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Book ; Online: Preparation of Novel Nanomaterial and Its Application in Food Industry

Wu, Hong / Zhang, Hui

2022

Keywords	Public health & preventive medicine ; nano/micro-structure ; pesticide detection card ; electrospinning ; hydrophilic modification ; sensitivity ; naringenin ; naringin ; nanoliposomes ; pH-driven ; stability ; thymol ; nanosuspensions ; caseinate ; pH-driven method ; water solubility ; cinnamaldehyde ; halloysite nanotubes ; sodium alginate ; release ; dexamethasone ; time-resolved fluorescent microspheres ; immunochromatographic assay ; milk ; pork ; emulsions ; soy protein ; soy polysaccharide ; soy lecithin ; delivery ; electrspinning ; Nervilia fordii extract ; nano-encapsulation ; antioxidant activity ; solution blow spinning ; gelatin ; nylon 66 ; modification ; rapid fabrication ; Zein ; 7,8-dihydroxyflavone ; sophorolipid ; polysaccharide ; ternary nanoparticles ; lutein ; bioaccessibility ; encapsulation ; microfluidics ; nodularin ; nanobody ; detection ; ic-ELISA ; fluorescence ; quantum dots ; copper (II) ions ; water ; photoelectrochemical detection ; aptamer ; Listeria monocytogenes ; exonuclease I ; n/a
Language	0\|e
Size	1 electronic resource (214 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021621689
ISBN	9783036544090 ; 3036544097
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Book: High-Throughput Mass Spectrometry in Drug Discovery

Liu, Chang / Zhang, Hui

2023

Author's details	Chang Liu, Ph.D., is a Staff Research Scientist at SCIEX, a global leader in the design and production of mass spectrometers. He has published extensively on using mass spectrometry in drug discovery and development. Hui Zhang, Ph.D., is the Vice President of Analytical Technologies at Entos, a biotech company focusing on Artificial Intelligence and High-Throughput Experimentation driving drug discovery. He has published widely on mass spectrometry and its pharmaceutical applications through his previous tenure at Pfizer
Language	English
Size	512 p.
Publisher	John Wiley & Sons Ltd
Document type	Book
Note	PDA Manuell_23
Format	157 x 235 x 32
ISBN	9781119678434 ; 1119678439
Database	PDA

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Article ; Online: Fuzzy comprehensive evaluation and quantitative weight analysis in structure management of human resources.

Zhang, Hui

PloS one

2023 Volume 18, Issue 7, Page(s) e0288795

Abstract: This research delves into the application effects of Fuzzy Comprehensive Evaluation (FCE) and quantitative weight analysis in the structure management of human resources (SMHR) to optimize the structure management. The research begins by analyzing the ... ...

Abstract	This research delves into the application effects of Fuzzy Comprehensive Evaluation (FCE) and quantitative weight analysis in the structure management of human resources (SMHR) to optimize the structure management. The research begins by analyzing the existing problems in SMHR, such as incomplete performance feedback and error-prone outsourcing decisions. By leveraging human resource management (HRM) characteristics, the researchers construct the SMHR evaluation index system. The Analytical Hierarchy Process (AHP) is employed to establish a hierarchical human resource structure model to determine the relative weight of each HRM indicator. Subsequently, the FCE method is utilized to build an SMHR optimization model, which is then scrutinized and assessed by means of an example. The findings indicate that the consistency ratio (C.R.) values of the first and second-level evaluation factors of the constructed model are less than 0.1, thus passing the consistency test and demonstrating credibility. Ultimately, the research effectively grades SMHR in the enterprise through the analysis of HRM optimization. Accordingly, this research presents a set of optimization suggestions and measures, including the establishment of a professional HRM operation team, acceleration of the construction of a professional talent team, enhancement of the intelligent level of the HRM center, and transition towards digital sharing. These proposed measures can serve as valuable experimental references for the optimization and improvement of HRM structures in future enterprises.
MeSH term(s)	Humans ; Workforce ; Outsourced Services
Language	English
Publishing date	2023-07-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0288795
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulation of DNA Replication Licensing and Re-Replication by Cdt1.

