuscitation has demonstrated higher survival rates and better neurological recovery compared to conventional cardiopulmonary resuscitation. The effectiveness of extracorporeal carbon dioxide removal varies among patients with different types of respiratory failure. Future research should focus on optimizing the application strategies and process management of ECLS technologies, investigating personalized therapy, and studying how to improve long-term rehabilitation and quality of life for survivors.
MeSH term(s)	Humans ; Extracorporeal Membrane Oxygenation ; Quality of Life ; Cardiopulmonary Resuscitation ; Patient Positioning ; Renal Dialysis
Language	Chinese
Publishing date	2024-03-06
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	2095-4352
ISSN	2095-4352
DOI	10.3760/cma.j.cn121430-20231204-01038
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Article ; Online: Video Analysis in Sports by Lightweight Object Detection Network under the Background of Sports Industry Development.

Zheng, Yifei / Zhang, Hongling

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 3844770

Abstract: This study uses the video image information in sports video image analysis to realize scientific sports training. In recent years, game video image analysis has referenced athletes' sports training. The sports video analysis is a widely used and ... ...

Abstract	This study uses the video image information in sports video image analysis to realize scientific sports training. In recent years, game video image analysis has referenced athletes' sports training. The sports video analysis is a widely used and effective method. First, the you only look once (YOLO) method is explored in lightweight object detection. Second, a sports motion analysis system based on the YOLO-OSA (you only look once-one-shot aggregation) target detection network is built based on the dense convolutional network (DenseNet) target detection network established by the one-shot aggregation (OSA) connection. Finally, object detection evaluation principles are used to analyze network performance and object detection in sports video. The results show that the more obvious the target feature, the larger the size, and the more motion information contained in the sports category feature, the more obvious the effect of the detected target. The higher the resolution of the sports video image, the higher the model detection accuracy of the YOLO-OSA target detection network, and the richer the visual video information. In sports video analysis, video images of the appropriate resolution are fed into the system. The YOLO-OSA network achieved 21.70% precision and 54.90% recall. In general, the YOLO-OSA network has certain pertinence for sports video image analysis, and it improves the detection speed of video analysis. The research and analysis of video in sports under the lightweight target detection network have certain reference significance.
MeSH term(s)	Humans ; Image Processing, Computer-Assisted/methods ; Neural Networks, Computer ; Sports ; Video Recording
Language	English
Publishing date	2022-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/3844770
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Article ; Online: Design of Moving Target Detection System Using Lightweight Deep Learning Model and Its Impact on the Development of Sports Industry.

Zhang, Hongling / Zheng, Yifei

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 3252032

Abstract: The intelligent tracking and detection of athletes' actions and the improvement of action standardization are of great practical significance to reducing the injury caused by sports in the sports industry. For the problems of nonstandard movement and ... ...

Abstract	The intelligent tracking and detection of athletes' actions and the improvement of action standardization are of great practical significance to reducing the injury caused by sports in the sports industry. For the problems of nonstandard movement and single movement mode, this exploration takes the video of sports events as the object and combines it with the video general feature extraction of convolutional neural network (CNN) in the field of deep learning and the filtering detection algorithm of motion trajectory. Then, a target detection and tracking system model is proposed to track and detect targets in sports in real-time. Moreover, through experiments, the performance of the proposed system model is analyzed. After testing the detection quantity, response rate, data loss rate, and target detection accuracy of the model, the results show that the model can track and monitor 50 targets with a loss rate of 3%, a response speed of 4 s and a target detection accuracy of 80%. It can play an excellent role in sports events and postgame video analysis, and provide a good basis and certain design ideas for the goal tracking of the sports industry.
MeSH term(s)	Algorithms ; Deep Learning ; Humans ; Motion ; Neural Networks, Computer ; Sports
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/3252032
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Article: Effect of thyroid dysfunction on N-terminal pro-B-type natriuretic peptide levels: A systematic review and meta-analysis.

Zhang, Hongling / Li, Xiaotao / Zhang, Nawen / Tian, Limin

Frontiers in endocrinology

2023 Volume 14, Page(s) 1083171

Abstract: Purpose: Thyroid hormones (THs) significantly affect the cardiovascular system. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a useful biomarker for diagnosing, evaluating, and predicting outcomes in heart failure (HF). This comprehensive ... ...

