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Article ; Online: Updates in Cervical Cancer Screening Guidelines, The Bethesda System for Reporting Cervical Cytology, and Clinical Management Recommendations.

Wang, Tiannan / Zhang, Huina / Liu, Yang / Zhao, Chengquan

Journal of clinical and translational pathology

2023 Volume 3, Issue 2, Page(s) 75–83

Abstract: Over the past decades, cervical cancer has been a worldwide public health problem. Population-based early cancer risk detection and prevention approaches, including vaccination, cytology screening and human papilloma virus (HPV) detection, with the ... ...

Abstract	Over the past decades, cervical cancer has been a worldwide public health problem. Population-based early cancer risk detection and prevention approaches, including vaccination, cytology screening and human papilloma virus (HPV) detection, with the aligned clinical management, have formed a well-rounded high-quality implementation system for cervical cancer control, and revolutionarily improved the quality of life of women: (1) the success of cervical cancer screening practices, (2) standardization of The Bethesda system for reporting cervicovaginal cytology, (3) improvement in the understanding of HPV pathogenesis in cervical cancer, and (4) the development of appropriate management approaches have significantly decreased the disease burden of cervical cancer worldwide. This scoping review aimed to understand the evolvement of cervical cancer screening and management guidelines, describe the Bethesda cervical cytology reporting system, and HPV vaccines and tests, and highlight the key information of present policies and practices.
Language	English
Publishing date	2023-04-21
Publishing country	United States
Document type	Journal Article
ISSN	2771-165X
ISSN (online)	2771-165X
DOI	10.14218/jctp.2023.00004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis.

Liu, Peng / Cao, Baige / Zhou, Yang / Zhang, Huina / Wang, Congrong

Journal of molecular cell biology

2023 Volume 15, Issue 5

Abstract: Hyperglycaemia-induced oxidative stress may disrupt insulin secretion and β-cell survival in diabetes mellitus by overproducing reactive oxygen species. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit antioxidant properties. ... ...

Abstract	Hyperglycaemia-induced oxidative stress may disrupt insulin secretion and β-cell survival in diabetes mellitus by overproducing reactive oxygen species. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit antioxidant properties. However, the mechanisms by which hUC-MSCs protect β-cells from high glucose-induced oxidative stress remain underexplored. In this study, we showed that intravenously injected hUC-MSCs engrafted into the injured pancreas and promoted pancreatic β-cell function in a mouse model of type 1 diabetes mellitus. The in vitro study revealed that hUC-MSCs attenuated high glucose-induced oxidative stress and prevented β-cell impairment via the Nrf2/HO-1 signalling pathway. Nrf2 knockdown partially blocked the anti-oxidative effect of hUC-MSCs, resulting in β-cell decompensation in a high-glucose environment. Overall, these findings provide novel insights into how hUC-MSCs protect β-cells from high glucose-induced oxidative stress.
MeSH term(s)	Animals ; Humans ; Mice ; Glucose/metabolism ; Mesenchymal Stem Cells/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Umbilical Cord
Chemical Substances	Glucose (IY9XDZ35W2) ; NF-E2-Related Factor 2 ; HMOX1 protein, human (EC 1.14.14.18) ; NFE2L2 protein, human
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2500949-7
ISSN	1759-4685 ; 1759-4685
ISSN (online)	1759-4685
ISSN	1759-4685
DOI	10.1093/jmcb/mjad035
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Article: The Evolution of Ki-67 and Breast Carcinoma: Past Observations, Present Directions, and Future Considerations.

Finkelman, Brian S / Zhang, Huina / Hicks, David G / Turner, Bradley M

Cancers

2023 Volume 15, Issue 3

Abstract: The 1983 discovery of a mouse monoclonal antibody-the Ki-67 antibody-that recognized a nuclear antigen present only in proliferating cells represented a seminal discovery for the pathologic assessment of cellular proliferation in breast cancer and other ... ...

