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Article ; Online: Precise Synthesis of Diastereomers of Spiro-oxindole Derivatives through Dynamic Covalent Transformation.

Liu, Xiao-Qian / Zhang, Jian-Dong / Ji, Shun-Jun / Xu, Xiao-Ping

2024 Volume 89, Issue 9, Page(s) 6027–6039

Abstract: In this study, [1+2+2] cyclization of tryptamine-derived isocyanides with 3-ylideneoxindoles was systematically investigated. A series of structurally complex spiro-oxindole derivatives were obtained. Characteristic dynamic covalent chemistry was ... ...

Abstract	In this study, [1+2+2] cyclization of tryptamine-derived isocyanides with 3-ylideneoxindoles was systematically investigated. A series of structurally complex spiro-oxindole derivatives were obtained. Characteristic dynamic covalent chemistry was observed and confirmed by experiments and density functional theory calculation. Through the regulation of the solvent, temperature, and time, the precise and stereodivergent synthesis of spiro-oxindoles was achieved.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c02966
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Article: The efficiency of indigenous isolates Bacillus sp. RCS1 and Bacillus cereus RCS3 on growth performance, blood biochemical indices and resistance against Vibrio harveyi in cobia fish (Rachycentron canadum) juveniles

Amenyogbe, Eric / Zhang, Jian-dong / Huang, Jian-sheng / Chen, Gang

Aquaculture reports. 2022 Aug., v. 25

2022

Abstract: In this study, cobia (Rachycentron canadum) juveniles were utilised as an aquatic model to explore growth performance and immune indices after 70 days of feeding with supplementation of viable isolated microbes’ concentrations of 1 × 10¹⁰ and 1 × 10¹² ... ...

Abstract	In this study, cobia (Rachycentron canadum) juveniles were utilised as an aquatic model to explore growth performance and immune indices after 70 days of feeding with supplementation of viable isolated microbes’ concentrations of 1 × 10¹⁰ and 1 × 10¹² CFU/mL indigenous isolates Bacillus sp. RCS1 and Bacillus cereus strain RCS3, respectively. Regarding growth performance, fish provided with the indigenous isolates exhibited a significant (P < 0.05) enhancement. The hematological indices such as red blood cells, white blood cells, corpuscular haemoglobin concentration, mean corpuscular volume, haemoglobin, and Mean corpuscular haemoglobin were all increased (P < 0.05) in the juvenile cobia fed with indigenous isolates Bacillus sp. RCS1 and B. cereus RCS3 as a nutritional supplement. This study also significantly differed in serum analysis (albumin, globulin, lysozyme, total protein) between all the treatments with the Bacillus sp. RCS1 1 × 10¹⁰ proven to be the best. In the present study, the expression of myostatin and insulin-like growth factor 2 showed no significant change (P > 0.05) among the treatment and control groups tested; nonetheless, their mRNA expression exhibited variations in all trial groups. The present study showed significant differences (P < 0.05) among groups in the case of insulin-like growth factor 1, peroxisome proliferator-activated receptors. The improved antioxidant enzyme activities of catalase (CAT) and superoxide dismutase (SOD) digestive enzyme activities (amylase, trypsin, pepsin, lipase, and cellulose) may be linked to the enhanced resistance of fish against Vibrio harveyi infection. The enhanced activities of digestive enzymes in indigenous isolates treatments could be linked to the improved digestion and enhanced food absorption that ultimately helps enhance feed utilisation and growth performance. The results showed that indigenous isolates addition to a commercial diet, had the prospective to enhance cobia juveniles' growth and immune response regardless of their dosage.
Keywords	Bacillus cereus ; Rachycentron canadum ; Vibrio harveyi ; absorption ; albumins ; amylases ; antioxidant enzymes ; aquaculture ; blood serum ; carboxylic ester hydrolases ; catalase ; cellulose ; diet ; digestion ; feed conversion ; fish ; gene expression ; globulins ; growth performance ; hemoglobin ; immune response ; insulin-like growth factor I ; insulin-like growth factor II ; juveniles ; lysozyme ; models ; myostatin ; pepsin ; protein content ; superoxide dismutase ; trypsin
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2835391-2
ISSN	2352-5134
ISSN	2352-5134
DOI	10.1016/j.aqrep.2022.101241
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Article ; Online: CERS6-AS1 promotes cell proliferation and represses cell apoptosis in pancreatic cancer via miR-195-5p/WIPI2 axis.

