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  1. Article ; Online: Injectable, self-healing poly(amino acid)-hydrogel based on phenylboronate ester bond for osteochondral tissue engineering.

    Li, Guifei / Shi, Zhen / Zong, Hongjie / Zhang, Kunxi / Yan, Shifeng / Yin, Jingbo

    Biomedical materials (Bristol, England)

    2023  Volume 18, Issue 5

    Abstract: A new generation of osteochondral integrated scaffolds is needed for articular osteochondral regeneration, which can not only facilitate the accurate construction of osteochondral scaffolds in a minimally invasive manner but also firmly combine the ... ...

    Abstract A new generation of osteochondral integrated scaffolds is needed for articular osteochondral regeneration, which can not only facilitate the accurate construction of osteochondral scaffolds in a minimally invasive manner but also firmly combine the subchondral bone layer and cartilage layer. Herein, an osteochondral integrated hydrogel scaffold was constructed by the poly(L-glutamic acid) (PLGA) based self-healing hydrogels with phenylboronate ester (PBE) as the dynamic cross-linking. The bone layer self-healing hydrogel (hydrogel O-S) was prepared by physically blending nanohydroxyapatite into the self-healing hydrogel PLGA-PBE-S, which was fabricated by 3-aminophenylboronic acid/glycidyl methacrylate-modified PLGA (PLGA-GMA-PBA) and 3-amino-1,2-propanediol/N-(2-aminoethyl) acrylamide-modified PLGA (PLGA-ADE-AP). The cartilage layer self-healing hydrogel (hydrogel C-S) was prepared by PLGA-GMA-APBA and glucosamine- modified PLGA-ADE-AP (PLGA-ADE-AP-G). Excellent injectability and self-healing profiles of hydrogel O-S and C-S were observed, the self-healing efficiencies were 97.02% ± 1.06% and 99.06% ± 0.57%, respectively. Based on the injectability and spontaneous healing on the interfaces of hydrogel O-S and C-S, the osteochondral hydrogel (hydrogel OC) was conveniently constructed in a minimally invasive manner. In addition,
    MeSH term(s) Tissue Engineering ; Hydrogels/chemistry ; Osteogenesis ; Amino Acids ; Tissue Scaffolds/chemistry
    Chemical Substances Hydrogels ; benzeneboronic acid (L12H7B02G5) ; Amino Acids
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2265222-X
    ISSN 1748-605X ; 1748-6041
    ISSN (online) 1748-605X
    ISSN 1748-6041
    DOI 10.1088/1748-605X/ace39b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6626: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Hyaluronic acid-

    Zhang, Shixi / Pan, Yuqing / Mao, Zhiyuan / Zhang, Jiahui / Zhang, Kunxi / Yin, Jingbo / Wang, Chen

    Bioengineering & translational medicine

    2022  Volume 8, Issue 2, Page(s) e10402

    Abstract: Diabetic patients are prone to developing chronic inflammation after trauma and have persistent nonhealing wounds. Reactive oxygen species (ROS) and recurrent bacterial infections at the site of long-term wounds also further delay skin wound healing and ... ...

    Abstract Diabetic patients are prone to developing chronic inflammation after trauma and have persistent nonhealing wounds. Reactive oxygen species (ROS) and recurrent bacterial infections at the site of long-term wounds also further delay skin wound healing and tissue regeneration. In this study, a granular gel (which exhibits ROS scavenging and antibacterial properties) is fabricated based on hyaluronic acid-
    Language English
    Publishing date 2022-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 2380-6761
    ISSN 2380-6761
    DOI 10.1002/btm2.10402
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  3. Article: Highly tough and elastic microspheric gel for transarterial catheter embolization in treatment of liver metastasis tumor.

    Wang, Shuyun / Yu, Hongjie / Wan, Guangsheng / Fang, Haowei / Mi, Jinxia / Xu, Wenqian / Sun, Kexiang / Zhang, Kunxi / Yin, Jingbo / Deng, Wanli

    Regenerative biomaterials

    2023  Volume 10, Page(s) rbad026

    Abstract: Transarterial embolization is a widely recognized clinical treatment method for liver tumors. Given that the soft and easily damaged features of embolic particles may limit tumor embolization efficiency, the present study carries out an attempt of ... ...