Abstract	The 1983 discovery of a mouse monoclonal antibody-the Ki-67 antibody-that recognized a nuclear antigen present only in proliferating cells represented a seminal discovery for the pathologic assessment of cellular proliferation in breast cancer and other solid tumors. Cellular proliferation is a central determinant of prognosis and response to cytotoxic chemotherapy in patients with breast cancer, and since the discovery of the Ki-67 antibody, Ki-67 has evolved as an important biomarker with both prognostic and predictive potential in breast cancer. Although there is universal recognition among the international guideline recommendations of the value of Ki-67 in breast cancer, recommendations for the actual use of Ki-67 assays in the prognostic and predictive evaluation of breast cancer remain mixed, primarily due to the lack of assay standardization and inconsistent inter-observer and inter-laboratory reproducibility. The treatment of high-risk ER-positive/human epidermal growth factor receptor-2 (HER2) negative breast cancer with the recently FDA-approved drug abemaciclib relies on a quantitative assessment of Ki-67 expression in the treatment decision algorithm. This further reinforces the urgent need for standardization of Ki-67 antibody selection and staining interpretation, which will hopefully lead to multidisciplinary consensus on the use of Ki-67 as a prognostic and predictive marker in breast cancer. The goals of this review are to highlight the historical evolution of Ki-67 in breast cancer, summarize the present literature on Ki-67 in breast cancer, and discuss the evolving literature on the use of Ki-67 as a companion diagnostic biomarker in breast cancer, with consideration for the necessary changes required across pathology practices to help increase the reliability and widespread adoption of Ki-67 as a prognostic and predictive marker for breast cancer in clinical practice.
Language	English
Publishing date	2023-01-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030808
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A description of ophthalmic management of late recovered facial paralysis with patient-tailored procedures: a case report.

Zhang, Hui-Na / Xie, Jia-Jun / Gao, Qi / Ye, Juan

International journal of ophthalmology

2023 Volume 16, Issue 4, Page(s) 668–670

Language	English
Publishing date	2023-04-18
Publishing country	China
Document type	Journal Article
ZDB-ID	2663246-9
ISSN	2227-4898 ; 2222-3959
ISSN (online)	2227-4898
ISSN	2222-3959
DOI	10.18240/ijo.2023.04.25
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Article: Clinical Efficacy of Medical Dextrose Tincture Liquid in the Treatment of Facial Photoaging.

Song, Yuexing / Liu, Qiuhui / Zhang, Yihan / Zhang, Huina / Li, Bin

Dermatology practical & conceptual

2023 Volume 13, Issue 1

Abstract: Introduction: Exogenous aging mainly refers to photo-aging, which is caused by environmental factors including ultraviolet exposure. Dextran is a homopolysaccharide composed of glucose as monosaccharide, and glucose units are connected by glycosidic ... ...

Abstract	Introduction: Exogenous aging mainly refers to photo-aging, which is caused by environmental factors including ultraviolet exposure. Dextran is a homopolysaccharide composed of glucose as monosaccharide, and glucose units are connected by glycosidic bonds. Objectives: The purpose of this study was to explore the clinical efficacy of medical dextrose tincture liquid (medical dextrose tincture) in the treatment of facial photoaging. Methods: Thirty-four volunteers were included in the randomized double-blind study. According to the random number table method, the subjects were randomized into control and treatment groups. The subjects in the control and treatment groups were treated with medical hyaluronic acid gel and medical dextrose tincture, respectively. They received mesotherapy therapy three times with an interval of 28 days between treatments. Video image acquisition was performed before treatment and 28 days after treatment. Skin moisture content, glossiness, heme content, collagen density, and elasticity were tested. The subjective evaluations of subjects and doctors before and after treatment were compared. Results: Compared with the pre-treatment baseline, medical dextran tincture significantly increased skin moisture retention, skin gloss, and skin collagen density (p<0.001). Additionally, the skin retraction time was significantly reduced, and the skin retraction time was also markedly decreased after treatment with medical dextran tincture (p<0.001). The effects of medical dextran tincture were more significant in comparison with medical hyaluronic acid gel (p<0.05). The subjective evaluation results of doctors showed that after 84 days of treatment, the overall skin photoaging score was significantly reduced (p<0.001). The subjective evaluation results of volunteers showed that the various skin problems of more than 50% of volunteers were improved after treatment. Conclusion: Medical dextran tincture has obvious effects of moisturizing, increasing luster, improving skin redness, increasing skin collagen content and enhancing skin elasticity.
Language	English
Publishing date	2023-01-01
Publishing country	Austria
Document type	Journal Article
ZDB-ID	2685397-8
ISSN	2160-9381
ISSN	2160-9381
DOI	10.5826/dpc.1301a15
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Article ; Online: Physical appearance perfectionism in blepharoplasty patients: A prospective observational study.

Lou, Lixia / Sun, Yiming / Zhang, Huina / Shi, Xin / Ye, Juan

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 80, Page(s) 102–106

Abstract: Background: Evaluation of physical appearance perfectionism (PAP) in individuals seeking blepharoplasty would be meaningful. This study aimed to explore the relationship of demographic and psychological variables with PAP in blepharoplasty patients and ... ...