Abstract	Purpose: Thyroid hormones (THs) significantly affect the cardiovascular system. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a useful biomarker for diagnosing, evaluating, and predicting outcomes in heart failure (HF). This comprehensive review and meta-analysis aimed to investigate the effects of thyroid dysfunction (hypothyroidism and hyperthyroidism) on NT-proBNP levels. Methods: Two investigators independently searched PubMed, Embase, Cochrane Library, and Web of Science databases for studies published from inception to July 31, 2022, without any restrictions on language. Results: 21 studies were included. In participants without HF, NT-proBNP levels may be elevated in those with overt hyperthyroidism (standardized mean difference [SMD] 2.38, 95% confidence interval [CI]:1.0-3.76). Notably, among patients with preexisting HF, significantly higher NT-proBNP levels were found in patients with overt hyperthyroidism, overt hypothyroidism, or subclinical hypothyroidism than in euthyroid subjects (SMD [95%CI] = 0.31[0.01, 0.62], 0.32[0.08, 0.56], and 0.33[0.21, 0.46], respectively). Seven trials compared NT-proBNP levels in patients with thyroid dysfunction before and after therapy, and significant drops in NT-proBNP levels were observed in patients with hyperthyroidism (SMD [95%CI] = -1.53[-2.50, -0.55]) upon achieving a euthyroid state. In contrast, increased NT-proBNP levels were observed in hypothyroid patients after treatment (SMD [95%CI] = 1.07[0.28, 1.85]). Conclusion: Thyroid dysfunction can significantly affect NT-proBNP levels, which may change upon achieving a euthyroid state. Notably, the effect of thyroid dysfunction on cardiac function may depend on the underlying cardiac status. Thus, timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction are mandatory because the prognosis of HF may be improved with appropriate treatment of thyroid dysfunction. Systematic review registration: https://www.crd.york.ac.uk/prospero, identifier CRD42022353700.
MeSH term(s)	Humans ; Natriuretic Peptide, Brain/therapeutic use ; Hypothyroidism/complications ; Hyperthyroidism/complications ; Hyperthyroidism/diagnosis ; Heart Failure
Chemical Substances	pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2023-01-26
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1083171
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Article ; Online: Effect of blood pressure variability on hypertensive retinopathy.

Jiao, Lei / Lv, Chaoran / Zhang, Hongling

Clinical and experimental hypertension (New York, N.Y. : 1993)

2023 Volume 45, Issue 1, Page(s) 2205050

Abstract: Purpose: This study intends to investigate the correlation between blood pressure variability (BPV) levels and the use of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to measure retinal microvasculature in ... ...

Abstract	Purpose: This study intends to investigate the correlation between blood pressure variability (BPV) levels and the use of optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) to measure retinal microvasculature in hypertensive patients. Methods: All individuals in the study had 24-hour ambulatory blood pressure monitoring and bilateral OCT and OCTA exams, and only data from the right eye were analyzed statistically. Results: The study included 170 individuals, with 60 in the control group. The experimental group was separated into two groups based on the average real variability (ARV) median, with 55 in the low ARV group and 55 in the high ARV group. The mean thicknesses of the Retinal Nerve Fiber Layer (RNFL), internal limiting membrane-retinal pigment epithelial cell layer (ILM-RPE), vessel density (VD), and perfusion density (PD) in the high-ARV group were substantially lower in the low-ARV and control groups (p＜0.05). Multiple linear regression analysis revealed that disease duration, age, and 24 h diastolic standard deviation all affected RNFL mean thickness (p＜0.05). VD and PD were influenced by disease duration, systolic-ARV, daytime systolic blood pressure, intraocular pressure(IOP), and best-corrected visual acuity (BCVA) (p＜0.05). And the change in VD was connected to best-corrected visual acuity. Conclusion: Hypertensive retinopathy is related to BPV. In clinical practice, we can assess the degree of BPV and retinopathy in hypertensive patients to track the progression of hypertension-mediated organ damage (HMOD). Correction of BPV may help treat or postpone the progression of HOMD.
MeSH term(s)	Humans ; Young Adult ; Adult ; Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Hypertensive Retinopathy ; Hypertension/complications ; Hypertension/diagnostic imaging ; Retina
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	604757-9
ISSN	1525-6006 ; 0730-0077
ISSN (online)	1525-6006
ISSN	0730-0077
DOI	10.1080/10641963.2023.2205050
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Article: Effect of Thyroid-Stimulating Hormone Suppression Therapy on Cardiac Structure and Function in Patients With Differentiated Thyroid Cancer After Thyroidectomy: A Systematic Review and Meta-Analysis.

