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Article: Exploring the Mechanism of Zilongjin in Treating Lung Adenocarcinoma Based on Network Pharmacology Combined with Experimental Verification.

Zhang, Kang / Chen, Xiaoqun

2024 Volume 44, Issue 5, Page(s) 27–40

Abstract: Zilongjin (ZLJ) is a common traditional Chinese medicine for lung adenocarcinoma (LUAD) treatment. However, its mechanisms of action remain to be elucidated. Network pharmacology was used to explore the underlying mechanisms of ZLJ on LUAD treatment. The ...

Abstract	Zilongjin (ZLJ) is a common traditional Chinese medicine for lung adenocarcinoma (LUAD) treatment. However, its mechanisms of action remain to be elucidated. Network pharmacology was used to explore the underlying mechanisms of ZLJ on LUAD treatment. The disease-related targets were determined from the Gene-Cards and DisGeNET databases. Active compounds and targets of ZLJ were obtained from the HIT, TCMSP, and TCMID databases. Then the protein-protein interaction (PPI) network was built by the STRING database to identify core-hub targets of ZLJ in LUAD. Next, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were employed to analyze the enriched regulatory pathways of targets. Molecular docking analysis was used to evaluate interactions between potential targets and active compounds. Finally, qRT-PCR was used to further verify the results of network pharmacology. A total of 124 LUAD-related targets of ZLJ and 5 active compounds of ZLJ from the relevant databases were screened out. Among these target proteins, JUN, CDH1, PPARG, and FOS were core hub-genes in the PPI network. GO and KEGG pathway enrichment analysis indicated that these targets might regulate the PPAR signaling pathway in LUAD. JUN, PPARG, and FOS levels were upregulated, while CDH1 level was downregulated in LUAD cells. This study discerned that ZLJ may target genes such as JUN, FOS, PPARG, and CDH1 via the PPAR signaling pathway in LUAD, offering foundational insights for further exploration of ZLJ in clinical applications.
MeSH term(s)	Humans ; Network Pharmacology ; Molecular Docking Simulation ; PPAR gamma ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Drugs, Chinese Herbal
Chemical Substances	zilongjin ; PPAR gamma ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-03-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	1353116-5
ISSN	1040-8401
ISSN	1040-8401
DOI	10.1615/CritRevImmunol.2024051316
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Article ; Online: Multiple-Time Scale Exciton Dynamics in Organic Photovoltaic Devices.

Zhang, Kang-Ning / Hao, Xiao-Tao

The journal of physical chemistry letters

2023 Volume 14, Issue 26, Page(s) 6051–6060

Abstract: Organic photovoltaics (OPVs) are regarded as one of the most promising candidates for various outdoor and indoor application scenarios. The development and application of nonfullerene acceptors have pushed power conversion efficiencies (PCEs) of single- ... ...

Abstract	Organic photovoltaics (OPVs) are regarded as one of the most promising candidates for various outdoor and indoor application scenarios. The development and application of nonfullerene acceptors have pushed power conversion efficiencies (PCEs) of single-junction cells to exceed 19%, and values approaching 20% are within sight. This progress has resulted in some unexpected photophysical observations deserving more in-depth spectroscopic research. In this Perspective, we have summarized recent photophysical advances in accordance with results of ultrafast spectroscopy in our and other groups and provide our point of view on multiple-time scale exciton dynamics involving the following aspects: long-range exciton diffusion driven by dual Förster resonance energy transfer, origins of driving force for hole transfer under small energy offsets, trap-induced charge recombination in outdoor and indoor OPVs, and a picture of real-time evolution of excitons and charge carriers regarding stability. Moreover, our understanding of the photophysical property-function relationship is proposed in state-of-the-art OPVs. Finally, we point out the remaining challenges devoted to the further development of versatile OPVs.
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1948-7185
ISSN (online)	1948-7185
DOI	10.1021/acs.jpclett.3c01004
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Article ; Online: A Linear Time-Varying Inequality Approach for Prescribed Time Stability and Stabilization.

Zhou, Bin / Zhang, Kang-Kang

IEEE transactions on cybernetics

2023 Volume 53, Issue 3, Page(s) 1880–1889

Abstract: This article studies the problem of finite-time, fixed-time, and prescribed-time stability analysis and stabilization. First, a linear time-varying (LTV) inequality-based approach is introduced for prescribed-time stability analysis. Then, it is shown ... ...