    Abstract Transarterial embolization is a widely recognized clinical treatment method for liver tumors. Given that the soft and easily damaged features of embolic particles may limit tumor embolization efficiency, the present study carries out an attempt of fabricating tough and elastic microspheric gel for promoting embolization efficiency. To promote the toughness of hydrogel, poly(ethylene glycol)-
    Language English
    Publishing date 2023-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2799042-4
    ISSN 2056-3426 ; 2056-3418
    ISSN (online) 2056-3426
    ISSN 2056-3418
    DOI 10.1093/rb/rbad026
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  4. Article ; Online: Comparative Physiological and Transcriptome Analysis Reveals Potential Pathways and Specific Genes Involved in Waterlogging Tolerance in Apple Rootstocks.

    Zhang, Kunxi / Chen, Xiaofei / Yuan, Penghao / Song, Chunhui / Song, Shangwei / Jiao, Jian / Wang, Miaomiao / Hao, Pengbo / Zheng, Xianbo / Bai, Tuanhui

    International journal of molecular sciences

    2023  Volume 24, Issue 11

    Abstract: Apple ( ...

    Abstract Apple (
    MeSH term(s) Malus/metabolism ; Gene Expression Profiling ; Fruit ; Plant Leaves/metabolism ; Hormones/metabolism ; Transcriptome ; Gene Expression Regulation, Plant ; Stress, Physiological/genetics
    Chemical Substances Hormones
    Language English
    Publishing date 2023-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24119298
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  5. Article ; Online: A "T.E.S.T." hydrogel bioadhesive assisted by corneal cross-linking for in situ sutureless corneal repair.

    Li, Meiyan / Wei, Ruoyan / Liu, Chang / Fang, Haowei / Yang, Weiming / Wang, Yunzhe / Xian, Yiyong / Zhang, Kunxi / He, Yong / Zhou, Xingtao

    Bioactive materials

    2023  Volume 25, Page(s) 333–346

    Abstract: Corneal transplantation is an effective clinical treatment for corneal diseases, which, however, is limited by donor corneas. It is of great clinical value to develop bioadhesive corneal patches with functions of "Transparency" and "Epithelium & Stroma ... ...

    Abstract Corneal transplantation is an effective clinical treatment for corneal diseases, which, however, is limited by donor corneas. It is of great clinical value to develop bioadhesive corneal patches with functions of "Transparency" and "Epithelium & Stroma generation", as well as "Suturelessness" and "Toughness". To simultaneously meet the "T.E.S.T." requirements, a light-curable hydrogel is designed based on methacryloylated gelatin (GelMA), Pluronic F127 diacrylate (F127DA) & Aldehyded Pluronic F127 (AF127) co-assembled bi-functional micelles and collagen type I (COL I), combined with clinically applied corneal cross-linking (CXL) technology for repairing damaged cornea. The patch formed after 5 min of ultraviolet irradiation possesses transparent, highly tough, and strongly bio-adhesive performance. Multiple cross-linking makes the patch withstand deformation near 600% and exhibit a burst pressure larger than 400 mmHg, significantly higher than normal intraocular pressure (10-21 mmHg). Besides, the slower degradation than GelMA-F127DA&AF127 hydrogel without COL I makes hydrogel patch stable on stromal beds
    Language English
    Publishing date 2023-02-11
    Publishing country China
    Document type Journal Article
    ISSN 2452-199X
    ISSN (online) 2452-199X
    DOI 10.1016/j.bioactmat.2023.02.006
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  6. Article ; Online: Building a Poly(amino acid)/Chitosan-Based Self-Healing Hydrogel via Host-Guest Interaction for Cartilage Regeneration.

    Li, Pengqiang / Zong, Hongjie / Li, Guifei / Shi, Zhen / Yu, Xi / Zhang, Kunxi / Xia, Pengfei / Yan, Shifeng / Yin, Jingbo

    ACS biomaterials science & engineering

    2023  Volume 9, Issue 8, Page(s) 4855–4866

    Abstract: Cartilage injury is a very common joint disease, and cartilage repair is a great challenge in clinical treatment due to the specific structure of cartilage tissue and its ... ...

