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Article ; Online: Commentary: Targeting chemoattractant chemokine (C-C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders.

Zhang, Jingdan / Cheng, Jinbo

2023 Volume 14, Page(s) 1279782

MeSH term(s)	Humans ; Neuromyelitis Optica/therapy ; Chemokine CCL2/metabolism ; Astrocytes/metabolism ; Aquaporin 4 ; Chemokines
Chemical Substances	Chemokine CCL2 ; Aquaporin 4 ; Chemokines
Language	English
Publishing date	2023-09-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1279782
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Article ; Online: Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases.

Zhang, Jingdan / Li, Ao / Gu, Runze / Tong, Yueyang / Cheng, Jinbo

Frontiers in immunology

2023 Volume 14, Page(s) 1238930

Abstract: MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central nervous system ( ... ...

Abstract	MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central nervous system (CNS) diseases. The ability of miRNAs to enhance or restrict neuroinflammatory signaling pathways in CNS diseases is an emerging and important research area, including neurodegenerative diseases, stroke, and traumatic brain injury (TBI). In this review, we summarize the roles and regulatory mechanisms of recently identified miRNAs involved in neuroinflammation-mediated CNS diseases, aiming to explore and provide a better understanding and direction for the treatment of CNS diseases.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Neuroinflammatory Diseases ; Brain Injuries, Traumatic/genetics ; Stroke
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1238930
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Article ; Online: Construction and Application of Psychological Quality Assessment Model for College Students Based on Extensive Data Analysis.

Zou, Ping / Wu, Yanjun / Zhang, Jingdan

publication RETRACTED

Occupational therapy international

2022 Volume 2022, Page(s) 7982808

Abstract: This paper constructs a platform framework for extensive data analysis of college students' psychological quality with the help of the thinking mode of big data and related technologies and proposes the construction principles, data sources, data ... ...

Abstract	This paper constructs a platform framework for extensive data analysis of college students' psychological quality with the help of the thinking mode of big data and related technologies and proposes the construction principles, data sources, data processing methods, data platform construction, and platform application of big data analysis platform for college students' psychological quality assessment. This paper combines the application methods of big data technology, collects the management data related to the psychological quality assessment of college students, saves them into the system database with certain storage logic, and realizes the function of psychological quality assessment through the design of selected psychological quality assessment data, data management and data resource management and other parts based on the data results of extensive data analysis. This study provides some insights into the psychological quality assessment of college students. The strength of association between the variables of psychological quality assessment of college students changes over time, but the overall psychological structure is more stable. This stable psychological structure characteristic is conducive to constructing the policy of constant psychological education in large universities.
MeSH term(s)	Data Analysis ; Humans ; Occupational Therapy ; Students/psychology ; Universities
Language	English
Publishing date	2022-05-20
Publishing country	England
Document type	Journal Article ; Retracted Publication
ZDB-ID	2095334-3
ISSN	1557-0703 ; 0966-7903
ISSN (online)	1557-0703
ISSN	0966-7903
DOI	10.1155/2022/7982808
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Article ; Online: Magnetic Hydroxyapatite-Coated Iron-Chromium Microspheres for Dental Surface Polishing and Plaque Removal.

Jiang, Cong / Sun, Yue / Li, Gaojie / Zhou, Tianyu / Wang, Qiqi / Zhang, Jingdan / Song, Yulai / Xu, Wenzhou / A, Lan

ACS applied materials & interfaces

2024 Volume 16, Issue 5, Page(s) 5554–5567

Abstract: This research aimed to engineer magnetic hydroxyapatite-coated iron-chromium (HAp-FeCr) microspheres to enhance dental surface polishing and plaque elimination. Utilizing a tailored sol-gel approach, the HAp-FeCr microspheres were synthesized and ... ...

Abstract	This research aimed to engineer magnetic hydroxyapatite-coated iron-chromium (HAp-FeCr) microspheres to enhance dental surface polishing and plaque elimination. Utilizing a tailored sol-gel approach, the HAp-FeCr microspheres were synthesized and exhaustively characterized via scanning electron microscopy, energy-dispersive X-ray spectroscopy, ζ-potential, X-ray diffractometry, and X-ray photoelectron spectroscopy methodologies. Key findings showcased that these microspheres retained their magnetic properties post-HAp coating, as evidenced by the magnetization curves. An innovative magnetic polishing system was developed, incorporating these microspheres and a 2000 rpm magnet. Comparative evaluations between traditional air-powder polishing and the proposed magnetic technique demonstrated the latter's superiority. Notably, the magnetic polishing led to a substantial reduction in dental plaque on the tooth surface, decreasing bacterial adhesion and early biofilm formation by
MeSH term(s)	Animals ; Durapatite/chemistry ; Iron ; Microspheres ; Powders ; Dental Plaque ; Magnetic Phenomena ; Surface Properties
Chemical Substances	Durapatite (91D9GV0Z28) ; Iron (E1UOL152H7) ; Powders
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c16398
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Article ; Online: Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.

