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  1. Article ; Online: Numeracy skills learning of children in Africa:-Are disabled children lagging behind?

    Zhang, Huafeng / Holden, Stein T

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0284821

    Abstract: Significant progress has been achieved in universal basic education in African countries since the late 1990s. This study provides empirical evidence on the within- and across-country variation in numeracy skills performance among children based on ... ...

    Abstract Significant progress has been achieved in universal basic education in African countries since the late 1990s. This study provides empirical evidence on the within- and across-country variation in numeracy skills performance among children based on nationally representative data from eight African countries (DR Congo, The Gambia, Ghana, Lesotho, Sierra Leone, Togo, Tunisia, and Zimbabwe). We assess whether and to what extent children with disabilities lag in numeracy skills and how much it depends on their type of disabilities. More specifically, we explore whether disabled children benefit equally from better school system quality. The assessment is analysed as a natural experiment using the performance of non-disabled children as a benchmark and considering the different types of disabilities as random treatments. We first evaluate the variation in average numeracy skills in the eight African countries. They can roughly be divided into low- and high-numeracy countries. We apply Instrumental Variable (IV) methods to control the endogeneity of completed school years when assessing subjects' school performance and heterogeneous disability effects. Children with vision and hearing disabilities are not especially challenged in numeracy skills performance. The low numeracy skills among physically and intellectually disabled children are mainly attributable to their limited school attendance. Children with multiple disabilities are constrained both by low school attendance and by poor numeracy skills return to schooling. The average differences in school performance across the high- versus low-numeracy skill country groups are larger than the within-group average differences for disabled versus non-disabled kids. This indicates that school enrolment and quality are crucial for children's learning of numeracy skills, and that disabled children benefit equally from better school quality across these African countries.
    MeSH term(s) Humans ; Child ; Learning ; Disabled Children ; Educational Status ; Schools ; Ghana
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0284821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: TRANS-CNN-Based Gesture Recognition for mmWave Radar.

    Zhang, Huafeng / Liu, Kang / Zhang, Yuanhui / Lin, Jihong

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 6

    Abstract: In order to improve the real-time performance of gesture recognition by a micro-Doppler map of mmWave radar, the point cloud based gesture recognition for mmWave radar is proposed in this paper. Two steps are carried out for mmWave radar-based gesture ... ...

    Abstract In order to improve the real-time performance of gesture recognition by a micro-Doppler map of mmWave radar, the point cloud based gesture recognition for mmWave radar is proposed in this paper. Two steps are carried out for mmWave radar-based gesture recognition. The first step is to estimate the point cloud of the gestures by 3D-FFT and the peak grouping. The second step is to train the TRANS-CNN model by combining the multi-head self-attention and the 1D-convolutional network so as to extract the features in the point cloud data at a deeper level to categorize the gestures. In the experiments, TI mmWave radar sensor IWR1642 is used as a benchmark to evaluate the feasibility of the proposed approach. The results show that the accuracy of the gesture recognition reaches 98.5%. In order to prove the effectiveness of our approach, a simply 2Tx2Rx radar sensor is developed in our lab, and the accuracy of recognition reaches 97.1%. The results show that our proposed gesture recognition approach achieves the best performance in real time with limited training data in comparison with the existing methods.
    Language English
    Publishing date 2024-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24061800
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact of the K-line in patients with ossification of the posterior longitudinal ligament: Analysis of sagittal cervical curvature changes and surgical outcomes.

    Tang, Zhongxin / Chen, Tailong / Tan, Jun / Zhang, Huafeng

    Frontiers in surgery

    2023  Volume 10, Page(s) 1095391

    Abstract: Objective: This study aimed to investigate the relationship of the K-line with sagittal cervical curvature changes and surgical outcomes in patients with cervical ossification of the posterior longitudinal ligament (OPLL).: Methods: We ... ...

    Abstract Objective: This study aimed to investigate the relationship of the K-line with sagittal cervical curvature changes and surgical outcomes in patients with cervical ossification of the posterior longitudinal ligament (OPLL).
    Methods: We retrospectively reviewed 84 patients with OPLL who underwent posterior cervical single-door laminoplasty. The patients were divided into a K-line-positive (+) group and a K-line-negative (-) group. Perioperative data, radiographic parameters, and clinical outcomes were compared between the two groups.
    Results: Of 84 total patients, 50 patients were in the K (+) group and 29 patients were in the K (-) group. Neurological function improved in both groups after laminoplasty. The C2-7 Cobb angle, T1 slope, and C2-7 sagittal vertical axis were significantly changed in the K(-) group compared with those in the K (+) group before the operation and at the 3-month and final follow-ups.
    Conclusion: Neurological function was recovered in both groups, and the clinical effect on the K (+) group was better than that on the K (-) group. The cervical curvature in patients with OPLL tends to be anteverted and kyphotic after laminoplasty and is an important factor in reducing the clinical effect.
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1095391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NQO1 Mediates Lenvatinib Resistance by Regulating ROS-induced Apoptosis in Hepatocellular Carcinoma.

