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Article ; Online: Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling.

Li, Cong / Zhang, Huishan / Mo, Jiali / Zuo, Jingye / Ye, Leping

2023 Volume 98, Issue 1, Page(s) 207–221

Abstract: Perfluorooctane sulfonate (PFOS) is widely used in industry and consumer products. Previous studies have showed that PFOS gestational exposure is associated with offspring lung damage in rat. However, the underlying mechanisms remain poorly understood. ... ...

Abstract	Perfluorooctane sulfonate (PFOS) is widely used in industry and consumer products. Previous studies have showed that PFOS gestational exposure is associated with offspring lung damage in rat. However, the underlying mechanisms remain poorly understood. In this study, we investigated the role of gasdermin E (GSDME) in lung injury of offspring and its underlying mechanisms using in vivo and in vitro approaches. Pregnant SD rats were exposed to PFOS (1 mg/kg BW/d) between gestational day 12-18, and the lung tissue of the offspring was evaluated on postnatal day 7. PFOS treated animals exhibited alveolar septal thickening and inflammation-related damages, with an increased expression of GSDME in alveolar type II epithelial cells (AECII). Furthermore, in vitro experiments demonstrated that PFOS exposure (with 225 μM and up) upregulated the caspase-3/GSDME signaling pathway in AECII. Also, ultrastructure analysis revealed significant changes in the endoplasmic reticulum (ER) structure in PFOS-induced pyroptotic cells, which is consistent with the ER stress detected in these cells. Additionally, PFOS exposure led to increased expression of ER stress-related proteins, including p-PERK, p-eIF2α, ATF4, and CHOP. Subsequently, using specific inhibitors, we found that the PERK/ATF4 pathway acted as an upstream signal regulating GSDME-dependent pyroptosis. Overall, our findings show that GSDME-dependent pyroptosis plays a crucial role in the lung injury induced by gestational PFOS exposure, and the PERK/ATF4 pathway may function as a possible mediator of this process.
MeSH term(s)	Animals ; Rats ; Activating Transcription Factor 4/metabolism ; Caspase 3/metabolism ; Endoplasmic Reticulum Stress ; Eukaryotic Initiation Factor-2/metabolism ; Lung Injury/chemically induced ; Pyroptosis ; Rats, Sprague-Dawley ; Signal Transduction ; Transcription Factor CHOP/metabolism
Chemical Substances	Activating Transcription Factor 4 (145891-90-3) ; Caspase 3 (EC 3.4.22.-) ; Eukaryotic Initiation Factor-2 ; Transcription Factor CHOP (147336-12-7) ; Gsdme protein, rat ; Casp3 protein, rat (EC 3.4.22.-)
Language	English
Publishing date	2023-11-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-023-03626-w
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Article ; Online: Based on Immune Microenvironment and Genomic Status, Exploring Immunotherapy in Advanced Hidradenocarcinoma: A Retrospective Analysis.

Lin, Jing / Zhu, Li / Chen, Yanping / Li, Qian / Ke, Zhiheng / Zhang, Huishan / Huang, Yufang / Lu, Jianping / Chen, Yu

Acta dermato-venereologica

2024 Volume 104, Page(s) adv22146

Abstract: There are no standard treatment guidelines for hidradenocarcinoma, and the immune microenvironment and genomic data are very limited. Thus, in this study the immune microenvironment and genomic indicators in hidradenocarcinoma was investigated, and ... ...

Abstract	There are no standard treatment guidelines for hidradenocarcinoma, and the immune microenvironment and genomic data are very limited. Thus, in this study the immune microenvironment and genomic indicators in hidradenocarcinoma was investigated, and immunotherapy for hidradenocarcinoma was initially explored. Forty-seven hidradenocarcinoma patients were retrospectively collected. Immunohistochemical staining was performed to identify CD3/CD8+ T cells and programmed death ligand-1 expression. In total, 89.4% and 10.6% of samples had Immunoscores of 0-25% and 25-70%. Tumour proportion score distribution was as follows: tumour proportion score < 1% in 72.4%, 1-5% in 17.0%, and > 5% in 10.6%. Combined positive score distribution was as follows: combined positive score < 1 in 63.8%, 1-5 in 14.9%, and > 5 in 21.3%. Next-generation sequencing revealed that TP53 (33%), PI3KCA (22%), and ERBB3 (22%) were the most frequently mutated genes. The PI3K-Akt signalling pathway, growth, and MAPK signalling pathways were significantly enriched. Five patients had a low TMB (< 10 muts/Mb), and 9 patients had MSS. Three patients treated with immune combined with chemotherapy achieved significant tumour regression, and the progression-free survival was 28.8 months. In conclusion, the hidradenocarcinoma immune microenvironment tends to be noninflammatory. Evidence-based targets for targeted therapy are lacking. Immunotherapy combined with chemotherapy may be better for most advanced hidradenocarcinoma patients with a noninflammatory microenvironment.
MeSH term(s)	Humans ; Tumor Microenvironment ; Retrospective Studies ; Sweat Gland Neoplasms/genetics ; Sweat Gland Neoplasms/pathology ; Sweat Gland Neoplasms/therapy ; Sweat Gland Neoplasms/immunology ; Male ; Female ; Middle Aged ; Adult ; Aged ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/analysis ; Mutation ; Treatment Outcome ; Lymphocytes, Tumor-Infiltrating/immunology ; B7-H1 Antigen ; Immunotherapy/methods ; Young Adult ; Antineoplastic Agents, Immunological/therapeutic use
Chemical Substances	Biomarkers, Tumor ; B7-H1 Antigen ; CD274 protein, human ; Antineoplastic Agents, Immunological
Language	English
Publishing date	2024-05-13
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/actadv.v104.22146
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Article ; Online: Obacunone, a Promising Phytochemical Triterpenoid: Research Progress on Its Pharmacological Activity and Mechanism.