Gao, Kan-Fei / Zhao, Yu-Fang / Liao, Wu-Jun / Xu, Guo-Li / Zhang, Jian-Dong

The Kaohsiung journal of medical sciences

2022 Volume 38, Issue 6, Page(s) 542–553

Abstract: Pancreatic cancer (PC) is a lethal malignancy that threatens human health. Long noncoding RNAs (lncRNAs) act as important mediators in PC development. Our study aimed to investigate the function and mechanism of lncRNA ceramide synthase 6 antisense RNA 1 ...

Abstract	Pancreatic cancer (PC) is a lethal malignancy that threatens human health. Long noncoding RNAs (lncRNAs) act as important mediators in PC development. Our study aimed to investigate the function and mechanism of lncRNA ceramide synthase 6 antisense RNA 1 (CERS6-AS1) in PC. As shown by RT-qPCR, CERS6-AS1 was significantly upregulated in PC cells and tissues. Silencing CERS6-AS1 suppressed PC cell viability and proliferation while enhancing cell apoptosis according to colony formation assays, EdU assays, and flow cytometry analyses. Mechanistically, CERS6-AS1 interacted with miR-195-5p to elevate the expression level of the WD repeat domain phosphoinositide interacting 2 (WIPI2), which is a downstream target gene of miR-195-5p in PC. Moreover, miR-195-5p expression was negatively associated with CERS6-AS1 expression (or WIPI2 expression) in PC tissues. Rescue assays revealed that WIPI2 overexpression rescued the effects of CERS6-AS1 deficiency on cell viability, proliferation, and apoptosis. In summary, CERS6-AS1 facilitates PC cell proliferation while inhibiting PC cell apoptosis by upregulating WIPI2 via miR-195-5p. This study might provide promising insight into the role of CERS6-AS1 in PC development.
MeSH term(s)	Apoptosis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Phosphatidylinositols ; RNA, Antisense ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Sphingosine N-Acyltransferase/genetics ; Sphingosine N-Acyltransferase/metabolism ; WD40 Repeats ; Pancreatic Neoplasms
Chemical Substances	MIRN195 microRNA, human ; Membrane Proteins ; MicroRNAs ; Phosphatidylinositols ; RNA, Antisense ; RNA, Long Noncoding ; CERS6 protein, human (EC 2.3.1.24) ; Sphingosine N-Acyltransferase (EC 2.3.1.24)
Language	English
Publishing date	2022-02-24
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	639302-0
ISSN	2410-8650 ; 0257-5655
ISSN (online)	2410-8650
ISSN	0257-5655
DOI	10.1002/kjm2.12522
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Article ; Online: Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis.

Bi, Qing / Wu, Ji-Yue / Qiu, Xue-Meng / Zhang, Jian-Dong / Sun, Ze-Jia / Wang, Wei

Journal of immunology research

2022 Volume 2022, Page(s) 3128933

Abstract: Tumorigenesis is a multistage progressive oncogenic process caused by alterations in the structure and expression level of multiple genes. Normal cells are continuously endowed with new capabilities in this evolution, leading to subsequent tumor ... ...

Abstract	Tumorigenesis is a multistage progressive oncogenic process caused by alterations in the structure and expression level of multiple genes. Normal cells are continuously endowed with new capabilities in this evolution, leading to subsequent tumor formation. Immune cells are the most important components of inflammation, which is closely associated with tumorigenesis. There is a broad consensus in cancer research that inflammation and immune response facilitate tumor progression, infiltration, and metastasis
MeSH term(s)	Carcinogenesis/metabolism ; Cell Transformation, Neoplastic ; Humans ; Inflammasomes ; Inflammation/pathology ; Neoplasms
Chemical Substances	Inflammasomes
Language	English
Publishing date	2022-06-13
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/3128933
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Article: Integrated transcriptomics and metabolomics analysis of the intestine of cobia (Rachycentron canadum) under hypoxia stress

Yang, Er-jun / Amenyogbe, Eric / Zhang, Jian-dong / Wang, Wei-zheng / Huang, Jian-sheng / Chen, Gang

Aquaculture reports. 2022 Aug., v. 25

2022

Abstract: In intensive aquaculture systems, dissolved oxygen (DO) is the most critical and limiting factor for the development and health of aquatic organisms. Hypoxia is a common phenomenon in aquaculture. Its effects on fish’s growth and immune system have been ... ...