    Xue, Wei / Wang, Ting / Tian, Wen-Jing / Pang, Si-Qi / Zhang, Hua-Feng / Jia, Wei-Dong

    Current medical science

    2024  Volume 44, Issue 1, Page(s) 168–179

    Abstract: Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide. As a first-line drug for advanced HCC treatment, lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired ... ...

    Abstract Objective: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide. As a first-line drug for advanced HCC treatment, lenvatinib faces a significant hurdle due to the development of both intrinsic and acquired resistance among patients, and the underlying mechanism remains largely unknown. The present study aims to identify the pivotal gene responsible for lenvatinib resistance in HCC, explore the potential molecular mechanism, and propose combinatorial therapeutic targets for HCC management.
    Methods: Cell viability and colony formation assays were conducted to evaluate the sensitivity of cells to lenvatinib and dicoumarol. RNA-Seq was used to determine the differences in transcriptome between parental cells and lenvatinib-resistant (LR) cells. The upregulated genes were analyzed by GO and KEGG analyses. Then, qPCR and Western blotting were employed to determine the relative gene expression levels. Afterwards, the intracellular reactive oxygen species (ROS) and apoptosis were detected by flow cytometry.
    Results: PLC-LR and Hep3B-LR were established. There was a total of 116 significantly upregulated genes common to both LR cell lines. The GO and KEGG analyses indicated that these genes were involved in oxidoreductase and dehydrogenase activities, and reactive oxygen species pathways. Notably, NAD(P)H:quinone oxidoreductase 1 (NQO1) was highly expressed in LR cells, and was involved in the lenvatinib resistance. The high expression of NQO1 decreased the production of ROS induced by lenvatinib, and subsequently suppressed the apoptosis. The combination of lenvatinib and NQO1 inhibitor, dicoumarol, reversed the resistance of LR cells.
    Conclusion: The high NQO1 expression in HCC cells impedes the lenvatinib-induced apoptosis by regulating the ROS levels, thereby promoting lenvatinib resistance in HCC cells.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Reactive Oxygen Species/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Dicumarol/pharmacology ; Dicumarol/therapeutic use ; Cell Line, Tumor ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Apoptosis ; Phenylurea Compounds ; Quinolines
    Chemical Substances Reactive Oxygen Species ; lenvatinib (EE083865G2) ; Dicumarol (7QID3E7BG7) ; NAD(P)H Dehydrogenase (Quinone) (EC 1.6.5.2) ; NQO1 protein, human (EC 1.6.5.2) ; Phenylurea Compounds ; Quinolines
    Language English
    Publishing date 2024-01-13
    Publishing country China
    Document type Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-023-2804-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The preliminary outcomes of vertebral body tethering in treating adolescent idiopathic scoliosis: a systematic review.

    Zhang, Huafeng / Fan, Yonggang / Ni, Shuangfei / Pi, Guofu

    Spine deformity

    2022  Volume 10, Issue 6, Page(s) 1233–1243

    Abstract: Purpose: VBT is a novel alternative to spinal fusion surgery to treat skeletally immature AIS and was approved to correct idiopathic scoliosis in August 2019 by US Federal Drug Administration (FDA). To systemically review the preliminary outcomes of ... ...