Zhang, Hui

International journal of molecular sciences

2021 Volume 22, Issue 10

Abstract: In eukaryotic cells, DNA replication licensing is precisely regulated to ensure that the initiation of genomic DNA replication in S phase occurs once and only once for each mitotic cell division. A key regulatory mechanism by which DNA re-replication is ... ...

Abstract	In eukaryotic cells, DNA replication licensing is precisely regulated to ensure that the initiation of genomic DNA replication in S phase occurs once and only once for each mitotic cell division. A key regulatory mechanism by which DNA re-replication is suppressed is the S phase-dependent proteolysis of Cdt1, an essential replication protein for licensing DNA replication origins by loading the Mcm2-7 replication helicase for DNA duplication in S phase. Cdt1 degradation is mediated by CRL4
MeSH term(s)	Animals ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA Replication ; Genomic Instability ; Humans
Chemical Substances	CDT1 protein, human ; Cell Cycle Proteins
Language	English
Publishing date	2021-05-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22105195
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Article: Propofol Modulates Gallbladder Cancer Progression via miR-4430/SLC19A3 Axis.

Zhang, Hui / Zhang, Bei

Alternative therapies in health and medicine

2024

Abstract: Background/aim: Propofol is a common anesthetic used during surgery. MircoRNA (miRNA), especially miR-4430, is currently a research hotspot in GBC. This study investigates whether propofol regulates GBC through the miR-4430/SLC19A3 axis.: Materials ... ...

Abstract	Background/aim: Propofol is a common anesthetic used during surgery. MircoRNA (miRNA), especially miR-4430, is currently a research hotspot in GBC. This study investigates whether propofol regulates GBC through the miR-4430/SLC19A3 axis. Materials and methods: NOZ and SGC996 cells, human gallbladder cancer cell lines, were obtained from BLUEFBIO (Shanghai, China). The cells were treated with propofol, and the experimental setup included a control group. qRT-PCR was used to measure the content of miR-4430 and solute carrier family 19 member 3 (SLC19A3). The cell viability, migration, and apoptosis were analyzed by colony formation assay, wound healing assay, and flow cytometry, respectively. Western blot tested the levels of SLC91A3, cyclin D-dependent kinases 6 (CDK6), and Bax proteins. Mechanically, dual-luciferase reporter assay notarized the link of miR-4430 with SLC19A3. Results: Propofol significantly repressed the proliferation of GBC cells, as indicated by a pronounced reduction in colony formation in both NOZ and SGC996 cells (P = .025, 95% CI:1.2, 2.4). The inhibitory effect of propofol was reversed by the enhanced expression of miR-4430 in GBC cells. Furthermore, SLC19A3 was identified as a direct target of miR-4430. Silencing SLC19A3 reversed the altered cell behavior observed in propofol-treated GBC cells (P = .019, 95% CI:1.6, 3.5). Additionally, overexpression of SLC19A3 significantly attenuated both cell proliferation and migration influenced by miR-4430 in propofol-treated GBC cells (P = .034, 95% CI:1.4, 2.8). Conclusion: Propofol changed the cell behaviors of GBC by modulating the miR-4430/SLC19A3 axis.
Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4504: Show issues

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Article: The Association Between

Zhang, Hui / Jiang, Wei

International journal of general medicine

2024 Volume 17, Page(s) 1213–1220

Abstract: Background: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promoting the angiogenic phenotype of ankylosing spondylitis (AS). Studies demonstrated that : Methods: To investigate the association between : Results: Our data ... ...

Abstract	Background: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promoting the angiogenic phenotype of ankylosing spondylitis (AS). Studies demonstrated that Methods: To investigate the association between Results: Our data indicated that Conclusion: In conclusion, this study indicated that
Language	English
Publishing date	2024-03-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S448976
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Article ; Online: A game-theoretical dynamic imitation model on networks.

Zhang, Hui

Journal of mathematical biology

2021 Volume 82, Issue 4, Page(s) 30

Abstract: A game-theoretical model is constructed to capture the effect of imitation on the evolution of cooperation. This imitation describes the case where successful individuals are more likely to be imitated by newcomers who will employ their strategies and ... ...