Zhou, Yuyang / Gu, Jifeng / Li, Jiahui / Zhang, Huishan / Wang, Mei / Li, Yuanyuan / Wang, Tianming / Wang, Jiajie / Shi, Rong

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 8

Abstract: Obacunone, a natural triterpenoid, is an active component of the ... ...

Abstract	Obacunone, a natural triterpenoid, is an active component of the herbs
MeSH term(s)	Humans ; Triterpenes/pharmacology ; Triterpenes/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/chemistry ; Animals ; Signal Transduction/drug effects ; Neoplasms/drug therapy
Chemical Substances	Triterpenes ; Phytochemicals
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29081791
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Article ; Online: Blood Type and Outcomes in Pregnant Women with Placenta Previa.

Fan, Dazhi / Rao, Jiaming / Zhang, Huishan / Lin, Dongxin / Guo, Xiaoling / Liu, Zhengping

Oxidative medicine and cellular longevity

2023 Volume 2023, Page(s) 4725064

Abstract: Background: Placenta previa increases the risks of obstetrical complications. Many studies have reported a link between various ABO blood types and pregnancy complications. This study is aimed at describing and comparing the characteristics and outcomes ...

Abstract	Background: Placenta previa increases the risks of obstetrical complications. Many studies have reported a link between various ABO blood types and pregnancy complications. This study is aimed at describing and comparing the characteristics and outcomes of women with placenta previa by ABO blood type. Methods: Data for this study was obtained from a retrospective cohort study between January 1, 2014, and June 30, 2019, of all clinically confirmed placenta previa in a university-based tertiary medical center. Both types of A, B, O, AB, and combining O and non-O blood types were compared to the characteristics and outcomes. Results: 1678 participants with placenta previa were included in this study. The highest participants were blood type O with 666 (39.7%), followed by type A with 508 (30.3%) and type B with 395 (23.5%), and the lowest participants were AB with 109 (6.5%). Blood type AB had a higher incidence of antepartum hemorrhage ( Conclusion: Type AB blood may be a potential risk factor for women with placenta previa. This finding may help provide any obstetrician to predict the risk of complication for placenta previa women by the ABO blood types.
MeSH term(s)	Infant, Newborn ; Pregnancy ; Female ; Humans ; Placenta Previa/epidemiology ; Pregnant Women ; Retrospective Studies ; Premature Birth/epidemiology ; Pregnancy Complications ; Risk Factors ; Placenta
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2023/4725064
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Article: Pediatric usage of Omalizumab: A promising one.

Yu, Lin / Zhang, Huishan / Pan, Jianwei / Ye, Leping

The World Allergy Organization journal

2021 Volume 14, Issue 12, Page(s) 100614

Abstract: Allergic and related diseases have a substantial epidemiological impact on the pediatric population. Small molecule-based medicines have been traditionally used to manage the diseases. Omalizumab is the first monoclonal antibody-based medicine used in ... ...

Abstract	Allergic and related diseases have a substantial epidemiological impact on the pediatric population. Small molecule-based medicines have been traditionally used to manage the diseases. Omalizumab is the first monoclonal antibody-based medicine used in children's allergy and shows great promises. It binds to free IgE and prevents it from binding to IgE receptors, thus interrupting the IgE-dependent allergic inflammatory cascade. Vast amounts of data demonstrate its effectiveness and well tolerance by patients, including the children. However, the drug was only approved to use in allergic asthma and chronic spontaneous urticaria (CSU), though other applications were explored in clinical trials. In this review, we summarized current pediatric applications of omalizumab in allergic diseases, focusing on its usages beyond asthma and CSU, including allergic rhinitis, allergic bronchopulmonary aspergillosis, vernal keratoconjunctivitis, food allergy and atopic dermatitis. In addition, we highlighted the unmet needs and controversial issues of anti-IgE therapy.
Language	English
Publishing date	2021-12-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2021.100614
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Article: Risk Factors of Prolonged Nausea and Vomiting During Pregnancy.