Abstract	This article studies the problem of finite-time, fixed-time, and prescribed-time stability analysis and stabilization. First, a linear time-varying (LTV) inequality-based approach is introduced for prescribed-time stability analysis. Then, it is shown that the existing nonlinear Lyapunov inequalities-based finite- and fixed-time stability criteria can be recast into the unified framework of the LTV inequality-based approach for prescribed-time stability. Finally, the unified LTV inequality-based approach is used to solve the global prescribed-time stabilization problem of the attitude control system of a rigid spacecraft with disturbance, and a bounded nonlinear time-varying controller is proposed via back stepping. Numerical simulations are presented to show the effectiveness of the proposed methods.
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2022.3164658
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Article: Pedicled myocutaneous flap transplantation for a large chest wall defect with infection in a 72-year-old female.

Zhang, Kang / Wang, Lei / He, Zhongliang

Heliyon

2024 Volume 10, Issue 1, Page(s) e24038

Abstract: Background: In the realm of thoracic surgery, addressing chest wall defects accompanied by infections remains a formidable task. Despite the availability of a spectrum of surgical options, attaining clinical resolution is particularly challenging in ... ...

Abstract	Background: In the realm of thoracic surgery, addressing chest wall defects accompanied by infections remains a formidable task. Despite the availability of a spectrum of surgical options, attaining clinical resolution is particularly challenging in intricate cases involving extensive chest wall defects in elderly patients. Thorough debridement followed by the utilization of autologous tissue for repair and reconstruction has emerged as a prevalent approach in current clinical practice. Case presentation: Herein, we present a 72-year-old female patient with a large chest wall defect and infection. She has experienced left breast cancer surgery, multi cycle radiotherapy and chemotherapy. Nine months ago, there was yellow purulent fluid in the left chest wall. She had undergone debridement in other hospital, and the treatment effect was poor. At our hospital, Chest computed tomography (CT) imaging revealed a soft tissue anomaly on the left side of the chest wall, along with partial rib bone deterioration. Considering the patient's clinical presentation and radiological findings, a tentative diagnosis of an infected chest wall defect and chronic osteomyelitis was established. Consequently, daily dressing changes were deemed necessary for the patient's infected chest wound. Surgery for chest wall repair and reconstruction was scheduled once the wound area exhibited cleanliness with emerging granulation tissue. Preoperatively, a myocutaneous flap of an appropriate size was meticulously planned. During the surgical procedure, initial debridement of the infected chest wall area was conducted, followed by the strategic placement of a harvested pedicled latissimus dorsi myocutaneous flap to rectify the defect. Postoperative care involved stringent anti-infective measures, anti-spasmodic treatment, and preventive anticoagulation, accompanied by vigilant monitoring of the myocutaneous flap's viability and the healing progress of the defect site. Conclusions: Utilizing the pedicled latissimus dorsi myocutaneous flap for repairing extensive defects in the chest wall presents a viable and efficient strategy. This technique preserves cardiopulmonary functionality and maintains the thoracic contour. The outcomes observed in the short to medium term postoperatively have been consistently gratifying.
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Case Reports
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Survey of Recent Practice of Artificial Life in Visual Art.

Wu, Zi-Wei / Qu, Huamin / Zhang, Kang

Artificial life

2024 Volume 30, Issue 1, Page(s) 106–135

Abstract: Nowadays, interdisciplinary fields between Artificial Life, artificial intelligence, computational biology, and synthetic biology are increasingly emerging into public view. It is necessary to reconsider the relations between the material body, identity, ...

Abstract	Nowadays, interdisciplinary fields between Artificial Life, artificial intelligence, computational biology, and synthetic biology are increasingly emerging into public view. It is necessary to reconsider the relations between the material body, identity, the natural world, and the concept of life. Art is known to pave the way to exploring and conveying new possibilities. This survey provides a literature review on recent works of Artificial Life in visual art during the past 40 years, specifically in the computational and software domain. Having proposed a set of criteria and a taxonomy, we briefly analyze representative artworks of different categories. We aim to provide a systematic overview of how artists are understanding nature and creating new life with modern technology.
MeSH term(s)	Artificial Intelligence ; Artificial Life ; Art ; Computational Biology ; Synthetic Biology
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2024100-8
ISSN	1530-9185 ; 1064-5462
ISSN (online)	1530-9185
ISSN	1064-5462
DOI	10.1162/artl_a_00433
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Goat milk exosomal microRNAs alleviate LPS-induced intestinal inflammation in mice.

