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  1. Book ; Online: Dynamic Agriculture in East Asia: Land-Livelihood Interactions

    Zhang, Le / Kono, Yasuyuki

    2023  

    Keywords Philosophy ; livelihood efficiency ; land use ; coupling coordination ; types of households ; poverty-alleviated mountainous areas ; spin-offs ; innovation spillover ; agricultural cluster ; vegetable cluster in Shouguang City ; Shandong Province ; China ; land endowment ; economic endowment ; farmer heterogeneity ; land transfer out ; local knowledge ; resilience thinking ; rural development ; agriculture ; household livelihood strategy ; agricultural diversification ; heterogeneity ; lag effect ; social capital ; rural revitalization ; crop specialization ; Poyang Lake ; fishermen ; policy ; livelihoods ; landscape patterns ; transformation ; livelihood resilience ; family life cycle ; GeoDetector ; LMG metric model ; dryland area ; livelihood strategies ; policy change ; inland fishermen ; employment conditions ; local food system ; vegetable production ; commitment ; cooperative relationship ; urban agricultural heritage system ; high bed-low ditch agroecosystem ; farmland ; land acquisition ; wetland ; nature reserve ; smart farming technology ; rice ; hilly and mountainous areas ; sustainable farmland ; Japan
    Language English
    Size 1 electronic resource (230 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030377130
    ISBN 9783036573342 ; 3036573348
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Protective Effect of Tertiary Butylhydroquinone against Obesity-induced Skeletal Muscle Pathology in Post-weaning High Fat Diet Fed Rats.

    Zhang, Le

    Current pharmaceutical biotechnology

    2023  

    Abstract: Background: Obesity deleteriously affects skeletal muscle functionality starting from infancy to adulthood, leading to dysfunctional skeletal muscle.: Objectives: This study, therefore, evaluated the protective action of tert-butylhydroquinone (tBHQ) ...

    Abstract Background: Obesity deleteriously affects skeletal muscle functionality starting from infancy to adulthood, leading to dysfunctional skeletal muscle.
    Objectives: This study, therefore, evaluated the protective action of tert-butylhydroquinone (tBHQ) against obesity-induced skeletal muscle pathology in high-fat diet (HFD) fed rats.
    Methods: Twenty post-weaning male albino rats were randomized into four groups of five rats each as: Group 1 (control), Group 2 (HFD), Group 3 (orlistat) and Group 4 (tBHQ). Group one received rat pellets for 12 weeks, while groups 2 to 4 received HFD for 12 weeks. At the end of week 8, obesity was confirmed with Lee Obesity Index and body mass index values of ≥ 303 and ≥ 0.68 gcm2, respectively. Group 3 was given oral administration of orlistat (10 mg/kg, once daily), while group 4 was given oral administration of tBHQ (25 mg/kg, once daily). Administration of orlistat and tBHQ commenced from week 9 to the end of the experiment.
    Results: Chronic exposure of post-weaning rats to HFD led to their development of the metabolic syndrome phenotypes in adulthood, characterized by obesity, hyperglycemia, dyslipidaemia, hyperinsulinaemia, insulin resistance as well as induction of oxidative stress and alteration of skeletal muscle markers, which were mitigated following supplementation with orlistat and tBHQ.
    Conclusion: The study showed the anti-obesity potentials of tBHQ and its protective action against HFD obesity-induced skeletal muscular pathology.
    Language English
    Publishing date 2023-08-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201024666230810094809
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6212: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Integrative Analysis Revealed LINC00847 as a Potential Target of Tumor Immunotherapy.

    Chen, Xiujuan / Zhang, Le

    Applied biochemistry and biotechnology

    2023  Volume 195, Issue 10, Page(s) 6345–6358

    Abstract: Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer-related death. Lung adenocarcinoma (LUAD) is the most common form of lung cancer and has a low 5-year survival rate. Therefore, much more research is needed to ... ...

