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  1. Article ; Online: Biomimetic engineering of nonribosomal peptide synthesis.

    Zhang, Kexin / Kries, Hajo

    Biochemical Society transactions

    2023  Volume 51, Issue 4, Page(s) 1521–1532

    Abstract: Nonribosomal peptides (NRPs) have gained attention due to their diverse biological activities and potential applications in medicine and agriculture. The natural diversity of NRPs is a result of evolutionary processes that have occurred over millions of ... ...

    Abstract Nonribosomal peptides (NRPs) have gained attention due to their diverse biological activities and potential applications in medicine and agriculture. The natural diversity of NRPs is a result of evolutionary processes that have occurred over millions of years. Recent studies have shed light on the mechanisms by which nonribosomal peptide synthetases (NRPSs) evolve, including gene duplication, recombination, and horizontal transfer. Mimicking natural evolution could be a useful strategy for engineering NRPSs to produce novel compounds with desired properties. Furthermore, the emergence of antibiotic-resistant bacteria has highlighted the urgent need for new drugs, and NRPs represent a promising avenue for drug discovery. This review discusses the engineering potential of NRPSs in light of their evolutionary history.
    MeSH term(s) Biomimetics ; Peptides/chemistry ; Bacteria ; Peptide Synthases/genetics ; Peptide Synthases/chemistry
    Chemical Substances Peptides ; Peptide Synthases (EC 6.3.2.-)
    Language English
    Publishing date 2023-07-05
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20221264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 944: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article: Suicide, self-injury and violence.

    Zhang, Kexin / Wang, Ziyang / Yu, Xin

    General psychiatry

    2024  Volume 37, Issue 1, Page(s) e101387

    Language English
    Publishing date 2024-02-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2941976-1
    ISSN 2517-729X ; 2517-729X ; 2096-5923
    ISSN (online) 2517-729X
    ISSN 2517-729X ; 2096-5923
    DOI 10.1136/gpsych-2023-101387
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  3. Article ; Online: CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.

    Liu, Yan / Zhang, Kexin / Yang, Xianxu

    Journal of the Egyptian National Cancer Institute

    2024  Volume 36, Issue 1, Page(s) 8

    Abstract: Background: CircRNAs and miRNAs are involved in the progression of tumor. CircMCTP2 is considered as a novel tumor promoter. However, the exact functions of circMCTP2 in bladder cancer are still unclear. This study was designed to explore the underlying ...

    Abstract Background: CircRNAs and miRNAs are involved in the progression of tumor. CircMCTP2 is considered as a novel tumor promoter. However, the exact functions of circMCTP2 in bladder cancer are still unclear. This study was designed to explore the underlying mechanisms of circMCTP2-modulated tumor development in bladder cancer.
    Methods: The present study is an original research. The levels of circMCTP2 in a total of 39 bladder cancer specimens and cell lines were determined by RT-qPCR. The expression of FZD8 in T24 and RT-4 cells treated with miR-99a-5p mimics were examined using western blotting. In addition, the proliferative, migrative and invasive abilities of transfected cells were determined by CCK8 and Transwell assays. Furthermore, the apoptosis of transfected cells was evaluated using flow cytometry. Dual luciferase reporter assay was performed to elucidate the relationship between miR-99a-5p and circMCTP2/FZD8.
    Results: The levels of circMCTP2 were elevated in bladder cancer samples and cells, and this was related to worse survival rate. Downregulation of circMCTP2 suppressed growth and metastasis of cells, whereas the apoptotic rate of cells was enhanced. The levels of miR-99a-5rp was elevated after the downregulation of circMCTP2. Moreover, reverse correlation between the expression of miR-99a-5p and circMCTP2 was revealed in bladder cancer specimens. Additionally, FZD8 was the putative target of miR-99a-5p and the mimics of miR-99a-5p inhibited the proliferation, migration and invasion of bladder cancer cells via the FZD8/Wnt-b-catenin axis. Moreover, circMCTP2 regulated the growth and metastasis of bladder cancer cells potentially through regulating the miR-99a-5p/FZD8/Wnt-b-catenin axis. In summary, circMCTP2 was considered as an oncogenic factor through regulating the miR-99a-5p/FZD8/Wnt-b-catenin axis.
    Conclusions: This novel signaling could regulate the biological behaviours of bladder cancer cells, and these findings highlighted circMCTP2 as a critical target for treating bladder cancer.
    MeSH term(s) Humans ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/pathology ; Catenins/metabolism
    Chemical Substances MicroRNAs ; Catenins
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1176790-x
    ISSN 2589-0409 ; 1110-0362
    ISSN (online) 2589-0409
    ISSN 1110-0362
    DOI 10.1186/s43046-024-00206-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3918: Show issues Location:
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  4. Article ; Online: Characterization of a Clove Essential Oil Slow-Release Microencapsulated Composite Film and Its Preservation Effects on Blueberry.

