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  1. Article ; Online: Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects.

    Wan, Qianyu / Zhang, Xinrui / Zhou, Dongfang / Xie, Rui / Cai, Yue / Zhang, Kehao / Sun, Xuanrong

    Journal of nanobiotechnology

    2023  Volume 21, Issue 1, Page(s) 215

    Abstract: It is reported that pulmonary fibrosis has become one of the major long-term complications of COVID-19, even in asymptomatic individuals. Currently, despite the best efforts of the global medical community, there are no treatments for COVID-induced ... ...

    Abstract It is reported that pulmonary fibrosis has become one of the major long-term complications of COVID-19, even in asymptomatic individuals. Currently, despite the best efforts of the global medical community, there are no treatments for COVID-induced pulmonary fibrosis. Recently, inhalable nanocarriers have received more attention due to their ability to improve the solubility of insoluble drugs, penetrate biological barriers of the lungs and target fibrotic tissues in the lungs. The inhalation route has many advantages as a non-invasive method of administration and the local delivery of anti-fibrosis agents to fibrotic tissues like direct to the lesion from the respiratory system, high delivery efficiency, low systemic toxicity, low therapeutic dose and more stable dosage forms. In addition, the lung has low biometabolic enzyme activity and no hepatic first-pass effect, so the drug is rapidly absorbed after pulmonary administration, which can significantly improve the bioavailability of the drug. This paper summary the pathogenesis and current treatment of pulmonary fibrosis and reviews various inhalable systems for drug delivery in the treatment of pulmonary fibrosis, including lipid-based nanocarriers, nanovesicles, polymeric nanocarriers, protein nanocarriers, nanosuspensions, nanoparticles, gold nanoparticles and hydrogel, which provides a theoretical basis for finding new strategies for the treatment of pulmonary fibrosis and clinical rational drug use.
    MeSH term(s) Humans ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/metabolism ; Gold/metabolism ; Administration, Inhalation ; COVID-19/metabolism ; Metal Nanoparticles ; Drug Delivery Systems ; Lung/metabolism ; Pharmaceutical Preparations/metabolism ; Nanoparticles/therapeutic use
    Chemical Substances Gold (7440-57-5) ; Pharmaceutical Preparations
    Language English
    Publishing date 2023-07-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2100022-0
    ISSN 1477-3155 ; 1477-3155
    ISSN (online) 1477-3155
    ISSN 1477-3155
    DOI 10.1186/s12951-023-01971-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Enhanced release, export, and transport of diffuse nutrients from litter in forested watersheds with climate warming

    Hao, Xin / Ouyang, Wei / Zhang, Kehao / Wan, Xinyue / Cui, Xintong / Zhu, Weihong

    Science of the total environment. 2022 Sept. 01, v. 837

    2022  

    Abstract: Variations in litter decomposition and nutrient migration are constraints to accurately estimate watershed diffuse forest pollution under the combined effects of topographic heterogeneity and climate change. In this study, remote sensing data, ... ...

    Abstract Variations in litter decomposition and nutrient migration are constraints to accurately estimate watershed diffuse forest pollution under the combined effects of topographic heterogeneity and climate change. In this study, remote sensing data, decomposition and leaching experiments, and the Soil and Water Assessment Tool (SWAT) were used to quantify the release, export, and transport characteristics of diffuse nutrients from forest litter under two climate scenarios (the current climate condition [S1] and the future warming and drying climate condition [S2]), and the impacts on aquatic environment were identified. The annual litter decomposition was 27.80 × 10⁶ t in S2, which was 1.39 times that of S1. Additionally, the annual litter nutrient release in S2 (C, N, and P was 8.65 × 10⁶, 3.31 × 10⁵, and 1.57 × 10⁴ t, respectively) also increased by 31.16%–45.62% compared with that of S1. The spatial patterns of nutrient export showed that the annual exports of C, N, and P in S1 were 109.77, 46.85, and 0.43 kg/ha, respectively. The annual nutrient export in S2 increased by 1.44 times, and S2 also had higher values of nutrient transport. In addition, variation trends of temperature and precipitation increased significantly with increasing altitude, which promoted differences in nutrient transport between S1 and S2 in the high-altitude areas. The response analysis of the diffuse nutrient in surface water also indicated that forest nutrient discharge load were critical factors affecting the aquatic environmental quality. This study indicated that climate warming accelerated litter decomposition and made litter a potential source of diffuse forest pollution, and watershed discharge load varied intensively with the terrestrial conditions. The combination of experiments and modeling can improve the accuracy of diffuse forest pollution simulation and provide valuable information for formulating watershed climate change adaptation strategies.
    Keywords Soil and Water Assessment Tool model ; altitude ; aquatic environment ; climatic factors ; environmental quality ; forest litter ; forests ; nutrient transport ; pollution ; surface water ; temperature
    Language English
    Dates of publication 2022-0901
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.155897
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 74/341: Show issues

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  3. Article ; Online: A Case Study of Swine Wastewater Treatment via Electrochemical Oxidation by Ti

    Wan, Hongyou / Wang, Ruifeng / Wang, Beibei / Zhang, Kehao / Shi, Huanhuan / Wang, Hailong

    International journal of environmental research and public health

    2022  Volume 19, Issue 21

    Abstract: With the rapid development of breeding industry, the efficient treatment of dramatically increasing swine wastewater is gradually becoming urgent. In particular, the development of application technologies suitable for the relatively small piggeries is ... ...