    Abstract Cartilage injury is a very common joint disease, and cartilage repair is a great challenge in clinical treatment due to the specific structure of cartilage tissue and its microenvironment
    MeSH term(s) Rats ; Animals ; Chitosan ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Amino Acids/pharmacology ; Cartilage ; Regeneration
    Chemical Substances Chitosan (9012-76-4) ; Hydrogels ; Amino Acids
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c01547
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  7. Article: Tissue adhesive, ROS scavenging and injectable PRP-based 'plasticine' for promoting cartilage repair.

    Li, Shiao / Niu, Dawei / Fang, Haowei / Chen, Yancheng / Li, Jinyan / Zhang, Kunxi / Yin, Jingbo / Fu, Peiliang

    Regenerative biomaterials

    2023  Volume 11, Page(s) rbad104

    Abstract: Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel ... ...

    Abstract Platelet-rich plasma (PRP) that has various growth factors has been used clinically in cartilage repair. However, the short residence time and release time at the injury site limit its therapeutic effect. The present study fabricated a granular hydrogel that was assembled from gelatin microspheres and tannic acid through their abundant hydrogen bonding. Gelatin microspheres with the gelatin concentration of 10 wt% and the diameter distribution of 1-10 μm were used to assemble by tannic acid to form the granular hydrogel, which exhibited elasticity under low shear strain, but flowability under higher shear strain. The viscosity decreased with the increase in shear rate. Meanwhile, the granular hydrogel exhibited self-healing feature during rheology test. Thus, granular hydrogel carrying PRP not only exhibited well-performed injectability but also performed like a 'plasticine' that possessed good plasticity. The granular hydrogel showed tissue adhesion ability and reactive oxygen species scavenging ability. Granular hydrogel carrying PRP transplanted to full-thickness articular cartilage defects could integrate well with native cartilage, resulting in newly formed cartilage articular fully filled in defects and well-integrated with the native cartilage and subchondral bone. The unique features of the present granular hydrogel, including injectability, plasticity, porous structure, tissue adhesion and reactive oxygen species scavenging provided an ideal PRP carrier toward cartilage tissue engineering.
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2799042-4
    ISSN 2056-3426 ; 2056-3418
    ISSN (online) 2056-3426
    ISSN 2056-3418
    DOI 10.1093/rb/rbad104
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  8. Article ; Online: Pluronic F127-Lipoic Acid Adhesive Nanohydrogel Combining with Ce

    Wang, Tao / Fang, Haowei / Yalikun, Subate / Li, Jinyan / Pan, Yuqing / Zhang, Kunxi / Yin, Jingbo / Cui, Haiyan

    Biomacromolecules

    2023  Volume 25, Issue 2, Page(s) 924–940

    Abstract: Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, ...

    Abstract Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, tissue adhesive, and anti-inflammatory performance. Briefly, Ce
    MeSH term(s) Thioctic Acid ; Adhesives ; Poloxamer ; Lipopolysaccharides ; Wound Healing ; Hydrogels/pharmacology ; Anti-Inflammatory Agents ; Anti-Bacterial Agents ; Glycoproteins ; Polyethylenes ; Polypropylenes ; Polyphenols
    Chemical Substances Thioctic Acid (73Y7P0K73Y) ; Adhesives ; UCON 50-HB-5100 (9038-95-3) ; urinastatin (OR3S9IF86U) ; Poloxamer (106392-12-5) ; Tannic Acid ; Lipopolysaccharides ; Hydrogels ; Anti-Inflammatory Agents ; Anti-Bacterial Agents ; Glycoproteins ; Polyethylenes ; Polypropylenes ; Polyphenols
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Poly(l‐glutamic acid)‐based micellar hydrogel with improved mechanical performance and proteins loading

    Yu, Xi / Zhang, Kunxi / Kong, Xiaobo / Yin, Jingbo

    Journal of polymer science. 2019 Sept. 1, v. 57, no. 17

    2019  

    Abstract: Soft tissues, such as fat and skin, present high flexibility and are capable of withstanding large deformation in various functions. Hydrogels that can resemble the mechanical performance of soft tissue are unique and widely demanded. In this study, ... ...