    Abstract Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer-related death. Lung adenocarcinoma (LUAD) is the most common form of lung cancer and has a low 5-year survival rate. Therefore, much more research is needed to identify cancer biomarkers, promote biomarker-driven therapy and improve treatment outcomes. LncRNAs have been reported to participate in various physiological and pathological processes, especially in cancer, and thus have attracted much attention. In this study, lncRNAs were screened from the single-cell RNA-seq dataset CancerSEA. Among them, four lncRNAs (HCG18, NNT-AS1 and LINC00847 and CYTOR) were closely associated with the prognosis of LUAD patients according to Kaplan-Meier analysis. Further study explored the correlations between these four lncRNAs and immune cell infiltration in cancer. In LUAD, LINC00847 was positively correlated with the immune infiltration of B cells, CD8 T cells, and dendritic cells. LINC00847 decreased the expression of PD-L1, immune checkpoint blockade (ICB) immunotherapy-related gene, which suggests that LINC00847 is a potential new target for tumor immunotherapy.
    MeSH term(s) Humans ; RNA, Long Noncoding/genetics ; Lung Neoplasms/genetics ; Lung Neoplasms/therapy ; Prognosis ; Immunotherapy ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism
    Chemical Substances RNA, Long Noncoding ; Biomarkers, Tumor
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392344-7
    ISSN 1559-0291 ; 0273-2289
    ISSN (online) 1559-0291
    ISSN 0273-2289
    DOI 10.1007/s12010-023-04387-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3053: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Trends and hot topics in linguistics studies from 2011 to 2021: A bibliometric analysis of highly cited papers.

    Yan, Sheng / Zhang, Le

    Frontiers in psychology

    2023  Volume 13, Page(s) 1052586

    Abstract: High citations most often characterize quality research that reflects the foci of the discipline. This study aims to spotlight the most recent hot topics and the trends looming from the highly cited papers (HCPs) in Web of Science category ... ...

    Abstract High citations most often characterize quality research that reflects the foci of the discipline. This study aims to spotlight the most recent hot topics and the trends looming from the highly cited papers (HCPs) in Web of Science category of
    Language English
    Publishing date 2023-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1052586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cytometry and analytical methods in COVID-19 diagnostics and potential treatment: A special issue on Cytometry Part A.

    Zhang, Le / Jin, Dayong

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2023  Volume 103, Issue 2, Page(s) 105–106

    MeSH term(s) Humans ; COVID-19/diagnosis ; Flow Cytometry ; Research ; COVID-19 Testing
    Language English
    Publishing date 2023-02-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.24719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 68: Show issues

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  6. Article ; Online: A Review of the Application of Spatial Transcriptomics in Neuroscience.

    Zhang, Le / Xiong, Zhenqi / Xiao, Ming

    Interdisciplinary sciences, computational life sciences

    2024  

    Abstract: Since spatial transcriptomics can locate and distinguish the gene expression of functional genes in special regions and tissue, it is important for us to investigate the brain development, the development mechanism of brain diseases, and the relationship ...

    Abstract Since spatial transcriptomics can locate and distinguish the gene expression of functional genes in special regions and tissue, it is important for us to investigate the brain development, the development mechanism of brain diseases, and the relationship between brain structure and function in Neuroscience (or Brain science). While previous studies have introduced the crucial spatial transcriptomic techniques and data analysis methods, there are few studies to comprehensively overview the key methods, data resources, and technological applications of spatial transcriptomics in Neuroscience. For these reasons, we first investigate several common spatial transcriptomic data analysis approaches and data resources. Second, we introduce the applications of the spatial transcriptomic data analysis approaches in Neuroscience. Third, we summarize the integrating spatial transcriptomics with other technologies in Neuroscience. Finally, we discuss the challenges and future research directions of spatial transcriptomics in Neuroscience.
    Language English
    Publishing date 2024-02-20
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2493085-4
    ISSN 1867-1462 ; 1913-2751
    ISSN (online) 1867-1462
    ISSN 1913-2751
    DOI 10.1007/s12539-024-00603-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long noncoding RNAs in human reproductive processes and diseases.

    Zhang, Le / Sun, Hailong / Chen, Xiujuan

    Molecular reproduction and development

    2024  Volume 91, Issue 1, Page(s) e23728

    Abstract: Infertility has become a global disease burden. Although assisted reproductive technologies are widely used, the assisted reproduction birth rate is no more than 30% worldwide. Therefore, understanding the mechanisms of reproduction can provide new ... ...