    Abstract With the rapid development of breeding industry, the efficient treatment of dramatically increasing swine wastewater is gradually becoming urgent. In particular, the development of application technologies suitable for the relatively small piggeries is critical due to the time cost and space requirements of conventional biological methods. In this study, Electrochemical oxidation (EO) was selected to systematically explore the treatment performance of three different swine wastewaters by Ti
    MeSH term(s) Swine ; Animals ; Wastewater ; Titanium/chemistry ; Water Pollutants, Chemical/analysis ; Water Purification/methods ; Electrodes ; Oxidation-Reduction ; Phosphorus ; Waste Disposal, Fluid/methods
    Chemical Substances Waste Water ; Titanium (D1JT611TNE) ; Water Pollutants, Chemical ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph192113840
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  4. Article ; Online: Enhanced release, export, and transport of diffuse nutrients from litter in forested watersheds with climate warming.

    Hao, Xin / Ouyang, Wei / Zhang, Kehao / Wan, Xinyue / Cui, Xintong / Zhu, Weihong

    The Science of the total environment

    2022  Volume 837, Page(s) 155897

    Abstract: Variations in litter decomposition and nutrient migration are constraints to accurately estimate watershed diffuse forest pollution under the combined effects of topographic heterogeneity and climate change. In this study, remote sensing data, ... ...

    Abstract Variations in litter decomposition and nutrient migration are constraints to accurately estimate watershed diffuse forest pollution under the combined effects of topographic heterogeneity and climate change. In this study, remote sensing data, decomposition and leaching experiments, and the Soil and Water Assessment Tool (SWAT) were used to quantify the release, export, and transport characteristics of diffuse nutrients from forest litter under two climate scenarios (the current climate condition [S1] and the future warming and drying climate condition [S2]), and the impacts on aquatic environment were identified. The annual litter decomposition was 27.80 × 10
    MeSH term(s) Climate Change ; Ecosystem ; Forests ; Nutrients ; Plant Leaves ; Soil ; Water
    Chemical Substances Soil ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-05-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.155897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Optimizing Feeding Strategies for Growing Rabbits: Impact of Timing and Amount on Health and Circadian Rhythms.

    Huang, Jie / Wang, Qiangjun / Zhang, Kehao / He, Shuai / Liu, Zhongying / Li, Mingyong / Liu, Man / Guo, Yao / Wu, Zhonghong

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 17

    Abstract: Mammals exhibit circadian rhythms in their behavior and physiological activities to adapt to the diurnal changes of the environment. Improper feeding methods can disrupt the natural habits of animals and harm animal health. This study investigated the ... ...

    Abstract Mammals exhibit circadian rhythms in their behavior and physiological activities to adapt to the diurnal changes of the environment. Improper feeding methods can disrupt the natural habits of animals and harm animal health. This study investigated the effects of feeding amount and feeding time on growing rabbits in northern China during spring. A total of 432 healthy 35-day-old weaned rabbits with similar body weight were randomly assigned to four groups: whole day diet-unrestricted feeding (WUF), whole day diet-restricted feeding (WRF), nighttime diet-unrestricted feeding (NUF), and nighttime diet-restricted feeding (NRF). The results showed that nighttime diet-unrestricted feeding improved performance, circadian rhythm of behavior, and body temperature, while reducing the risk of diarrhea and death. WRF group increased daytime body temperature but had no significant difference in feed conversion rate. The study suggests that nighttime diet-unrestricted feeding in spring can improve the growth and welfare of rabbits in northern China. Our study underscores the pivotal role of feeding timing in enhancing animal health. Future investigations should delve into the underlying mechanisms and expand the application of this strategy across seasons and regions to improve rabbit husbandry practices.
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13172742
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  6. Article ; Online: Quality enhancement of low temperature metal organic chemical vapor deposited MoS

    Islam, Zahabul / Zhang, Kehao / Robinson, Joshua / Haque, Aman

    Nanotechnology

    2019  Volume 30, Issue 39, Page(s) 395402

    Abstract: Electronic quality of chemical vapor deposited ... ...