Abstract	In intensive aquaculture systems, dissolved oxygen (DO) is the most critical and limiting factor for the development and health of aquatic organisms. Hypoxia is a common phenomenon in aquaculture. Its effects on fish’s growth and immune system have been widely reported, but the molecular mechanisms of hypoxic stress on damage to the fish gut are not fully understood. Additionally, studies on the effects of hypoxic stress on the intestinal metabolism of cobia (Rachycentron canadum) are still limited. Therefore, this study used cobia to explore the effects of hypoxic stress on intestinal metabolism. In this study, the combination of high-throughput RNA sequencing (RNA-Seq) and non-targeted liquid chromatography-mass spectrometry (LC-MS) based metabolomics analyses were used to investigate changes in key genes and metabolites in the intestinal tract of juvenile cobia after 28 days of hypoxic stress (DO: 3.15 ± 0.21 mg/L). Transcriptomics analysis revealed the significant enrichment of 62 metabolic pathways, including glutathione metabolism, fat digestion and absorption, bile secretion, glycerolipid metabolism, tricarboxylic acid cycle, glycolysis/gluconeogenesis, and other pathways. Metabolomics analysis revealed that most of the significantly differential metabolites were related to the metabolism of amino acids and lipids. The combined transcriptomics and metabolomics analyses showed that the sustained hypoxic stress could cause some degree of oxidative damage to the gut of cobia, thereby interfering with its digestive absorption and physiological and metabolic processes, such as abnormalities in antioxidant and detoxification functions, disturbances in the metabolisms of amino acids, lipids, and carbohydrates, and reduction of ion transport capacity. These findings might help understand the molecular mechanisms of the intestinal tract under hypoxic stress in cobia, thereby reducing the damage caused by hypoxic stress to farmed fish.
Keywords	RNA ; Rachycentron canadum ; absorption ; antioxidants ; bile secretion ; farmed fish ; gluconeogenesis ; glutathione ; glycolysis ; hypoxia ; immune system ; intestinal absorption ; intestines ; juveniles ; lipid metabolism ; liquid chromatography ; mass spectrometry ; metabolites ; metabolomics ; oxygen ; transcriptomics ; tricarboxylic acid cycle
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	2835391-2
ISSN	2352-5134
ISSN	2352-5134
DOI	10.1016/j.aqrep.2022.101261
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Article ; Online: Kinetic Study on the Crystal Transformation of Fe-Doped TiO

Zhang, Lu / Luo, Xian / Zhang, Jian-Dong / Long, Yong-Fu / Xue, Xin / Xu, Ben-Jun

ACS omega

2021 Volume 6, Issue 1, Page(s) 965–975

Abstract: Titanium dioxide ( ... ...

Abstract	Titanium dioxide (TiO
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c05609
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Article ; Online: Photocatalyst- and Transition-Metal-Free Visible-Light-Promoted Intramolecular C(sp

Wang, Hao / Wu, Qi / Zhang, Jian-Dong / Li, Hai-Yan / Li, Hong-Xi

Organic letters

2021 Volume 23, Issue 6, Page(s) 2078–2083

Abstract: A photocatalyst- and transition-metal-free visible-light-induced cyclization ... ...

Abstract	A photocatalyst- and transition-metal-free visible-light-induced cyclization of
Language	English
Publishing date	2021-02-26
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.1c00235
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Article ; Online: Cloning of Mn-SOD gene and its mRNA expression difference and antioxidant enzyme activities under hypoxia stress of cobia Rachycentron canadum.

Zhang, Jian-Dong / Li, Hong-Juan / Amenyogbe, Eric / Wang, Wei-Zheng / Huang, Jian-Sheng / Chen, Gang

Molecular biology reports

2021 Volume 48, Issue 10, Page(s) 6897–6909

Abstract: Background: Environmental hypoxia affects the survival and development of organisms. It is also an important environmental factor that leads to oxidative damage. Hypoxia is a condition in which tissues are deprived of oxygen; reoxygenation is the ... ...

Abstract	Background: Environmental hypoxia affects the survival and development of organisms. It is also an important environmental factor that leads to oxidative damage. Hypoxia is a condition in which tissues are deprived of oxygen; reoxygenation is the phenomenon in which hypoxic tissues are exposed to oxygen. Hypoxia-reoxygenation is vital in pathogenesis, where the production of reactive oxygen species and antioxidant disparity significantly contribute to disease progression, and it is one of the most common physiological stressors in the aquaculture industry. Methods and results: In this study, the full length of complementary DNA (cDNA) of the manganese superoxide dismutase (Mn-SOD) gene of healthy cobia Rachycentron canadum was analysed using rapid amplification of cDNA ends. The real-time quantitative Polymerase Chain Reaction was used to measure the expression levels of Mn-SOD mRNAs in various tissues (heart, muscle, brain, liver, kidney, gill, intestine, and spleen). The 2 Conclusions: These results provide valuable information on the role of Mn-SOD regulation in oxidative stress caused by hypoxia.
MeSH term(s)	Amino Acid Sequence ; Animals ; Antioxidants/metabolism ; Base Sequence ; Cell Hypoxia ; Cloning, Molecular ; DNA, Complementary/genetics ; Gene Expression Profiling ; Gene Expression Regulation, Enzymologic ; Models, Molecular ; Oxidative Stress/genetics ; Perciformes/genetics ; Phylogeny ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Stress, Physiological ; Superoxide Dismutase/chemistry ; Superoxide Dismutase/genetics
Chemical Substances	Antioxidants ; DNA, Complementary ; RNA, Messenger ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2021-08-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-021-06692-4
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Zs.A 1140: Show issues