    Abstract Purpose: VBT is a novel alternative to spinal fusion surgery to treat skeletally immature AIS and was approved to correct idiopathic scoliosis in August 2019 by US Federal Drug Administration (FDA). To systemically review the preliminary outcomes of vertebral body tethering (VBT) in treating adolescent idiopathic scoliosis.
    Methods: The electronic databases PubMed, EMBASE, and Web of Science were queried up to January 2022 for articles regarding VBT. Basic characteristics of patients, changes of radiographic parameters in coronal and sagittal planes, and clinical outcomes of surgical treatment of VBT including complication and revision rates were summarized.
    Results: Twenty five studies met the inclusion criteria. Most studies (23/25) included patients with only skeletal immaturity. The average % correction of the main/tethered curve at final follow-up, and % correction of thoracic kyphosis at final follow-up were reported to be 15.6-106.5% and - 31.8 to 20.0%, respectively. The most common complications for VBT were tether breakage (n = 145;21.3%), pulmonary complications (n = 49; 6.9%), and overcorrection (n = 30; 4.2%). The revision rate was 13.1%.
    Conclusion: VBT could effectively and safely correct spinal deformity in skeletally immature patients with AIS and preserve the motion and growth of the spine. However, VBT has a relatively high complication and revision rates. Therefore, surgeons should cautiously consider VBT for treating AIS. Future research efforts are needed to lower the complication and revision rates. Whatever, VBT is still in its infancy and may have a promising future as a non-fusion solution for AIS.
    MeSH term(s) Humans ; Adolescent ; Scoliosis/diagnostic imaging ; Scoliosis/surgery ; Vertebral Body ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/surgery ; Treatment Outcome ; Kyphosis
    Language English
    Publishing date 2022-07-16
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2717704-X
    ISSN 2212-1358 ; 2212-134X ; 2212-1358
    ISSN (online) 2212-1358 ; 2212-134X
    ISSN 2212-1358
    DOI 10.1007/s43390-022-00546-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: HIF-1 suppresses lipid catabolism to promote cancer progression.

    Zhang, Huafeng

    Molecular & cellular oncology

    2015  Volume 2, Issue 4, Page(s) e980184

    Abstract: Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes ... ...

    Abstract Hypoxia-inducible factor 1 (HIF-1) promotes glycolysis in cancer cells, hence sustaining survival. We recently reported that HIF-1 suppresses fatty acid β-oxidation in malignant cells through medium- and long-chain acyl-CoA dehydrogenases. This promotes tumor progression by controlling the level of reactive oxygen species and via crosstalk between metabolism and PTEN signaling.
    Language English
    Publishing date 2015-07-07
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.4161/23723556.2014.980184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Surgical Outcomes and Prognostic Factors for Cervical Spine Fractures in Patients with Ankylosing Spondylitis.

    Tang, Zhongxin / Chen, Tailong / Tan, Jun / Zhang, Huafeng

    World neurosurgery

    2022  Volume 166, Page(s) e278–e284

    Abstract: Background: Ankylosing spondylitis (AS) often results in progressive spinal stiffness, making patients prone to spinal fractures. Cervical spine fractures in AS mostly occur in the lower segment and cause progressive neurological deficits. However, the ... ...

    Abstract Background: Ankylosing spondylitis (AS) often results in progressive spinal stiffness, making patients prone to spinal fractures. Cervical spine fractures in AS mostly occur in the lower segment and cause progressive neurological deficits. However, the optimal approach to treating this patient population is still controversial, and it is unclear what factors have an impact on prognosis. Thus, this study aimed to investigate the choice of surgical approach and prognostic factors in AS patients with cervical spine fractures.
    Methods: A total of 22 AS patients with cervical fracture who were treated in our institution were reviewed from 2015 to 2020. We analyzed demographic data, perioperative complications, postoperative results, and radiographic results. The Japanese Orthopaedic Association (JOA) score was used to assess preoperative and postoperative spinal cord function, and the improvement rate was calculated.
    Results: Twenty-two patients were enrolled, including 6 patients in the anterior approach group, 11 in the posterior approach group, and 5 in the combined approach group. The operative time and intraoperative blood loss in the anterior approach group were significantly less than those in the posterior approach group and combined approach group (P = 0.00). Patients who underwent surgery within 48 hours of injury had a lower JOA score than patients who underwent surgery later (P = 0.01). Basic AS treatment before injury significantly improved JOA scores after surgery (P = 0.01).
    Conclusions: All approaches can provide good clinical results, and thus, the surgical approach should be individualized. It remains unclear whether the operation should be performed as soon as possible. Basic AS treatment is an independent factor that affects the prognosis of cervical spine fracture patients with AS.
    MeSH term(s) Cervical Vertebrae/diagnostic imaging ; Cervical Vertebrae/injuries ; Cervical Vertebrae/surgery ; Fractures, Bone/complications ; Humans ; Neck Injuries/complications ; Prognosis ; Retrospective Studies ; Spinal Fractures/complications ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/surgery ; Spondylitis, Ankylosing/complications ; Spondylitis, Ankylosing/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-07-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2022.06.151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Associations of Copper Intake with Bone Mineral Density and Osteoporosis in Adults: Data from the National Health and Nutrition Examination Survey

    Fan, Yonggang / Ni, Shuangfei / Zhang, Huafeng

    Biological trace element research. 2022 May, v. 200, no. 5

    2022  

    Abstract: Some studies have suggested an association between serum copper and bone density. Few studies have explored the association between copper intake and osteoporosis and bone mineral density (BMD). Our research aims to assess the associations of copper ... ...