Zhang, Huishan / Wu, Shuzhen / Feng, Jingping / Liu, Zhengping

Risk management and healthcare policy

2020 Volume 13, Page(s) 2645–2654

Abstract: Background: Determination of the risk factors associated with prolonged nausea and vomiting during pregnancy (NVP) helps to develop prevention strategies. However, there is a lack of studies regarding risk factors of prolonged NVP. Thus, the potential ... ...

Abstract	Background: Determination of the risk factors associated with prolonged nausea and vomiting during pregnancy (NVP) helps to develop prevention strategies. However, there is a lack of studies regarding risk factors of prolonged NVP. Thus, the potential risk factors of prolonged moderate and severe NVP were examined. Methods: This is a retrospective study among pregnant women in South of China. The Pregnancy-Unique Quantification of Emesis (PUQE) scale was used to evaluate NVP. Onset before 12 weeks and persistence after 20 weeks of gestation were defined as prolonged NVP. Data on NVP and other variables were collected by standard questionnaires and medical records. Results: A finally sample of 1739 participants were analyzed. The incidence of prolonged moderate and severe NVP was 42.1% and 1.1%, respectively. Among those with NVP, the increased risk of prolonged moderate NVP was associated with lower gestational age (OR = 0.95 per SD increase, 95% CI=0.93-0.97), being a housewife (OR = 1.30, 95% CI=1.02-1.65), pre-pregnant longer sedentary time (OR = 2.02, 95% CI=1.16-1.83), pre-pregnant lower exercise frequency (OR = 1.84, 95% CI=1.20-2.82), and history of gastrointestinal (GI) diseases (OR = 2.21, 95% CI=1.61-3.03). Persons who were a housewife (OR = 6.39, 95% CI=1.90-21.47), with pre-pregnant high frequent (always) cold drinking (OR=11.12, 95% CI=1.24-100.73), and had a history of GI diseases (OR=10.10, 95% CI=2.63-38.86) were more likely to experience prolonged severe NVP. Conclusion: The results of the present study suggested that pregnant women unemployed, with lower gestational age, pre-pregnant longer sedentary time, less exercise, high frequent (always) cold drinking and history of GI diseases had a higher risk of prolonged NVP and should be taken more care.
Language	English
Publishing date	2020-11-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2495128-6
ISSN	1179-1594
ISSN	1179-1594
DOI	10.2147/RMHP.S273791
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Article ; Online: Evolution of Early-Phase Anticancer Drug Investigations in China.

Wang, Shuhang / Yu, Yue / Jiang, Yale / Zhang, Huishan / Ma, Peiwen / Liu, Gang / Li, Ning

JAMA oncology

2022 Volume 8, Issue 11, Page(s) 1692–1694

MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; China
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-09-08
Publishing country	United States
Document type	Letter
ISSN	2374-2445
ISSN (online)	2374-2445
DOI	10.1001/jamaoncol.2022.3856
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Article: Effective treatment of a child with adenoidal hypertrophy and severe asthma by omalizumab: a case report.

Sui, Haijing / Zhang, Huishan / Ding, Wei / Zhao, Zuotao / Mo, Jiali / Yuan, Jiexin / Ye, Leping

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

2022 Volume 18, Issue 1, Page(s) 94

Abstract: Background: Childhood adenoid hypertrophy (AH) is common and is often associated with allergic asthma, resulting in complications like obstructive sleep apnea syndrome (OSAS). Management of the disease and its complications is often challenging.: Case ...

Abstract	Background: Childhood adenoid hypertrophy (AH) is common and is often associated with allergic asthma, resulting in complications like obstructive sleep apnea syndrome (OSAS). Management of the disease and its complications is often challenging. Case presentation: We report here a case of a 10-year-old boy who suffered from severe allergic asthma and rhinitis and was treated with omalizumab. Before the treatment, the childhood asthma control test (C-ACT, 14), visal analog scale (VAS, 7) and lung function (mild obstructive ventilation dysfunction and moderate to severe dysfunction in ventilation in small airway) were seriously affected. Polysomnography showed OSAS (apnea hypopnea index, AHI, 6.4), low hypooxia saturation (lowest pulse oxygen saturation, LoSpO2, 70%), and adenoid hypertrophy (at grade III). After treating with omalizumab for 4 weeks (once treatment), the ventilation function, symptoms of asthma and allergic rhinitis (C-ACT, 24; VAS, 2), and OSAS (AHI: 1.8 and LoSpO2: 92.6%) were all improved, and the adenoids size was also significantly reduced to grade II. And during the following 3 times of treatment, the allergic symptoms continued improving, and the size of adenoid was reduced to grade I. Even 6.5 months after cessation of omalizumab, the size of adenoid remained at grade I. Conclusion: This is the first documented case that childhood adenoid hypertrophy can be significantly improved by omalizumab.
Language	English
Publishing date	2022-10-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2434973-2
ISSN	1710-1492 ; 1710-1484
ISSN (online)	1710-1492
ISSN	1710-1484
DOI	10.1186/s13223-022-00732-9
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Article ; Online: Clinical features and prognosis of cardiac metastatic tumors.

