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Article ; Online: Sacculatane Diterpenoids from the Liverwort

Han, Jingjing / Sun, Yan / Zhou, Jinchuan / Li, Yi / Jin, Xueyang / Zhu, Mingzhu / Xu, Zejun / Zhang, Jiaozhen / Lou, Hongxiang

Journal of natural products

2024 Volume 87, Issue 4, Page(s) 1124–1130

Abstract: Seven new terpenoids, including six sacculatane diterpenoids plagiochilarins A-F ( ...

Abstract	Seven new terpenoids, including six sacculatane diterpenoids plagiochilarins A-F (
MeSH term(s)	Hepatophyta/chemistry ; Diterpenes/chemistry ; Diterpenes/pharmacology ; Diterpenes/isolation & purification ; China ; Candida albicans/drug effects ; Molecular Structure ; Microbial Sensitivity Tests ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Crystallography, X-Ray
Chemical Substances	Diterpenes ; Antifungal Agents
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.4c00071
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Article ; Online: Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.

Miao, Huicong / Cui, Wenbo / Zhang, Tao / Zhang, Yue / Zhang, Jiaozhen / Lou, Hongxiang / Fan, Peihong

European journal of medicinal chemistry

2023 Volume 264, Page(s) 115996

Abstract: Mitochondria, responsible for ATP production and apoptosis regulation, play a key role in cancer cells. Honokiol regulates apoptosis through the endogenous mitochondrial pathway but does not specifically target tumor cells. We designed 28 novel ... ...

Abstract	Mitochondria, responsible for ATP production and apoptosis regulation, play a key role in cancer cells. Honokiol regulates apoptosis through the endogenous mitochondrial pathway but does not specifically target tumor cells. We designed 28 novel derivatives of honokiol using triple-function delocalized lipophilic cations such as berberine and F16 as mitochondrion-targeting carriers. While all derivatives exhibited enhanced cytotoxicity toward tumor cells compared to honokiol, the derivative 2E-3-F16 exhibited a substantial tumor cell selectivity between NCI-H446 cancer cells and HBE cells by one order of magnitude and enhanced the sensitivity of A549 cells to cisplatin. Mechanistically, it targeted mitochondria and induced apoptosis by preventing tumor cells from entering the G0/G1 phases as well as inducing an abnormal elevation of reactive oxygen species, thereby decreasing the mitochondrial membrane potential level. It also showed lower toxicity toward Caenorhabditis elegans than honokiol. This study provides a possible method for developing mitochondrion-targeting antitumor drugs with high efficiency and low toxicity based on natural products.
MeSH term(s)	Animals ; Caenorhabditis elegans ; Antineoplastic Agents/pharmacology ; Apoptosis ; Lignans/pharmacology ; Biphenyl Compounds/pharmacology ; Cell Line, Tumor
Chemical Substances	honokiol (11513CCO0N) ; Antineoplastic Agents ; Lignans ; Biphenyl Compounds
Language	English
Publishing date	2023-12-03
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2023.115996
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Article: Neurobiology and Neural Circuits of Aggression.

Helmy, Mohamed / Zhang, Jiaozhen / Wang, Hao

Advances in experimental medicine and biology

2020 Volume 1284, Page(s) 9–22

Abstract: Aggression takes several forms and can be offensive or defensive. Aggression between animals of the same species or society aims to inflict harm upon another for the purpose of protecting a resource such as food, reproductive partners, territory, or ... ...

Abstract	Aggression takes several forms and can be offensive or defensive. Aggression between animals of the same species or society aims to inflict harm upon another for the purpose of protecting a resource such as food, reproductive partners, territory, or status. This chapter explores the neurobiology of aggression. We summarize the behavior of aggression, rodent models of aggression, and the correlates of aggressive behavior in the context of neuroendocrinology, neurotransmitter systems, and neurocircuitry. Translational implications of rodent studies are briefly discussed, applying basic research to brain imaging data and therapeutic approaches to conditions where aggression is problematic.
MeSH term(s)	Aggression ; Animals ; Brain/physiology ; Models, Animal ; Neurobiology ; Neurotransmitter Agents
Chemical Substances	Neurotransmitter Agents
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-981-15-7086-5_2
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Article ; Online: Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections.

Jin, Xueyang / Hou, Xuben / Wang, Xue / Zhang, Ming / Chen, Jinyao / Song, Minghui / Zhang, Jiaozhen / Zheng, Hongbo / Chang, Wenqiang / Lou, Hongxiang

Cell chemical biology

2023 Volume 30, Issue 5, Page(s) 553–568.e7

Abstract: Filamentation is an important virulence factor of the pathogenic fungus Candida albicans. The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an important concept for the development of antifungal drugs with high safety. ... ...