Abstract	A game-theoretical model is constructed to capture the effect of imitation on the evolution of cooperation. This imitation describes the case where successful individuals are more likely to be imitated by newcomers who will employ their strategies and social networks. Two classical repeated strategies 'always defect (ALLD)' and 'tit-for-tat (TFT)' are adopted. Mathematical analyses are mainly conducted by the method of coalescence theory. Under the assumption of a large population size and weak selection, the results show that the evolution of cooperation is promoted in this dynamic network. As we observed that the critical benefit-to-cost ratio is smaller compared to that in well-mixed populations. The critical benefit-to-cost ratio approaches a specific value which depends on three parameters, the repeated rounds of the game, the effective strategy mutation rate, and the effective link mutation rate. Specifically, for a very high value of the effective link mutation rate, the critical benefit-to-cost ratio approaches 1. Remarkably, for a low value of the effective link mutation rate, by letting the effective strategy mutation is nearly equal to zero, the critical benefit-to-cost ratio approaches [Formula: see text] for the resulting highly connected networks, which allows TFT to be evolutionary stable. It illustrates that dominance of TFTs is associated with more connected networks. This research can enrich the theory of the coevolution of game strategy and network structure with dynamic imitation.
Language	English
Publishing date	2021-03-08
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	187101-8
ISSN	1432-1416 ; 0303-6812
ISSN (online)	1432-1416
ISSN	0303-6812
DOI	10.1007/s00285-021-01573-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1495: Show issues

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Article ; Online: Lysine Methylation-Dependent Proteolysis by the Malignant Brain Tumor (MBT) Domain Proteins.

Sun, Hong / Zhang, Hui

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Lysine methylation is a major post-translational protein modification that occurs in both histones and non-histone proteins. Emerging studies show that the methylated lysine residues in non-histone proteins provide a proteolytic signal for ubiquitin- ... ...

Abstract	Lysine methylation is a major post-translational protein modification that occurs in both histones and non-histone proteins. Emerging studies show that the methylated lysine residues in non-histone proteins provide a proteolytic signal for ubiquitin-dependent proteolysis. The SET7 (SETD7) methyltransferase specifically transfers a methyl group from S-Adenosyl methionine to a specific lysine residue located in a methylation degron motif of a protein substrate to mark the methylated protein for ubiquitin-dependent proteolysis. LSD1 (Kdm1a) serves as a demethylase to dynamically remove the methyl group from the modified protein. The methylated lysine residue is specifically recognized by L3MBTL3, a methyl-lysine reader that contains the malignant brain tumor domain, to target the methylated proteins for proteolysis by the CRL4
MeSH term(s)	Humans ; Proteolysis ; Lysine/metabolism ; Methylation ; Protein Processing, Post-Translational ; Histones/metabolism ; Brain Neoplasms ; Ubiquitins/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Chromosomal Proteins, Non-Histone/metabolism
Chemical Substances	Lysine (K3Z4F929H6) ; methyl-lysine ; Histones ; Ubiquitins ; SETD7 protein, human (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; PHF20L1 protein, human ; Chromosomal Proteins, Non-Histone
Language	English
Publishing date	2024-02-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042248
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nurse Supervised at Institutes versus Nurse Counseling Home-Based Resistance Exercise Training for Acute Pancreatitis.

Huang, Jing / Zhang, Hui

Digestive diseases and sciences

2024 Volume 69, Issue 3, Page(s) 692–701

Abstract: Background: The physical and mental quality of life of patients with acute pancreatitis is poor. Professional nurses have the necessary knowledge, art, and skills to aid in resistance exercise training.: Aims: To evaluate the effectiveness of 6 ... ...