Lin, Zhongqiao / Xiao, Huazhen / Liu, Jun / Chen, Ling / Zhang, Huishan / Huang, Yufang / Chen, Yu / Lin, Jing

BMC cancer

2023 Volume 23, Issue 1, Page(s) 1235

Abstract: Background: This study aimed to explore the clinical features and prognosis of cardiac metastatic tumors. In addition, whether continuing antitumor therapy after the development of cardiac metastases can benefit patients and the response of cardiac ... ...

Abstract	Background: This study aimed to explore the clinical features and prognosis of cardiac metastatic tumors. In addition, whether continuing antitumor therapy after the development of cardiac metastases can benefit patients and the response of cardiac metastases were investigated. Methods: A retrospective analysis was conducted on patients with malignancies who were admitted to Fujian Cancer Hospital and Fujian Provincial Hospital from January 2007 to September 2022, and the follow-up period ended in March 2023. Clinical data were gathered, treatment efficacy was evaluated, and survival analysis was performed. Results: After the patients developed cardiac metastasis, the overall 30-day, 3-month, 6-month, and 12-month survival rates were 85.00%, 59.00%, 51.00% and 38.00%, respectively. With continued treatment, the average survival time was 27.33 months (95% confidence interval [CI]: 16.88-37.79), which exceeded the 6.6 months (95% confidence interval [CI]: 0.03-13.69) observed for patients who withdrew from treatment (P < 0.001). The responses of cardiac metastases corresponded to the responses of the primary tumors. Patients with a cardiac response had a median survival time of 55.60 months, which exceeded the 13.40 months observed for those without a cardiac response. However, there was no significant difference (P = 0.375). Conclusions: In conclusion, continuing antitumor therapy after the development of cardiac metastases can significantly prolong patient survival. Cardiac metastases and primary tumors respond consistently to antitumor treatment. The risk of death due to heart failure in cancer patients with cardiac metastases needs to be further investigated.
MeSH term(s)	Humans ; Retrospective Studies ; Prognosis ; Treatment Outcome ; Survival Analysis ; Heart Neoplasms/therapy
Language	English
Publishing date	2023-12-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2041352-X
ISSN	1471-2407 ; 1471-2407
ISSN (online)	1471-2407
ISSN	1471-2407
DOI	10.1186/s12885-023-11733-1
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Article ; Online: Tactile corpuscle-inspired piezoresistive sensors based on (3-aminopropyl) triethoxysilane-enhanced CNPs/carboxylated MWCNTs/cellulosic fiber composites for textile electronics.

Guo, Xiaohui / Zhang, Tianxu / Wang, Ziang / Zhang, Huishan / Yan, Zihao / Li, Xianghui / Hong, Weiqiang / Zhang, Anqi / Qian, Zhibin / Zhang, Xinyi / Shu, Yuxin / Wang, Jiahao / Hua, Liangping / Hong, Qi / Zhao, Ynong

Journal of colloid and interface science

2024 Volume 660, Page(s) 203–214

Abstract: Recently, wearable electronic products and gadgets have developed quickly with the aim of catching up to or perhaps surpassing the ability of human skin to perceive information from the external world, such as pressure and strain. In this study, by first ...

Abstract	Recently, wearable electronic products and gadgets have developed quickly with the aim of catching up to or perhaps surpassing the ability of human skin to perceive information from the external world, such as pressure and strain. In this study, by first treating the cellulosic fiber (modal textile) substrate with (3-aminopropyl) triethoxysilane (APTES) and then covering it with conductive nanocomposites, a bionic corpuscle layer is produced. The sandwich structure of tactile corpuscle-inspired bionic (TCB) piezoresistive sensors created with the layer-by-layer (LBL) technology consists of a pressure-sensitive module (a bionic corpuscle), interdigital electrodes (a bionic sensory nerve), and a PU membrane (a bionic epidermis). The synergistic mechanism of hydrogen bond and coupling agent helps to improve the adhesive properties of conductive materials, and thus improve the pressure sensitive properties. The TCB sensor possesses favorable sensitivity (1.0005 kPa
MeSH term(s)	Humans ; Wearable Electronic Devices ; Electronics ; Nanocomposites/chemistry ; Textiles ; Silanes
Chemical Substances	triethoxysilane (8T460WDH89) ; Silanes
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2024.01.059
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