    Abstract Electronic quality of chemical vapor deposited MoS
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ab2c3a
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  7. Article: The tolerance to saline-alkaline stress was dependent on the roots in wheat.

    Zhang, Kehao / Tang, Jingru / Wang, Yi / Kang, Houyang / Zeng, Jian

    Physiology and molecular biology of plants : an international journal of functional plant biology

    2020  Volume 26, Issue 5, Page(s) 947–954

    Abstract: Saline-alkaline stress is one of the most serious global problems affecting agriculture, causing enormous economic and yield losses in agricultural production. Wheat, one of the most important crops worldwide, is often subjected to saline-alkaline stress. ...

    Abstract Saline-alkaline stress is one of the most serious global problems affecting agriculture, causing enormous economic and yield losses in agricultural production. Wheat, one of the most important crops worldwide, is often subjected to saline-alkaline stress. In this study, two wheat cultivars with different saline-alkaline tolerance, XC-12 (non-tolerance) and XC-45 (tolerance), were used to investigate the influence of saline-alkaline stress on photosynthesis and nitrogen (N) metabolism through hydroponic experiment with aim of elucidating the mechanism of resistance to salt-alkali. These results showed that saline-alkaline stress significantly reduced biomass accumulation, chlorophyll content, photosynthetic ability and N absorption but increased N utilization efficiency. There was no significant difference in photosynthesis between XC-12 and XC-45 under saline-alkaline stress. In addition, XC-45 had lower ratio of Na
    Language English
    Publishing date 2020-04-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 2487126-6
    ISSN 0974-0430 ; 0971-5894
    ISSN (online) 0974-0430
    ISSN 0971-5894
    DOI 10.1007/s12298-020-00799-x
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  8. Article: The effects of ambient temperature and feeding regimens on cecum bacteria composition and circadian rhythm in growing rabbits.

    Shuai He / Zhang, Ke-Hao / Jin, Qiong-Yu / Wang, Qiang-Jun / Huang, Jie / Li, Jun-Jiao / Guo, Yao / Liu, Peng / Liu, Zhong-Ying / Liu, Dan / Geng, Shi-Xia / Li, Qin / Li, Ming-Yong / Liu, Man / Wu, Zhong-Hong

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1344992

    Abstract: Seasonal environmental shifts and improper eating habits are the important causes of diarrhea in children and growing animals. Whether adjusting feeding time at varying temperatures can modify cecal bacterial structure and improve diarrhea remains ... ...

    Abstract Seasonal environmental shifts and improper eating habits are the important causes of diarrhea in children and growing animals. Whether adjusting feeding time at varying temperatures can modify cecal bacterial structure and improve diarrhea remains unknown. Three batches growing rabbits with two groups per batch were raised under different feeding regimens (fed at daytime vs. nighttime) in spring, summer and winter separately, and contents were collected at six time points in 1 day and used 16S rRNA sequencing to investigate the effects of feeding regimens and season on the composition and circadian rhythms of cecum bacteria. Randomized forest regression screened 12 genera that were significantly associated with seasonal ambient temperature changes. Nighttime feeding reduced the abundance of the conditionally pathogenic bacteria
    Language English
    Publishing date 2024-02-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1344992
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Van der Waals interfaces in epitaxial vertical metal/2D/3D semiconductor heterojunctions of monolayer

    Ruzmetov, Dmitry / Neupane, Mahesh R / Herzing, Andrew / O'Regan, Terrance P / Mazzoni, Alex / Chin, Matthew L / Burke, Robert A / Crowne, Frank J / Birdwell, A Glen / Taylor, DeCarlos E / Kolmakov, Andrei / Zhang, Kehao / Robinson, Joshua A / Davydov, Albert V / Ivanov, Tony G

    2d materials

    2024  Volume 5, Issue 4

    Abstract: A promising approach for high speed and high power electronics is to integrate two-dimensional (2D) materials with conventional electronic components such as bulk (3D) semiconductors and metals. In this study we explore a basic integration step of ... ...

    Abstract A promising approach for high speed and high power electronics is to integrate two-dimensional (2D) materials with conventional electronic components such as bulk (3D) semiconductors and metals. In this study we explore a basic integration step of inserting a single monolayer
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ISSN 2053-1583
    ISSN 2053-1583
    DOI 10.1088/2053-1583/aad1b7
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  10. Article: Construction of Z-Scheme TiO

    Zhang, Kai / Zhang, Kehao / Ma, Yuxiang / Wang, Hailong / Shao, Junyong / Li, Mingliang / Shao, Gang / Fan, Bingbing / Lu, Hongxia / Xu, Hongliang / Zhang, Rui / Shi, Huanhuan

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 2

    Abstract: ... ...

    Abstract TiO
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16020868
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