Abstract	Background: The physical and mental quality of life of patients with acute pancreatitis is poor. Professional nurses have the necessary knowledge, art, and skills to aid in resistance exercise training. Aims: To evaluate the effectiveness of 6 months of nurse-supervised resistance exercise training plus nutritional supplements and 6 months of nurse counseling home-based resistance exercise training plus nutritional supplements for patients with pancreatitis. Methods: Patients with acute pancreatitis (age ≥ 18 years) received nurse-supervised resistance exercise training at the institute (NEN cohort, n = 103), nurse counseling for home-based resistance exercise (HEN cohort, n = 123), or usual care (UCN cohort, n = 155) for 6 months. All patients received advice regarding nutritional especially protein supplements. Results: Before non-treatment intervention(s) (BL), quality of life score of patients was 53, mild-to-moderate self-reported pain episodes, or worse pain, and a total of 22% of patients were disabled. Patients in the NEN cohort had improved quality of life and decreased pain and disability after 6 months of non-treatment intervention(s) (EL) compared to their BL condition and those of the UCN and HEN cohorts at EL (p < 0.05 for all). A smaller number of patients were hospitalized and died in the NEN cohort than in the UCN and HEN cohorts (p ≤ 0.001 for both) during the follow-up period. Conclusion: The quality of life, pain, and disability condition(s) of patients with acute pancreatitis should be improved. Nurse-supervised resistance exercise training at the institute associated with improvement in the quality of life and decrease of pain, disability, hospitalization, and death of patients with acute pancreatitis.
MeSH term(s)	Humans ; Adolescent ; Exercise Therapy/psychology ; Resistance Training ; Quality of Life ; Acute Disease ; Pancreatitis/therapy ; Counseling ; Pain
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-08241-4
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Article ; Online: Efficacy and safety of solifenacin combined with biofeedback in children with overactive bladder.

Hu, Yan / Zhang, Hui

BMC urology

2024 Volume 24, Issue 1, Page(s) 97

Abstract: Background: Overactive bladder is a common chronic urological disorder in children, liable to impact normal social activities, disrupt sleep and even impair self-esteem. We aimed to evaluate the efficacy and safety of solifenacin combined with ... ...

Abstract	Background: Overactive bladder is a common chronic urological disorder in children, liable to impact normal social activities, disrupt sleep and even impair self-esteem. We aimed to evaluate the efficacy and safety of solifenacin combined with biofeedback for paediatric overactive bladder. Method: Forty-five children with overactive bladder were enrolled and divided into three groups: 15 patients in Group A were treated with solifenacin, 15 cases in Group B with biofeedback, and the other 15 patients in Group C with the combination of solifenacin plus biofeedback. Each group was subdivided into the non-urge incontinence (non-UI) and urge incontinence (UI) groups. The remission rates were compared among the three groups at 2, 4, 8 and 12 weeks from the beginning of treatment. The side effects of solifenacin were recorded and followed up. Result: After 2 weeks since initial treatment, the complete response rates were 33.3% (5/15), 20.0% (3/15), and 53.3% (8/15) in the three groups. At 4 weeks, the complete remission rates were 46.7% (7/15), 33.3% (5/15), and 60.0% (9/15) respectively. Moreover, the complete remission rates of the UI groups were higher than the non-UI groups (p < 0.05). At 8 weeks, the complete response rates were 53.3% (8/15), 40.0% (6/15), and 67.7% (10/15). At 12 weeks, the complete response rates were 67.8% (10/15), 60.0% (9/15), and 86.7% (13/15). The complete response rates were higher and urodynamic parameters were improved obviously in group C than the other two groups (p < 0.05) during the follow-ups. The median voiding frequency decreased and median functional bladder capacity increased obviously in Group C after 4 weeks (p < 0.05). Dry mouth was observed in 2 patients (4.4%). 2 patients experienced constipation (4.4%), and neither case was severe. The symptoms of these four patients had relieved by reducing the dose of solifenacin. Conclusion: Solifenacin combined with biofeedback had good efficacy and compliance for children experiencing overactive bladder. It took only 2 weeks to achieve the complete response rate over 50%, especially for the improvement of UI symptoms.
MeSH term(s)	Humans ; Solifenacin Succinate/therapeutic use ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/therapy ; Child ; Female ; Male ; Treatment Outcome ; Biofeedback, Psychology ; Combined Modality Therapy ; Muscarinic Antagonists/therapeutic use ; Adolescent ; Child, Preschool
Chemical Substances	Solifenacin Succinate (KKA5DLD701) ; Muscarinic Antagonists
Language	English
Publishing date	2024-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2059857-9
ISSN	1471-2490 ; 1471-2490
ISSN (online)	1471-2490
ISSN	1471-2490
DOI	10.1186/s12894-024-01486-9
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