He, Lingyuan / Shi, Mengchen / Ren, Shuwei / Zhang, Jingdan / Tian, Yu / Yang, Xiangling / Liu, Huanliang

Biomolecules & biomedicine

2023 Volume 23, Issue 6, Page(s) 1026–1037

Abstract: Apolipoprotein E (apoE) has previously been reported to play vital roles in tumor progression. However, the impact of apoE on colorectal cancer (CRC) metastasis remains largely unexplored. This study aimed to investigate the role of apoE in CRC ... ...

Abstract	Apolipoprotein E (apoE) has previously been reported to play vital roles in tumor progression. However, the impact of apoE on colorectal cancer (CRC) metastasis remains largely unexplored. This study aimed to investigate the role of apoE in CRC metastasis and to identify the transcription factor and receptor of apoE involved in regulation of CRC metastasis. Bioinformatic analyses were conducted to examine the expression pattern and prognosis of apolipoproteins. APOE-overexpressing cell lines were utilized to explore the effects of apoE on proliferation, migration and invasion of CRC cells. Additionally, the transcription factor and receptor of apoE were screened via bioinformatics, and further validated through knockdown experiments. We discovered that the mRNA levels of APOC1, APOC2, APOD and APOE were higher in lymphatic invasion group, and a higher apoE level indicated poorer overall survival and progression-free interval. In vitro studies demonstrated that APOE-overexpression did not affect proliferation but promoted the migration and invasion of CRC cells. We also reported that APOE-expression was modulated by the transcription factor Jun by activating the proximal promoter region of APOE, and APOE-overexpression reversed the metastasis suppression of JUN knockdown. Furthermore, bioinformatics analysis suggested an interaction between apoE and low-density lipoprotein receptor-related protein 1 (LRP1). LRP1 was highly expressed in both the lymphatic invasion group and the APOEHigh group. Additionally, we found that APOE-overexpression upregulated LRP1 protein levels, and LRP1 knockdown attenuated the metastasis-promoting function of APOE. Overall, our study suggests that the Jun-APOE-LRP1 axis contributes to tumor metastasis in CRC.
MeSH term(s)	Humans ; Apolipoproteins E/metabolism ; Low Density Lipoprotein Receptor-Related Protein-1/genetics ; Transcription Factors/metabolism ; Cell Movement/genetics ; Carrier Proteins ; Colorectal Neoplasms/genetics
Chemical Substances	Apolipoproteins E ; Low Density Lipoprotein Receptor-Related Protein-1 ; Transcription Factors ; Carrier Proteins ; LRP1 protein, human
Language	English
Publishing date	2023-11-03
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ISSN	2831-090X
ISSN (online)	2831-090X
DOI	10.17305/bb.2023.9248
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Article ; Online: Potential roles of serum ATPase and AMPase in predicting diagnosis of colorectal cancer patients.

Shi, Mengchen / Tian, Yu / He, Lingyuan / Zhang, Jingdan / Yang, Xiangling / Liu, Huanliang

Bioengineered

2022 Volume 13, Issue 6, Page(s) 14204–14214

Abstract: Colorectal cancer (CRC) is a common gastrointestinal cancer with high incidence and mortality rates. CRC may be associated with regulation of circulating nucleotides. This study aimed to evaluate the serum levels of nucleotide-metabolizing enzymes ( ... ...

Abstract	Colorectal cancer (CRC) is a common gastrointestinal cancer with high incidence and mortality rates. CRC may be associated with regulation of circulating nucleotides. This study aimed to evaluate the serum levels of nucleotide-metabolizing enzymes (ATPase and AMPase) in patients with CRC and to explore the clinical diagnostic value of these enzymes. The gene set variation analysis (GSVA) score of the ATP-adenosine signature was calculated using tumor samples from The Cancer Genome Atlas (TCGA). ATP-adenosine signaling plays a central role in CRC progression. A total of 135 subjects, including 87 patients with CRC and 48 healthy controls, were included. The serum levels of ATPase and AMPase in the CRC group were significantly higher than those in the control group (
MeSH term(s)	Adenosine Monophosphate/blood ; Adenosine Triphosphatases/blood ; Adenosine Triphosphatases/genetics ; Adenosine Triphosphate/blood ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; CA-19-9 Antigen/blood ; Carcinoembryonic Antigen/metabolism ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/enzymology ; Colorectal Neoplasms/genetics ; Humans ; Nucleotidases/blood ; Nucleotidases/genetics
Chemical Substances	Biomarkers, Tumor ; CA-19-9 Antigen ; Carcinoembryonic Antigen ; Adenosine Monophosphate (415SHH325A) ; Adenosine Triphosphate (8L70Q75FXE) ; Nucleotidases (EC 3.1.3.-) ; adenosine monophosphatase (EC 3.1.3.-) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	English
Publishing date	2022-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2737830-5
ISSN	2165-5987 ; 2165-5979
ISSN (online)	2165-5987
ISSN	2165-5979
DOI	10.1080/21655979.2022.2084423
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Article ; Online: Targeting RPA promotes autophagic flux and the antitumor response to radiation in nasopharyngeal carcinoma.