Zhang, Hongling / Yang, Yanlong / Gao, Cuixia / Tian, Limin

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

2023 Volume 30, Issue 2, Page(s) 177–186

Abstract: Objective: We aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppression therapy on cardiac structure and function in patients with differentiated thyroid cancer (DTC) following thyroidectomy.: Methods: Two investigators ... ...

Abstract	Objective: We aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppression therapy on cardiac structure and function in patients with differentiated thyroid cancer (DTC) following thyroidectomy. Methods: Two investigators independently searched the PubMed, Embase, Cochrane Library, and Web of Science databases for relevant studies published from inception to January 6, 2023, without any restrictions on language. Standard mean differences and 95% confidence intervals were calculated using fixed or random effects models. Thirteen clinical outcomes were analyzed, mainly evaluating cardiac morphology, systolic function, and diastolic function. Results: Thirteen studies were included in the quantitative analysis. Compared to healthy controls, left ventricular mass index, left ventricular posterior wall thickness, interventricular septal thickness, and isovolumic relaxation time values increased; the ratio of E-wave velocity to A-wave velocity and E-wave velocity values decreased. The left ventricular ejection fraction and cardiac output did not change in patients with DTC who underwent long-term TSH suppression therapy. Interventricular septal thickness values were significantly correlated with the duration of TSH suppression therapy. Conclusion: Long-term TSH suppression therapy leads to cardiac hypertrophy and impaired cardiac diastolic function in patients with DTC. These changes may be related to the duration of TSH suppression therapy. Large prospective studies with long follow-up periods are needed to validate these findings.
MeSH term(s)	Humans ; Thyroxine/therapeutic use ; Stroke Volume ; Thyroidectomy ; Prospective Studies ; Thyrotropin ; Ventricular Function, Left ; Thyroid Neoplasms/surgery
Chemical Substances	Thyroxine (Q51BO43MG4) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	1473503-9
ISSN	1530-891X
ISSN	1530-891X
DOI	10.1016/j.eprac.2023.11.006
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Article ; Online: Analysis of maternal genetic structure of mitochondrial DNA control region from Tai-Kadai-speaking Buyei population in southwestern China.

Feng, Yuhang / Chen, Li / Wang, Xiaoxue / Zhang, Hongling / Wang, Qiyan / Liu, Yubo / Jin, Xiaoye / Yang, Meiqing / Huang, Jiang / Ren, Zheng

BMC genomics

2024 Volume 25, Issue 1, Page(s) 50

Abstract: Background: Even though the Buyei are a recognised ethnic group in southwestern China, there hasn't been much work done on forensic population genetics, notably using mitochondrial DNA. The sequences and haplogroups of mitochondrial DNA control regions ... ...

Abstract	Background: Even though the Buyei are a recognised ethnic group in southwestern China, there hasn't been much work done on forensic population genetics, notably using mitochondrial DNA. The sequences and haplogroups of mitochondrial DNA control regions of the Buyei peoples were studied to provide support for the establishment of a reference database for forensic DNA analysis in East Asia. Methods and results: The mitochondrial DNA control region sequences of 200 Buyei individuals in Guizhou were investigated. The haplotype frequencies and haplogroup distribution of the Buyei nationality in Guizhou were calculated. At the same time, the paired Fst values of the study population and other populations around the world were computed, to explore their genetic polymorphism and population relationship. A total of 179 haplotypes were detected in the Buyei population, with frequencies of 0.005-0.015. All haplotypes were assigned to 89 different haplogroups. The haplotype diversity and random matching probability were 0.999283 and 0.0063, respectively. The paired Fst genetic distances and correlation p-values among the 54 populations revealed that the Guizhou Buyei was most closely related to the Henan Han and the Guizhou Miao, and closer to the Hazara population in Pakistan and the Chiang Mai population. Conclusions: The study of mitochondrial DNA based on the maternal genetic structure of the Buyei nationality in Guizhou will benefit the establishment of an East Asian forensic DNA reference database and provide a reference for anthropological research in the future.
MeSH term(s)	Humans ; DNA, Mitochondrial/genetics ; Polymorphism, Genetic ; Genetics, Population ; Haplotypes ; China ; Microsatellite Repeats ; Phylogeny
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2041499-7
ISSN	1471-2164 ; 1471-2164
ISSN (online)	1471-2164
ISSN	1471-2164
DOI	10.1186/s12864-023-09941-x
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Article ; Online: Correction to "Enhanced Intracellular Ca

Xu, Lihua / Tong, Guihua / Song, Qiaoli / Zhu, Chunyu / Zhang, Hongling / Shi, Jinjin / Zhang, Zhenzhong

ACS nano

2023 Volume 17, Issue 22, Page(s) 23220

Language	English
Publishing date	2023-11-07
Publishing country	United States
Document type	Published Erratum
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c10523
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Article ; Online: Net-Neutral Nanoparticles-Extruded Microcapsules for Oral Delivery of Insulin.