    Abstract Infertility has become a global disease burden. Although assisted reproductive technologies are widely used, the assisted reproduction birth rate is no more than 30% worldwide. Therefore, understanding the mechanisms of reproduction can provide new strategies to improve live birth rates and clinical outcomes of enhanced implantation. Long noncoding RNAs (lncRNAs) have been reported to exert regulatory roles in various biological processes and diseases in many species. In this review, we especially focus on the role of lncRNAs in human reproduction. We summarize the function and mechanisms of lncRNAs in processes vital to reproduction, such as spermatogenesis and maturation, sperm motility and morphology, follicle development and maturation, embryo development and implantation. Then, we highlight the importance and diverse potential of lncRNAs as good diagnostic molecular biomarkers and therapeutic targets for infertility treatment.
    MeSH term(s) Humans ; Male ; RNA, Long Noncoding/genetics ; Sperm Motility ; Reproduction/genetics ; Spermatogenesis/genetics ; Infertility
    Chemical Substances RNA, Long Noncoding
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 20321-x
    ISSN 1098-2795 ; 1040-452X
    ISSN (online) 1098-2795
    ISSN 1040-452X
    DOI 10.1002/mrd.23728
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2759: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The correlation between iodine and metabolism: a review.

    Zhang, Le / Shang, Fangjian / Liu, Cong / Zhai, Xiaodan

    Frontiers in nutrition

    2024  Volume 11, Page(s) 1346452

    Abstract: Iodine is involved in the synthesis of thyroid hormones and plays a crucial role in human life. Both iodine deficiency and excess are common issues in certain populations. Iodine also has extrathyroidal effects on organs that can uptake it independently ... ...

    Abstract Iodine is involved in the synthesis of thyroid hormones and plays a crucial role in human life. Both iodine deficiency and excess are common issues in certain populations. Iodine also has extrathyroidal effects on organs that can uptake it independently of thyroid hormones. Recently, multiple clinical studies have shown a connection between iodine intake and metabolic disorders, such as metabolic syndrome, obesity, diabetes, hypertension, and dyslipidemia. However, the results of these studies have been inconsistent, and the mechanisms behind these associations are still not well understood. Therefore, in this review, we aim to examine the recent research progress regarding the relationship between iodine and metabolic disorders, along with the relevant mechanisms.
    Language English
    Publishing date 2024-03-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2024.1346452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Porous rod-shaped Fe

    Chen, Hang / Han, Caiqin / Zhang, Le / Wu, Ying

    Nanotechnology

    2024  Volume 35, Issue 19

    Abstract: A surface enhanced Raman scattering (SERS) substrate of porous rod-shaped ferric oxide ( ... ...

    Abstract A surface enhanced Raman scattering (SERS) substrate of porous rod-shaped ferric oxide (Fe
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/ad27ab
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Melatonin improves stroke through MDM2-mediated ubiquitination of ACSL4.

    Ji, Qing / Zhang, Le / Ye, Hui

    Aging

    2024  Volume 16, Issue 2, Page(s) 1925–1937

    Abstract: The objective of this study is to investigate the impact of melatonin on ischemic brain injury and elucidate its underlying molecular mechanism. In this investigation, a mouse model of middle cerebral artery occlusion (MCAO) was established using the ... ...

    Abstract The objective of this study is to investigate the impact of melatonin on ischemic brain injury and elucidate its underlying molecular mechanism. In this investigation, a mouse model of middle cerebral artery occlusion (MCAO) was established using the thread occlusion method, followed by treatment with two different doses of melatonin: 5 mg/kg and 10 mg/kg. Additionally, HT-22 cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) and treated with varying concentrations of melatonin. The findings demonstrated that melatonin significantly reduced the extent of cerebral ischemia, nerve damage, brain edema, and neuronal apoptosis in MCAO mice.
    MeSH term(s) Animals ; Mice ; Apoptosis ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Glucose/pharmacology ; Infarction, Middle Cerebral Artery/metabolism ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Stroke/drug therapy ; Stroke/metabolism ; Proto-Oncogene Proteins c-mdm2/metabolism ; Coenzyme A Ligases/metabolism ; Ubiquitination
    Chemical Substances Glucose (IY9XDZ35W2) ; Melatonin (JL5DK93RCL) ; Mdm2 protein, mouse (EC 2.3.2.27) ; Acsl4 protein, mouse (EC 6.2.1.-) ; Proto-Oncogene Proteins c-mdm2 (EC 2.3.2.27) ; Coenzyme A Ligases (EC 6.2.1.-)
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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