Gao, Feng / Wu, Shenghui / Zhang, Kang / Xu, Zhiming / Quan, Fusheng

International journal of biological macromolecules

2024 , Page(s) 131698

Abstract: Intestinal inflammation is a common digestive system disease. Milk-derived exosomes can participate in intercellular communication and transport a variety of bioactive components, and the microRNAs (miRNAs) they carry play important roles in a variety of ...

Abstract	Intestinal inflammation is a common digestive system disease. Milk-derived exosomes can participate in intercellular communication and transport a variety of bioactive components, and the microRNAs (miRNAs) they carry play important roles in a variety of biological processes in the body. At present, the preventive effect and mechanism of action of goat milk exosomes and their derived miRNAs on intestinal inflammation are still unclear. In this study, the protective effect of goat milk exosomes on LPS-induced intestinal inflammation was investigated using mouse intestinal inflammation model and IEC-6 cell inflammation model. Small RNA sequencing was used to analyze the miRNA expression profile of goat milk exosomes. In this study, C-Exo and M-Exo alleviated intestinal inflammation by reducing the LPS-induced release of proinflammatory cytokines, inhibiting the increase in the NLRP3 protein and the activation of the TLR4/NFκB signaling pathway. C-Exo has a more significant inhibitory effect on them, and better therapeutic efficacy than M-Exo. Notably, the target genes of miRNAs in C-Exo and M-Exo were significantly enriched in immune-related pathways. Furthermore, their derived miR-26a-5p and miR-30a-5p were found to ameliorate the IEC-6 inflammatory response. These findings suggest that miRNAs in goat milk exosomes have the potential to attenuate LPS-induced intestinal inflammation.
Language	English
Publishing date	2024-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131698
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Article ; Online: Region Anomaly Detection via Spatial and Semantic Attributed Graph in Human Monitoring.

Zhang, Kang / Fadjrimiratno, Muhammad Fikko / Suzuki, Einoshin

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: This paper proposes a graph-based deep framework for detecting anomalous image regions in human monitoring. The most relevant previous methods, which adopt deep models to obtain salient regions with captions, focus on discovering anomalous single regions ...

Abstract	This paper proposes a graph-based deep framework for detecting anomalous image regions in human monitoring. The most relevant previous methods, which adopt deep models to obtain salient regions with captions, focus on discovering anomalous single regions and anomalous region pairs. However, they cannot detect an anomaly involving more than two regions and have deficiencies in capturing interactions among humans and objects scattered in multiple regions. For instance, the region of a man making a phone call is normal when it is located close to a kitchen sink and a soap bottle, as they are in a resting area, but abnormal when close to a bookshelf and a notebook PC, as they are in a working area. To overcome this limitation, we propose a spatial and semantic attributed graph and develop a Spatial and Semantic Graph Auto-Encoder (SSGAE). Specifically, the proposed graph models the "context" of a region in an image by considering other regions with spatial relations, e.g., a man sitting on a chair is adjacent to a white desk, as well as other region captions with high semantic similarities, e.g., "a man in a kitchen" is semantically similar to "a white chair in the kitchen". In this way, a region and its context are represented by a node and its neighbors, respectively, in the spatial and semantic attributed graph. Subsequently, SSGAE is devised to reconstruct the proposed graph to detect abnormal nodes. Extensive experimental results indicate that the AUC scores of SSGAE improve from 0.79 to 0.83, 0.83 to 0.87, and 0.91 to 0.93 compared with the best baselines on three real-world datasets.
MeSH term(s)	Male ; Humans ; Semantics ; Household Articles ; Rest ; Sitting Position ; Telecommunications
Language	English
Publishing date	2023-01-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031307
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Article ; Online: LFLDNet: Lightweight Fingerprint Liveness Detection Based on ResNet and Transformer.

Zhang, Kang / Huang, Shu / Liu, Eryun / Zhao, Heng

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 15

Abstract: With the rapid development of fingerprint recognition systems, fingerprint liveness detection is gradually becoming regarded as the main countermeasure to protect the fingerprint identification system from spoofing attacks. Convolutional neural networks ... ...