    Li, Yang / Bian, Boya / Tang, Rongrong / Zhang, Kexin

    ACS omega

    2024  Volume 9, Issue 11, Page(s) 12643–12656

    Abstract: In order to extend the shelf life of fruits and vegetables, a sodium alginate-sodium carboxymethyl cellulose composite film loaded with poly(vinyl alcohol) microcapsules was prepared in this paper. The optimal film substrate ratios were obtained after ... ...

    Abstract In order to extend the shelf life of fruits and vegetables, a sodium alginate-sodium carboxymethyl cellulose composite film loaded with poly(vinyl alcohol) microcapsules was prepared in this paper. The optimal film substrate ratios were obtained after the response surface optimization. Poly(vinyl alcohol) microcapsules were prepared, clove essential oil was loaded into them to investigate the effects of microcapsules on the composite film properties, and the microcapsule composite film with the best overall performance was selected to be applied to blueberry preservation. The results showed that the composite film of 0.84% sodium alginate, 0.25% sodium carboxymethyl cellulose, and 0.56% glycerol presented excellent mechanical properties after adding 1.75% microcapsules. It had a good inhibitory effect on
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Different Microeukaryotic Trophic Groups Show Different Latitudinal Spatial Scale Dependences in Assembly Processes across the Continental Shelves of China.

    Zhang, Yong / Qu, Zhishuai / Zhang, Kexin / Li, Jiqiu / Lin, Xiaofeng

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: The relative role of stochasticity versus determinism is critically dependent on the spatial scale over which communities are studied. However, only a few studies have attempted to reveal how spatial scales influence the balance of different assembly ... ...

    Abstract The relative role of stochasticity versus determinism is critically dependent on the spatial scale over which communities are studied. However, only a few studies have attempted to reveal how spatial scales influence the balance of different assembly processes. In this study, we investigated the latitudinal spatial scale dependences in assembly processes of microeukaryotic communities in surface water and sediment along the continental shelves of China. It was hypothesized that different microeukaryotic trophic groups (i.e., autotroph, heterotroph, mixotroph, and parasite) showed different latitudinal scale dependences in their assembly processes. Our results disclosed that the relative importance of different assembly processes depended on a latitudinal space scale for planktonic microeukaryotes. In surface water, as latitudinal difference increased, the relative contributions of homogenous selection and homogenizing dispersal decreased for the entire community, while those of heterogeneous selection and drift increased. The planktonic autotrophic and heterotrophic groups shifted from stochasticity-dominated processes to heterogeneous selection as latitudinal differences surpassed thresholds of 8° and 16°, respectively. For mixotrophic and parasitic groups, however, the assembly processes were always dominated by drift across different spatial scales. The balance of different assembly processes for the autotrophic group was mainly driven by temperature, whereas that of the heterotrophic group was driven by salinity and geographical distance. In sediment, neither the entire microeukaryotic community nor the four trophic groups showed remarkable spatial scale dependences in assembly processes; they were always overwhelmingly dominated by the drift. This work provides a deeper understanding of the distribution mechanisms of microeukaryotes along the continental shelves of China from the perspective of trophic groups.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010124
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  6. Article ; Online: Primary NUT carcinoma of the lung diagnosed using EBUS-TBNA biopsy specimen: A case report.

    Zhang, Ke-Xin / Zhang, Hai-Ning / Liu, Li-Dan / Xu, Hong-Tao

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-02-19
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.02.034
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  7. Article: [Application of artificial intelligence in the diagnosis of prostate cancer].

    Zhang, Ke-Xin / Yu, Zhan-Peng / Shen, Tian-Yi / Tang, Hao

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 12, Page(s) 1043–1047

    Abstract: With the rise of precision medicine, the continuous expansionWith the rise of precision medicine, the continuous expansion the collective push from many other the application of Artificial Intelligence (AI) in prostate cancer diagnosis is increasingly ... ...

    Abstract With the rise of precision medicine, the continuous expansionWith the rise of precision medicine, the continuous expansion the collective push from many other the application of Artificial Intelligence (AI) in prostate cancer diagnosis is increasingly becoming a focal point. AI technology can effectively utilize diverse detection methods such as Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), and whole pathology slide imaging to efficiently identify and differentiate between benign and malignant lesions. The encouraging results from numerous studies herald the enormous potential of this field. This article aims to provide a comprehensive summary and analysis of the research progress made in AI for prostate cancer diagnosis, in order to better grasp the trends in this area of development.
    MeSH term(s) Male ; Humans ; Artificial Intelligence ; Prostatic Neoplasms/diagnostic imaging ; Prostate ; Pelvis ; Magnetic Resonance Imaging
    Language Chinese
    Publishing date 2024-04-19
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6577: Show issues Location:
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  8. Article ; Online: Regulation of phosphoglycerate kinase 1 and its critical role in cancer.