Abstract	Background: Evaluation of physical appearance perfectionism (PAP) in individuals seeking blepharoplasty would be meaningful. This study aimed to explore the relationship of demographic and psychological variables with PAP in blepharoplasty patients and further investigate the impact of blepharoplasty on PAP in these patients. Methods: This prospective observational study included 153 patients undergoing blepharoplasty between October 2017 and June 2019. Demographic and psychological variables, and PAP, were collected preoperatively. Postoperative satisfaction with eye appearance and PAP was collected with a 6-month follow-up. Results: Partial correlations analyses revealed that hope for perfection was positively associated with self-esteem (r = 0.246; P < 0.01) in 153 blepharoplasty patients. Worry about imperfection was positively related to facial appearance concern (r = 0.703; P < 0.001) and negatively related to satisfaction with eye appearance (r = -0.242; P < 0.01) and self-esteem (r = -0.533; P < 0.001). After blepharoplasty, the mean± standard deviation of satisfaction with eye appearance increased (preoperatively vs. postoperatively: 5.1 ± 2.2 vs. 7.4 ± 2.2; P < 0.001), and worry about imperfection decreased (17.0 ± 4.2 vs. 15.9 ± 4.6; P < 0.001). Whereas hope for perfection remained unchanged (23.9 ± 3.9 vs. 23.6 ± 3.9; P > 0.05). Conclusions: Appearance perfectionism was related to psychological variables rather than demographic variables in blepharoplasty patients. Preoperative evaluation of appearance perfectionism could be helpful for oculoplastic surgeons to screen for perfectionistic patients. Although some improvement in perfectionism has been observed after blepharoplasty, long-term follow-up is needed in the future.
MeSH term(s)	Humans ; Blepharoplasty/psychology ; Perfectionism ; Eyelids/surgery ; Physical Appearance, Body ; Surveys and Questionnaires
Language	English
Publishing date	2023-02-09
Publishing country	Netherlands
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.02.003
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Article ; Online: Composition analysis and microencapsulation of Eucommia ulmoides seed oil

Zhang Huirong / Zhang huina / Chen Nifeng / Li Li

BMC Chemistry, Vol 15, Iss 1, Pp 1-

2021 Volume 10

Abstract: Abstract Background Eucommia ulmoides seed oil is a functional health oil with a high content of unsaturated fatty acids. However, excessively high content of unsaturated fatty acids can cause E. ulmoides seed oil to easily spoil. Microencapsulation ... ...

Abstract	Abstract Background Eucommia ulmoides seed oil is a functional health oil with a high content of unsaturated fatty acids. However, excessively high content of unsaturated fatty acids can cause E. ulmoides seed oil to easily spoil. Microencapsulation technology can effectively encapsulate substances, thereby prolonging the spoilage time of oil products. Methods In the present study, E. ulmoides seed oil from different manufacturers were analyzed by Agilent 7890B-5977A gas chromatography–mass spectrometry. Encapsulation efficiency, yield rate, and scanning electron microscopy results between microcapsules prepared use different wall materials and different methods (spray drying and complex coagulation) were compared to determine the best preparation process for microcapsules. The Wantong 892 professional oil oxidation stability tester was used to measure the induced oxidation time of the E. ulmoides seed oil and microcapsules. Conclusion E. ulmoides seed oil comprises > 80% unsaturated fatty acids with a high α-linolenic acid content, followed by linoleic acid. The most promising combination was chitosan:gum arabic at 1:8 as the wall material and complex coagulation. The best preparation had a wall material concentration, stirring speed, aggregation pH, and core-to-wall ratio of 2.5%, 500 rpm, 4.2, and 1:4, respectively. Microcapsules prepared under these conditions exhibited higher yield and encapsulation efficiency (94.0% and 73.3%, respectively). The induced oxidation time of the E. ulmoides seed oil and microcapsules were 3.8 h and 13.9 h, respectively, indicating that microencapsulation can increase the oxidation induction time of this oil.
Keywords	Eucommia ulmoides seed oil ; GC–MS ; Component analysis ; Microencapsulation ; Complex coagulation ; Oxidation stability ; Chemistry ; QD1-999
Subject code	660
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Morphine increases myocardial triacylglycerol through regulating adipose triglyceride lipase S406 phosphorylation

Li, Linghai / Wang, Jinghui / Li, Ding / Zhang, Huina

Life sciences. 2021 Oct. 15, v. 283

2021

Abstract: Morphine, a commonly used drug for anesthesia, affects lipid metabolism in different tissues, but the mechanism is currently unclear. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme responsible for the first step of triglyceride (TG) ... ...