    Abstract Some studies have suggested an association between serum copper and bone density. Few studies have explored the association between copper intake and osteoporosis and bone mineral density (BMD). Our research aims to assess the associations of copper intake with the risk of osteoporosis in United States adults using the National Health and Nutritional Examination Surveys (NHANES). A total of 8224 individuals were included in our study. Osteoporosis was defined that BMD values surpass 2.5 standard deviations (SD) below the mean of the young adult reference group. Copper intake from diets and supplements was estimated by using two 24-h recall surveys. After adjustment for all the covariates of interest, the odds ratios (ORs) (95% confidence interval (CI)) between the risk of osteoporosis and total copper intake across quartiles 3 and 4 compared with quartile 1 were 0.48 (0.31–0.74) (P < 0.01) and 0.41 (0.26–0.65) (P < 0.01), respectively. The mean total femur BMD and total spine BMD of the highest dietary copper intake quartile (Cu 1.51 mg/d) was 0.03 g/cm² and 0.02 g/cm² greater than the lowest quartile. Our results indicate that dietary and total copper intake was positively associated with increasing BMD in US adults and negatively associated with the risk of osteoporosis in US adults.
    Keywords National Health and Nutrition Examination Survey ; blood serum ; bone density ; confidence interval ; copper ; femur ; osteoporosis ; research ; risk ; young adults
    Language English
    Dates of publication 2022-05
    Size p. 2062-2068.
    Publishing place Springer US
    Document type Article
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-021-02845-5
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: Structural insights into the specific recognition of mitochondrial ribosome-binding factor hsRBFA and 12 S rRNA by methyltransferase METTL15.

    Lv, Mengqi / Zhou, Wanwan / Hao, Yijie / Li, Fudong / Zhang, Huafeng / Yao, Xuebiao / Shi, Yunyu / Zhang, Liang

    Cell discovery

    2024  Volume 10, Issue 1, Page(s) 11

    Abstract: Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The ... ...

    Abstract Mitochondrial rRNA modifications are essential for mitoribosome assembly and its proper function. The m
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2056-5968
    ISSN 2056-5968
    DOI 10.1038/s41421-023-00634-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Small antisense RNA ThfR positively regulates Thf1 in Synechocystis sp. PCC 6803.

    Li, Xiang / Xue, Chunling / Chen, Hui / Zhang, Huafeng / Wang, Qiang

    Journal of plant physiology

    2022  Volume 271, Page(s) 153642

    Abstract: Thylakoid formation1 (Thf1), encoded by sll1414 (thf1), is a multifunctional protein conserved in all photosynthetic organisms. thf1 expression is highly induced by high light in Synechocystis during photosynthesis-related stress. In this study, ... ...

    Abstract Thylakoid formation1 (Thf1), encoded by sll1414 (thf1), is a multifunctional protein conserved in all photosynthetic organisms. thf1 expression is highly induced by high light in Synechocystis during photosynthesis-related stress. In this study, differential RNA sequencing analysis of the Synechocystis sp. PCC 6803 revealed a small antisense RNA (asRNA) gene located on the reverse-complementary strand of the thf1 gene. The full length of this asRNA (designated ThfR) was determined by 5' and 3' RACE analysis. The accumulation of thf1 mRNA was up-regulated synchronously with the ThfR level during survival after high-light stress or nitrogen starvation. Under nitrogen starvation or high-light stress, compared with the wild type, a ThfR overexpression mutant demonstrated relatively more Thf1 protein content, while a ThfR reduced-expression mutant accumulated less Thf1 protein. Furthermore, the overexpression of ThfR enhanced the electron transport rate and the proliferation of cyanobacteria under high-light stress. These results, which we confirmed further using an Escherichia coli sRNA expression platform, suggest that the thf1 gene is positively regulated by ThfR, possibly through protection of the RAUUW element at the RNase E cleavage site. This study represents the first report, to our knowledge, of a cis-transcript antisense RNA that targets thf1 in Synechocystis sp. PCC 6803 and provides evidence that ThfR regulates photosynthesis by positively modulating thf1 under high-light conditions.
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Light ; Photosynthesis/genetics ; RNA, Antisense/genetics ; RNA, Antisense/metabolism ; RNA, Messenger/genetics ; Synechocystis/genetics ; Thylakoids/metabolism
    Chemical Substances Bacterial Proteins ; RNA, Antisense ; RNA, Messenger
    Language English
    Publishing date 2022-02-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 283647-6
    ISSN 1618-1328 ; 0176-1617
    ISSN (online) 1618-1328
    ISSN 0176-1617
    DOI 10.1016/j.jplph.2022.153642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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