Feng, Yanchun / Jiang, Yingming / Liu, Jun / Liu, Jiaqi / Shi, Mengchen / Chen, Junxiong / Zhang, Jingdan / Tian, Yu / Yang, Xiangling / Liu, Huanliang

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 738

Abstract: Background: Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of ... ...

Abstract	Background: Autophagy is involved in nasopharyngeal carcinoma (NPC) radioresistance. Replication protein A 1 (RPA1) and RPA3, substrates of the RPA complex, are potential therapeutic targets for reversing NPC radioresistance. Nevertheless, the role of RPA in autophagy is not adequately understood. This investigation was performed to reveal the cytotoxic mechanism of a pharmacologic RPA inhibitor (RPAi) in NPC cells and the underlying mechanism by which RPAi-mediated autophagy regulates NPC radiosensitivity. Methods and results: We characterized a potent RPAi (HAMNO) that was substantially correlated with radiosensitivity enhancement and proliferative inhibition of in vivo and in NPC cell lines in vitro. We show that the RPAi induced autophagy at multiple levels by inducing autophagic flux, AMPK/mTOR pathway activation, and autophagy-related gene transcription by decreasing glycolytic function. We hypothesized that RPA inhibition impaired glycolysis and increased NPC dependence on autophagy. We further demonstrated that combining autophagy inhibition with chloroquine (CQ) treatment or genetic inhibition of the autophagy regulator ATG5 and RPAi treatment was more effective than either approach alone in enhancing the antitumor response of NPC to radiation. Conclusions: Our study suggests that HAMNO is a potent RPAi that enhances radiosensitivity and induces autophagy in NPC cell lines by decreasing glycolytic function and activating autophagy-related genes. We suggest a novel treatment strategy in which pharmacological inhibitors that simultaneously disrupt RPA and autophagic processes improve NPC responsiveness to radiation.
MeSH term(s)	Humans ; Antineoplastic Agents/therapeutic use ; Apoptosis ; Autophagy/drug effects ; Autophagy/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Carcinoma/radiotherapy ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/genetics ; Nasopharyngeal Neoplasms/radiotherapy ; Radiation Tolerance/drug effects ; Radiation Tolerance/genetics ; Replication Protein A/antagonists & inhibitors ; Replication Protein A/genetics ; Autophagy-Related Protein 5/genetics
Chemical Substances	Antineoplastic Agents ; RPA1 protein, human ; Replication Protein A ; ATG5 protein, human ; Autophagy-Related Protein 5
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04574-w
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Article ; Online: Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia.

Bo, Xuena / Xie, Fei / Zhang, Jingdan / Gu, Runze / Li, Xiaoheng / Li, Shuoshuo / Yuan, Zengqiang / Cheng, Jinbo

Theranostics

2023 Volume 13, Issue 6, Page(s) 1809–1822

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Animals ; Mice ; Calcium-Binding Proteins ; Disease Models, Animal ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/pathology ; Neuroinflammatory Diseases ; Signal Transduction ; Parkinson Disease, Secondary/chemically induced ; Parkinson Disease, Secondary/genetics ; Calcium Channels/genetics
Chemical Substances	Calcium-Binding Proteins ; EFHD2 protein, mouse ; Calcium Channels ; Stat3 protein, mouse
Language	English
Publishing date	2023-03-13
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.83082
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Article ; Online: Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-κB/MAPK signaling pathway in microglia.

Yan, Meichen / Bo, Xuena / Zhang, Jingdan / Liu, Shuhan / Li, Xiaoheng / Liao, Yajin / Liu, Qingshan / Cheng, Yong / Cheng, Jinbo

Experimental neurology

2023 Volume 365, Page(s) 114426

Abstract: Major depressive disorder (MDD) is a common psychiatric disorder that severely affects human life and health. However, the pathological mechanism of MDD is unclear, and effective treatment strategies are urgently needed. Microglia-mediated ... ...