Abstract	Filamentation is an important virulence factor of the pathogenic fungus Candida albicans. The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an important concept for the development of antifungal drugs with high safety. Here, we conduct a high-throughput screen using a C. albicans strain expressing green fluorescent protein-labeled Dpp3 to identify anti-hypha agents by interfering with ergosterol synthesis. The antipyrine derivative H55 is characterized to have minimal cytotoxicity and potent inhibition of C. albicans hyphal formation in multiple cultural conditions. H55 monotherapy exhibits therapeutic efficacy in mouse models of azole-resistant candidiasis. H55 treatment increases the accumulation of zymosterol, the substrate of C-24 sterol methyltransferase (Erg6). The results of enzyme assays, photoaffinity labeling, molecular simulation, mutagenesis, and cellular thermal shift assays support H55 as an allosteric inhibitor of Erg6. Collectively, H55, an inhibitor of the fungal-specific enzyme Erg6, holds potential to treat C. albicans infections.
MeSH term(s)	Animals ; Mice ; Candida albicans ; Sterols/therapeutic use ; Methyltransferases ; Candidiasis/drug therapy ; Antifungal Agents/pharmacology ; Antifungal Agents/therapeutic use
Chemical Substances	Sterols ; Methyltransferases (EC 2.1.1.-) ; Antifungal Agents
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2451-9448
ISSN (online)	2451-9448
DOI	10.1016/j.chembiol.2023.04.010
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Article ; Online: Dissection of the bed nucleus of the stria terminalis neuronal subtypes in feeding regulation.

Zhang, Jiaozhen / Wang, Liangliang / Yang, Yiwen / Wang, Siyu / Huang, Changgang / Yang, Li / Li, Baoming / Wang, Lang / Wang, Hao / Hao, Sijia

Physiology & behavior

2023 Volume 271, Page(s) 114333

Abstract: The bed nucleus of the stria terminalis (BNST) plays an important role in feeding regulation through projections to other brain areas. However, whether functional distinctions exist within different BNST cells is not clear. Here, we found optogenetic ... ...

Abstract	The bed nucleus of the stria terminalis (BNST) plays an important role in feeding regulation through projections to other brain areas. However, whether functional distinctions exist within different BNST cells is not clear. Here, we found optogenetic activation of LH-projecting BNST neurons induced aversion and significantly reduced consumption of normal chow but not high-fat diets (HFD). In contrast, photoactivation of vlPAG-projecting BNST neurons induced place preference and promoted HFD intake, without affecting normal chow consumption. Moreover, optogenetic silencing of LH-projecting BNST neurons reduced the consumption of normal chow in fasted mice, while photoinhibition of vlPAG-projecting BNST neurons decreased the consumption of HFD in both fed and fasted mice. We then labeled the LH- and vlPAG-projecting BNST neurons using retroAAV-GFP and retroAAV-mCherry, respectively, and found these two populations of neurons have different anatomical distribution and electrophysiological properties. Taken together, we identified vlPAG-projecting and LH-projecting BNST neurons are two distinct populations of cells with significant differences in functional and anatomic characteristics.
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114333
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Zs.A 747: Show issues

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Article ; Online: N-acetyldopamine oligomers from Periplaneta americana with anti-inflammatory and vasorelaxant effects and their spatial distribution visualized by mass spectrometry imaging.

Zhang, Jiaozhen / Dong, Fangfang / Wang, Yongjie / Wang, Chan / Zhang, Chengmin / Xu, Ke / Shen, Tao / Lou, Hongxiang

Journal of ethnopharmacology

2023 Volume 318, Issue Pt B, Page(s) 116989

Abstract: Ethnopharmacological relevance: Periplaneta americana is a medicinal insect that has been applied to promote blood circulation and remove blood stasis based on traditional Chinese medicine (TCM) for a long time. Its modern preparation, Xinmailong ... ...

Abstract	Ethnopharmacological relevance: Periplaneta americana is a medicinal insect that has been applied to promote blood circulation and remove blood stasis based on traditional Chinese medicine (TCM) for a long time. Its modern preparation, Xinmailong injection, was adopted for the treatment of congestive heart failure (CHF). The bioactive constituents of P. americana and their correlation with its traditional uses need further investigation. Aim of the study: This study aimed to elucidate the N-acetyldopamine (NADA) oligomers from P. american, determine their spatial distribution, and investigate their anti-inflammatory and vasorelaxant effects to provide scientific evidence supporting the clinical use of this medicinal insect. Material and methods: NADA oligomers were isolated from the CH Results: Seven new NADA trimers, peridopamines A-G (1-7), two new NADA dimers, peridopamines H and I (8 and 9), and six known NADA derivatives (10-15), were obtained from P. americana. The trimers and dimers were detected and showed similar pattern of distribution with accumulation in peripheral and rigid parts of P. americana, based on quasimolecular ion AP-SMALDI MS images of sections from the whole body and dissected areas of the insect. Furthermore, the anti-inflammatory and vasorelaxant effects of isolated compounds were investigated. Compounds 8 and 9 presented significant and moderate anti-inflammatory potentials, respectively. Compounds 8, 10, 12 and 15 possess significant vasorelaxant potentials at concentrations correlated with EC Conclusion: Fifteen NADA oligomers were isolated from P. americana. The distribution of these compounds was visualized by AP-SMALDI imaging experiments and NADA oligomers were mainly observed in peripheral parts. Bioassays showed that the tested compounds had anti-inflammatory and vasorelaxant activities, which indicated that NADA oligomers are active ingredients of this insect-based TCM and have potential for the treatment of cardiovascular disease.
MeSH term(s)	Animals ; Periplaneta/chemistry ; Anti-Inflammatory Agents/pharmacology ; Medicine, Chinese Traditional ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical Substances	N-acetyldopamine (2494-12-4) ; Anti-Inflammatory Agents
Language	English
Publishing date	2023-07-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116989
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Zs.A 1494: Show issues

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Article ; Online: Liverwort-Derived Metabolites Retard Endophyte Growth and Inspire Antifungal Application.