Lu, Xiang / Li, Jing / Xue, Meng / Wang, Mingjin / Guo, Rong / Wang, Binghua / Zhang, Hongling

ACS applied materials & interfaces

2023 Volume 15, Issue 28, Page(s) 33491–33503

Abstract: Oral delivery of insulin could widely improve the quality of life of diabetic patients but still requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the intestinal mucus barrier, thus greatly hurdling their therapeutic ...

Abstract	Oral delivery of insulin could widely improve the quality of life of diabetic patients but still requires further exploration. Commonly utilized oral delivery vehicles hardly penetrate the intestinal mucus barrier, thus greatly hurdling their therapeutic efficacy. State-of-the-art technology shows that coating particles with neutral surface charge could reduce adsorption of mucins and improved the transport of particles within mucus. However, the synthesis of net-neutral particles (NNs) usually need complex purification and processing procedure. Herein, the NNs were conveniently constructed by simply adjusting the ratio of positive (chitosan) and negative (γ-glutamic acid) materials. To further achieve the optimal bioavailability of NNs, NNs formed materials were package in to wild chrysanthemum pollens, obtaining pH-triggered nanoparticles-extruding microcapsules (PNMs@insulin). At the small intestine pH value (∼6.0), the amino groups of CS deprotonate gradually and trigger the swelling, followed by the rapid extrusion of NNs through nano-orifices on the pollens' surface. After oral administration of the microcapsules, plasma insulin levels were enhanced significantly with a high oral bioavailability of >40%, leading to a remarkable and longer-sustained blood glucose-reducing effect. Moreover, we discovered that the empty pollen shells could act as a potential saccharide-adsorbing agent, which helps to manage sugar intake. This oral strategy of insulin will provide a vast potential for daily and facile diabetes treatment.
MeSH term(s)	Humans ; Insulin ; Drug Carriers ; Capsules ; Quality of Life ; Nanoparticles ; Administration, Oral ; Chitosan ; Drug Delivery Systems/methods
Chemical Substances	Insulin ; Drug Carriers ; Capsules ; Chitosan (9012-76-4)
Language	English
Publishing date	2023-07-05
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c07124
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Article ; Online: Spatiotemporal transformable nano-assembly for on-demand drug delivery to enhance anti-tumor immunotherapy.

Liang, Chenglin / Zhang, Ge / Guo, Linlin / Ding, Xinyi / Yang, Heng / Zhang, Hongling / Zhang, Zhenzhong / Hou, Lin

Asian journal of pharmaceutical sciences

2024 Volume 19, Issue 1, Page(s) 100888

Abstract: Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy, but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration. Herein, we designed a cancer-associated fibroblasts (CAFs) ...

Abstract	Induction of tumor cell senescence has become a promising strategy for anti-tumor immunotherapy, but fibrotic matrix severely blocks senescence inducers penetration and immune cells infiltration. Herein, we designed a cancer-associated fibroblasts (CAFs) triggered structure-transformable nano-assembly (HSD-P@V), which can directionally deliver valsartan (Val, CAFs regulator) and doxorubicin (DOX, senescence inducer) to the specific targets. In detail, DOX is conjugated with hyaluronic acid (HA) via diselenide bonds (Se-Se) to form HSD micelles, while CAFs-sensitive peptide is grafted onto the HSD to form a hydrophilic polymer, which is coated on Val nanocrystals (VNs) surface for improving the stability and achieving responsive release. Once arriving at tumor microenvironment and touching CAFs, HSD-P@V disintegrates into VNs and HSD micelles due to sensitive peptide detachment. VNs can degrade the extracellular matrix, leading to the enhanced penetration of HSD. HSD targets tumor cells, releases DOX to induce senescence, and recruits effector immune cells. Furthermore, senescent cells are cleared by the recruited immune cells to finish the integrated anti-tumor therapy.
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2650931-3
ISSN	2221-285X ; 1818-0876 ; 2221-285X
ISSN (online)	2221-285X
ISSN	1818-0876 ; 2221-285X
DOI	10.1016/j.ajps.2024.100888
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