    Zhang, Kexin / Sun, Lixue / Kang, Yuanyuan

    Cell communication and signaling : CCS

    2023  Volume 21, Issue 1, Page(s) 240

    Abstract: Cells that undergo normal differentiation mainly rely on mitochondrial oxidative phosphorylation to provide energy, but most tumour cells rely on aerobic glycolysis. This phenomenon is called the "Warburg effect". Phosphoglycerate kinase 1 (PGK1) is a ... ...

    Abstract Cells that undergo normal differentiation mainly rely on mitochondrial oxidative phosphorylation to provide energy, but most tumour cells rely on aerobic glycolysis. This phenomenon is called the "Warburg effect". Phosphoglycerate kinase 1 (PGK1) is a key enzyme in aerobic glycolysis. PGK1 is involved in glucose metabolism as well as a variety of biological activities, including angiogenesis, EMT, mediated autophagy initiation, mitochondrial metabolism, DNA replication and repair, and other processes related to tumorigenesis and development. Recently, an increasing number of studies have proven that PGK1 plays an important role in cancer. In this manuscript, we discussed the effects of the structure, function, molecular mechanisms underlying PGK1 regulation on the initiation and progression of cancer. Additionally, PGK1 is associated with chemotherapy resistance and prognosis in tumour patients. This review presents an overview of the different roles played by PGK1 during tumorigenesis, which will help in the design of experimental studies involving PGK1 and enhance the potential for the use of PGK1 as a therapeutic target in cancer. Video Abstract.
    MeSH term(s) Humans ; Phosphoglycerate Kinase ; Neoplasms ; Carcinogenesis ; Cell Transformation, Neoplastic ; Autophagy
    Chemical Substances Phosphoglycerate Kinase (EC 2.7.2.3)
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Video-Audio Media ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2126315-2
    ISSN 1478-811X ; 1478-811X
    ISSN (online) 1478-811X
    ISSN 1478-811X
    DOI 10.1186/s12964-023-01256-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fe-Doped Metal Complex (LaCo

    Zhang, Kexin / Wang, Rui / Jiang, Fubin

    ACS omega

    2023  Volume 8, Issue 20, Page(s) 18090–18105

    Abstract: Photocatalytic water decomposition provides an environmentally friendly method of hydrogen production similar to "photosynthesis", while current research aims to develop affordable yet efficient photocatalysts. Oxygen vacancy is one of the most ... ...

    Abstract Photocatalytic water decomposition provides an environmentally friendly method of hydrogen production similar to "photosynthesis", while current research aims to develop affordable yet efficient photocatalysts. Oxygen vacancy is one of the most significant defects in metal oxide semiconductors, including perovskite, which substantially influences the semiconductor material's efficiency. To enhance the oxygen vacancy in the perovskite, we worked on doping Fe. A perovskite oxide nanostructure of LaCo
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c01393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Application and risk prediction of thrombolytic therapy in cardio-cerebrovascular diseases: a review.

    Zhang, Kexin / Jiang, Yao / Zeng, Hesong / Zhu, Hongling

    Thrombosis journal

    2023  Volume 21, Issue 1, Page(s) 90

    Abstract: Cardiocerebrovascular diseases (CVDs) are the leading cause of death worldwide, consuming huge healthcare budget. For CVD patients, the prompt assessment and appropriate administration is the crux to save life and improve prognosis. Thrombolytic therapy, ...

    Abstract Cardiocerebrovascular diseases (CVDs) are the leading cause of death worldwide, consuming huge healthcare budget. For CVD patients, the prompt assessment and appropriate administration is the crux to save life and improve prognosis. Thrombolytic therapy, as a non-invasive approach to achieve recanalization, is the basic component of CVD treatment. Still, there are risks that limits its application. The objective of this review is to give an introduction on the utilization of thrombolytic therapy in cardiocerebrovascular blockage diseases, including coronary heart disease and ischemic stroke, and to review the development in risk assessment of thrombolytic therapy, comparing the performance of traditional scales and novel artificial intelligence-based risk assessment models.
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118392-2
    ISSN 1477-9560
    ISSN 1477-9560
    DOI 10.1186/s12959-023-00532-0
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