Abstract	With the rapid development of fingerprint recognition systems, fingerprint liveness detection is gradually becoming regarded as the main countermeasure to protect the fingerprint identification system from spoofing attacks. Convolutional neural networks have shown great potential in fingerprint liveness detection. However, the generalization ability of the deep network model for unknown materials, and the computational complexity of the network, need to be further improved. A new lightweight fingerprint liveness detection network is here proposed to distinguish fake fingerprints from real ones. The method includes mainly foreground extraction, fingerprint image blocking, style transfer based on CycleGan and an improved ResNet with multi-head self-attention mechanism. The proposed method can effectively extract ROI and obtain the end-to-end data structure, which increases the amount of data. For false fingerprints generated from unknown materials, the use of CycleGan network improves the model generalization ability. The introduction of Transformer with MHSA in the improved ResNet improves detection performance and reduces computing overhead. Experiments on the LivDet2011, LivDet2013 and LivDet2015 datasets showed that the proposed method achieves good results. For example, on the LivDet2015 dataset, our methods achieved an average classification error of 1.72 across all sensors, while significantly reducing network parameters, and the overall parameter number was only 0.83 M. At the same time, the experiment on small-area fingerprints yielded an accuracy of 95.27%.
Language	English
Publishing date	2023-08-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23156854
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Article ; Online: Overexpression of the class A penicillin-binding protein PonA in Bacillus improves recombinant protein production.

Zhu, Xuyang / Zhang, Kang / Luo, Hui / Wu, Jing

Bioresource technology

2023 Volume 383, Page(s) 129219

Abstract: The bottleneck of recombinant protein production in microbial cell factories is sometimes determined by limited manipulable targets and the lack of gene annotation related to protein expression. PonA is the major class A penicillin-binding protein in ... ...

Abstract	The bottleneck of recombinant protein production in microbial cell factories is sometimes determined by limited manipulable targets and the lack of gene annotation related to protein expression. PonA is the major class A penicillin-binding protein in Bacillus, which polymerizes and cross-links peptidoglycan. Here, we described its novel functions during recombinant protein expression in Bacillus subtilis and analyzed the mechanism of its chaperone activity. When PonA was overexpressed, the expression of hyperthermophilic amylase significantly increased 3.96- and 1.26-fold in shake flasks and fed-batch processes, respectively. Increased cell diameter and reinforced cell walls were observed in PonA-overexpressing strains. Furthermore, the FN3 structural domain and the natural dimeric structure of PonA may be critical for exerting its chaperone activity. These data suggest that PonA can be an effective target for modification of the expression of recombinant proteins in B. subtilis.
MeSH term(s)	Penicillin-Binding Proteins/genetics ; Penicillin-Binding Proteins/metabolism ; Bacillus/genetics ; Bacillus/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Recombinant Proteins/metabolism ; Bacillus subtilis/genetics ; Bacillus subtilis/metabolism
Chemical Substances	Penicillin-Binding Proteins ; Bacterial Proteins ; Recombinant Proteins
Language	English
Publishing date	2023-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129219
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Article ; Online: Overexpression of the class A penicillin-binding protein PonA in Bacillus improves recombinant protein production

Zhu, Xuyang / Zhang, Kang / Luo, Hui / Wu, Jing

Bioresource Technology. 2023 Sept., v. 383 p.129219-

2023

Abstract	The bottleneck of recombinant protein production in microbial cell factories is sometimes determined by limited manipulable targets and the lack of gene annotation related to protein expression. PonA is the major class A penicillin-binding protein in Bacillus, which polymerizes and cross-links peptidoglycan. Here, we described its novel functions during recombinant protein expression in Bacillus subtilis and analyzed the mechanism of its chaperone activity. When PonA was overexpressed, the expression of hyperthermophilic amylase significantly increased 3.96- and 1.26-fold in shake flasks and fed-batch processes, respectively. Increased cell diameter and reinforced cell walls were observed in PonA-overexpressing strains. Furthermore, the FN3 structural domain and the natural dimeric structure of PonA may be critical for exerting its chaperone activity. These data suggest that PonA can be an effective target for modification of the expression of recombinant proteins in B. subtilis.
Keywords	Bacillus subtilis ; amylases ; crosslinking ; genes ; peptidoglycans ; protein synthesis ; recombinant proteins ; technology ; PonA ; Chaperone ; Recombinant expression
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129219
Database	NAL-Catalogue (AGRICOLA)

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