Zhu, Mingzhu / He, Chen / Zhou, Jinchuan / Li, Yi / Qian, Lilin / Zhang, Jiaozhen / Qiao, Yanan / Chang, Wenqiang / Lou, Hongxiang

Journal of agricultural and food chemistry

2023 Volume 71, Issue 12, Page(s) 4863–4875

Abstract: Liverwort secondary metabolites play an important role in the peaceful relationship between liverwort endophytic fungi and the host. This study identified potential antifungal agents based on interactions between host plants and endophytic fungi. Two ... ...

Abstract	Liverwort secondary metabolites play an important role in the peaceful relationship between liverwort endophytic fungi and the host. This study identified potential antifungal agents based on interactions between host plants and endophytic fungi. Two endophytic fungi strains and 25 metabolites, including nine new compounds, were isolated from the Chinese liverwort
MeSH term(s)	Animals ; Humans ; Antifungal Agents/chemistry ; Endophytes ; Hepatophyta/metabolism ; Plants/metabolism ; Candida albicans ; Fungi/metabolism
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2023-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.2c08866
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Article ; Online: Identification and Functional Characterization of UDP-Glycosyltransferases Involved in Isoflavone Biosynthesis in

Hao, Yue / Fu, Jie / Zhang, Jiaozhen / Du, Nihong / Ta, He / Zhu, Ting-Ting / Wang, Hailong / Lou, Hong-Xiang / Cheng, Ai-Xia

Journal of agricultural and food chemistry

2023 Volume 71, Issue 34, Page(s) 12775–12784

Abstract: Isoflavones are rich natural compounds present in legumes and are essential for plant growth and development. Moreover, they are beneficial for animals and humans. Isoflavones are primarily found as glycoconjugates, including calycosin-7- ...

Abstract	Isoflavones are rich natural compounds present in legumes and are essential for plant growth and development. Moreover, they are beneficial for animals and humans. Isoflavones are primarily found as glycoconjugates, including calycosin-7-
MeSH term(s)	Animals ; Humans ; Glycosyltransferases/genetics ; Astragalus propinquus/genetics ; Isoflavones ; Glycosylation ; Flavonoids ; Fabaceae ; Vegetables ; Glucosides
Chemical Substances	Glycosyltransferases (EC 2.4.-) ; Isoflavones ; Flavonoids ; Glucosides
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.3c03563
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Article ; Online: Heterodimers of Aromadendrane Sesquiterpenoid with Benzoquinone from the Chinese Liverwort

Zhang, Chun-Yang / Zhang, Jiao-Zhen / Li, Yue-Lan / Xu, Ze-Jun / Qiao, Ya-Nan / Yuan, Shuang-Zhi / Tang, Ya-Jie / Lou, Hong-Xiang

Journal of natural products

2023 Volume 87, Issue 1, Page(s) 132–140

Abstract: Mylnudones A-G ( ...

Abstract	Mylnudones A-G (
MeSH term(s)	Hepatophyta/chemistry ; Molecular Structure ; Sesquiterpenes/pharmacology ; Sesquiterpenes/chemistry ; China ; Alkanes ; Sesquiterpenes, Guaiane
Chemical Substances	aromadendrane ; undecane (JV0QT00NUE) ; Sesquiterpenes ; Alkanes ; Sesquiterpenes, Guaiane
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00921
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Article ; Online: Efficient Production of Flavonoid Glucuronides in

Du, Ni-Hong / Xiong, Rui-Lin / Zhu, Ting-Ting / Liu, Xin-Yan / Zhang, Jiao-Zhen / Fu, Jie / Wang, Hai-Long / Lou, Hong-Xiang / Cheng, Ai-Xia

Journal of natural products

2024 Volume 87, Issue 2, Page(s) 228–237

Abstract: As a model liverwort, ...

Abstract	As a model liverwort,
MeSH term(s)	Flavonoids/chemistry ; Apigenin ; Glucuronides/metabolism ; Marchantia/metabolism ; Glucuronosyltransferase/chemistry ; Glucuronosyltransferase/metabolism ; Escherichia coli/metabolism ; Flavanones ; Glucose ; Glucuronic Acid ; Uridine Diphosphate
Chemical Substances	Flavonoids ; Apigenin (7V515PI7F6) ; Glucuronides ; Glucuronosyltransferase (EC 2.4.1.17) ; Flavanones ; Glucose (IY9XDZ35W2) ; Glucuronic Acid (8A5D83Q4RW) ; Uridine Diphosphate (58-98-0)
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00880
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