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Article ; Online: Syn

Cao, Wen-Bin / Zhang, Jian-Dong / Xu, Meng-Meng / Liu, Hua-Wei / Li, Hai-Yan / Xu, Xiao-Ping / Ji, Shun-Jun

Organic letters

2022 Volume 24, Issue 25, Page(s) 4620–4624

Abstract: By utilizing an underexplored reaction mode ... ...

Abstract	By utilizing an underexplored reaction mode of
Language	English
Publishing date	2022-06-22
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.2c01736
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Article ; Online: The association between abnormal serum magnesium levels and prognosis of elderly patients with community-acquired pneumonia.

Wang, Si-Qiong / Lu, Dong-Xi / Zhang, Jian-Dong / Wang, Zhi-Wei / Li, Xiao-Wei / Ma, Chun-Ming

Magnesium research

2022 Volume 34, Issue 4, Page(s) 159–165

Abstract: To investigate the association between abnormal serum magnesium levels and the prognosis of elderly patients with community-acquired pneumonia (CAP). Methods: A retrospective study was conducted on 1381 elderly patients with CAP in the First Hospital of ... ...

Abstract	To investigate the association between abnormal serum magnesium levels and the prognosis of elderly patients with community-acquired pneumonia (CAP). Methods: A retrospective study was conducted on 1381 elderly patients with CAP in the First Hospital of Qinhuangdao between January 2015 and December 2018. Serum magnesium concentrations in the range of 0.75-1.25 mmol/L were defined as normal. Patients were assigned into normal, hypomagnesemia, and hypermagnesemia groups. The primary outcome was in-hospital mortality, indicating whether a patient died at the time of discharge from the hospital. The percentages of respiratory failure and mechanical ventilation were 18.6% and 10.6 % in the normal group, 29% and 16.5 % in the hypomagnesemia, and 42.9% and 35.7% in the hypermagnesemia groups. The occurrence of shock was 8.5% and 4.5% in the hypomagnesemia group and the normal group. The percentages of the length of stay at ICU were 14.9%, 18.8%, and 57.1% in the hypomagnesemia, normal, and hypermagnesemia groups. The in-hospital mortality rate was 5.3%, 9.1%, and 35.7% in the normal, hypomagnesemia, and hypermagnesemia groups, respectively. The results of univariate analysis showed that the in-hospital mortality in the hypomagnesemia group was 1.790 (95% confidence interval (CI): 1.009∼3.176, P=0.046) times higher than that in the normal group; in the hypermagnesemia group, it was 9.947 (95% CI: 3.238-30.556, P<0.001) times higher than that in the normal group. The results of multivariate logistic regression analysis showed that after adjusting for gender, age, diabetes, heart failure, cerebrovascular disease, cancer, estimated glomerular filtration rate (eGFR), glucose, and CURB-65 score, in the hypomagnesemia group, the in-hospital mortality was 1.746 (95% confidence interval (CI): 0.956∼3.186, P=0.070) times higher than that in the normal group, and 5.689 (95% CI: 1.583- 20.446, P=0.008) times higher in the hypermagnesemia group than that in the normal group. Abnormal serum magnesium levels are strongly associated with in-hospital mortality in elderly patients with CAP. The measurement of serum magnesium levels in elderly patients with CAP at admission may assist clinicians to determine the prognosis of such patients.
MeSH term(s)	Aged ; Critical Illness ; Humans ; Magnesium ; Pneumonia/diagnosis ; Prognosis ; Retrospective Studies
Chemical Substances	Magnesium (I38ZP9992A)
Language	English
Publishing date	2022-02-25
Publishing country	England
Document type	Journal Article
ZDB-ID	1036384-1
ISSN	1952-4021 ; 0953-1424
ISSN (online)	1952-4021
ISSN	0953-1424
DOI	10.1684/mrh.2022.0493
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