    Abstract Soft tissues, such as fat and skin, present high flexibility and are capable of withstanding large deformation in various functions. Hydrogels that can resemble the mechanical performance of soft tissue are unique and widely demanded. In this study, micellar hydrogels based on biocompatible poly(l‐glutamic acid) (PLGA) were designed with the enhanced capacity to bear large deformation. Amphipathic triblock copolymer poly(ethylene glycol) acrylate‐co‐poly(ε‐caprolactone)‐co‐poly (ethylene glycol) acrylate (APEG‐PCL‐APEG) with two terminal double bonds was synthesized and self‐assembled into micelles. At the same time, graft copolymers, poly(l‐glutamic acid)‐g‐hydroxyethyl methacrylate (PLGA‐g‐HEMA) with double bonds were synthesized. APEG‐PCL‐APEG micelles and PLGA‐g‐HEMA were mixed to construct micellar hydrogel via radical polymerization. The crystalline structure and hydrophobic aggregation of copolymers (APEG‐PCL‐APEG) were found to associate with PCL molecular weight. Due to the hydrophobic stress dissipation and crystalline structure of the micelles, the softness and toughness of hydrogels were promoted, exhibiting a 25% increase in ultimate strain. Moreover, the micellar hydrogels were able to load proteins with long‐term retention. In addition, under dynamic mechanical stimulation, the release of proteins could be accelerated. Besides, the micellar hydrogels also supported rabbit adipose‐derived stem cells (rASCs) growth, thus exhibiting the potential toward soft tissue engineering. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2019, 57, 1115–1125
    Keywords chemical bonding ; composite polymers ; crystal structure ; deformation ; hardness ; hydrogels ; hydrophobicity ; lactones ; micelles ; molecular weight ; polyethylene glycol ; polyglutamic acid ; polymerization ; proteins ; rabbits ; stem cells ; surfactants ; tissue engineering ; tissues
    Language English
    Dates of publication 2019-0901
    Size p. 1115-1125.
    Publishing place John Wiley & Sons, Inc.
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1473448-5
    ISSN 1099-0488 ; 0887-6266
    ISSN (online) 1099-0488
    ISSN 0887-6266
    DOI 10.1002/polb.24866
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: A rice tubulin tyrosine ligase like 12 regulates phospholipase D activity and tubulin synthesis

    Zhang, Kunxi / Shi, Wenjing / Zheng, Xin / Liu, Xuan / Wang, Lixin / Riemann, Michael / Heintz, Dimitri / Nick, Peter

    Plant science. 2022 Mar., v. 316

    2022  

    Abstract: All plant α-tubulins encode a C-terminal tyrosine. An elusive tubulin tyrosine carboxypeptidase can cleave off, and a tubulin tyrosine ligase (TTL) re-ligate this tyrosine. The biological function of this cycle remains unclear but may correlate with ... ...

    Abstract All plant α-tubulins encode a C-terminal tyrosine. An elusive tubulin tyrosine carboxypeptidase can cleave off, and a tubulin tyrosine ligase (TTL) re-ligate this tyrosine. The biological function of this cycle remains unclear but may correlate with microtubule stability. To get insight into the functional context of this phenomenon, we used cold-induced elimination of microtubules as experimental model. In previous work, we had analysed a rice TTL-like 12 (OsTTLL12), the only potential candidate of plant TTL. To follow the effect of OsTTLL12 upon microtubule responses in vivo, we expressed OsTTLL12-RFP into tobacco BY-2 cells stably overexpressing NtTUA3-GFP. We found that overexpression of OsTTLL12-RFP made microtubules disappear faster in response to cold stress, accompanied with more rapid Ca²⁺ influx, culminating in reduced cold tolerance. Treatment with different butanols indicated that α-tubulin detyrosination/tyrosination differently interacts with phospholipase D (PLD) dependent signalling. In fact, rice PLDα1 decorated microtubules and increased detyrosinated α-tubulin. Unexpectedly, overexpression of the two proteins (OsTTLL12-RFP, NtTUA3-GFP) mutually regulated the accumulation of their transcripts, leading us to a model, where tubulin detyrosination feeds back upon tubulin transcripts and defines a subset of microtubules for interaction with PLD dependent stress signalling.
    Keywords calcium ; cold stress ; cold tolerance ; ligases ; microtubules ; models ; phospholipases ; rice ; tobacco ; tubulin ; tyrosine
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 742010-9
    ISSN 1873-2259 ; 0168-9452
    ISSN (online) 1873-2259
    ISSN 0168-9452
    DOI 10.1016/j.plantsci.2021.111155
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    In stock of ZB MED Bonn / Germany

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