Abstract	Major depressive disorder (MDD) is a common psychiatric disorder that severely affects human life and health. However, the pathological mechanism of MDD is unclear, and effective treatment strategies are urgently needed. Microglia-mediated neuroinflammation is closely associated with the pathophysiology of depression. Bergapten (BG) is a natural pharmaceutical monomer with anti-inflammatory effects; however, its role in neuroinflammation and depression remains unclear. In this study, we employed a lipopolysaccharide (LPS) injection-induced acute depression mouse model, and found that treatment with BG significantly alleviated LPS-induced depression-like behavior in mice. BG administration largely decreased the increase in microglial numbers and rescued the microglial morphological changes induced by LPS injection. Furthermore, transcriptomic changes revealed a protective role of BG in the hippocampus of mice. Mechanistically, we found that BG directly inhibited cyclooxygenase 2 (COX2) activity, and suppressed nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in microglia. Together, these results highlight the important role of BG in microglial activation, neuroinflammation, and depression-like behavior, thus providing a new candidate drug for depression treatment.
MeSH term(s)	Animals ; Humans ; Mice ; 5-Methoxypsoralen/pharmacology ; Cyclooxygenase 2/metabolism ; Depression/drug therapy ; Depression/chemically induced ; Depressive Disorder, Major/metabolism ; Lipopolysaccharides/toxicity ; Microglia/metabolism ; Mitogen-Activated Protein Kinases/metabolism ; Neuroinflammatory Diseases ; NF-kappa B ; Signal Transduction
Chemical Substances	5-Methoxypsoralen (4FVK84C92X) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Lipopolysaccharides ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; NF-kappa B
Language	English
Publishing date	2023-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2023.114426
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Article ; Online: Trichoderma asperellum boosts nitrogen accumulation and photosynthetic capacity of wolfberry (Lycium chinense) under saline soil stress.

Yan, Kun / Zhu, Mingye / Su, Hongyan / Liu, Xiao / Li, Shuxin / Zhi, Yibo / Li, Yuxin / Zhang, Jingdan

Tree physiology

2023 Volume 44, Issue 1

Abstract: Trichoderma can promote plant growth under saline stress, but the mechanisms remain to be revealed. In this study, we investigate photosynthetic gas exchange, photosystem II (PSII) performance, nitrogen absorption and accumulation in a medicinal plant ... ...

Abstract	Trichoderma can promote plant growth under saline stress, but the mechanisms remain to be revealed. In this study, we investigate photosynthetic gas exchange, photosystem II (PSII) performance, nitrogen absorption and accumulation in a medicinal plant wolfberry (Lycium chinense) in saline soil supplemented with Trichoderma biofertilizer (TF). Larger nitrogen and biomass accumulation were found in plants supplemented with TF than with organic fertilizer (OF), suggesting that Trichoderma asperellum promoted plant growth and nitrogen accumulation under saline stress. T. asperellum strengthened root nitrogen (N) absorption according to greater increased root NH4+ and NO3- influxes under supplement with TF than OF, while nitrogen assimilative enzymes such as nitrate reductase, nitrite reductase and glutamine synthetase activities in roots and leaves were also stimulated. Thus, the elevated N accumulation derived from the induction of T. asperellum on nitrogen absorption and assimilation. Greater increased photosynthetic rate (Pn) and photosynthetic N-use efficiency under supplement with TF than OF illustrated that T. asperellum enhanced photosynthetic capacity and N utilization under saline stress. Although increased leaf stomatal conductance contributed to carbon (C) isotope fractionation under TF supplement, leaf 13C abundance was significantly increased by supplement with TF rather than OF, indicating that T. asperellum raised CO2 assimilation to a greater extent, reducing C isotope preference. Trichoderma asperellum optimized electron transport at PSII donor and acceptor sides under saline stress because of lower K and J steps in chlorophyll fluorescence transients under supplement with TF than OF. The amount of PSII active reaction centers was also increased by T. asperellum. Thus, PSII performance was upgraded, consistent with greater heightened delayed chlorophyll fluorescence transients and I1 peak under supplement with TF than OF. In summary, TF acted to increase N nutrient acquisition and photosynthetic C fixation resulting in enhanced wolfberry growth under saline soil stress.
MeSH term(s)	Lycium/metabolism ; Chlorophyll ; Nitrogen ; Soil ; Photosynthesis ; Plant Leaves/metabolism ; Photosystem II Protein Complex ; Isotopes ; Hypocreales
Chemical Substances	Chlorophyll (1406-65-1) ; Nitrogen (N762921K75) ; Soil ; Photosystem II Protein Complex ; Isotopes
Language	English
Publishing date	2023-12-22
Publishing country	Canada
Document type	Journal Article
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpad148
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