Abstract	Morphine, a commonly used drug for anesthesia, affects lipid metabolism in different tissues, but the mechanism is currently unclear. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme responsible for the first step of triglyceride (TG) hydrolysis. Here we aim to investigate whether ATGL phosphorylation is involved in morphine-induced TG accumulation.Oil red O staining and TG content analysis were used to detect the effect of morphine on lipid storage. A series of ATGL phosphoamino acid site mutant plasmids were constructed by gene synthesis and transfected to HL-1 cells to evaluate the phosphorylation levels of ATGL phosphoamino acid in morphine-treated HL-1 cells with immunoprecipitation and immunoblotting assay.Morphine acute treatment induced excessive accumulation of TG and decreased the phosphorylation level of ATGL Ser406 in HL-1 cells. Of note, the phosphorylation positive mutation of ATGL Ser406 to aspartic acid effectively reversed morphine-induced excessive accumulation of TG in HL-1 cells.This discovery will help to fully understand the lipid regulation function of morphine in a new scope. In addition, it will expand the phosphorylation research of ATGL more comprehensively and provide powerful clues for lipid metabolism regulation.
Keywords	anesthesia ; aspartic acid ; genes ; hydrolysis ; immunoblotting ; lipid metabolism ; morphine ; mutants ; mutation ; phosphorylation ; plasmids ; precipitin tests ; triacylglycerol lipase ; triacylglycerols
Language	English
Dates of publication	2021-1015
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2021.119866
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Machine learning-based construction of immunogenic cell death-related score for improving prognosis and response to immunotherapy in melanoma.

Li, Guoyin / Zhang, Huina / Zhao, Jin / Liu, Qiongwen / Jiao, Jinke / Yang, Mingsheng / Wu, Changjing

Aging

2023 Volume 15, Issue 7, Page(s) 2667–2688

Abstract: Background: Immunogenic cell death (ICD) is a form of regulated cell death (RCD) which could drive the activation of the innate and adaptive immune responses. In this work, we aimed to develop an ICD-related signature to facilitate the assessment of ... ...

Abstract	Background: Immunogenic cell death (ICD) is a form of regulated cell death (RCD) which could drive the activation of the innate and adaptive immune responses. In this work, we aimed to develop an ICD-related signature to facilitate the assessment of prognosis and immunotherapy response for melanoma patients. Methods: A set of machine learning methods, including consensus clustering, non-negative matrix factorization (NMF) method and least absolute shrinkage and selection operator (LASSO) logistic regression model, and bioinformatics analytic tools were integrated to construct an ICD-related risk score (ICDscore). CIBERSORT and ESTIMATE algorithm were used to evaluate the infiltration of immune cells. The 'pRRophetic' package in R and 6 cohorts of melanoma patients receiving immunotherapy were used for therapy sensitivity analyses. The predictive performance between ICDscore with other mRNA signatures were also compared. Results: The ICDscore could predict prognosis and immunotherapy response in multiple cohorts, and displayed superior performance than other forms of cell death-related signatures or 52 published signatures. The melanoma patients with low ICDscore were marked with high infiltration of immune cells, high expression of immune checkpoint inhibitor-related genes, and increased tumor mutation burden. Conclusions: In conclusion, we constructed a stable and robust ICD-related signature for evaluating the prognosis and benefits of immunotherapy, and it could serve as a promising tool to guide decision-making and surveillance for individual melanoma patients.
MeSH term(s)	Humans ; Immunogenic Cell Death ; Melanoma/therapy ; Prognosis ; Immunotherapy ; Machine Learning ; Tumor Microenvironment
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.204636
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Eyelid squamous cell carcinoma in the setting of epidermodysplasia verruciformis (EV) diagnosed by next-generation sequencing: A case report and literature review.

Wang, Linyan / Fang, Hong / Shao, An / Zhang, Huina / Ye, Juan

Advances in ophthalmology practice and research

2022 Volume 2, Issue 3, Page(s) 100066

Language	English
Publishing date	2022-06-26
Publishing country	United States
Document type	Case Reports
ISSN	2667-3762
ISSN (online)	2667-3762
DOI	10.1016/j.aopr.2022.100066
Database	MEDical Literature Analysis and Retrieval System OnLINE

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